Kupferschmidt K. Cruise ship outbreak spotlights a little-studied hantavirus. Science. 6799;392(6799):672–3. https://doi.org/10.1126/science.aei8221.

Article  Google Scholar 

World Health Organization. Disease outbreak news. Hantavirus cluster linked to cruise ship travel—multi-country. 2026. Available at: https://www.who.int/emergencies/disease-outbreak-news/item/2026-DON601.

Andes Virus Outbreak Working G. Andes hantavirus outbreak on a cruise ship, 2026. N Engl J Med. 2026. https://doi.org/10.1056/NEJMc2606496.

Mora-Rillo M, Gupta N, Gkrania-Klotsas E, Drexler JF, Jokelainen P, Tsiodras S, et al. Andes hantavirus outbreak on a cruise ship - an ESCMID Emerging Infections Subcommittee (EIS) rapid assessment. Clin Microbiol Infect. 2026. https://doi.org/10.1016/j.cmi.2026.05.016.

Article  PubMed  Google Scholar 

Rubin R. Hantavirus outbreak: first test of US public health response after WHO withdrawal. JAMA. 2026. https://doi.org/10.1001/jama.2026.9419.

Article  PubMed  Google Scholar 

Battisti AJ, Chu YK, Chipman PR, Kaufmann B, Jonsson CB, Rossmann MG. Structural studies of Hantaan virus. J Virol. 2011;85(2):835–41. https://doi.org/10.1128/JVI.01847-10.

Article  CAS  PubMed  Google Scholar 

Huiskonen JT, Hepojoki J, Laurinmaki P, Vaheri A, Lankinen H, Butcher SJ, et al. Electron cryotomography of Tula hantavirus suggests a unique assembly paradigm for enveloped viruses. J Virol. 2010;84(10):4889–97. https://doi.org/10.1128/JVI.00057-10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Parvate A, Williams EP, Taylor MK, Chu YK, Lanman J, Saphire EO, et al. Diverse morphology and structural features of old and new world hantaviruses. Viruses. 2019. https://doi.org/10.3390/v11090862.

Article  PubMed  PubMed Central  Google Scholar 

Jonsson CB, Figueiredo LT, Vapalahti O. A global perspective on hantavirus ecology, epidemiology, and disease. Clin Microbiol Rev. 2010;23(2):412–41. https://doi.org/10.1128/CMR.00062-09.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palma RE, Polop JJ, Owen RD, Mills JN. Ecology of rodent-associated hantaviruses in the Southern Cone of South America: Argentina, Chile, Paraguay, and Uruguay. J Wildl Dis. 2012;48(2):267–81. https://doi.org/10.7589/0090-3558-48.2.267.

Article  PubMed  Google Scholar 

de Oliveira RC, Guterres A, Fernandes J, D’Andrea PS, Bonvicino CR, de Lemos ER. Hantavirus reservoirs: current status with an emphasis on data from Brazil. Viruses. 2014;6(5):1929–73. https://doi.org/10.3390/v6051929.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee HW, Lee PW, Baek LJ, Song CK, Seong IW. Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg. 1981;30(5):1106–12. https://doi.org/10.4269/ajtmh.1981.30.1106.

Article  CAS  PubMed  Google Scholar 

Easterbrook JD, Klein SL. Immunological mechanisms mediating hantavirus persistence in rodent reservoirs. PLoS Pathog. 2008;4(11):e1000172. https://doi.org/10.1371/journal.ppat.1000172.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toro J, Vega JD, Khan AS, Mills JN, Padula P, Terry W, et al. An outbreak of hantavirus pulmonary syndrome, Chile, 1997. Emerg Infect Dis. 1997;4(4):687–94. https://doi.org/10.3201/eid0404.980425.

Article  Google Scholar 

Lopez N, Padula P, Rossi C, Lazaro ME, Franze-Fernandez MT. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology. 1996;220(1):223–6. https://doi.org/10.1006/viro.1996.0305.

Article  CAS  PubMed  Google Scholar 

Centers for Disease C, Prevention. Hantavirus pulmonary syndrome -- Chile, 1997. MMWR Morb Mortal Wkly Rep. 1997;46(40):949–51.

Padula PJ, Edelstein A, Miguel SD, Lopez NM, Rossi CM, Rabinovich RD. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology. 1998;241(2):323–30. https://doi.org/10.1006/viro.1997.8976.

Article  CAS  PubMed  Google Scholar 

Enria D, Padula P, Segura EL, Pini N, Edelstein A, Posse CR, et al. Hantavirus pulmonary syndrome in Argentina. Possibility of person to person transmission. Medicina (B Aires). 1996;56(6):709–11.

Chaparro J, Vega J, Terry W, Vera JL, Barra B, Meyer R, et al. Assessment of person-to-person transmission of hantavirus pulmonary syndrome in a Chilean hospital setting. J Hosp Infect. 1998;40(4):281–5. https://doi.org/10.1016/s0195-6701(98)90304-8.

Article  CAS  PubMed  Google Scholar 

Ferres M, Vial P, Marco C, Yanez L, Godoy P, Castillo C, et al. Prospective evaluation of household contacts of persons with hantavirus cardiopulmonary syndrome in Chile. J Infect Dis. 2007;195(11):1563–71. https://doi.org/10.1086/516786.

Article  PubMed  Google Scholar 

Schmaljohn CS, Hasty SE, Harrison SA, Dalrymple JM. Characterization of Hantaan virions, the prototype virus of hemorrhagic fever with renal syndrome. J Infect Dis. 1983;148(6):1005–12. https://doi.org/10.1093/infdis/148.6.1005.

Article  CAS  PubMed  Google Scholar 

Schmaljohn CS, Jennings GB, Hay J, Dalrymple JM. Coding strategy of the S genome segment of Hantaan virus. Virology. 1986;155(2):633–43. https://doi.org/10.1016/0042-6822(86)90223-0.

Article  CAS  PubMed  Google Scholar 

Schmaljohn CS, Hasty SE, Dalrymple JM, LeDuc JW, Lee HW, von Bonsdorff CH, et al. Antigenic and genetic properties of viruses linked to hemorrhagic fever with renal syndrome. Science. 4690;227(4690):1041–4. https://doi.org/10.1126/science.2858126.

Article  Google Scholar 

Khaiboullina SF, Morzunov SP, St Jeor SC. Hantaviruses: molecular biology, evolution and pathogenesis. Curr Mol Med. 2005;5(8):773–90. https://doi.org/10.2174/156652405774962317.

Article  CAS  PubMed  Google Scholar 

Bradfute SB, Calisher CH, Klempa B, Klingstrom J, Kuhn JH, Laenen L, et al. ICTV virus taxonomy profile: Hantaviridae 2024. J Gen Virol. 2024. https://doi.org/10.1099/jgv.0.001975.

Article  PubMed  PubMed Central  Google Scholar 

Kuhn JH, Bradfute SB, Calisher CH, Klempa B, Klingstrom J, Laenen L, et al. Pending reorganization of Hantaviridae to include only completely sequenced viruses: a call to action. Viruses. 2023. https://doi.org/10.3390/v15030660.

Article  PubMed  PubMed Central  Google Scholar 

Gavrilovskaya IN, Brown EJ, Ginsberg MH, Mackow ER. Cellular entry of hantaviruses which cause hemorrhagic fever with renal syndrome is mediated by beta3 integrins. J Virol. 1999;73(5):3951–9. https://doi.org/10.1128/JVI.73.5.3951-3959.1999.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gavrilovskaya IN, Shepley M, Shaw R, Ginsberg MH, Mackow ER. beta3 Integrins mediate the cellular entry of hantaviruses that cause respiratory failure. Proc Natl Acad Sci U S A. 1998;95(12):7074–9. https://doi.org/10.1073/pnas.95.12.7074.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Larson RS, Brown DC, Ye C, Hjelle B. Peptide antagonists that inhibit Sin Nombre virus and hantaan virus entry through the beta3-integrin receptor. J Virol. 2005;79(12):7319–26. https://doi.org/10.1128/JVI.79.12.7319-7326.2005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Somanath PR, Ciocea A, Byzova TV. Integrin and growth factor receptor alliance in angiogenesis. Cell Biochem Biophys. 2009;53(2):53–64. https://doi.org/10.1007/s12013-008-9040-5.

Article  CAS  PubMed  Google Scholar 

Krautkramer E, Zeier M. Hantavirus causing hemorrhagic fever with renal syndrome enters from the apical surface and requires decay-accelerating factor (DAF/CD55). J Virol. 2008;82(9):4257–64. https://doi.org/10.1128/JVI.02210-07.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buranda T, Wu Y, Perez D, Jett SD, BonduHawkins V, Ye C, et al. Recognition of decay accelerating fa