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Plasma metabolomic and inflammatory profiles associated with low physical function in heart failure: an integrated cardiac–metabolic–muscular phenotype
Plasma metabolomic and inflammatory profiles associated with low physical function in heart failure: an integrated cardiac–metabolic–muscular phenotype
Dysregulated metabolomic profiles (dysmetabolism) have been observed in patients with heart failure (HF). In this study, w...
TTV virome marks immune exhaustion, α7nAChR alteration, and mortality in elderly patients with severe COPD
TTV virome marks immune exhaustion, α7nAChR alteration, and mortality in elderly patients with severe COPD
Torque teno virus (TTV) viremia, part of the human virome, is emerging as a dynamic marker of immune competence, yet its l...
Interaction of moderate-to-vigorous physical activity and brain amyloid accumulation on longitudinal cognitive change
Interaction of moderate-to-vigorous physical activity and brain amyloid accumulation on longitudinal cognitive change
Amyloid β (Aβ)–related cognitive decline is a key target for dementia prevention; however, the intensity-d...
Epileptiform discharges in neurodegenerative diseases linked to atrophy but not associated with iron depositions
Epileptiform discharges in neurodegenerative diseases linked to atrophy but not associated with iron depositions
Epileptiform discharges in Alzheimer’s disease (AD) and Lewy body dementia (DLB) may be associated with cognitive de...
Telomere length dynamics do not predict subclinical atherosclerosis progression over a six-year period
Telomere length dynamics do not predict subclinical atherosclerosis progression over a six-year period
Subclinical atherosclerosis (SA) burden and progression are independently associated with all-cause mortality. However, mo...
Multimorbidity as a predictor of mortality in companion dogs
Multimorbidity as a predictor of mortality in companion dogs
Multimorbidity, the presence of two or more conditions, is associated with a higher risk of death as individuals age. Howe...
The role of cellular senescence in immune-metabolic features and prognosis of ovarian cancer: an integrated analysis based on single-cell sequencing and multi-omics data
The role of cellular senescence in immune-metabolic features and prognosis of ovarian cancer: an integrated analysis based on single-cell sequencing and multi-omics data
Ovarian cancer is characterized by a high recurrence rate, and platinum resistance often contributes to poor patient outco...
Association of high-intensity evening light exposure with risk of incident age-related macular degeneration, cataract, and glaucoma: a prospective cohort study of 82,826 participants
Association of high-intensity evening light exposure with risk of incident age-related macular degeneration, cataract, and glaucoma: a prospective cohort study of 82,826 participants
Excessive artificial light at night (ALAN) disrupts circadian rhythms and may accelerate ocular aging; however, personal o...
Andes virus and the aging host: lessons from the 2026 outbreak and a framework for age-related disease severity
Andes virus and the aging host: lessons from the 2026 outbreak and a framework for age-related disease severity
Andes virus (ANDV) is the most virulent New World orthohantavirus, responsible for hantavirus cardiopulmonary syndrome (HC...
Age and sex dependent shift in murine gut microbiome reveals pathological links to host cardiovascular and metabolic pathways
Age and sex dependent shift in murine gut microbiome reveals pathological links to host cardiovascular and metabolic pathways
The gut microbiome undergoes dynamic, sex-dependent changes across the lifespan. However, comprehensive studies examining ...
Quantitative sleep EEG identifies CSF core biomarker-related subgroups in Alzheimer’s disease
Quantitative sleep EEG identifies CSF core biomarker-related subgroups in Alzheimer’s disease
Early detection and biological characterization of Alzheimer’s disease (AD) remain challenging, as current diagnosti...
Combating Alzheimer’s through sleep and exercise (CASE): A study protocol
Combating Alzheimer’s through sleep and exercise (CASE): A study protocol
Dementia affects over 55 million people worldwide, with Alzheimer’s disease (AD) comprising most cases. Because cura...
Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study
Associations of cardiorespiratory fitness with structural brain networks in ageing: insights from The Maastricht Study
Higher cardiorespiratory fitness (CRF) has been linked to healthier brain ageing, which includes preservation of white mat...
Expected lifespan and healthspan among rural and urban individuals in Java, Indonesia
Expected lifespan and healthspan among rural and urban individuals in Java, Indonesia
In Indonesia, adults living in rural areas have a longer life expectancy than their urban counterparts. Beyond observed lo...
Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation
Licochalcone a enhances cognitive resilience in APP/PS1 Mice by modulating glucose metabolism, Aβ burden, and neuroinflammation
Alzheimer's disease (AD) is a complex neurodegenerative disorder. Current therapeutic approaches targeting a single pa...
Neurovascular decoupling and compensatory network recruitment during speech perception in aging: evidence from EEG-fNIRS
Neurovascular decoupling and compensatory network recruitment during speech perception in aging: evidence from EEG-fNIRS
Age-related decline in speech perception is a prominent challenge in auditory aging, especially under noise conditions. Ho...
Health insurance, healthcare access, and their roles in the association between blood lead levels and epigenetic aging in United States adults
Health insurance, healthcare access, and their roles in the association between blood lead levels and epigenetic aging in United States adults
Lead exposure remains a significant public health problem, and even within current standards, most individuals have limite...
In memoriam: Thomas Eugene Johnson
In memoriam: Thomas Eugene Johnson
The alternative text for this image may have been generated using AI.Tom (as he was k...
Cognitive trajectories and mortality risk in older adults: a 9-year follow-up study
Cognitive trajectories and mortality risk in older adults: a 9-year follow-up study
Cognitive decline is a central feature of aging and a major determinant of disability and mortality. Understanding cogniti...
International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus
International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus
Normative ageingEvery individual ages uniquely. Whilst the literature has used terms such as ‘average’ and ‘typical’ agein...
The senolytic ABT-263 improves cognitive functions in middle-aged male, but not female, atherosclerotic LDLr;hApoB mice
The senolytic ABT-263 improves cognitive functions in middle-aged male, but not female, atherosclerotic LDLr;hApoB mice
Accumulation of cerebral senescent cells may compromise the continuum between vascular and neuronal function, leading to d...
Persisting blood–brain barrier disruption following cisplatin treatment in a mouse model of chemotherapy-associated cognitive impairment
Persisting blood–brain barrier disruption following cisplatin treatment in a mouse model of chemotherapy-associated cognitive impairment
Chemotherapy-related cognitive impairment, commonly referred to as “chemobrain,” significantly affects cancer ...
ChatGPT-estimated occupational complexity predicts cognitive outcomes and cortical thickness above and beyond socioeconomic status among older adults
ChatGPT-estimated occupational complexity predicts cognitive outcomes and cortical thickness above and beyond socioeconomic status among older adults
Many aging cohort studies have collected data on participants’ job titles, yet these job titles were seldom analyzed...
Awareness, knowledge, and motivations about lifespan, healthspan, and Healthy Longevity Medicine in the general population: the HEalthy LOngevity (HELO) conceptual framework
Awareness, knowledge, and motivations about lifespan, healthspan, and Healthy Longevity Medicine in the general population: the HEalthy LOngevity (HELO) conceptual framework
The global population is ageing and the gap between lifespan (total years lived) and healthspan (years lived free of disea...
SenSkin™: a human skin-specific cellular senescence gene set
SenSkin™: a human skin-specific cellular senescence gene set
Cellular senescence gene sets have been leveraged to overcome the inadequate sensitivity or specificity of single markers....
Improving care interactions (and training) in nursing homes with artificial intelligence
Improving care interactions (and training) in nursing homes with artificial intelligence
As the population continues to age, nursing homes will increasingly play a key role in caring for dependent individuals. T...
Decoding cognitive aging: how white matter tracts and demographics distinguish potential Super-Agers
Decoding cognitive aging: how white matter tracts and demographics distinguish potential Super-Agers
Most adults experience age-related cognitive decline. However, “Positive-Agers” exhibit superior cognition com...
Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle
Resistance exercise training in older men reduces ATF4-activated and senescence-associated mRNAs in skeletal muscle
Sarcopenia increases the risk of frailty, morbidity, and mortality in older adults. Resistance exercise training improves ...
Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice
Restoring neuropetide Y levels in the hypothalamus ameliorates premature aging phenotype in mice
The hypothalamus has been recognized as a regulator of whole-body aging. Neuropeptide Y (NPY), highly abundant in the cent...
Associations between shift work and biological age acceleration: A population-based study
Associations between shift work and biological age acceleration: A population-based study
This study aimed to examine the associations between shift work and biological age acceleration (BAA) and to explore poten...
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