Corley C, McElroy T, Sridharan B, Trujillo M, Simmons P, Kandel S, Sykes DJ, Robeson MS 2nd, Allen AR. Physiological and cognitive changes after treatments of cyclophosphamide, methotrexate, and fluorouracil: implications of the gut microbiome and depressive-like behavior. Front Neurosci. 2023;17:1212791. https://doi.org/10.3389/fnins.2023.1212791.
Article PubMed PubMed Central Google Scholar
Ibrahim EY, Domenicano I, Nyhan K, Elfil M, Mougalian SS, Cartmel B, Ehrlich BE. Cognitive Effects and Depression Associated With Taxane-Based Chemotherapy in Breast Cancer Survivors: A Meta-Analysis. Front Oncol. 2021;11:642382. https://doi.org/10.3389/fonc.2021.642382.
Article CAS PubMed PubMed Central Google Scholar
Wefel JS, Saleeba AK, Buzdar AU, Meyers CA. Acute and late onset cognitive dysfunction associated with chemotherapy in women with breast cancer. Cancer. 2010;116:3348–56. https://doi.org/10.1002/cncr.25098.
Wefel JS, Lenzi R, Theriault RL, Davis RN, Meyers CA. The cognitive sequelae of standard-dose adjuvant chemotherapy in women with breast carcinoma: results of a prospective, randomized, longitudinal trial. Cancer. 2004;100:2292–9. https://doi.org/10.1002/cncr.20272.
Article CAS PubMed Google Scholar
Tao L, Lin H, Yan Y, Xu X, Wang L, Zhang J, Yu Y. Impairment of the executive function in breast cancer patients receiving chemotherapy treatment: a functional MRI study. Eur J Cancer Care (Engl). 2017;26. https://doi.org/10.1111/ecc.12553
Tager FA, McKinley PS, Schnabel FR, El-Tamer M, Cheung YK, Fang Y, Golden CR, Frosch ME, Habif U, Mulligan MM, Chen IS, Hershman DL. The cognitive effects of chemotherapy in post-menopausal breast cancer patients: a controlled longitudinal study. Breast Cancer Res Treat. 2010;123:25–34. https://doi.org/10.1007/s10549-009-0606-8.
Soussain C, Ricard D, Fike JR, Mazeron JJ, Psimaras D, Delattre JY. CNS complications of radiotherapy and chemotherapy. Lancet. 2009;374:1639–51. https://doi.org/10.1016/S0140-6736(09)61299-X.
Article CAS PubMed Google Scholar
Jansen CE, Miaskowski C, Dodd M, Dowling G, Kramer J. A metaanalysis of studies of the effects of cancer chemotherapy on various domains of cognitive function. Cancer. 2005;104:2222–33. https://doi.org/10.1002/cncr.21469.
Jansen CE, Dodd MJ, Miaskowski CA, Dowling GA, Kramer J. Preliminary results of a longitudinal study of changes in cognitive function in breast cancer patients undergoing chemotherapy with doxorubicin and cyclophosphamide. Psychooncology. 2008;17:1189–95. https://doi.org/10.1002/pon.1342.
Hermelink K, Untch M, Lux MP, Kreienberg R, Beck T, Bauerfeind I, Munzel K. Cognitive function during neoadjuvant chemotherapy for breast cancer: results of a prospective, multicenter, longitudinal study. Cancer. 2007;109:1905–13. https://doi.org/10.1002/cncr.22610.
Article CAS PubMed Google Scholar
Ahire C, Nyul-Toth A, DelFavero J, Gulej R, Faakye JA, Tarantini S, Kiss T, Kuan-Celarier A, Balasubramanian P, Ungvari A, Tarantini A, Nagaraja R, Yan F, Tang Q, Mukli P, Csipo T, Yabluchanskiy A, Campisi J, Ungvari Z, Csiszar A. Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)-induced chemobrain. Aging Cell. 2023:e13832. https://doi.org/10.1111/acel.13832
Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 2019;99:21–78. https://doi.org/10.1152/physrev.00050.2017.
Article CAS PubMed Google Scholar
Jacobs S, McCully CL, Murphy RF, Bacher J, Balis FM, Fox E. Extracellular fluid concentrations of cisplatin, carboplatin, and oxaliplatin in brain, muscle, and blood measured using microdialysis in nonhuman primates. Cancer Chemother Pharmacol. 2010;65:817–24. https://doi.org/10.1007/s00280-009-1085-7.
Article CAS PubMed Google Scholar
Nyul-Toth A, Patai R, Csiszar A, Ungvari A, Gulej R, Mukli P, Yabluchanskiy A, Benyo Z, Sotonyi P, Prodan CI, Liotta EM, Toth P, Elahi F, Barsi P, Maurovich-Horvat P, Sorond FA, Tarantini S, Ungvari Z. Linking peripheral atherosclerosis to blood-brain barrier disruption: elucidating its role as a manifestation of cerebral small vessel disease in vascular cognitive impairment. Geroscience. 2024. https://doi.org/10.1007/s11357-024-01194-0
Knopp RC, Erickson MA, Rhea EM, Reed MJ, Banks WA. Cellular senescence and the blood-brain barrier: Implications for aging and age-related diseases. Exp Biol Med (Maywood). 2023;248:399–411. https://doi.org/10.1177/15353702231157917.
Article CAS PubMed Google Scholar
Gulej R, Csik B, Faakye J, Tarantini S, Shanmugarama S, Chandragiri SS, Mukli P, Conley S, Csiszar A, Ungvari Z, Yabluchanskiy A, Nyul-Toth A. Endothelial deficiency of insulin-like growth factor-1 receptor leads to blood-brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype. Microcirculation. 2023:e12840. https://doi.org/10.1111/micc.12840
Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T. Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown. Stroke. 2016;47:1068–77. https://doi.org/10.1161/STROKEAHA.115.010835.
Article PubMed PubMed Central Google Scholar
Toth P, Tarantini S, Csiszar A, Ungvari Z. Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging. Am J Physiol Heart Circ Physiol. 2017;312:H1–20. https://doi.org/10.1152/ajpheart.00581.2016.
Gulej R, Nyul-Toth A, Ahire C, DelFavero J, Balasubramanian P, Kiss T, Tarantini S, Benyo Z, Pacher P, Csik B, Yabluchanskiy A, Mukli P, Kuan-Celarier A, Krizbai IA, Campisi J, Sonntag WE, Csiszar A, Ungvari Z. Elimination of senescent cells by treatment with Navitoclax/ABT263 reverses whole brain irradiation-induced blood-brain barrier disruption in the mouse brain. Geroscience. 2023;45:2983–3002. https://doi.org/10.1007/s11357-023-00870-x.
Article CAS PubMed PubMed Central Google Scholar
Zhou W, Kavelaars A, Heijnen CJ. Metformin Prevents Cisplatin-Induced Cognitive Impairment and Brain Damage in Mice. PLoS ONE. 2016;11:e0151890. https://doi.org/10.1371/journal.pone.0151890.
Article CAS PubMed PubMed Central Google Scholar
Lomeli N, Di K, Czerniawski J, Guzowski JF, Bota DA. Cisplatin-induced mitochondrial dysfunction is associated with impaired cognitive function in rats. Free Radic Biol Med. 2017;102:274–86. https://doi.org/10.1016/j.freeradbiomed.2016.11.046.
Article CAS PubMed Google Scholar
Huo X, Reyes TM, Heijnen CJ, Kavelaars A. Cisplatin treatment induces attention deficits and impairs synaptic integrity in the prefrontal cortex in mice. Sci Rep. 2018;8:17400. https://doi.org/10.1038/s41598-018-35919-x.
Article CAS PubMed PubMed Central Google Scholar
Ongnok B, Chattipakorn N, Chattipakorn SC. Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions. Exp Neurol. 2020;324:113118. https://doi.org/10.1016/j.expneurol.2019.113118.
Article CAS PubMed Google Scholar
Oliveros A, Yoo KH, Rashid MA, Corujo-Ramirez A, Hur B, Sung J, Liu Y, Hawse JR, Choi DS, Boison D, Jang MH. Adenosine A(2A) receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function. Proc Natl Acad Sci U S A. 2022;119:e2206415119. https://doi.org/10.1073/pnas.2206415119.
Article CAS PubMed PubMed Central Google Scholar
Mahmoud AMA, Mantawy EM, Wahdan SA, Ammar RM, El-Demerdash E. Vildagliptin restores cognitive function and mitigates hippocampal neuronal apoptosis in cisplatin-induced chemo-brain: Imperative roles of AMPK/Akt/CREB/ BDNF signaling cascades. Biomed Pharmacother. 2023;159:114238. https://doi.org/10.1016/j.biopha.2023.114238.
Article CAS PubMed Google Scholar
Alotayk LI, Aldubayan MA, Alenezi SK, Anwar MJ, Alhowail AH. Comparative evaluation of doxorubicin, cyclophosphamide, 5-fluorouracil, and cisplatin on cognitive dysfunction in rats: Delineating the role of inflammation of hippocampal neurons and hypothyroidism. Biomed Pharmacother. 2023;165:115245. https://doi.org/10.1016/j.biopha.2023.115245.
Article CAS PubMed Google Scholar
Elbeltagy M, Al-Horani RA, Alsharaeh TS, Alkhatib AH, Alawaisheh I, Abuhani AA, Salman A. The Counter Effect of Exercise on Cisplatin-Induced Cognitive and Proliferation Impairments. Cureus. 2024;16:e52526. https://doi.org/10.7759/cureus.52526.
Article PubMed PubMed Central Google Scholar
Magdy O, Eshra M, Rashed L, Maher M, Hosny SA, ShamsEldeen AM. Amelioration of cisplatin-induced neurodegenerative changes in rats and restoration of mitochondrial biogenesis by 6-bromoindirubin-3′-oxime: The implication of the GSK-3beta/PGC1-alpha axis. Tissue Cell. 2024;88:102393. https://doi.org/10.1016/j.tice.2024.102393.
Article CAS PubMed Google Scholar
Qutifan S, Saleh T, Shahin NA, ELBeltagy M, Obeidat F, Qattan D, Kalbouneh H, Barakat NA, Alsalem M. Melatonin mitigates cisplatin-induced cognitive impairment in rats and improves hippocampal dendritic spine density. Neuroreport. 2024;35:657–63. https://doi.org/10.1097/WNR.0000000000002049.
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