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Bioinformatics identification of potential biomarkers and therapeutic targets for ischemic stroke and vascular dementia
Bioinformatics identification of potential biomarkers and therapeutic targets for ischemic stroke and vascular dementia
Ischemic stroke and vascular dementia, as common cerebrovascular diseases, with the former causing irreversible neurologic...
Risk stratification for frailty, impairment and assessment of sleep disorders in community-dwelling older adults
Risk stratification for frailty, impairment and assessment of sleep disorders in community-dwelling older adults
BackgroundFrailty is associated with an increased susceptibility to functional decline, impairment, hospitalization, and m...
Exhaustive exercise decreases tau phosphorylation and modifies biological processes associated with the protein translation and electron transport chain in P301L tau transgenic mice
Exhaustive exercise decreases tau phosphorylation and modifies biological processes associated with the protein translation and electron transport chain in P301L tau transgenic mice
KeywordsExhaustive exercise (EE)Mitochondrial stressProteomicsWeighted correlation network analysis (WGCNA)Data availabili...
Alterations in the diversity, composition and function of the gut microbiota in Uyghur individuals with sarcopenia
Alterations in the diversity, composition and function of the gut microbiota in Uyghur individuals with sarcopenia
BackgroundResearch on the gut microbiota has emerged as a new direction for understanding pathophysiologic changes in dise...
Does excess body weight accelerate immune aging?
Does excess body weight accelerate immune aging?
BackgroundOverweight and obesity in older adults increase the risk of a range of comorbidities by sustaining chronic infla...
Sarcopenic patients “get even”: The impact of COVID-19 vaccination on mortality
Sarcopenic patients “get even”: The impact of COVID-19 vaccination on mortality
BackgroundCoronavirus Disease-2019 (COVID-19), driven by the SARS-CoV-2 virus, has disproportionately affected the elderly...
The role of mitochondrial quality control mechanisms in chondrocyte senescence
The role of mitochondrial quality control mechanisms in chondrocyte senescence
Chondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs the healt...
Path analysis to identify factors influencing osteoporosis: A cross-sectional study
Path analysis to identify factors influencing osteoporosis: A cross-sectional study
AbbreviationsGFRglomerular filtration rateDXAdual-energy X-ray absorptiometryRMSEAroot mean square error of approximationK...
Kaempferol: Paving the path for advanced treatments in aging-related diseases
Kaempferol: Paving the path for advanced treatments in aging-related diseases
Aging-related diseases (ARDs) are a major global health concern, and the development of effective therapies is urgently ne...
Pilates versus Zumba training effects on postural control under conflicting sensory conditions in postmenopausal women
Pilates versus Zumba training effects on postural control under conflicting sensory conditions in postmenopausal women
The current study aimed to compare the effects of Pilates versus Zumba training on postural performance in middle-aged pos...
Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the Training IMCT study
Multimodal and conventional resistance training interventions improve muscle function in older adults: Findings from the Training IMCT study
Age-associated remodeling processes affect the intramuscular connective tissue (IMCT) network, which may significantly imp...
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration
Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration
ObjectiveIntervertebral disc degeneration (IVDD) constitutes a crucial pathological foundation for spinal degenerative dis...
Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults
Laboratory-assessed gait cycle entropy for classifying walking limitations among community-dwelling older adults
Volume 188, April 2024, 112381Author links open overlay panel, , , , , Highlights•Older people with walking issues show hi...
Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates
Fatigue and perceived energy in a sample of older adults over 10 years: A resting state functional connectivity study of neural correlates
PurposeDeclining energy and increasing fatigue, common in older age, predict neurodegenerative conditions, but their neura...
Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-α in older adults: A case-control study
Sarcopenia is associated with hypomethylation of TWEAK and increased plasma levels of TWEAK and its downstream inflammatory factor TNF-α in older adults: A case-control study
BackgroundSarcopenia is a harmful condition common among older adults for which no treatment is available. Tumor necrosis ...
Relationship between glycated hemoglobin levels at admission and chronic post-stroke fatigue in patients with acute ischemic stroke
Relationship between glycated hemoglobin levels at admission and chronic post-stroke fatigue in patients with acute ischemic stroke
BackgroundChronic Post-Stroke Fatigue (PSF) is a common and persistent complications among ischemic stroke survivors. The ...
CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p
CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p
ObjectiveDysregulation of covalently closed circular RNAs (circRNAs) has been associated with neurological disorders, the ...
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
p53 accelerates endothelial cell senescence in diabetic retinopathy by enhancing FoxO3a ubiquitylation and degradation via UBE2L6
Diabetic retinopathy (DR) is the most common ocular fundus disease in diabetic patients. Chronic hyperglycemia not only pr...
Tangshen Formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism
Tangshen Formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism
Diabetic kidney disease (DKD) is leading causes and one of the fastest growing causes of chronic kidney disease worldwide,...
Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults
Combined effects of sleep and objectively-measured daily physical activity on arterial stiffness in middle-aged and older adults
KeywordsAgingSleep disorderPulse wave velocityModerate-to-vigorous-intensity physical activityDaily step countData availab...
Experimental models for elderly patients with membranous nephropathy: Application and advancements
Experimental models for elderly patients with membranous nephropathy: Application and advancements
Membranous nephropathy (MN) occurs predominantly in middle-aged and elderly individuals and ranks among the most prevalent...
Sex differences in frailty among older adults
Sex differences in frailty among older adults
By definition, aging is a natural, gradual and continuous process. On the other hand, frailty reflects the increase in vul...
Effects of free versus restricted arm movements on postural control in normal and modified sensory conditions in young and older adults
Effects of free versus restricted arm movements on postural control in normal and modified sensory conditions in young and older adults
Volume 184, December 2023, 112338Author links open overlay panel, , , , Highlights•We explored how arm movements influence...
The combined deleterious effects of multiple sclerosis and ageing on neuromuscular function
The combined deleterious effects of multiple sclerosis and ageing on neuromuscular function
BackgroundThe prevalence of older (>60 years) people with multiple sclerosis (pwMS) is increasing. This introduces nume...
Dietary supplementation with nacre reduces cortical bone loss in aged female mice
Dietary supplementation with nacre reduces cortical bone loss in aged female mice
Aging is associated with detrimental bone loss leading to fragility fractures in both men and women. Notably, a majority o...
Introduction to special issue on ‘physiological and evolutionary mechanisms of aging’
Introduction to special issue on ‘physiological and evolutionary mechanisms of aging’
We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of c...
Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy
Heme oxygenase-1: A potential therapeutic target for improving skeletal muscle atrophy
Skeletal muscle atrophy is a common muscle disease that is directly caused by an imbalance in protein synthesis and degrad...
Old age as a risk factor for liver diseases: Modern therapeutic approaches
Old age as a risk factor for liver diseases: Modern therapeutic approaches
Recent scientific interest has been directed towards age-related diseases, driven by the significant increase in global li...
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Fermented food is commonly viewed as healthy, mostly due to its probiotic and digestion-enhancing properties and recently ...
Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
Association between maximal oxygen consumption and physical performance tests among older adults with cognitive frailty
IntroductionCardiorespiratory fitness has an inverse relationship with cognitive impairment and frailty in older adults. D...
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