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The Relationship between Anxiety, Depression-Like Behavior, and Arterial Pressure: A Comparative Study in 13-Month-Old Wistar, WKY, and SHR Rats
The Relationship between Anxiety, Depression-Like Behavior, and Arterial Pressure: A Comparative Study in 13-Month-Old Wistar, WKY, and SHR Rats
It is known that hypertension may be associated with some mental disorders and cognitive impairment. The complex relations...
Defining Aging: Past, Present, and Possible Future
Defining Aging: Past, Present, and Possible Future
Various views on the “correct” definition of aging are analyzed. It is emphasized that a huge number of such d...
Let-7a MicroRNA Expression in the Mediobasal Hypothalamus during Aging
Let-7a MicroRNA Expression in the Mediobasal Hypothalamus during Aging
The hypothalamus is a key integrator of autonomic and endocrine regulation and is also involved in aging mechanisms. It is...
Transcriptional Responses of Autophagy-Related Genes in the Rat Liver to Fasting and Chloroquine Treatment
Transcriptional Responses of Autophagy-Related Genes in the Rat Liver to Fasting and Chloroquine Treatment
Autophagy is a dynamic process of delivery of non-functional cytoplasmic components into lysosomes for subsequent degradat...
Visual Impairment and Handgrip Strength in Aging: Evidence from Bidirectional Mendelian Randomization
Visual Impairment and Handgrip Strength in Aging: Evidence from Bidirectional Mendelian Randomization
Observational studies link handgrip strength (HGS, a key sarcopenia sign) and visual impairment (VI), but their causality ...
The Burden of Polypharmacy and PIMs Use in the Elderly Pakistani Patients: Findings from Cross-Sectional Study in Tertiary Care Hospitals
The Burden of Polypharmacy and PIMs Use in the Elderly Pakistani Patients: Findings from Cross-Sectional Study in Tertiary Care Hospitals
Background: Polypharmacy and the use of potentially inappropriate medications (PIMs) are major issues in the elderly regar...
Mechanisms of Educational Attainment on Frailty in Older Adults with Colorectal Cancer: The Mediating Roles of Health Awareness, Physical Activity, and Stress Management
Mechanisms of Educational Attainment on Frailty in Older Adults with Colorectal Cancer: The Mediating Roles of Health Awareness, Physical Activity, and Stress Management
Aim: This study aims to clarify how educational attainment influences frailty in older adults with colorectal cancer (CRC)...
Fungal Melanin as a Potential Geroprotector: First In Vitro Insights
Fungal Melanin as a Potential Geroprotector: First In Vitro Insights
Natural compounds possess significant potential for pharmacological applications. This study investigates melanin derived ...
Influence of Diet Quality on Biopsychosocial Risk Factors in the Elders: A Cross-Sectional Study from Ecuador
Influence of Diet Quality on Biopsychosocial Risk Factors in the Elders: A Cross-Sectional Study from Ecuador
This research was a non-experimental retrospective cross-sectional study, where the existing influence between the quality...
Associations between Number of Different Medications per Day and Physical Function in Icelandic Community Dwelling Older Adults
Associations between Number of Different Medications per Day and Physical Function in Icelandic Community Dwelling Older Adults
The number of different medications per day has been linked to reduced physical function in older adults. The aim of the p...
Determining the Reference Values for Hand Grip Strength and Its Influencing Factors in the Elderly of Amirkola
Determining the Reference Values for Hand Grip Strength and Its Influencing Factors in the Elderly of Amirkola
Background: The aging phenomenon is occurring at a faster rate in the developing countries compared to the developed count...
Eight-week Combined Exercise Reduces Fall Risk in Older Females: Posttest-Only Randomized Experimental Study
Eight-week Combined Exercise Reduces Fall Risk in Older Females: Posttest-Only Randomized Experimental Study
Falls among older adults represent a significant public health concern. This study, using a two-group posttest-only random...
Relationship between Tongue Pressure and Upper- and Lower-Body Muscle Strength in Community-Dwelling Older Adults: A Cross-Sectional Study
Relationship between Tongue Pressure and Upper- and Lower-Body Muscle Strength in Community-Dwelling Older Adults: A Cross-Sectional Study
A decline in oral function, including tongue pressure, decreases physical function and increases the risk of physical frai...
Proposal of a Training Protocol for Muscle Strength and Postural Balance in Older Adults: An Integrative Review
Proposal of a Training Protocol for Muscle Strength and Postural Balance in Older Adults: An Integrative Review
Guidelines promote high-quality care for older adults. Exercise training recommendations have not been fully characterized...
The Signaling Role of Several Mitochondrial Metabolites in the Regulation of Mitochondrial Homeostasis
The Signaling Role of Several Mitochondrial Metabolites in the Regulation of Mitochondrial Homeostasis
This review systematizes contemporary data on the signaling role of mitochondrial metabolites in regulating mitochondrial ...
Associations of IGF-1 and IGFBP-3 with Aging and the Development of Age-Associated Diseases
Associations of IGF-1 and IGFBP-3 with Aging and the Development of Age-Associated Diseases
Aging is a complex biological process that impacts various systems of the body with changes occurring at molecular, cellul...
Social Virtual Reality as a Solution for Aging Services and Gerontology: Understanding the Older Adults’ Acceptance of Virtual Reality Applications
Social Virtual Reality as a Solution for Aging Services and Gerontology: Understanding the Older Adults’ Acceptance of Virtual Reality Applications
A demographic shift towards an ageing population necessitates a comprehensive examination of the quality of life of the ol...
Evaluation of the Psychometric Properties of the Turkish Form of the Will-to-Live Scale in Older Adults
Evaluation of the Psychometric Properties of the Turkish Form of the Will-to-Live Scale in Older Adults
The Will-to-Live (WTL) scale measures desire for life and life commitment across populations. However, psychometric eviden...
Interaction between Body Mass Index and Depressive Symptoms in Older Adults: Evidence from a Large-Scale Population-Based Cohort Study
Interaction between Body Mass Index and Depressive Symptoms in Older Adults: Evidence from a Large-Scale Population-Based Cohort Study
There are mixed results on the correlation between body mass index and depressive symptoms among older adults. This observ...
Elevating Skeletal Muscle GLUT4 Abundance Does Not Result in a Calorie Restriction-Induced Elevation in Insulin-Stimulated Glucose Uptake by Skeletal Muscle from Female AS160-Knockout Rats
Elevating Skeletal Muscle GLUT4 Abundance Does Not Result in a Calorie Restriction-Induced Elevation in Insulin-Stimulated Glucose Uptake by Skeletal Muscle from Female AS160-Knockout Rats
Calorie restriction (CR: ∼20–40% below AL: ad libitum intake) can increase insulin sensitivity in various spec...
Age-Related Changes in the Tissue Antioxidant Defense of the Northern Birch Mouse (, Rodentia) at the Northern Periphery of Its Range
Age-Related Changes in the Tissue Antioxidant Defense of the Northern Birch Mouse (, Rodentia) at the Northern Periphery of Its Range
The study is aimed at determining tissue antioxidant levels in juvenile and adult northern birch mice (Sicista betulina Pa...
Impact of Sleep Habits on 5-Year Survival in Elderly Individuals and Long-Livers
Impact of Sleep Habits on 5-Year Survival in Elderly Individuals and Long-Livers
Background. Healthy, good quality sleep is one of the necessary conditions for achieving longevity and improving survival....
Intestinal Overexpression of Circadian Clock Genes Modulates Lifespan and Thermotolerance in Male
Intestinal Overexpression of Circadian Clock Genes Modulates Lifespan and Thermotolerance in Male
This study investigates how overexpression of circadian clock genes affects longevity and stress resistance in male Drosop...
Longitudinal Association between Persistent Subjective Cognitive Decline and Frailty Progression: A Three-Year Study
Longitudinal Association between Persistent Subjective Cognitive Decline and Frailty Progression: A Three-Year Study
Subjective cognitive decline (SCD) is a self-perceived deterioration in cognitive function and has been linked to both cog...
The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease
The Role of the Serotonin Pathway of Tryptophan Metabolism in the Development of Neuroinflammation in Alzheimer’s Disease
Despite the fact that more than 90% of tryptophan is metabolized via the kynurenine pathway, the serotonin pathway is of g...
Role of BKCa Channels in Pial-Vessel Dilation in Rats of Different Ages
Role of BKCa Channels in Pial-Vessel Dilation in Rats of Different Ages
Studying the mechanisms of age-related changes in vascular reactions and applying the acquired knowledge in clinics can he...
Should We Consider Water and Antibiotics to Be Geroprotectors?
Should We Consider Water and Antibiotics to Be Geroprotectors?
The authors try to consider the current situation with experimental gerontological research aimed at finding means to slow...
Larval Heat Stress Affects the Lifespan and Stress Resistance of Drosophila melanogaster Adults
Larval Heat Stress Affects the Lifespan and Stress Resistance of Drosophila melanogaster Adults
In modern conditions of constant adverse effects on living organisms, such as environmental pollution or global climate ch...
On the Concentration of Vitamins A and E in the Tissues of the Bank Vole (Myodes (Clethrionomys) glareolus) and Common Shrew (Sorex araneus) Inhabiting Karelia
On the Concentration of Vitamins A and E in the Tissues of the Bank Vole (Myodes (Clethrionomys) glareolus) and Common Shrew (Sorex araneus) Inhabiting Karelia
We have studied the concentration of vitamins A (retinol) and E (α-tocopherol) in the tissues of the bank vole (Myode...
Effects of Time-of-Day on the Expression of Autophagy Genes at the Different Stages of Age-Related Macular Degeneration-Like Retinopathy in Rat’s Retina
Effects of Time-of-Day on the Expression of Autophagy Genes at the Different Stages of Age-Related Macular Degeneration-Like Retinopathy in Rat’s Retina
Age-related macular degeneration (AMD) is a complex progressive eye disease, resulting in loss of central vision in the ag...
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