Defining Aging: Past, Present, and Possible Future

Khokhlov, A.N., Reflections of a pessimistic gerontologist or why we still do not live 1000 years, Moscow Univ. Biol. Sci. Bull., 2021, vol. 76, no. 4, pp. 239–243. https://doi.org/10.3103/S0096392521040040

Article  Google Scholar 

Khokhlov, A.N., The renewed ‘Advances in Gerontology’ 2025: Results, prospects, changing strategy, Adv. Gerontol., 2025, vol. 15, no. 2, pp. 43–45. https://doi.org/10.1134/S2079057025600429

Article  Google Scholar 

Khokhlov, A.N., From Carrel to Hayflick and back, or what we got from the 100-year cytogerontological studies, Biophysics, 2010, vol. 55, no. 5, pp. 859–864. https://doi.org/10.1134/S0006350910050313

Article  Google Scholar 

Khokhlov, A.N., Does aging need its own program, or is the program of development quite sufficient for it? Stationary cell cultures as a tool to search for anti-aging factors, Curr. Aging Sci., 2013, vol. 6, no. 1, pp. 14–20. https://doi.org/10.2174/18746098112059990009

Article  CAS  PubMed  Google Scholar 

Khokhlov, A.N., Basics of biology of aging for MSU non-biologists, Moscow Univ. Biol. Sci. Bull., 2023, vol. 78, no. 2, pp. 111–114. https://doi.org/10.3103/S0096392523020025

Article  Google Scholar 

Khokhlov, A.N., Gerontology in the 21st century: From failures to advances. Hopefully, Adv. Gerontol., 2023, vol. 13, no. 1, pp. 1–3. https://doi.org/10.1134/S2079057024600289

Article  Google Scholar 

Khokhlov, A.N., Why freshwater hydra does not get Alzheimer’s disease, Moscow Univ. Biol. Sci. Bull., 2023, vol. 78, no. 3, pp. 198–204. https://doi.org/10.3103/S0096392523700104

Article  Google Scholar 

Khokhlov, A.N., Klebanov, A.A., and Morgunova, G.V., On choosing control objects in experimental gerontological research, Moscow Univ. Biol. Sci. Bull., 2018, vol. 73, no. 2, pp. 59–62. https://doi.org/10.3103/S0096392518020049

Article  Google Scholar 

Khokhlov, A.N. and Morgunova, G.V., Should we consider water and antibiotics to be geroprotectors?, Adv. Gerontol., 2023, vol. 13, no. 4, pp. 202–205. https://doi.org/10.1134/S2079057024600460

Article  Google Scholar 

Khokhlov, A.N., Antioxidants: Good, bad, or ineffective in terms of aging and lifespan? It depends, Adv. Gerontol., 2024, vol. 14, no. 4, pp. 171–174. https://doi.org/10.1134/S2079057025600090

Article  Google Scholar 

Descartes, R., Règles pour la direction de l’esprit, Vrin, 1970.

Google Scholar 

Anisimov, V.N., Aging and age-related diseases, Klin. gerontologiya, 2005, vol. 11, no. 1, pp. 42–49.

Strehler, B.L., Time, Cells and Aging, New York: Acad. Press, 1962.

Google Scholar 

Comfort, A., Ageing: The Biology of Senescence, New York: Holt, Rinehart and Winston, 1964.

Google Scholar 

Lamb, M.J., Biology of Ageing, Glasgow: Blackie, 1977.

Google Scholar 

Rose, M., Evolutionary Biology of Aging, New York: Oxford Univ. Press, 1991.

Google Scholar 

Finch, C.E., Senescence, Longevity, and the Genome, Chicago: The Univ. of Chicago Press, 1990.

Google Scholar 

Hayflick, L., How and Why We Age, New York: Ballantine Books, 1994.

Google Scholar 

Holliday, R., Aging: The Paradox of Life. Why We Age, Springer Science and Business Media, 2007.

Google Scholar 

Harman, D., Free radical theory of aging: An update. Increasing the functional life span, Ann. N. Y. Acad. Sci., 2006, vol. 1067, no. 1, pp. 10–21. https://doi.org/10.1196/annals.1354.003

Article  CAS  PubMed  Google Scholar 

Austad, S.N., Rebuttal to Bredesen: ‘The non-existent aging program: How does it work?,’ Aging Cell, 2004, vol. 3, no. 5, pp. 253–254. https://doi.org/10.1111/j.1474-9728.2004.00119.x

Article  CAS  PubMed  Google Scholar 

Austad, S.N., Diverse aging rates in metazoans: Targets for functional genomics, Mech. Ageing Dev., 2005, vol. 126, no. 1, pp. 43–49. https://doi.org/10.1016/j.mad.2004.09.022

Article  CAS  PubMed  Google Scholar 

Flatt, T., A new definition of aging?, Front. Genet., 2012, vol. 3, p. 148. https://doi.org/10.3389/fgene.2012.00148

Article  PubMed  PubMed Central  Google Scholar 

Lemoine, M., Defining aging, Biol. Philos., 2020, vol. 35, no. 5, p. 46. https://doi.org/10.1007/s10539-020-09765-z

Article  Google Scholar 

Hayflick, L., The future of ageing, Nature, 2000, vol. 408, no. 6809, pp. 267–269. https://doi.org/10.1038/35041709

Article  CAS  PubMed  Google Scholar 

Rose, M.R., Flatt, T., Graves, J.L., Greer, L.F., Martinez, D.E., Matos, M., and Mueller, L.D., Shmookler Reis, R.J., and Shahrestani, P., What is aging?, Front. Genet., 2012, vol. 3, p. 134. https://doi.org/10.3389/fgene.2012.00134

Article  PubMed  PubMed Central  Google Scholar 

López-Otín, C., Blasco, M.A., Partridge, L., Serrano, M., and Kroemer, G., The hallmarks of aging, Cell, 2013, vol. 153, no. 6, pp. 1194–1217. https://doi.org/10.1016/j.cell.2013.05.039

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mori, M.A., Aging: A new perspective on an old issue, An. Acad. Bras. Cienc., 2020, vol. 92, no. 2, p. e20200437. https://doi.org/10.1590/0001-3765202020200437

Article  CAS  PubMed  Google Scholar 

Gladyshev, V.N., The ground zero of organismal life and aging, Trends Mol. Med., 2021, vol. 27, no. 1, pp. 11–19. https://doi.org/10.1016/j.molmed.2020.08.012

Article  CAS  PubMed  Google Scholar 

Khokhlov, A.N., On the cholesterol theory of aging-2022, Moscow Univ. Biol. Sci. Bull., 2022, vol. 77, no. 4, pp. 292–296. https://doi.org/10.3103/S0096392522040034

Article  CAS  Google Scholar 

Khokhlov, A.N., Evolution of the term “cellular senescence” and its impact on the current cytogerontological research, Moscow Univ. Biol. Sci. Bull., 2013, vol. 68, no. 4, pp. 158–161. https://doi.org/10.3103/S0096392513040123

Article  Google Scholar 

Morgunova, G.V. and Khokhlov, A.N., Signs of similarities and differences in cellular models of aging: A scoping review, Moscow Univ. Biol. Sci. Bull., 2022, vol. 77, no. 3, pp. 139–146. https://doi.org/10.3103/S0096392522030087

Article  Google Scholar 

Khokhlov, A.N., Stationary cell cultures as a tool for gerontological studies, Ann. N.Y. Acad. Sci., 1992, vol. 663, pp. 475–476. https://doi.org/10.1111/j.1749-6632.1992.tb38706.x

Article  CAS  PubMed  Google Scholar 

Khokhlov, A.N., Cell kinetic approaches to the search for anti-aging drugs: Thirty years after, Moscow Univ. Biol. Sci. Bull., 2018, vol. 73, no. 4, pp. 185–190. https://doi.org/10.3103/S0096392518040041

Article  Google Scholar 

Demaria, M., Rethinking healthcare through aging biology, Aging (Albany NY), 2025, vol. 17, no. 5, pp. 1077–1079. https://doi.org/10.18632/aging.206262

Article  CAS  PubMed  Google Scholar 

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