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Photocatalytic proximity labeling in primary samples

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Recent advances in mapping protein networks regulated by post-translational modifications via proximity tagging

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Chemical and synthetic biology tools to interrogate and control cell–cell interactions in vivo

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Always on the move: Mapping spatiotemporal interactome with proximity labeling in mammalian cells

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Recent development of fluorescent probes for hydrogen per/polysulfides

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From generation to validation: Deep generative models for antimicrobial peptide discovery

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Genetic code expansion: Bridging synthetic biology precision and cellular complexity to decipher molecular mechanisms of diseases

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Synthetic DNA circuits for programming cell functions

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Defining the rules of biocompatible chemistry

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Controlling distance, time and reactivity: Chemical principles of proximity labeling

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Medical isotope-labeled nucleic acids: A decade of progress toward theranostics (2015–2025)

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Discovery and engineering of polymerases and ligases for the synthesis of modified nucleic acids

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Proximity labeling tools for studying chromatin interactomes

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Advances in proximity labeling strategies for interactome mapping and functional interrogation

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Recent advances in spatial proteomics by super-resolution proximity labeling

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Light-driven spatial proteomics: Photocatalytic strategies for mapping protein microenvironments

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Proximity chemistries to study RNA biology at the subcellular scale

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Imaging genome dynamics in real time with CRISPR-based technologies

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Therapeutic potential and resistance of proline-rich antimicrobial peptides

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Self-resistance as a guide to discovering bioactive natural products

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Integrated MINFLUX tracking reveals two distinct chromatin dynamics classes across cell types

Chromatin dynamics control the timescales of essential biological processes and reflect how chromatin is organized in the ...

Nature Structural & Molecular Biology

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Cracking the (zip)code of dynein-dependent RNA localization

Subcellular mRNA localization relies on the recognition of cis-regulatory elements by trans-acting complexes, which mediat...

Nature Structural & Molecular Biology

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Structural basis for recognition of diverse localizing mRNAs by Egl–BicD

Localization of mRNAs is a widespread mechanism for dictating where proteins operate in cells and underpins many fundament...

Nature Structural & Molecular Biology

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When membrane insertion sets the pace of mitochondrial translation

Human mitochondrial ribosomes synthesize membrane proteins while docked at the inner membrane, but how insertion feeds bac...

Nature Structural & Molecular Biology

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Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed

The human mitochondrial genome encodes 13 subunits of the oxidative phosphorylation system essential for energy metabolism...

Nature Structural & Molecular Biology

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Evaluating generalization in protein–ligand cofolding methods

Deep learning has driven major breakthroughs in protein structure prediction; however, one of the next critical steps forw...

Nature Structural & Molecular Biology

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How ligands tune the parathyroid hormone receptor’s grip on β-arrestin

β-arrestins are known modulators of GPCR signaling, but their precise interaction with class B GPCRs is poorly unders...

Nature Structural & Molecular Biology

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Structural basis of PTH1R–β-arrestin core engagement reveals design principles for G-protein-biased therapeutics

G-protein-coupled receptors (GPCRs) transmit cellular signals through both G protein and arrestin pathways and biased sign...

Nature Structural & Molecular Biology

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Green Synthesis of Iron Oxide-Chitosan-Glutathione Nanosystem for Wound Healing Enhancement

Wound healing is a complex biological process influenced by oxidative stress, inflammation, and impaired tissue regenerati...

Cell Biochemistry And Biophysics

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C620Y Mutation–Induced Destabilization of the Androgen Receptor Disrupts DNA Recognition Specificity in Prostate Cancer: Insights from Extensive Parametric Normal Mode Simulations

The rising surge of prostate cancer (PC) and its evolution to metastatic castration resistant prostate cancer (mCRPC) all ...

Cell Biochemistry And Biophysics

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