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Green Synthesis of Iron Oxide-Chitosan-Glutathione Nanosystem for Wound Healing Enhancement
Green Synthesis of Iron Oxide-Chitosan-Glutathione Nanosystem for Wound Healing Enhancement
Wound healing is a complex biological process influenced by oxidative stress, inflammation, and impaired tissue regenerati...
C620Y Mutation–Induced Destabilization of the Androgen Receptor Disrupts DNA Recognition Specificity in Prostate Cancer: Insights from Extensive Parametric Normal Mode Simulations
C620Y Mutation–Induced Destabilization of the Androgen Receptor Disrupts DNA Recognition Specificity in Prostate Cancer: Insights from Extensive Parametric Normal Mode Simulations
The rising surge of prostate cancer (PC) and its evolution to metastatic castration resistant prostate cancer (mCRPC) all ...
Expression Profile and Role of the Genes During Human in vitro Osteogenic Differentiation
Expression Profile and Role of the Genes During Human in vitro Osteogenic Differentiation
MicroRNAs (miRNAs), including the let-7 family, have been shown to regulate osteogenic differentiation of human mesenchyma...
Proteomic Analysis gives Novel Insights into Morphogenesis in the Wake of Ubiquitin Mutation UbEP42
Proteomic Analysis gives Novel Insights into Morphogenesis in the Wake of Ubiquitin Mutation UbEP42
Ubiquitin is pivotal to the regulation of protein homeostasis, signal transduction, and various cellular processes. Mutati...
Comparative Evaluation of Antiaging Potential of Conjugated Silver Nanoparticles and Citral Against D-galactose Induced Aging in Mice
Comparative Evaluation of Antiaging Potential of Conjugated Silver Nanoparticles and Citral Against D-galactose Induced Aging in Mice
Aging and age-associated disorders are a major global concern leading to morbidity and mortality. A key player is oxidativ...
Andrographolide Alleviates Inflammation in Chronic Obstructive Pulmonary Disease by Inhibiting Alveolar Macrophage Pyroptosis Through the JNK/NLRP3 Pathway
Andrographolide Alleviates Inflammation in Chronic Obstructive Pulmonary Disease by Inhibiting Alveolar Macrophage Pyroptosis Through the JNK/NLRP3 Pathway
Pyroptosis is involved in the progression of chronic obstructive pulmonary disease (COPD). Andrographolide (AG) possesses ...
In Vitro Ocular Cytotoxicity of BEE Venom in ARPE-19, NTM5, HCET, and HCEC-12 Cell Lines
In Vitro Ocular Cytotoxicity of BEE Venom in ARPE-19, NTM5, HCET, and HCEC-12 Cell Lines
Bee venom (BV) is a complex natural secretion of Apis mellifera with documented anti-inflammatory, antimicrobial, and anti...
Multifunctional Curcumin Nanoparticles: Oncolytic, Radical Scavenging, Regenerative, Hepatoprotective, and Bactericidal Effects
Multifunctional Curcumin Nanoparticles: Oncolytic, Radical Scavenging, Regenerative, Hepatoprotective, and Bactericidal Effects
Curcumin is a potent anticancer agent as it inhibits cell proliferation, tumor growth, and promotes cell death. It works b...
Doxorubicin-Induced Cardiotoxicity: Molecular Mechanisms to Novel Therapeutic Frontiers of Recent Preclinical Discoveries
Doxorubicin-Induced Cardiotoxicity: Molecular Mechanisms to Novel Therapeutic Frontiers of Recent Preclinical Discoveries
Cardiotoxicity is the most common side effect of various chemotherapy medications. Doxorubicin (DOX), which belongs to the...
Orchestrating Ovarian Dysfunction- The Role of Programmed Cell Death in PCOS
Orchestrating Ovarian Dysfunction- The Role of Programmed Cell Death in PCOS
Polycystic ovarian syndrome (PCOS) has various etiologies, including insulin resistance (IR), hyperandrogenemia, and chron...
Heat-Killed KABP-042 and KABP-051 Prevent Scopolamine-Induced BDNF Reduction and Memory Impairment in Mice
Heat-Killed KABP-042 and KABP-051 Prevent Scopolamine-Induced BDNF Reduction and Memory Impairment in Mice
Brain-derived neurotrophic factor (BDNF) plays a pivotal role in learning and memory, and reductions in BDNF levels are cl...
Extracellular levels of glutamate, glutamine, cystine, glutathione, and xanthine correlate with transporter expression in tamoxifen - resistant MCF-7 cells and poor overall survival in breast cancer patients
Extracellular levels of glutamate, glutamine, cystine, glutathione, and xanthine correlate with transporter expression in tamoxifen - resistant MCF-7 cells and poor overall survival in breast cancer patients
Tamoxifen resistance development in breast cancer cells is a major clinical challenge. Metabolic alterations play a fundam...
attenuates hepatic fibrosis in mice by suppressing hepatic stellate cells activation and modulating inflammatory chemokine signaling
attenuates hepatic fibrosis in mice by suppressing hepatic stellate cells activation and modulating inflammatory chemokine signaling
Hepatic fibrosis is a chronic and progressive liver disease that can lead to cirrhosis or hepatocellular carcinoma. It rep...
Optimization of Non-Cross-Linked Hyaluronic Acid and Adipose-Derived Mesenchymal Stem Cells for Regenerative Applications: an in Vitro Study
Optimization of Non-Cross-Linked Hyaluronic Acid and Adipose-Derived Mesenchymal Stem Cells for Regenerative Applications: an in Vitro Study
Hyaluronic acid (HA) and adipose-derived mesenchymal stem cells (AD-MSCs) are both promising agents for skin rejuvenation....
Synthesis of Apolipoprotein A-I in Human Macrophages Enhances their Migratory Activity
Synthesis of Apolipoprotein A-I in Human Macrophages Enhances their Migratory Activity
Apolipoprotein A-I (ApoA-I) is the major structural and functional protein of high density lipoprotein (HDL) particles. Ap...
Chemical Epigenetics: Small Molecules Targeting Chromatin Modifiers in Disease Modulation
Chemical Epigenetics: Small Molecules Targeting Chromatin Modifiers in Disease Modulation
Epigenetic regulation controls gene expression through reversible chromatin modifications, including DNA methylation, hist...
Enhancing the Efficacy of Paclitaxel with Nano-Activators: A Novel Approach to Mitigating the Chemotherapies Side-Effects
Enhancing the Efficacy of Paclitaxel with Nano-Activators: A Novel Approach to Mitigating the Chemotherapies Side-Effects
In the modern era of medical science, nanotechnology plays a pivotal role in drug repurposing, remodelling, novel drug del...
Naringin Potentiates Docetaxel-Induced Apoptosis in Breast Cancer Cells via Transient Interaction with the TUBB3 GTP-Binding Site
Naringin Potentiates Docetaxel-Induced Apoptosis in Breast Cancer Cells via Transient Interaction with the TUBB3 GTP-Binding Site
Breast cancer (BC) is associated with the overexpression of tubulin isotypes, promoting malignant progression and poor pro...
Indoleamine 2, 3-dioxygenase Regulates the Differentiation of T Lymphocytes to Promote the Growth of Gastric Cancer Cells through the PI3K/Akt/mTOR Pathway
Indoleamine 2, 3-dioxygenase Regulates the Differentiation of T Lymphocytes to Promote the Growth of Gastric Cancer Cells through the PI3K/Akt/mTOR Pathway
To investigate the regulatory mechanism of indoleamine 2, 3-dioxygenase (IDO) in T lymphocyte differentiation and its role...
Caffeic Acid Phenethyl Ester Enhances Bone Repair-related Factors in MC3T3-E1 Cells
Caffeic Acid Phenethyl Ester Enhances Bone Repair-related Factors in MC3T3-E1 Cells
Apical periodontitis is an inflammatory disease caused by bacterial infection in the root canal that spreads to the apical...
Berberine and Cyperus rotundus extract nanoformulations protect the rats against Staphylococcus-induced mastitis via antioxidant and anti-inflammatory activities: role of MAPK signaling
Berberine and Cyperus rotundus extract nanoformulations protect the rats against Staphylococcus-induced mastitis via antioxidant and anti-inflammatory activities: role of MAPK signaling
Berberine (BER) and Cyperus rotundus rhizomes extract (CRE) are phytochemicals characterized by broad-spectrum pharmacolog...
Apatinib Mesylate Inhibits Cell Proliferation and the Metastasis of Esophageal Squamous Cell Carcinoma Through ERK/ELK-1/Snail Pathway
Apatinib Mesylate Inhibits Cell Proliferation and the Metastasis of Esophageal Squamous Cell Carcinoma Through ERK/ELK-1/Snail Pathway
This study aimed to evaluate the impact of apatinib (APT) mesylate on the growth, migration ability, and underlying mechan...
Evaluating the Synergistic Antioxidant, Anti-microbial and Adsorbent Potential of Andrographis Paniculata Extract and Gold Nanoparticles
Evaluating the Synergistic Antioxidant, Anti-microbial and Adsorbent Potential of Andrographis Paniculata Extract and Gold Nanoparticles
The present study introduces a minimalistic and cost-effective approach to synthesising Gold nanoparticles (AuNPs) using a...
The Activation of the CCND1 Promoter by AP-1 and SOX Transcription Factors in PC3 Prostate Cancer Cells Can Be Prevented by Anacardic Acid Analogs
The Activation of the CCND1 Promoter by AP-1 and SOX Transcription Factors in PC3 Prostate Cancer Cells Can Be Prevented by Anacardic Acid Analogs
Targeting more than one in nine men before age 70, prostate cancer is the most common type of cancer in men. The increased...
Expression of Elastin, F-Box and WD-40 Domain-Containing Protein 2, Fibrillin-1, and Alpha-Smooth Muscle Actin in Utilized Blood Vessels for explant culture—A New 3D in Vitro Vascular Model from Bovine Legs
Expression of Elastin, F-Box and WD-40 Domain-Containing Protein 2, Fibrillin-1, and Alpha-Smooth Muscle Actin in Utilized Blood Vessels for explant culture—A New 3D in Vitro Vascular Model from Bovine Legs
Elastic fibers of the internal and external elastic laminae maintain blood vessel shapes. Impairment of smooth muscle cell...
Interaction Between Allopregnanolone and Amiloride Binding Sites on the GABAA Receptor
Interaction Between Allopregnanolone and Amiloride Binding Sites on the GABAA Receptor
Allopregnanolone (Allo) is a positive allosteric modulator of the GABAA receptor, and amiloride (Ami) is a competitive ant...
Suppression of FcεRI-evoked Degranulation in RBL-2H3 Cells on Gelatin Methacryloyl Hydrogel
Suppression of FcεRI-evoked Degranulation in RBL-2H3 Cells on Gelatin Methacryloyl Hydrogel
Cell–extracellular matrix (ECM) interactions play multiple roles in developmental, physiological, and pathological p...
Sudachitin Reduces Inflammatory Mediator Expression in Toll-Like Receptor 2 Ligand-Stimulated Human Dental Pulp Cells
Sudachitin Reduces Inflammatory Mediator Expression in Toll-Like Receptor 2 Ligand-Stimulated Human Dental Pulp Cells
Sudachitin, which is a polymethoxy flavonoid derived from the peer of Citrus sudachi, has several biological properties. H...
Cardioprotective Potential of d-limonene against Isoproterenol induced Myocardial Infarction in Rats
Cardioprotective Potential of d-limonene against Isoproterenol induced Myocardial Infarction in Rats
d-limonene is a type of colorless liquid hydrocarbon that falls under the category of cyclic monoterpene. It is the compon...
Mechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells
Mechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells
Silymarin, a flavonoid complex isolated from Silybum marianum, possesses various biological properties, including antioxid...
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