Naringin Potentiates Docetaxel-Induced Apoptosis in Breast Cancer Cells via Transient Interaction with the TUBB3 GTP-Binding Site

Filho, A. M., Laversanne, M., Ferlay, J., Colombet, M., Piñeros, M., Znaor, A., Parkin, D. M., Soerjomataram, I., & Bray, F. (2024). The GLOBOCAN 2022 cancer estimates: Data sources, methods, and a snapshot of the cancer burden worldwide. int j cancer. https://doi.org/10.1002/ijc.35278

Article  PubMed  Google Scholar 

Kim, J., Harper, A., McCormack, V., Sung, H., Houssami, N., Morgan, E., Mutebi, M., Garvey, G., & Soerjomataram, I. (2025). Fidler Benaoudia, Global patterns and trends in breast cancer incidence and mortality across 185 countries. Nature Medicine. https://doi.org/10.1038/s41591-025-03502-3

Article  PubMed  PubMed Central  Google Scholar 

Orrantia Borunda, E., Anchondo Nuñez, P., Acuña, L. E., Aguilar, F. O., & Gómez Valles, C. A. (2022). Ramírez Valdespino, Subtypes of breast cancer. in Breast Cancer Exon Publications, 31–42. https://doi.org/10.36255/exon-publications-breast-cancer-subtypes

Barzaman, K., Karami, J., Zarei, Z., Hosseinzadeh, A., Kazemi, M. H., Moradi Kalbolandi, S., Safari, E., & Farahmand, L. (2020). Breast cancer: Biology, biomarkers, and treatments. International Immunopharmacology, 84, 106535. https://doi.org/10.1016/j.intimp.2020.106535

Article  CAS  PubMed  Google Scholar 

Xiong, X., Zheng, L., Ding, Y., Chen, Y., Cai, Y., Wang, L., Huang, L., Liu, C., Shao, Z., & Yu, K. (2025). Breast cancer: pathogenesis and treatments, Signal Transduct. Target Ther, 10(1). https://doi.org/10.1038/s41392-024-02108-4

Burguin, A., Diorio, C., & Durocher, F. (2021). Breast cancer treatments: updates and new challenges. J Pers Med, 11(8), 808. https://doi.org/10.3390/jpm11080808

Article  PubMed  PubMed Central  Google Scholar 

Kamath, K., Wilson, L., Cabral, F., & Jordan, M. A. (2005). βIII Tubulin induces paclitaxel resistance in association with reduced effects on microtubule dynamic instability. Journal Of Biological Chemistry, 280(13), 12902–12907. https://doi.org/10.1074/jbc.M414477200

Article  CAS  PubMed  Google Scholar 

Shalli, K., Brown, I., Heys, S. D., & Schofield, C. A. (2005). Alterations of β tubulin isotypes in breast cancer cells resistant to docetaxel. The Faseb Journal, 19(10), 1299–1301. https://doi.org/10.1096/fj.04-3178fje

Article  CAS  PubMed  Google Scholar 

Anitei, M., & Hoflack, B. (2011). Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways. Nature Cell Biology, 14(1), 11–19. https://doi.org/10.1038/ncb2409

Article  CAS  PubMed  Google Scholar 

Mimori, Y., & Kiyosue (2011). Shaping microtubules into diverse patterns: Molecular connections for setting up both ends. Cytoskeleton, 68(11), 603–618. https://doi.org/10.1002/cm.20540

Article  CAS  Google Scholar 

De Forges, H., Bouissou, A., & Perez, F. (2011). Interplay between microtubule dynamics and intracellular organization. International Journal Of Biochemistry & Cell Biology, 44(2), 266–274. https://doi.org/10.1016/j.biocel.2011.11.009

Article  CAS  Google Scholar 

Cooper, G. M. (2000). The Cell: A Molecular Approach, 2nd ed., Sinauer Associates, Sunderland (MA), Microtubules, Available from: https://www.ncbi.nlm.nih.gov/books/NBK9932/

Stumpff, J., Ghule, P. N., Shimamura, A., Stein, J. L., & Greenblatt, M. (2014). Spindle microtubule dysfunction and cancer predisposition. Journal Of Cellular Physiology, 229(12), 1881–1883. https://doi.org/10.1002/jcp.24691

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kanakkanthara, A., & Miller, J. H. (2021). βIII tubulin overexpression in cancer: Causes, consequences, and potential therapies. Biochimica Et Biophysica Acta - Reviews On Cancer, 1876(2), 188607. https://doi.org/10.1016/j.bbcan.2021.188607

Article  CAS  PubMed  Google Scholar 

Kanojia, D., Morshed, R. A., Zhang, L., Miska, J. M., Qiao, J., Kim, J. W., Pytel, P., Balyasnikova, I. V., Lesniak, M. S., & Ahmed, A. U. (2015). βIII Tubulin regulates breast cancer metastases to the brain, Mol. Cancer Ther, 14(5), 1152–1161. https://doi.org/10.1158/15357163.MCT140950

Article  CAS  Google Scholar 

Parekh, M., & Jurkunas, U. V. (2024). Regulation of corneal endothelial cell proliferation. in Elsevier eBooks. https://doi.org/10.1016/B978-0-443-13820-1.00171-7

Article  Google Scholar 

Stoicescu, E. A., Burcea, M., Iancu, R. C., Zivari, M., Cherecheanu, A. P., Bujor, I. A., Rastoaca, C., & Iancu, G. (2021). Docetaxel for breast cancer treatment—Side effects on ocular surface, a systematic review. Processes, 9(7), 1086. https://doi.org/10.3390/pr9071086

Article  CAS  Google Scholar 

Pienta, K. J. (2001). Preclinical mechanisms of action of docetaxel and docetaxel combinations in prostate cancer. Seminars In Oncology, 28(4 M), 3–7. https://doi.org/10.1053/sonc.2001.26892

Article  CAS  PubMed  Google Scholar 

Imran, M., Saleem, S., Chaudhuri, A., Ali, J., & Baboota, S. (2020). Docetaxel: An update on its molecular mechanisms, therapeutic trajectory and nanotechnology in the treatment of breast, lung and prostate cancer. Journal Of Drug Delivery Science And Technology, 60, 101959. https://doi.org/10.1016/j.jddst.2020.101959

Article  CAS  Google Scholar 

Crown, J., O’Leary, M., & Ooi, W. (2004). Docetaxel and paclitaxel in the treatment of breast cancer: A review of clinical experience. The Oncologist, 9(Suppl 2), 24–32. https://doi.org/10.1634/theoncologist.9-S2-24

Article  CAS  PubMed  Google Scholar 

Diéras, V., Furnoleau, P., Kalla, S., Misset, J. L., Azli, N., & Pouillart, P. (1997). Docetaxel in combination with doxorubicin or vinorelbine. European Journal Of Cancer, 33, 20–22. https://doi.org/10.1016/S0959-8049(97)90005-8

Article  Google Scholar 

Liskova, A., Samec, M., Koklesova, L., Brockmueller, A., Zhai, K., Abdellatif, B., Siddiqui, M., Biringer, K., Kudela, E., Pec, M., Gadanec, L. K., Šudomová, M., Hassan, S. T. S., Zulli, A., Shakibaei, M., Giordano, F. A., Büsselberg, D., Golubnitschaja, O., & Kubatka, P. (2021). Flavonoids as an effective sensitizer for anti-cancer therapy: insights into multi-faceted mechanisms and applicability towards individualized patient profiles. EPMA J, 12(2), 155–176. https://doi.org/10.1007/s13167-021-00242-5

Article  PubMed  PubMed Central  Google Scholar 

Zhang, H., Hu, J., Fu, R., Liu, X., Zhang, Y., Li, J., Liu, L., Li, Y., Deng, Q., Luo, Q., Ouyang, O., & Gao, N. (2018). Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3K γ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Scientific Reports, 8(1). https://doi.org/10.1038/s41598-018-29308-7

Erdogan, S., Doganlar, O., Doganlar, Z. B., & Turkekul, K. (2017). Naringin sensitizes human prostate cancer cells to paclitaxel therapy. Prostate Int, 6(4), 126–135. https://doi.org/10.1016/j.prnil.2017.11.001

Article  PubMed  PubMed Central  Google Scholar 

Cleary, J. M., & Hancock, W. O. (2021). Molecular mechanisms underlying microtubule growth dynamics. Current Biology, 31(10), R560–R573. https://doi.org/10.1016/j.cub.2021.02.035

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dasgupta, A., Kalidass, K., Farisha, S., Saha, R., Ghosh, S., & Ampasala, D. R. (2024). Identification of novel brain penetrant GSK-3β inhibitors toward Alzheimer’s disease therapy by virtual screening, molecular docking, dynamic simulation, and MMPBSA analysis. Journal Of Biomolecular Structure & Dynamics, 1–27. https://doi.org/10.1080/07391102.2024.2411524

Gangadharappa, B. S., Sharath, R., Revanasiddappa, P. D., Chandramohan, V., Balasubramaniam, M., & Vardhineni, T. P. (2019). Structural insights of metallo-beta-lactamase revealed an effective way of inhibition of enzyme by natural inhibitors. Journal Of Biomolecular Structure & Dynamics, 38(13), 3757–3771. https://doi.org/10.1080/07391102.2019.1667265

Article  CAS  Google Scholar 

Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. Journal Of Immunological Methods, 65, 55–63. https://doi.org/10.1016/0022-1759(83)90303-4

Article  CAS  PubMed  Google Scholar 

Chou, T., & Talalay, P. (1984). Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Advances In Enzyme Regulation, 22, 27–55. https://doi.org/10.1016/0065-2571(84)90007-4

Article  CAS  PubMed  Google Scholar 

Mitchison, T., & Kirschner, M. (1984). Dynamic instability of microtubule growth. Nature, 312(5991), 237–242. https://doi.org/10.1038/312237a0

Article  CAS  PubMed  Google Scholar 

Zhuang, S. H., Hung, Y. E., Hung, L., Robey, R. W., Sackett, D. L., Linehan, W. M., Bates, S. E., Fojo, T., & Poruchynsky, M. S. (2007). Evidence for microtubule target engagement in tumors of patients receiving ixabepilone, Clin. Cancer Research, 13(24), 7480–7486. https://doi.org/10.1158/1078-0432.CCR-06-2883

Article  CAS  Google Scholar 

Tsaur, I., Heidegger, A., Kretschmer, H., Borgmann, C., Mirvald, G., Gandaglia, A., Briganti, R., Van Den Bergh, D., Tilki, P., Ost, G., Ploussard, C., & Surcel (2018). Combining anticancer drugs with osteoprotective agents in prostate cancer—A contemporary update. Urol Oncol Semin Orig Investig, 36(11), 488–497. https://doi.org/10.1016/j.urolonc.2018.08.016

Article  CAS 

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