Expression Profile and Role of the Genes During Human in vitro Osteogenic Differentiation

Krol, J., Loedige, I., & Filipowicz, W. (2010). The widespread regulation of microRNA biogenesis, function and decay. Nature Reviews Genetics, 11, 597–610.

Article  CAS  PubMed  Google Scholar 

Ranganathan, K., & Sivasankar, V. (2014). MicroRNAs - Biology and clinical applications. J Oral Maxillofac Pathol, 18, 229–234.

Article  PubMed  PubMed Central  Google Scholar 

Wei, J., Li, H., Wang, S., Li, T., Fan, J., Liang, X., Li, J., Han, Q., Zhu, L., Fan, L., & Zhao, R. C. (2014). let-7 enhances osteogenesis and bone formation while repressing adipogenesis of human stromal/mesenchymal stem cells by regulating HMGA2. Stem Cells And Development, 23, 1452–1463.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yuan, H., Zhao, H., Wang, J., Zhang, H., Hong, L., Li, H., Che, H., & Zhang, Z. (2019). MicroRNA let-7c-5p promotes osteogenic differentiation of dental pulp stem cells by inhibiting lipopolysaccharide-induced inflammation via HMGA2/PI3K/Akt signal blockade. Clinical And Experimental Pharmacology And Physiology, 46, 389–397.

Article  CAS  PubMed  Google Scholar 

de Vasconcellos, J. F., Jackson, W. M., Dimtchev, A., & Nesti, L. J. (2020). A microRNA Signature for Impaired Wound-Healing and Ectopic Bone Formation in Humans. Journal Of Bone And Joint Surgery. American Volume, 102, 1891–1899.

PubMed  Google Scholar 

Benjamin Boyerinas, B., Park, S., Shomron, N., Hedegaard, M. M., Vinther, J., Andersen, J. S., Feig, C., Xu, J., Burge, C. B., & Peter, M. E. (2008). Identification of let-7-regulated oncofetal genes. Cancer Research, 68, 2587–2591.

Article  PubMed  Google Scholar 

Bell, J. L., Wächter, K., Mühleck, B., Pazaitis, N., Köhn, M., Lederer, M., & Hüttelmaier, S. (2013). Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression? Cellular And Molecular Life Sciences, 70, 2657–2675.

Article  CAS  PubMed  Google Scholar 

Busch, B., Bley, N., Müller, S., Glaß, M., Misiak, D., Lederer, M., Vetter, M., Strauß, H., Thomssen, C., & Hüttelmaier, S. (2016). The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Research, 44, 3845–3864.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Waly, A. A., El-Ekiaby, N., Assal, R. A., Abdelrahman, M. M., Hosny, K. A., El Tayebi, H. M., Esmat, G., & Kai Breuhahn, Abdelaziz, A. I. (2019). Methylation in MIRLET7A3 Gene Induces the Expression of IGF-II and Its mRNA Binding Proteins IGF2BP-2 and 3 in Hepatocellular Carcinoma. Front Physiol. 9, 1918.

Yan, L., Sun, J., Wang, Y., Liu, X., Hu, J., Sun, M., Suo, X., Duan, R., & Yuan, C. (2024). Lin28 affects the proliferation and osteogenic differentiation of human dental pulp stem cells by directly inhibiting let-7b maturation. BDJ Open, 10, 17.

Article  PubMed  PubMed Central  Google Scholar 

Nesti, L. J., Jackson, W. M., Shanti, R. M., Koehler, S. M., Aragon, A. B., Bailey, J. R., Sracic, M. K., Freedman, B. A., Giuliani, J. R., & Tuan, R. S. (2008). Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissue. Journal Of Bone And Joint Surgery. American Volume, 90, 2390–2398.

PubMed  PubMed Central  Google Scholar 

Woodard, G. E., Ji, Y., Christopherson, G. T., Wolcott, K. M., Hall, D. J., Jackson, W. M., & Nesti, L. J. (2014). Characterization of discrete subpopulations of progenitor cells in traumatic human extremity wounds. PLoS One, 9(12), e114318. https://doi.org/10.1371/journal.pone.0114318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dingle, M., Fernicola, S. D., de Vasconcellos, J. F., Zicari, S., Daniels, C., Dunn, J. C., Dimtchev, A., & Nesti, L. J. (2021). Characterization of traumatized muscle-derived multipotent progenitor cells from low-energy trauma. Stem Cell Research & Therapy, 12, 6.

Article  CAS  Google Scholar 

Livak, K. J., & Schmittgen, T. D. (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods, 25, 402–408.

Article  CAS  PubMed  Google Scholar 

de Vasconcellos, J. F., Westbrook, P., Dingle, M., Dimtchev, A., Raiciulescu, S., Schellhase, C. W., Piscoya, A., Putko, R., Bedrin, M., Cole, H., Cubbage, N., Dargan, L. J., PellegriniJr, V. D., & Nesti, L. J. (2025). Preclinical validation of TGFβ inhibitors as a novel therapeutic strategy for post-traumatic heterotopic ossification. Scientific Reports, 15, 14277.

Article  PubMed  PubMed Central  Google Scholar 

Clough, E., Barrett, T., Wilhite, S. E., Ledoux, P., Evangelista, C., Kim, I. F., Tomashevsky, M., Marshall, K. A., Phillippy, K. H., Sherman, P. M., Lee, H., Zhang, N., Serova, N., Wagner, L., Zalunin, V., Kochergin, A., & Soboleva, A. (2024). NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update. Nucleic Acids Research, 52, D138–D144.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Vasconcellos, J. F., Byrnes, C., Lee, Y. T., Allwardt, J. M., Kaushal, M., Rabel, A., & Miller, J. L. (2017). Tough decoy targeting of predominant let-7 miRNA species in adult human hematopoietic cells. J Transl Med, 15, 169.

Article  PubMed  PubMed Central  Google Scholar 

Roush, S., & Slack, F. J. (2008). The let-7 family of microRNAs. Trends In Cell Biology, 18, 505–516.

Article  CAS  PubMed  Google Scholar 

Liu, G., Lu, Y., Mai, Z., Liu, R., Peng, Z., Chen, L., Chen, Z., Wang, R., & Ai, H. (2019). Suppressing MicroRNA-30b by Estrogen Promotes Osteogenesis in Bone Marrow Mesenchymal Stem Cells. Stem Cells Int, 2019, 7547506.

Article  PubMed  PubMed Central  Google Scholar 

Wang, Y., Pang, X., Wu, J., Jin, L., Yu, Y., Gobin, R., & Yu, J. (2018). MicroRNA hsa-let-7b suppresses the odonto/osteogenic differentiation capacity of stem cells from apical papilla by targeting MMP1. Journal Of Cellular Biochemistry, 119, 6545–6554.

Article  CAS  PubMed  Google Scholar 

Bakhshandeh, B., Soleimani, M., Hafizi, M., Paylakhi, S. H., & Ghaemi, N. (2012). MicroRNA signature associated with osteogenic lineage commitment. Molecular Biology Reports, 39, 7569–7581.

Article  CAS  PubMed  Google Scholar 

Huang, C., Geng, J., & Jiang, S. (2017). MicroRNAs in regulation of osteogenic differentiation of mesenchymal stem cells. Cell And Tissue Research, 368, 229–238.

Article  CAS  PubMed  Google Scholar 

Avendaño-Félix, M., Fuentes-Mera, L., Ramos-Payan, R., Aguilar-Medina, M., Pérez-Silos, V., Moncada-Saucedo, N., Marchat, L. A., González-Barrios, J. A., Ruiz-García, E., Astudillo-de, la Vega, H., Cruz-Colin, J. L., & López-Camarillo, C. (2019). A Novel OsteomiRs Expression Signature for Osteoblast Differentiation of Human Amniotic Membrane-Derived Mesenchymal Stem Cells. Biomed Res Int. 2019, 8987268.

Noh, S., Miller, S. H., Lee, Y. T., Goh, S., Marincola, F. M., Stroncek, D. F., Reed, C., Wang, E., & Miller, J. L. (2009). Let-7 microRNAs are developmentally regulated in circulating human erythroid cells. J Transl Med, 7, 98.

Article  PubMed  PubMed Central  Google Scholar 

de Vasconcellos, J. F., Tumburu, L., Byrnes, C., Lee, Y. T., Xu, P. C., Li, M., Rabel, A., Clarke, B. A., Guydosh, N. R., Proia, R. L., & Miller, J. L. (2017). IGF2BP1 overexpression causes fetal-like hemoglobin expression patterns in cultured human adult erythroblasts. Proc Natl Acad Sci U S A, 114, E5664–E5672.

Article  PubMed  PubMed Central  Google Scholar 

Alrashed, M. M., Alshehry, A. S., Ahmad, M., He, J., Wang, Y., & Xu, Y. (2022). miRNA Let-7a-5p targets RNA KCNQ1OT1 and Participates in Osteoblast Differentiation to Improve the Development of Osteoporosis. Biochemical Genetics, 60, 370–381.

Article  CAS  PubMed  Google Scholar 

Zhang, J., Yu, X., Yu, Y., & Gong, Y. (2017). MicroRNA expression analysis during FK506-induced osteogenic differentiation in rat bone marrow stromal cells. Molecular Medicine Reports, 16, 581–590.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goff, L. A., Boucher, S., Ricupero, C. L., Fenstermacher, S., Swerdel, M., Chase, L. G., Adams, C. C., Chesnut, J., Lakshmipathy, U., & Hart, R. P. (2008). Differentiating human multipotent mesenchymal stromal cells regulate microRNAs: prediction of microRNA regulation by PDGF during osteogenesis. Experimental Hematology, 36, 1354–1369.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oskowitz, A. Z., Lu, J., Penfornis, P., Ylostalo, J., McBride, J., Flemington, E. K., Prockop, D. J., & Pochampally, R. (2008). Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression. Proc Natl Acad Sci U S A, 105, 18372–18377.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chang, C., Venø, M. T., Chen, L., Ditzel, N., Le, D. Q. S., Dillschneider, P., Kassem, M., & Kjems, J. (2018). Global MicroRNA Profiling in Human Bone Marrow Skeletal-Stromal or Mesenchymal-Stem Cells Identified Candidates for Bone Regeneration. Molecular Therapy, 26, 593–605.

Article  CAS 

Comments (0)

No login
gif