Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies

Wehrwein EA, Orer HS, Barman SM. Overview of the anatomy, physiology, and pharmacology of the autonomic nervous system. Compr Physiol. 2016;6:1239–78. https://doi.org/10.1002/cphy.c150037.

Article  PubMed  Google Scholar 

Jaul E, Barron J. Age-related diseases and clinical and public health implications for the 85 years old and over population. Front Public Health. 2017;5:335. https://doi.org/10.3389/fpubh.2017.00335. eCollection 2017.

Article  PubMed  PubMed Central  Google Scholar 

Jiang Y, Yabluchanskiy A, Deng J, Amil FA, Po SS, Dasari TW. The role of age-associated autonomic dysfunction in inflammation and endothelial dysfunction. Geroscience. 2022;44:2655–70. https://doi.org/10.1007/s11357-022-00616-1.

Article  PubMed  PubMed Central  Google Scholar 

Uusitalo AL, Vanninen E, Levälahti E, Battié MC, Videman T, Kaprio J. Role of genetic and environmental influences on heart rate variability in middle-aged men. Am J Physiol Heart Circ Physiol. 2007;293:H1013–22. https://doi.org/10.1152/ajpheart.00475.2006.

Article  CAS  PubMed  Google Scholar 

Seals DR, Esler MD. Human ageing and the sympathoadrenal system. J Physiol. 2000;5283:407–17. https://doi.org/10.1111/j.1469-7793.2000.00407.x.

Article  Google Scholar 

Verdú E, Ceballos D, Vilches JJ, Navarro X. Influence of aging on peripheral nerve function and regeneration. J Peripher Nerv Syst. 2000;5:191–208. https://doi.org/10.1046/j.1529-8027.2000.00026.x.

Article  PubMed  Google Scholar 

Kovacic U, Sketelj J, Bajrović FF. Chapter 26: age-related differences in the reinnervation after peripheral nerve injury. Int Rev Neurobiol. 2009;87:465–82. https://doi.org/10.1016/S0074-7742(09)87026-8.

Article  CAS  PubMed  Google Scholar 

Maita KC, Garcia JP, Avila FR, Torres-Guzman RA, Ho O, Chini CCS, Chini EN, Forte AJ. Evaluation of the aging effect on peripheral nerve regeneration: a systematic review. J Surg Res. 2023;288:329–40. https://doi.org/10.1016/j.jss.2023.03.017.

Article  PubMed  Google Scholar 

Tsuji H, Larson MG, Venditti FJ, Manders ES, Evans JC, Feldman CL, Levy D. Impact of reduced heart rate variability on risk for cardiac events. The Framingham Heart Study. Circulation. 1996;94:2850–5.

Article  CAS  PubMed  Google Scholar 

Dekker JM, Schouten EG, Klootwijk P, Pool J, Swenne CA, Kromhout D. Heart rate variability from short electrocardiographic recordings predicts mortality from all causes in middle-aged and elderly men. The Zutphen Study. Am J Epidemiol. 1997;145:899–908. https://doi.org/10.1093/oxfordjournals.aje.a009049.

Article  CAS  PubMed  Google Scholar 

Dekker JM, Crow RS, Folsom AR, Hannan PJ, Liao D, Swenne CA, Schouten EG. Low heart rate variability in a 2-minute rhythm strip predicts risk of coronary heart disease and mortality from several causes: the ARIC Study. Atherosclerosis risk in communities. Circulation. 2000;102:1239–44. https://doi.org/10.1161/01.cir.102.11.1239.

Article  CAS  PubMed  Google Scholar 

Piccirillo G, Bucca C, Bauco C, Cinti AM, Michele D, Fimognari FL, Cacciafesta M, Marigliano V. Power spectral analysis of heart rate in subjects over a hundred years old. Int J Cardiol. 1998;63:53–61. https://doi.org/10.1016/s0167-5273(97)00282-9.

Article  CAS  PubMed  Google Scholar 

Hotta H, Sae Uchida S. Aging of the autonomic nervous system and possible improvements in autonomic activity using somatic afferent stimulation. Geriatr Gerontol Int. 2010;10:S127–36.

Article  PubMed  Google Scholar 

Tracey KJ. The inflammatory reflex. Nature. 2002;420:853–9.

Article  CAS  PubMed  Google Scholar 

Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G. Inflamm-aging: an evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 2000;908:244–54. https://doi.org/10.1111/j.1749-6632.2000.tb06651.x.

Article  CAS  PubMed  Google Scholar 

Giunta S. Is inflammaging an auto[innate]immunity subclinical syndrome? Immun Ageing. 2006;3:12. https://doi.org/10.1186/1742-4933-3-12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia S, Zhang X, Zheng S, Khanabdali R, Kalionis B, Wu J, Wan W, Tai X. An update on inflamm-aging: mechanisms, prevention, and treatment. J Immunol Res. 2016;2016:8426874–8426812.

Article  PubMed  PubMed Central  Google Scholar 

Herranz N, Gil J. Mechanisms and functions of cellular senescence. J Clin Invest. 2018;128:1238–46. https://doi.org/10.1172/JCI95148.

Article  PubMed  PubMed Central  Google Scholar 

Olivieri F, Prattichizzo F, Grillari J, Balistreri CR. Cellular senescence and inflammaging in age-related diseases. Mediators Inflamm. 2018;1–6. https://doi.org/10.1155/2018/9076485.

Wei Y, Jia S, Ding Y, Xia S, Giunta S. Balanced basal-levels of ROS (redox-biology), and very-low-levels of pro-inflammatory cytokines (cold-inflammaging), as signaling molecules can prevent or slow-down overt-inflammaging, and the aging-associated decline of adaptive-homeostasis. Exp Gerontol. 2023;172: 112067.

Article  CAS  PubMed  Google Scholar 

Thomas R, Wang W, Su DM. Contributions of age-related thymic involution to immunosenescence and inflammaging. Immun Ageing. 2020;17:1–17. https://doi.org/10.1186/s12979-020-0173-8.

Article  CAS  Google Scholar 

Sayed N, Huang Y, Nguyen K, Krejciova-Rajaniemi Z, Grawe AP, Gao T, Tibshirani R, Hastie T, Alpert A, Cui L, Kuznetsova T, Rosenberg-Hasson Y, Ostan R, Monti D, Lehallier B, Shen-Orr SS, Maecker HT, Dekker CL, Wyss-Coray T, Franceschi C, Jojic V, Haddad F, Montoya JG, Wu JC, Davis MM, Furman D. An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nat Aging. 2021;1:598–615. https://doi.org/10.1038/s43587-021-00082-y.

Article  PubMed  PubMed Central  Google Scholar 

Frasca D, Blomberg BB. Inflammaging decreases adaptive and innate immune responses in mice and humans. Biogerontology. 2016;17:7–19. https://doi.org/10.1007/s10522-015-9578-8.

Article  CAS  PubMed  Google Scholar 

Serrano-López J, Martín-Antonio B. Inflammaging, an imbalanced immune response that needs to be restored for cancer prevention and treatment in the elderly. Cells. 2021;10:2562. https://doi.org/10.3390/cells10102562.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Storci G, De Carolis S, Olivieri F, Bonafè M. Changes in the biochemical taste of cytoplasmic and cell-free DNA are major fuels for inflamm-aging. Semin Immunol. 2018;40:6–16. https://doi.org/10.1016/j.smim.2018.08.003.

Article  CAS  PubMed  Google Scholar 

Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev. 2011;21:107–12. https://doi.org/10.1016/j.gde.2010.10.005.

Article  CAS  PubMed  Google Scholar 

Matacchione G, Perugini J, Di Mercurio E, Sabbatinelli J, Prattichizzo F, Senzacqua M, Storci G, Dani C, Lezoche G, Guerrieri M, Giordano A, Bonafè M, Olivieri F. Senescent macrophages in the human adipose tissue as a source of inflammaging. Geroscience. 2022;44:1941–60. https://doi.org/10.1007/s11357-022-00536-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Afonina IS, Zhong Z, Karin M, Beyaert R. Limiting inflammation-the negative regulation of NF-Κb and the NLRP3 inflammasome. Nat Immunol. 2017;18:861–9. https://doi.org/10.1038/ni.3772.

Article  CAS  PubMed  Google Scholar 

Prattichizzo F, Bonafè M, Olivieri F, Franceschi C. Senescence associated macrophages and “macroph-aging”: are they pieces of the same puzzle? Aging (Albany NY). 2016;8:3159–60. https://doi.org/10.18632/aging.101133.

Article  CAS  PubMed  Google Scholar 

Teissier T, Boulanger E, Cox LS. Interconnections between inflammageing and immunosenescence during ageing. Cells. 2022;11:359. https://doi.org/10.3390/cells11030359.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aiello A, Farzaneh F, Candore G, Caruso C, Davinelli S, Gambino CM, Ligotti ME, Zareian N, Accardi G. Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention. Front Immunol. 2019;10:2247. https://doi.org/10.3389/fimmu.2019.02247. eCollection 2019.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fulop T, Larbi A, Pawelec G, Khalil A, Cohen AA, Hirokawa K, Witkowski JM, Franceschi C. Immunology of aging: the birth of inflammaging. Clin Rev Allergy Immunol. 2023;64:109–22. https://doi.org/10.1007/s12016-021-08899-6.

Article  CAS  PubMed  Google Scholar 

Schmauck-Medina T, Molière A, Lautrup S, Zhang J, Chlopicki S, Madsen HB, Cao S, Soendenbroe C, Mansell E, Vestergaard MB, Li Z, Shiloh Y, Opresko PL, Egly JM, Kirkwood T, Verdin E, Bohr VA, Cox LS, Stevnsner T, Rasmussen LJ, Fang EF. New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary. Aging (Albany NY). 2022;14:6829–39. https://doi.org/10.18632/aging.204248.

Article  PubMed  Google Scholar 

Neves J, Sousa-Victor P. Regulation of inflammation as an anti-aging intervention. FEBS J. 2020;287:43–52. https://doi.org/10.1111/febs.15061.

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