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Identification of lysosomal lipolysis as an essential noncanonical mediator of adipocyte fasting and cold-induced lipolysis
Research ArticleEndocrinologyMetabolism Open Access | 10.1172/JCI185340 Yu-Sheng Yeh,1,2 ...
Nonvesicular cholesterol transport in physiology
The absorption of dietary lipids takes place mainly in the proximal small intestine. In the intestinal lumen, cholesterol...
Safety and efficacy of pharmacological inhibition of ketohexokinase in hereditary fructose intolerance
Research LetterEndocrinologyMetabolism Open Access | 10.1172/JCI187376 Evi J.C. Koene,1,2 ...
Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence
MUC5AC-rich mucus plugs in asthma are tethered to an epithelium that is buckled to form mucosal folds. We used histology ...
Sensing mycobacteria through unconventional pathways
At present, the factors driving the CD4+ bias of CD1b-TMM–restricted cells remain unclear. Interestingly, CD1b-GMM– and C...
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Ischemic injury to tubular epithelium. The most common form of tubular injury in patients occurs due to renal hypoperfusi...
Targeting ubiquitin-independent proteasome with small molecule increases susceptibility in pan-KRAS–mutant cancer models
Research ArticleOncology Open Access | 10.1172/JCI185278 Shihui Shen,1,2 Qiansen Zhang,1 ...
High PRMT5 levels, maintained by KEAP1 inhibition, drive chemoresistance in high-grade serous ovarian cancer
Sex as a biological variable. Our study exclusively examined female mice because the disease modeled is only relevant in ...
Estrogen receptor-α ablation reverses muscle fibrosis and inguinal hernias
Fibroblast-specific ablation of ESR1 prevents herniation in Aromhum mice. All Aromhum mice developed a fibrotic process c...
Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritis
Research ArticleAutoimmunityImmunology Open Access | 10.1172/JCI185217 Jun Inamo,1,2 Josh...
Macrophages: key conductors behind perivascular inflammation and vascular remodeling in hypoxia-induced pulmonary hypertension
Importantly, further studies that explore alternative CCL2 sources and alternative stimuli beyond hypoxia that contribute...
ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis
Clinical Research and Public HealthEndocrinologyMetabolism Open Access | 10.1172/JCI184740 Aa...
Activating antiviral immune responses potentiates immune checkpoint inhibition in glioblastoma models
Research ArticleOncologyVirology Open Access | 10.1172/JCI183745 Deepa Seetharam,1,2 Jay ...
KRAS mutants confer platinum resistance by regulating ALKBH5 posttranslational modifications in lung cancer
KRAS constitutively active mutations are associated with NSCLC platinum resistance. Despite the widespread occurrence of ...
Monocytes and interstitial macrophages contribute to hypoxic pulmonary hypertension
Research ArticleInflammationVascular biology Open Access | 10.1172/JCI176865 Rahul Kumar,1,2 ...
Oncostatin M silence and neopeptide: the value of exploring patients with rare inherited bone marrow failure
In this issue of the JCI, Garrigue, Kermasson, and colleagues demonstrate that human oncostatin M (OSM) deficiency underl...
Human oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome
Research ArticleGeneticsHematology Open Access | 10.1172/JCI180981 Alexandrine Garrigue,1 ...
ZDHHC18 promotes renal fibrosis development by regulating HRAS palmitoylation
Research ArticleNephrology Open Access | 10.1172/JCI180242 Di Lu,1 Gulibositan Aji,2 ...
Extracranial arteriovenous malformations: towards etiology-based therapeutic management
The unraveling of the major initiating mechanisms for AVM formation has propelled the field to think of targeted molecula...
Hepatitis B virus infection disrupts homologous recombination in hepatocellular carcinoma by stabilizing resection inhibitor ADRM1
Research ArticleHepatologyVirology Open Access | 10.1172/JCI171533 Ming Zeng,1 Zizhi Tang,1...
Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis
Research ArticleDermatologyImmunology Open Access | 10.1172/JCI171088 Satoshi Nakamizo,1,2 ...
Bone-derived PDGF-BB drives brain vascular calcification in male mice
Aged mice develop brain calcification primarily in the thalamus region. Brain calcification is commonly detected in elder...
OSR1 disruption contributes to uterine factor infertility via impaired Müllerian duct development and endometrial receptivity
Research ArticleDevelopmentReproductive biology Open Access | 10.1172/JCI161701 Adriana Lofrano...
Does activating brown fat contribute to important metabolic benefits in humans? Yes!
Research on mouse FA metabolism has shown how triglyceride-rich lipoproteins (TRL) are taken up through a sequence of tis...
High-frequency home self-collection of capillary blood correlates IFI27 expression kinetics with SARS-CoV-2 viral clearance
Research LetterCOVID-19Infectious disease Open Access | 10.1172/JCI173715 Fang Yun Lim,1,2 ...
A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T
Research ArticleMetabolismTherapeutics Open Access | 10.1172/JCI163464 Kentaro Ito,1,2 Go T...
Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses
Research ArticleVaccines Open Access | 10.1172/JCI166827 Atsushi Kawai,1,2 Nagisa Tokunoh,2...
Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters
Clinical MedicineAutoimmunityDermatology Open Access | 10.1172/JCI166357 Dawoon Han,1 A Yeo...
The gift of preexisting immunity for developing an alternative vaccine strategy
The SARS-CoV-2 pandemic brought an immense advancement in vaccine development, resulting in the worldwide distribution of...
Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets
Research ArticleCell biologyOncology Open Access | 10.1172/JCI168146 Ricardo Cruz-Acuña,1 S...
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