Research ArticleOncology Open Access | 10.1172/JCI185278

Shihui Shen,1,2 Qiansen Zhang,1 Yuhan Wang,1 Hui Chen,2 Shuangming Gong,1 Yun Liu,1 Conghao Gai,3 Hansen Chen,1 Enhao Zhu,1 Bo Yang,1 Lin Liu,1 Siyuan Cao,1 Mengting Zhao,1 Wenjie Ren,1 Mengjuan Li,1 Zhuoya Peng,1 Lu Zhang,1 Shaoying Zhang,1 Juwen Shen,1 Bianhong Zhang,1 Patrick K.H. Lee,4 Kun Li,5 Lei Li,2 and Huaiyu Yang1

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Shen, S. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Zhang, Q. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Wang, Y. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Chen, H. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Gong, S. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Liu, Y. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Gai, C. in: JCI | PubMed | Google Scholar |

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Chen, H. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Zhu, E. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Yang, B. in: JCI | PubMed | Google Scholar |

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Liu, L. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Cao, S. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Zhao, M. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Ren, W. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Li, M. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Peng, Z. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Zhang, L. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Zhang, S. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Shen, J. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Zhang, B. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Lee, P. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Li, K. in: JCI | PubMed | Google Scholar |

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Li, L. in: JCI | PubMed | Google Scholar

1Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, Shanghai, China.

2Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, Shanghai, China.

3Organic Chemistry Group, College of Pharmacy, Naval Medical University, Shanghai, China.

4School of Energy and Environment, City University of Hong Kong, Hong Kong SAR, China.

5Health Science Center, East China Normal University, Shanghai, China.

Address correspondence to: Huaiyu Yang, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Phone: 86.21.54345015; Email: hyyang@bio.ecnu.edu.cn. Or to: Qiansen Zhang, Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences, School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: qszhang@bio.ecnu.edu.cn. Or to: Kun Li, Health Science Center, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: kli@hsc.ecnu.edu.cn. Or to: Lei Li, Joint Center for Translational Medicine, Shanghai Fifth People’s Hospital, Fudan University and School of Life Science, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China. Email: lli@bio.ecnu.edu.cn.

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Find articles by Yang, H. in: JCI | PubMed | Google Scholar

Authorship note: SS, QZ, YW, and HC contributed equally to this work.

Published March 17, 2025 - More info

Published in Volume 135, Issue 6 on March 17, 2025
J Clin Invest. 2025;135(6):e185278. https://doi.org/10.1172/JCI185278.
© 2025 Shen et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Published March 17, 2025 - Version history
Received: July 25, 2024; Accepted: January 16, 2025 View PDF Abstract

Despite advances in the development of direct KRAS inh