B. March, S. Faulkner, P. Jobling, A. Steigler, A. Blatt, J. Denham, H. Hondermarck, Tumour innervation and neurosignalling in prostate cancer. Nat. Rev. Urol. 17, 119–130 (2020)
A.H. Zahalka, P.S. Frenette, Nerves in cancer. Nat. Rev. Cancer 20, 143–157 (2020)
Article CAS PubMed PubMed Central Google Scholar
U. Mehraj, R.A. Ganai, M.A. Macha, A. Hamid, M.A. Zargar, A.A. Bhat, M.W. Nasser, M. Haris, S.K. Batra, B. Alshehri, R.S. Al-Baradie, M.A. Mir, N.A. Wani, The tumor microenvironment as driver of stemness and therapeutic resistance in breast cancer: new challenges and therapeutic opportunities. Cell. Oncol. (Dordr.) 44, 1209–1229 (2021)
J. Hu, W. Chen, L. Shen, Z. Chen, J. Huang, Crosstalk between the peripheral nervous system and breast cancer influences tumor progression. Biochim. Biophys. Acta Rev. Cancer 1877, 188828 (2022)
Article CAS PubMed Google Scholar
S.M. Gysler, R. Drapkin, Tumor innervation: peripheral nerves take control of the tumor microenvironment. J. Clin. Investig. 131, (2021)
H.D. Reavis, H.I. Chen, R. Drapkin, Tumor innervation: cancer has some nerve, trends. Cancer 6, 1059–1067 (2020)
S.H. Jiang, L.P. Hu, X. Wang, J. Li, Z.G. Zhang, Neurotransmitters: emerging targets in cancer. Oncogene 39, 503–515 (2020)
Article CAS PubMed Google Scholar
B.W. Renz, R. Takahashi, T. Tanaka, M. Macchini, Y. Hayakawa, Z. Dantes, H.C. Maurer, X. Chen, Z. Jiang, C.B. Westphalen, M. Ilmer, G. Valenti, S.K. Mohanta, A.J.R. Habenicht, M. Middelhoff, T. Chu, K. Nagar, Y. Tailor, R. Casadei, M. Di Marco, A. Kleespies, R.A. Friedman, H. Remotti, M. Reichert, D.L. Worthley, J. Neumann, J. Werner, A.C. Iuga, K.P. Olive, T.C. Wang, beta2 adrenergic-neurotrophin feedforward loop promotes pancreatic cancer. Cancer Cell 33, 75-90 e77 (2018)
Article CAS PubMed Google Scholar
C.M. Zhao, Y. Hayakawa, Y. Kodama, S. Muthupalani, C.B. Westphalen, G.T. Andersen, A. Flatberg, H. Johannessen, R.A. Friedman, B.W. Renz, A.K. Sandvik, V. Beisvag, H. Tomita, A. Hara, M. Quante, Z. Li, M.D. Gershon, K. Kaneko, J.G. Fox, T.C. Wang, D. Chen, Denervation suppresses gastric tumorigenesis. Sci. Transl. Med. 6, 250ra115 (2014)
Article PubMed PubMed Central Google Scholar
N. Vaes, M. Idris, W. Boesmans, M.M. Alves, V. Melotte, Nerves in gastrointestinal cancer: from mechanism to modulations. Nat. Rev. Gastroenterol. Hepatol. 19, 768–784 (2022)
N. Erin, Role of sensory neurons, neuroimmune pathways, and transient receptor potential vanilloid 1 (TRPV1) channels in a murine model of breast cancer metastasis. Cancer Immunol. Immunother. 69, 307–314 (2020)
Article CAS PubMed Google Scholar
N. Bencze, C. Schvarcz, G. Kriszta, L. Danics, E. Szoke, P. Balogh, A. Szallasi, P. Hamar, Z. Helyes, B. Botz, Desensitization of capsaicin-sensitive afferents accelerates early tumor growth via increased vascular leakage in a murine model of triple negative breast cancer. Front. Oncol. 11, 685297 (2021)
Article CAS PubMed PubMed Central Google Scholar
J. Gatherwright, R. Knackstedt, Targeted breast re-innervation (TBR) for post-mastectomy pain. J. Plast. Reconstr. Aesthet. Surg. 72, 1700–1738 (2019)
M. Amit, S. Na’ara, Z. Gil, Mechanisms of cancer dissemination along nerves. Nat. Rev. Cancer 16, 399–408 (2016)
Article CAS PubMed Google Scholar
C. Liebig, G. Ayala, J.A. Wilks, D.H. Berger, D. Albo, Perineural invasion in cancer: a review of the literature. Cancer 115, 3379–3391 (2009)
Article CAS PubMed Google Scholar
K. Hosoya, M. Wakahara, K. Ikeda, Y. Umekita, Perineural invasion predicts unfavorable prognosis in patients with invasive breast cancer. Cancer Diagn. Progn. 3, 208–214 (2023)
Article PubMed PubMed Central Google Scholar
P. Narayan, J. Flynn, Z. Zhang, E.F. Gillespie, B. Mueller, A.J. Xu, J. Cuaron, B. McCormick, A.J. Khan, O. Cahlon, S.N. Powell, H. Wen, L.Z. Braunstein, Perineural invasion as a risk factor for locoregional recurrence of invasive breast cancer. Sci. Rep. 11, 12781 (2021)
Article CAS PubMed PubMed Central Google Scholar
F. Marchesi, L. Piemonti, A. Mantovani, P. Allavena, Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis. Cytokine Growth Factor Rev. 21, 77–82 (2010)
Article CAS PubMed Google Scholar
W.K. Cowan, P. Kelly, A. Sawan, W.J. Cunliffe, L. Henry, M.J. Higgs, L.G. Lunt, J.R. Young, C.H. Horne, B. Angus, The pathological and biological nature of screen-detected breast carcinomas: a morphological and immunohistochemical study. J. Pathol. 182, 29–35 (1997)
Article CAS PubMed Google Scholar
Y. Jiang, H. Zhang, J. Wang, Y. Liu, T. Luo, H. Hua, Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy. J. Hematol. Oncol. 15, 34 (2022)
Article PubMed PubMed Central Google Scholar
M. Najafi, B. Farhood, K. Mortezaee, Extracellular matrix (ECM) stiffness and degradation as cancer drivers. J. Cell. Biochem. 120, 2782–2790 (2019)
Article CAS PubMed Google Scholar
V. Mohan, A. Das, I. Sagi, Emerging roles of ECM remodeling processes in cancer. Semin. Cancer Biol. 62, 192–200 (2020)
Article CAS PubMed Google Scholar
C. Bonnans, J. Chou, Z. Werb, Remodelling the extracellular matrix in development and disease. Nat. Rev. Mol. Cell Biol. 15, 786–801 (2014)
Article CAS PubMed PubMed Central Google Scholar
O. Chaudhuri, J. Cooper-White, P.A. Janmey, D.J. Mooney, V.B. Shenoy, Effects of extracellular matrix viscoelasticity on cellular behaviour. Nature 584, 535–546 (2020)
Article CAS PubMed PubMed Central Google Scholar
A. Hupfer, A. Brichkina, A. Koeniger, C. Keber, C. Denkert, P. Pfefferle, F. Helmprobst, A. Pagenstecher, A. Visekruna, M. Lauth, Matrix stiffness drives stromal autophagy and promotes formation of a protumorigenic niche. Proc. Natl. Acad. Sci. U. S. A. 118, (2021)
K.R. Levental, H. Yu, L. Kass, J.N. Lakins, M. Egeblad, J.T. Erler, S.F. Fong, K. Csiszar, A. Giaccia, W. Weninger, M. Yamauchi, D.L. Gasser, V.M. Weaver, Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139, 891–906 (2009)
Article CAS PubMed PubMed Central Google Scholar
K. Yoshihara, M. Shahmoradgoli, E. Martinez, R. Vegesna, H. Kim, W. Torres-Garcia, V. Trevino, H. Shen, P.W. Laird, D.A. Levine, S.L. Carter, G. Getz, K. Stemke-Hale, G.B. Mills, R.G.W. Verhaak, Inferring tumour purity and stromal and immune cell admixture from expression data. Nat. Commun. 4, (2013)
Z. Gil, O. Cavel, K. Kelly, P. Brader, A. Rein, S.P. Gao, D.L. Carlson, J.P. Shah, Y. Fong, R.J. Wong, Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves. J. Natl. Cancer Inst. 102, 107–118 (2010)
Article CAS PubMed PubMed Central Google Scholar
A. Samani, J. Zubovits, D. Plewes, Elastic moduli of normal and pathological human breast tissues: an inversion-technique-based investigation of 169 samples. Phys. Med. Biol. 52, 1565–1576 (2007)
R.S. Banh, D.E. Biancur, K. Yamamoto, A.S.W. Sohn, B. Walters, M. Kuljanin, A. Gikandi, H. Wang, J.D. Mancias, R.J. Schneider, M.E. Pacold, A.C. Kimmelman, Neurons release serine to support mRNA translation in pancreatic cancer. Cell 183, 1202-1218 e1225 (2020)
Article CAS PubMed Central Google Scholar
L. Lorenzini, V.A. Baldassarro, A. Stanzani, L. Giardino, Nerve growth factor: the first molecule of the neurotrophin family. Adv. Exp. Med. Biol. 1331, 3–10 (2021)
Article CAS PubMed Google Scholar
J.Z. Kechagia, J. Ivaska, P. Roca-Cusachs, Integrins as biomechanical sensors of the microenvironment. Nat. Rev. Mol. Cell Biol. 20, 457–473 (2019)
Article CAS PubMed Google Scholar
X. Chen, S. Wanggou, A. Bodalia, M. Zhu, W. Dong, J.J. Fan, W.C. Yin, H.K. Min, M. Hu, D. Draghici, W. Dou, F. Li, F.J. Coutinho, H. Whetstone, M.M. Kushida, P.B. Dirks, Y. Song, C.C. Hui, Y. Sun, L.Y. Wang, X. Li, X. Huang, A feedforward mechanism mediated by mechanosensitive ion channel PIEZO1 and tissue mechanics promotes glioma aggression. Neuron 100, 799-815 e797 (2018)
Article CAS PubMed Google Scholar
T. Zhou, B. Gao, Y. Fan, Y. Liu, S. Feng, Q. Cong, X. Zhang, Y. Zhou, P.S. Yadav, J. Lin, N. Wu, L. Zhao, D. Huang, S. Zhou, P. Su, Y. Yang, Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1-ss-catenin. Elife 9, (2020)
S. Li, C. Li, Y. Zhang, X. He, X. Chen, X. Zeng, F. Liu, Y. Chen, J. Chen, Targeting mechanics-induced fibroblast activation through CD44-RhoA-YAP pathway ameliorates crystalline silica-induced silicosis. Theranostics 9, 4993–5008 (2019)
Article CAS PubMed PubMed Central Google Scholar
S. Dupont, Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction. Exp. Cell Res. 343, 42–53 (2016)
Article CAS PubMed Google Scholar
S. Dupont, L. Morsut, M. Aragona, E. Enzo, S. Giulitti, M. Cordenonsi, F. Zanconato, J. Le Digabel, M. Forcato, S. Bicciato, N. Elvassore, S. Piccolo, Role of YAP/TAZ in mechanotransduction. Nature 474, 179–183 (2011)
Article CAS PubMed Google Scholar
A.A. Bapat, G. Hostetter, D.D. Von Hoff, H. Han, Perineural invasion and associated pain in pancreatic cancer. Nat. Rev. Cancer 11, 695–707 (2011)
Comments (0)