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Small molecule inhibits KCNQ channels with a non-blocking mechanism
Small molecule inhibits KCNQ channels with a non-blocking mechanism
Voltage-gated ion channels (VGICs) are crucial targets for neuropsychiatric therapeutics owing to their role in controllin...
PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins
PROTAR Vaccine 2.0 generates influenza vaccines by degrading multiple viral proteins
Manipulating viral protein stability using the cellular ubiquitin-proteasome system (UPS) represents a promising approach ...
A DNA phosphorothioation pathway via adenylated intermediate modulates Tdp machinery
A DNA phosphorothioation pathway via adenylated intermediate modulates Tdp machinery
In prokaryotes, the non-bridging oxygen in the DNA sugar-phosphate backbone can be enzymatically replaced by a sulfur atom...
Continuous selection in E. coli to identify cyclic peptide inhibitors of protein aggregation
Continuous selection in E. coli to identify cyclic peptide inhibitors of protein aggregation
Targeting of protein aggregates is technologically challenging. We developed a phage-assisted continuous evolution platfor...
Hashing the message with cells
Hashing the message with cells
The programming of multicellular processes for biological computation requires increasingly complex genetic circuit design...
Rolling toward circular solutions
Circular RNAs (circRNAs) are more stable than linear RNAs because they are resistant to degradation by exonucleases, makin...
TRIMming the nuclear pore
Molecular glues are small-molecule compounds that promote interactions between a protein of interest and an E3 ubiquitin l...
An influenza mutation switch
The highly pathogenic influenza H5N1 clade 2.3.4.4b virus has been dominant in birds and bovines in North America since 20...
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase
Biocatalytic cyclization of small macrolactams by a penicillin-binding protein-type thioesterase
Macrocyclic peptides represent promising scaffolds for chemical tools and potential therapeutics. Synthetic methods for pe...
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM
Compact Cas9 nucleases hold great promise for therapeutic applications. Although several compact Cas9 nucleases have been ...
In search of chemical rationales
In search of chemical rationales
Small molecules and drugs are not homogenously distributed across cells, and are instead enriched in distinct subcellular ...
Author Correction: An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity
Authors and AffiliationsDepartment of Chemistry, The University of Chicago, Chicago, IL, USATong Wu, Chang Liu, Siyuan Zou...
Characterizing the metabolomes of phase-separated condensates
Characterizing the metabolomes of phase-separated condensates
Cells contain compartments composed of phase-separated protein condensates. We find that these condensates have a unique c...
Medicine from modified mRNA
Medicine from modified mRNA
As the COVID-19 pandemic rapidly spread around the world, the scientific community desperately searched for therapeutic in...
Survival of the sweetest tooth
The development of multidrug resistance in bacteria is a global public health concern, and the genetic and molecular deter...
Traffic control
Lysosomal degradation of extracellular and membrane proteins can be facilitated by lysosome-targeted chimeras (LYTACs). LY...
RNA-based anti-CRISPRs
RNA-based anti-CRISPRs
Using a type I-F SRU as an example, Camara-Wilpert et al. demonstrate that SRUs inhibit CRISPR–Cas immunity via an RNA-bas...
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides
The modular nature of nonribosomal peptide biosynthesis has driven efforts to generate peptide analogs by substituting ami...
Accelerating the design of pili-enabled living materials using an integrative technological workflow
Accelerating the design of pili-enabled living materials using an integrative technological workflow
Bacteria can be programmed to create engineered living materials (ELMs) with self-healing and evolvable functionalities. H...
An allosteric redox switch involved in oxygen protection in a CO2 reductase
An allosteric redox switch involved in oxygen protection in a CO2 reductase
Metal-dependent formate dehydrogenases reduce CO2 with high efficiency and selectivity, but are usually very oxygen sensit...
A single-component, light-assisted uncaging switch for endoproteolytic release
A single-component, light-assisted uncaging switch for endoproteolytic release
Proteases function as pivotal molecular switches, initiating numerous biological events. Notably, potyviral protease, deri...
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
Mechanistic plasticity in ApmA enables aminoglycoside promiscuity for resistance
The efficacy of aminoglycoside antibiotics is waning due to the acquisition of diverse resistance mechanisms by bacteria. ...
Biomolecular condensates create phospholipid-enriched microenvironments
Biomolecular condensates create phospholipid-enriched microenvironments
Proteins and RNA can phase separate from the aqueous cellular environment to form subcellular compartments called condensa...
Micropolarity governs the structural organization of biomolecular condensates
Micropolarity governs the structural organization of biomolecular condensates
Membraneless organelles within cells have unique microenvironments that play a critical role in their functions. However, ...
Proximity-inducing pharmacology
Proximity-inducing pharmacology
Controlled interactions between macromolecules are fundamental regulatory layers. Hijacking these circuits via proximity-i...
Switching on stress
Switching on stress
The integrated stress response affects cell survival or death under stress conditions, and depends on the activity of the ...
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis
After the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating in...
Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis
Cofactorless oxygenases guide anthraquinone-fused enediyne biosynthesis
The anthraquinone-fused enediynes (AFEs) combine an anthraquinone moiety and a ten-membered enediyne core capable of gener...
A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling
A helical fulcrum in eIF2B coordinates allosteric regulation of stress signaling
The integrated stress response (ISR) enables cells to survive a variety of acute stresses, but chronic activation of the I...
Structure of GPR101–Gs enables identification of ligands with rejuvenating potential
Structure of GPR101–Gs enables identification of ligands with rejuvenating potential
GPR101 is an orphan G protein-coupled receptor actively participating in energy homeostasis. Here we report the cryo-elect...
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