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The Crystal Structure and Biochemical Analyses of Escherichia coli YqgF Illuminate Its Diverse Functions
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High-resolution Sequencing Reveals that the Paf1 Complex May be a Conserved Transcription Elongation Factor for Eukaryotic RNA Polymerase I
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PerturbSeq.db: An Integrated Repository for Comprehensive Analysis of Single-cell Perturbation Data
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Disease-associated Kv1.3 Variants are Energy Compromised with Impaired Nascent Chain Folding
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Structural Impact of Ex Vivo Resistance Mutations on HIV-1 Integrase Polymers Induced by Allosteric Inhibitors
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Universe of Lasso Proteins: Exploring the Limit of Entanglement of Proteins Predicted by AlphaFold
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Immunoproteasome-specific Subunit Alterations as a Potential Therapeutic Target for Mitochondriopathies
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Mycobacterial Methionine Aminopeptidase Type 1c Moonlights as an Anti-association Factor on the 30S Ribosomal Subunit
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VWA7 – A Putative Human Phosphatidylcholine-specific Phospholipase C
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Structural Basis of the LARP4-Filamin A Interaction and Competition with Integrin β7 Tails
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Allostery Links hACE2 Binding, Pan-variant Neutralization and Helical Extension in the SARS-CoV-2 Spike Protein
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A key region of Tau that is able to drive assembly and modulate inhibition by Hydromethylthionine
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Human Rhinovirus B14 with Non-functional Drug-binding Pockets Recovers Infectivity through Stereochemically Constrained Mutations that Restore Capsid Flexibility
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Arkadia and Ark2C Promote Substrate Ubiquitylation with Multiple E2 Enzymes
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The OSCP Subunit of ATP Synthase is a Dimer in Solution: Strategy to Induce the Monomeric Protein as a New Tool for Drug Discovery
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Versatile Methodology for Efficient Large-sized DNA Delivery Between Microorganisms Without In vitro Purification
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ATP as a Key Modulator of Fused-in-sarcoma Phase Separation and Aggregation: Insights into Amyotrophic Lateral Sclerosis Pathogenesis
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Membrane Disruption Properties of Poly-Glycine Arginine Dipeptide Repeats Affected by Peptide Repeats Continuity and Membrane Composition
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Structural Insights into Minor and Core Proteins of Bovine Adenovirus 3: Bridging Capsid and Genomic Core
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A Fluorescent Probe Targeting EGFR for the Stratification of Prostate Cancer Cells
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Chi hotspot Control of RecBCD Helicase-nuclease: Enzymatic Tests Support the Intramolecular Signal-transduction Model
Chi hotspot Control of RecBCD Helicase-nuclease: Enzymatic Tests Support the Intramolecular Signal-transduction Model
When their DNA is broken, cells must repair it or they die. Faithful repair occurs by the reactions that can promote homol...
Assembly of Protein Complexes in and on the Membrane with Predicted Spatial Arrangement Constraints
Assembly of Protein Complexes in and on the Membrane with Predicted Spatial Arrangement Constraints
Protein-protein interactions are fundamental to many biological processes in living cells. Membrane proteins play an essen...
Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter
Structure of a DNA G-quadruplex that Modulates SP1 Binding Sites Architecture in HIV-1 Promoter
G-quadruplexes (or “G4s”) are non-canonical nucleic acid structures formed by guanine-rich DNA or RNA sequences. They are ...
Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling
Aberrant Topologies of Bacterial Membrane Proteins Revealed by High Sensitivity Fluorescence Labelling
Keywordsmembrane protein topologyperiplasmfluorescenceTat protein transportEscherichia coliData availabilityCustom written...
Tetrameric UvrD Helicase Is Located at the E. Coli Replisome due to Frequent Replication Blocks
Tetrameric UvrD Helicase Is Located at the E. Coli Replisome due to Frequent Replication Blocks
Journal of Molecular BiologyVolume 436, Issue 2, 15 January 2024, 168369Author links open overlay panel, , , , , , , , , H...
Mycobacterium tuberculosis Ku Stimulates Multi-round DNA Unwinding by UvrD1 Monomers
Mycobacterium tuberculosis Ku Stimulates Multi-round DNA Unwinding by UvrD1 Monomers
About one-third of the human population is estimated to be infected with Mycobacterium tuberculosis (Mtb), the causative a...
Near-Infrared Optogenetic Module for Conditional Protein Splicing
Near-Infrared Optogenetic Module for Conditional Protein Splicing
Inteins are a unique class of proteins that are capable of self-excision from larger polypeptides by ligation of flanking ...
Different Low-complexity Regions of SFPQ Play Distinct Roles in the Formation of Biomolecular Condensates
Different Low-complexity Regions of SFPQ Play Distinct Roles in the Formation of Biomolecular Condensates
Keywordsphase separationprion-likeDrosophila-behaviour human splicing proteinsDNA repairparaspeckleAbbreviationsCsatsatura...
Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation
Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation
Transcription is the first step in gene regulation and is performed by RNA polymerase (RNAP). RNAP core enzyme that cataly...
Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery
Molecular Architecture of Salmonella Typhimurium Virus P22 Genome Ejection Machinery
Salmonella enterica Serovar typhimurium infects 100,000 people annually and causes Salmonellosis, which can be potentially...
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