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Design, synthesis and evaluation of quinolone quaternary ammonium antibacterial agent with killing ability to biofilm
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Design, synthesis, docking, DFT, and MD simulation studies of new piperazine, 1,3,4-oxadiazole, and quinoline conjugates: A search for potent antiepileptic agents
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Development and evaluation of chitosan conjugated Isatin-linked Pyrazole derivative to target anti-inflammatory and anti-fibrotic in ethanol induced liver fibrosis using an in-vivo zebra fish model
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Converting indoprofen to moderate selective COX-2 inhibitors: Design, synthesis and biological evaluation
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Discovery of novel diarylurea derivatives as potent type II TRK inhibitors for combating multiple acquired resistant mutants
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Design, synthesis and biological evaluation of benzamide derivatives as novel anticancer agents
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Lysosome-specific fluorescent probe for malondialdehyde/formaldehyde detection in oxidative/carbonyl stressed nerve cells and foods
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Design of antinociceptive peptide by grafting domains between scorpion β-neurotoxins
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Development of an adenosine deaminase-resistant cordycepin prodrug activated by Pseudomonas carboxypeptidase G2
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Design, synthesis, and in-vitro/in-vivo pharmacodynamic studies of novel aza-fused heterocyclic compounds against herpes simplex virus type 1
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Antitumor activity of topoisomerase I targeted by camptothecin 7-propionyl derivatives against ampullary carcinoma
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Design, synthesis, and biological evaluation of novel 2-substituted aniline pyrimidine derivatives as potential and orally bioavailable Mer inhibitors with antitumor activities
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Studies on DNA/HSA binding properties of new triazole-based imine functionalized derivatives using spectroscopic and computational methods
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[68Ga]Ga-NOTA-C-IPB-AIT: A novel radiotracer for in vivo detection of TREM-1 expression
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Design, synthesis, and aldose reductase inhibition assessment of novel Quinazolin-4(3H)-one derivatives with 4-Bromo-2-Fluorobenzene functionality
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Development of dual-function disulfaneyl oxadiazole bactericides by structurally incorporating β-carboline moieties
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Structures and biological activities of anti-osteoporotic drugs: An overview of promising small-molecule therapeutics for the treatment of osteoporosis
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Targets and promising adjuvants for improving breast tumor response to radiotherapy
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Targeting CAFs and extracellular matrix (ECM) in lung cancer: Potential of adjuvants and nanoparticles
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Novel synthesis of 2-amino-6-[(4-hydroxy-1-oxopentyl)amino]hexanoic acid from lysine and γ-valerolactone
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Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy
Selective inhibition of SIRT2: A disputable therapeutic approach in cancer therapy
Sirtuin (silent information regulator 2-related proteins, SIRT) enzymes belong to a family of nicotinamide adenine dinucle...
Pathology, target discovery, and the evolution of XO inhibitors from the first discovery to recent advances (2020–2023)
Pathology, target discovery, and the evolution of XO inhibitors from the first discovery to recent advances (2020–2023)
Uric acid (UA) is an organic heterocyclic compound with molecular formula of C5H4N4O3. UA is biosynthesized in the liver a...
Recent advances in the synthesis and antimalarial activity of 1,2,4-trioxanes
Recent advances in the synthesis and antimalarial activity of 1,2,4-trioxanes
Malaria has been derived from an Italian word i.e., ‘mal’ ‘area’ which describes ‘bad air’ as the disease is said to be ea...
RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective
RNA-binding MSI proteins and their related cancers: A medicinal chemistry perspective
Musashi is a very famous samurai in Japanese culture, but the term has a disparate meaning in biology. In 1994, Craig Mont...
Recent advances of vacuolar protein-sorting 34 inhibitors targeting autophagy
Recent advances of vacuolar protein-sorting 34 inhibitors targeting autophagy
Autophagy, ubiquitous in eukaryotic cells (from yeast to mammals), is an antioxidant response mechanism in cells under oxi...
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy
Advances in synthesis and biological evaluation of CDK2 inhibitors for cancer therapy
Cancer is an increasingly severe health issue that affects individuals of all ages. In 2022, it was estimated that there w...
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
Tubulin inhibitors. Selected scaffolds and main trends in the design of novel anticancer and antiparasitic agents
Design of tubulin inhibitors as anticancer drugs dynamically developed over the past 20 years. The modern arsenal of poten...
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
A comprehensive review of small molecules targeting PI3K pathway: Exploring the structural development for the treatment of breast cancer
Cancer is one of the deadliest diseases that is spreading across the world [1]. Nearly 10 million deaths were reported fro...
Biological activity and structural modification of isosteviol over the past 15 years
Biological activity and structural modification of isosteviol over the past 15 years
Natural products are significant sources of lead compounds and functional organic molecules used in pharmaceuticals. Scree...
C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)
C3-Spirooxindoles: Divergent chemical synthesis and bioactivities (2018–2023)
Because of their widespread distribution in natural products and synthesized compounds with potential bioactivities, spiro...
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