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Practical and versatile hypochlorite sensor using a xanthene scaffold: Integrating theoretical analysis with environmental and biological applications

Flavan derivatives from the fruits of Daemonorops draco Bl. and their protective effects on oxygen-glucose deprivation-induced endothelial cell injury

Bioorganic Chemistry

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Ginsenoside derivative AD-1 suppresses colitis-associated colorectal cancer progression by reprogramming tumor-associated macrophage polarization via the AMPK/mTOR–glycolysis pathway

Bioorganic Chemistry

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“Tandem Biginelli approach to Quinoline–Dihydropyrimidinone/Thione conjugates: A synergistic exploration through biological, ADME, DFT profiling”

Bioorganic Chemistry

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Synthesis and in vitro/in silico evaluation of novel aroyl thiourea derivatives based on substituted phenethylamine: antibacterial, antioxidant, and anticancer activities

Bioorganic Chemistry

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Mechanism of ginsenoside AD-1 improving pulmonary fibrosis by regulating the HIF-1α/ HSP/TGF-β1 signaling pathway and mesenchymal transition

Bioorganic Chemistry

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Multicomponent synthesis, insecticidal evaluation and molecular dynamics studies of new nicotinonitrile derivatives bearing pyrazole or triazole moieties

Bioorganic Chemistry

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Targeting fungal biofilms: Design, synthesis and evaluation of pyrrolidino-hydrazinyl-thiazole derivatives via in vitro, transcriptomic and in silico approaches

Bioorganic Chemistry

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Zexie-Baizhu herb pair attenuates MASH via the gut-liver Axis by suppressing NLRP3 Inflammasome activation and M1-macrophage polarization

Bioorganic Chemistry

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Distribution- and metabolism-based drug discovery: SAR and SMR exploration of alkoxy-substituted vonoprazan derivatives as new potassium-competitive acid blockers

Bioorganic Chemistry

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Natural products as payloads for antibody-drug conjugates: Cyclopamine linked to cetuximab for hedgehog pathway inhibition

Bioorganic Chemistry

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Metabolomics accelerates drug development and facilitates the discovery of new targets, mechanisms and structures

Bioorganic Chemistry

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Breaking through the bacterial resistance defense line: "Trojan horse" antibiotic conjugates precision strike road

Bioorganic Chemistry

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Research progress of drugs targeting GPC3 in cancer therapy

Bioorganic Chemistry

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Advances in light-controllable PROTACs: Design strategies, therapeutic applications and current challenges

Bioorganic Chemistry

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Peptide–drug conjugates: Emerging strategies in glioma therapy

Bioorganic Chemistry

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Sustainable sonochemistry in medicinal heterocycle design: Advances and anticancer implications

Bioorganic Chemistry

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Recent process in the development of TIM-3 antibodies and small-molecule inhibitors for cancer immunotherapy

Bioorganic Chemistry

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Synthesis and radiolabelling strategies of fibroblast activation protein ligands: a review

Bioorganic Chemistry

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Design, synthesis and evaluation of quinolone quaternary ammonium antibacterial agent with killing ability to biofilm

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Design, synthesis, docking, DFT, and MD simulation studies of new piperazine, 1,3,4-oxadiazole, and quinoline conjugates: A search for potent antiepileptic agents

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Bioorganic Chemistry

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Development and evaluation of chitosan conjugated Isatin-linked Pyrazole derivative to target anti-inflammatory and anti-fibrotic in ethanol induced liver fibrosis using an in-vivo zebra fish model

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Bioorganic Chemistry

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Converting indoprofen to moderate selective COX-2 inhibitors: Design, synthesis and biological evaluation

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Bioorganic Chemistry

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Discovery of novel diarylurea derivatives as potent type II TRK inhibitors for combating multiple acquired resistant mutants

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Bioorganic Chemistry

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Design, synthesis and biological evaluation of benzamide derivatives as novel anticancer agents

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Lysosome-specific fluorescent probe for malondialdehyde/formaldehyde detection in oxidative/carbonyl stressed nerve cells and foods

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Design of antinociceptive peptide by grafting domains between scorpion β-neurotoxins

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Development of an adenosine deaminase-resistant cordycepin prodrug activated by Pseudomonas carboxypeptidase G2

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Design, synthesis, and in-vitro/in-vivo pharmacodynamic studies of novel aza-fused heterocyclic compounds against herpes simplex virus type 1

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