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-mediated co-regulation of and modulates epicardial cell migration and myocardial specification
-mediated co-regulation of and modulates epicardial cell migration and myocardial specification
The heart is the first functional organ to develop in the vertebrate embryos. In mice, the primitive tubular heart begins ...
Dapagliflozin alleviates mitochondrial damage in the myocardium under diabetic conditions by targeting sortilin
Dapagliflozin alleviates mitochondrial damage in the myocardium under diabetic conditions by targeting sortilin
Type 2 diabetes patients are particularly vulnerable to myocardial injury, including mitochondrial damage in the myocardiu...
miR-29a-3p and TGF-β Axis in Fanconi anemia: mechanisms driving metabolic dysfunction and genome stability
miR-29a-3p and TGF-β Axis in Fanconi anemia: mechanisms driving metabolic dysfunction and genome stability
Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. The FA cellular ...
AP-1-dependent c-Fos activation by TREX1 drives M2 macrophage polarization and mitigates osteoarthritis progression
AP-1-dependent c-Fos activation by TREX1 drives M2 macrophage polarization and mitigates osteoarthritis progression
Inflammation significantly contributes to the pathogenesis of osteoarthritis (OA). Recent studies have elucidated the crit...
Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation
Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation
SLC35A2-CDG is an X-linked congenital disorder of glycosylation (CDG), characterized by defective UDP-galactose transport ...
Piezo1 disrupts blood–brain barrier via CaMKII/Nrf2 in ischemic stroke
Piezo1 disrupts blood–brain barrier via CaMKII/Nrf2 in ischemic stroke
Ischemic stroke (IS) leads to the disruption of blood–brain barrier (BBB) integrity, resulting in brain edema. In th...
Circadian ontogenetic metabolomics atlas: an interactive resource with insights from rat plasma, tissues, and feces
Circadian ontogenetic metabolomics atlas: an interactive resource with insights from rat plasma, tissues, and feces
Circadian rhythms regulate key physiological processes through clock genes in central and peripheral tissues. While circad...
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis
The African swine fever virus (ASFV) has been reported to cause oxidative damage and inhibit IFN-β production. Howeve...
PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain
PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain
Activating mutations in p21-activated kinase 1 (PAK1) cause intellectual disability, neurodevelopmental abnormality, macro...
NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition
NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition
In the early stage of intracerebral hemorrhage (ICH), rebleeding occurs when blood from the initial hematoma permeates the...
The impact of C heavy ion irradiation-induced cellular mutations on the replication of the foot-and-mouth disease virus and the role of
The impact of C heavy ion irradiation-induced cellular mutations on the replication of the foot-and-mouth disease virus and the role of
Foot-and-mouth disease (FMD) is an infectious disease in animals caused by the foot-and-mouth disease virus (FMDV). Howeve...
The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from
The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from
Clostridioides (C.) difficile is a spore-forming, toxin-producing nosocomial human gut pathogen and a causative agent of g...
SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1
SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1
Folliculogenesis is a crucial process for production functional female gametes in mammals. The imbalance of apoptosis and ...
NSD proteins in anti-tumor immunity and their therapeutic targeting by protein degraders
NSD proteins in anti-tumor immunity and their therapeutic targeting by protein degraders
Chromatin modifiers, owing to their enzymatic activities and frequent overexpression or hyperactivation in cancer, have em...
Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer
Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer
Poly(ADP-ribose)polymerase 2 (PARP2) is a nuclear protein, DNA damage sensor and an emerging target for development of ant...
Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice
Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice
Cell division cycle protein 42 (Cdc42) is a member of the Rho GTPase subfamily that serves as a signal mediating factor in...
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation
Sorafenib, a multikinase inhibitor targeting cell growth and angiogenesis, was approved for advanced unresectable hepatoce...
HUWE1 is involved in Sertoli cell polarity establishment by ubiquitination mediated degradation of WT1
HUWE1 is involved in Sertoli cell polarity establishment by ubiquitination mediated degradation of WT1
HUWE1, a member of HECT E3 ubiquitin ligase family, is implicated in a variety of cellular processes. Recent studies find ...
Organoids as powerful models of endometrium epithelium in transcriptomic, cellular and functional mimicry
Organoids as powerful models of endometrium epithelium in transcriptomic, cellular and functional mimicry
Organoids have emerged as revolutionary biomimetic systems that offer a physiologically relevant in vitro model to study t...
Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation
Obesity is characterized by chronic low-grade inflammation, which is driven by macrophage infiltration in adipose tissue a...
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
Mfsd7b facilitates choline transport and missense mutations affect choline transport function
MFSD7b belongs to the Major Facilitator Superfamily of transporters that transport small molecules. Two isoforms of MFSD7b...
The senescent mesothelial matrix accentuates colonization by ovarian cancer cells
The senescent mesothelial matrix accentuates colonization by ovarian cancer cells
Ovarian cancer is amongst the most morbid of gynecological malignancies due to its diagnosis at an advanced stage, a trans...
Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids
Molecular modeling of apoE in complexes with Alzheimer’s amyloid-β fibrils from human brain suggests a structural basis for apolipoprotein co-deposition with amyloids
Apolipoproteins co-deposit with amyloids, yet apolipoprotein–amyloid interactions are enigmatic. To understand how a...
CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
CCDC146 is required for sperm flagellum biogenesis and male fertility in mice
Multiple morphological abnormalities of the flagella (MMAF) is a severe disease of male infertility, while the pathogeneti...
Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Polymorphic USP8 allele promotes Parkinson’s disease by inducing the accumulation of α-synuclein through deubiquitination
Parkinson’s disease (PD) is one of the most common neuro-degenerative diseases characterized by α-synuclein acc...
Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system
Unraveling the lymphatic system in the spinal cord meninges: a critical element in protecting the central nervous system
The lymphatic vasculature plays a crucial role in fluid clearance and immune responses in peripheral organs by connecting ...
Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division
Unconventional roles of chromatin remodelers and long non-coding RNAs in cell division
The aim of this review article is to focus on the unconventional roles of epigenetic players (chromatin remodelers and lon...
SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
Evasion and antagonism of host cellular immunity upon SARS-CoV-2 infection provide replication advantage to the virus and ...
Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease
Thalamic Foxp2 regulates output connectivity and sensory-motor impairments in a model of Huntington’s Disease
Huntington's Disease (HD) is a disorder that affects body movements. Altered glutamatergic innervation of the striatum...
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons
STIM2 regulates NMDA receptor endocytosis that is induced by short-term NMDA receptor overactivation in cortical neurons
Recent findings suggest an important role for the dysregulation of stromal interaction molecule (STIM) proteins, activator...
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