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ZNF711 promotes enzalutamide resistance through transcriptional and epigenetic modification of the androgen receptor signaling pathway
ZNF711 promotes enzalutamide resistance through transcriptional and epigenetic modification of the androgen receptor signaling pathway
Although androgen receptor (AR) inhibitors such as enzalutamide are initially effective in castration resistant prostate c...
Decoding vascular calcification: mechanistic insights and translational strategies
Decoding vascular calcification: mechanistic insights and translational strategies
Vascular calcification (VC) is a complex, multifactorial process strongly associated with ageing, atherosclerosis, chronic...
GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation
GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation
Pulmonary inflammatory response represents a predominant complication arising from influenza virus infections. This invest...
Beyond the membrane: rethinking EGFR signaling in physiology and cancer
Beyond the membrane: rethinking EGFR signaling in physiology and cancer
The epidermal growth factor receptor (EGFR) functions as a central signaling hub that integrates biochemical and mechanica...
Interaction of CSN4 to DDB1 regulates its stability and function in DNA damage signaling
Interaction of CSN4 to DDB1 regulates its stability and function in DNA damage signaling
The COP9 signalosome (CSN) regulates Cullin–RING E3 ligases (CRLs) through deneddylation and complex stabilization. ...
Histone lactylation leads to perioperative neurocognitive disorders by promoting the expression of and inducing excessive mitochondrial fission in hippocampal neurons
Histone lactylation leads to perioperative neurocognitive disorders by promoting the expression of and inducing excessive mitochondrial fission in hippocampal neurons
Perioperative neurocognitive disorders (PND) is the most prevalent central nervous system (CNS) complication in older pati...
IFIT3 stabilizes STING via USP18 to drive M1 macrophage polarization and early inflammation in acute lung injury
IFIT3 stabilizes STING via USP18 to drive M1 macrophage polarization and early inflammation in acute lung injury
The imbalance in macrophage M1/M2 polarization is a critical driver of excessive inflammation during the early stage of ac...
Modern resources for intrinsic disorder predictions: protein language models, deep learning, meta-servers, and databases
Modern resources for intrinsic disorder predictions: protein language models, deep learning, meta-servers, and databases
Computational prediction of intrinsic disorder in protein sequences is an impactful and growing research area, recently in...
Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases
Chronic IL-21 exposure reshapes pulmonary environment, elevating risk of respiratory diseases
Age-related pulmonary diseases pose a significant health burden, yet the underlying mechanisms remain poorly understood. T...
Tracking DNA damage localization and chromatin remodeling in live cells using time-resolved quantitative analysis of DNA counterstains
Tracking DNA damage localization and chromatin remodeling in live cells using time-resolved quantitative analysis of DNA counterstains
DNA damage profoundly impacts genome stability and cellular homeostasis, and its repair is tightly coordinated with local ...
MYBPC3 (c.194 C > T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of DCM revealed by HiPSC modeling
MYBPC3 (c.194 C > T) mutation-mediated RyR2 dysfunction contributes to pathogenic phenotypes of DCM revealed by HiPSC modeling
Dilated cardiomyopathy (DCM) is a leading cause of heart failure and the primary indication for heart transplantation. The...
ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of , and synergy with ALDH6A1
ALDH2 inhibits head and neck tumorigenesis through RAS signaling suppression, transactivation of , and synergy with ALDH6A1
Head and neck squamous cell carcinoma (HNSC) ranks among the most common malignancies globally, with ALDH2 mutations linke...
-mediated co-regulation of and modulates epicardial cell migration and myocardial specification
-mediated co-regulation of and modulates epicardial cell migration and myocardial specification
The heart is the first functional organ to develop in the vertebrate embryos. In mice, the primitive tubular heart begins ...
Dapagliflozin alleviates mitochondrial damage in the myocardium under diabetic conditions by targeting sortilin
Dapagliflozin alleviates mitochondrial damage in the myocardium under diabetic conditions by targeting sortilin
Type 2 diabetes patients are particularly vulnerable to myocardial injury, including mitochondrial damage in the myocardiu...
miR-29a-3p and TGF-β Axis in Fanconi anemia: mechanisms driving metabolic dysfunction and genome stability
miR-29a-3p and TGF-β Axis in Fanconi anemia: mechanisms driving metabolic dysfunction and genome stability
Fanconi anemia (FA) is a genetic disorder characterized by bone marrow failure and cancer predisposition. The FA cellular ...
AP-1-dependent c-Fos activation by TREX1 drives M2 macrophage polarization and mitigates osteoarthritis progression
AP-1-dependent c-Fos activation by TREX1 drives M2 macrophage polarization and mitigates osteoarthritis progression
Inflammation significantly contributes to the pathogenesis of osteoarthritis (OA). Recent studies have elucidated the crit...
Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation
Glycosphingolipid synthesis is impaired in SLC35A2-CDG and improves with galactose supplementation
SLC35A2-CDG is an X-linked congenital disorder of glycosylation (CDG), characterized by defective UDP-galactose transport ...
Piezo1 disrupts blood–brain barrier via CaMKII/Nrf2 in ischemic stroke
Piezo1 disrupts blood–brain barrier via CaMKII/Nrf2 in ischemic stroke
Ischemic stroke (IS) leads to the disruption of blood–brain barrier (BBB) integrity, resulting in brain edema. In th...
Circadian ontogenetic metabolomics atlas: an interactive resource with insights from rat plasma, tissues, and feces
Circadian ontogenetic metabolomics atlas: an interactive resource with insights from rat plasma, tissues, and feces
Circadian rhythms regulate key physiological processes through clock genes in central and peripheral tissues. While circad...
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis
African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis
The African swine fever virus (ASFV) has been reported to cause oxidative damage and inhibit IFN-β production. Howeve...
PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain
PAK1 regulates oligodendroglial proliferation and repopulation in homeostatic and demyelinating brain
Activating mutations in p21-activated kinase 1 (PAK1) cause intellectual disability, neurodevelopmental abnormality, macro...
NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition
NR4A2 attenuates early brain injury after intracerebral hemorrhage by promoting M2 microglial polarization via TLR4/TRAF6/NF-κB pathway inhibition
In the early stage of intracerebral hemorrhage (ICH), rebleeding occurs when blood from the initial hematoma permeates the...
The impact of C heavy ion irradiation-induced cellular mutations on the replication of the foot-and-mouth disease virus and the role of
The impact of C heavy ion irradiation-induced cellular mutations on the replication of the foot-and-mouth disease virus and the role of
Foot-and-mouth disease (FMD) is an infectious disease in animals caused by the foot-and-mouth disease virus (FMDV). Howeve...
The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from
The antimicrobial peptide Angie 5 inhibits TcdA and TcdB from
Clostridioides (C.) difficile is a spore-forming, toxin-producing nosocomial human gut pathogen and a causative agent of g...
SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1
SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1
Folliculogenesis is a crucial process for production functional female gametes in mammals. The imbalance of apoptosis and ...
NSD proteins in anti-tumor immunity and their therapeutic targeting by protein degraders
NSD proteins in anti-tumor immunity and their therapeutic targeting by protein degraders
Chromatin modifiers, owing to their enzymatic activities and frequent overexpression or hyperactivation in cancer, have em...
Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer
Poly(ADP-ribose)polymerase 2 is zinc-dependent enzyme and nucleosome reorganizer
Poly(ADP-ribose)polymerase 2 (PARP2) is a nuclear protein, DNA damage sensor and an emerging target for development of ant...
Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice
Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice
Cell division cycle protein 42 (Cdc42) is a member of the Rho GTPase subfamily that serves as a signal mediating factor in...
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation
Aquaglyceroporin-7 ameliorates sorafenib resistance and immune evasion in hepatocellular carcinoma through inhibition of lipid accumulation
Sorafenib, a multikinase inhibitor targeting cell growth and angiogenesis, was approved for advanced unresectable hepatoce...
HUWE1 is involved in Sertoli cell polarity establishment by ubiquitination mediated degradation of WT1
HUWE1 is involved in Sertoli cell polarity establishment by ubiquitination mediated degradation of WT1
HUWE1, a member of HECT E3 ubiquitin ligase family, is implicated in a variety of cellular processes. Recent studies find ...
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