Quigley JG, Burns CC, Anderson MM, Lynch ED, Sabo KM, Overbaugh J, Abkowitz JL (2000) Cloning of the cellular receptor for feline leukemia virus subgroup C (FeLV-C), a retrovirus that induces red cell aplasia. Blood 95:1093–1099
Article CAS PubMed Google Scholar
Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, Sabath DE, Berg CL, Sassa S, Wood BL, Abkowitz JL (2004) Identification of a human heme exporter that is essential for erythropoiesis. Cell 118:757–766
Article CAS PubMed Google Scholar
Rajadhyaksha AM, Elemento O, Puffenberger EG, Schierberl KC, Xiang JZ, Putorti ML, Berciano J, Poulin C, Brais B, Michaelides M, Weleber RG, Higgins JJ (2010) Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. Am J Hum Genet 87:643–654
Article CAS PubMed PubMed Central Google Scholar
Ishiura H, Fukuda Y, Mitsui J, Nakahara Y, Ahsan B, Takahashi Y, Ichikawa Y, Goto J, Sakai T, Tsuji S (2011) Posterior column ataxia with retinitis pigmentosa in a Japanese family with a novel mutation in FLVCR1. Neurogenetics 12:117–121
Yanatori I, Yasui Y, Miura K, Kishi F (2012) Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity. Blood Cells Mol Dis 49:60–66
Article CAS PubMed Google Scholar
Chiabrando D, Castori M, di Rocco M, Ungelenk M, Giesselmann S, Di Capua M, Madeo A, Grammatico P, Bartsch S, Hubner CA, Altruda F, Silengo L, Tolosano E, Kurth I (2016) Mutations in the heme exporter FLVCR1 cause sensory neurodegeneration with loss of pain perception. PLoS Genet 12:e1006461
Article PubMed PubMed Central Google Scholar
Chiabrando D, Marro S, Mercurio S, Giorgi C, Petrillo S, Vinchi F, Fiorito V, Fagoonee S, Camporeale A, Turco E, Merlo GR, Silengo L, Altruda F, Pinton P, Tolosano E (2012) The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation. J Clin Invest 122:4569–4579
Article CAS PubMed PubMed Central Google Scholar
Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL (2008) A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319:825–828
Article CAS PubMed Google Scholar
Byon JC, Chen J, Doty RT, Abkowitz JL (2013) FLVCR is necessary for erythroid maturation, may contribute to platelet maturation, but is dispensable for normal hematopoietic stem cell function. Blood 122:2903–2910
Article CAS PubMed PubMed Central Google Scholar
Doty RT, Phelps SR, Shadle C, Sanchez-Bonilla M, Keel SB, Abkowitz JL (2015) Coordinate expression of heme and globin is essential for effective erythropoiesis. J Clin Invest 125:4681–4691
Article PubMed PubMed Central Google Scholar
Mercurio S, Petrillo S, Chiabrando D, Bassi ZI, Gays D, Camporeale A, Vacaru A, Miniscalco B, Valperga G, Silengo L, Altruda F, Baron MH, Santoro MM, Tolosano E (2015) The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation. Haematologica 100:720–729
Article CAS PubMed PubMed Central Google Scholar
Petrillo S, Chiabrando D, Genova T, Fiorito V, Ingoglia G, Vinchi F, Mussano F, Carossa S, Silengo L, Altruda F, Merlo GR, Munaron L, Tolosano E (2018) Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis. Cell Death Differ 25:573–588
Article CAS PubMed Google Scholar
Vinchi F, Ingoglia G, Chiabrando D, Mercurio S, Turco E, Silengo L, Altruda F, Tolosano E (2014) Heme exporter FLVCR1a regulates heme synthesis and degradation and controls activity of cytochromes P450. Gastroenterology 146:1325–1338
Article CAS PubMed Google Scholar
Fiorito V, Forni M, Silengo L, Altruda F, Tolosano E (2015) Crucial role of FLVCR1a in the maintenance of intestinal heme homeostasis. Antioxid Redox Signal 23:1410–1423
Article CAS PubMed Google Scholar
Tsuchiya M, Tachibana N, Nagao K, Tamura T, Hamachi I (2023) Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism. Cell Metab 35:1072-1083 e1079
Article CAS PubMed Google Scholar
Kenny TC, Khan A, Son Y, Yue L, Heissel S, Sharma A, Pasolli HA, Liu Y, Gamazon ER, Alwaseem H, Hite RK, Birsoy K (2023) Integrative genetic analysis identifies FLVCR1 as a plasma-membrane choline transporter in mammals. Cell Metab 35:1057-1071 e1012
Article CAS PubMed Google Scholar
An X, Schulz VP, Li J, Wu K, Liu J, Xue F, Hu J, Mohandas N, Gallagher PG (2014) Global transcriptome analyses of human and murine terminal erythroid differentiation. Blood 123:3466–3477
Article CAS PubMed PubMed Central Google Scholar
Fiorito V, Allocco AL, Petrillo S, Gazzano E, Torretta S, Marchi S, Destefanis F, Pacelli C, Audrito V, Provero P, Medico E, Chiabrando D, Porporato PE, Cancelliere C, Bardelli A, Trusolino L, Capitanio N, Deaglio S, Altruda F, Pinton P, Cardaci S, Riganti C, Tolosano E (2021) The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation. Cell Rep 35:109252
Article CAS PubMed Google Scholar
Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 103:129–135
Article CAS PubMed PubMed Central Google Scholar
Radhakrishnan N, Yadav SP, Sachdeva A, Pruthi PK, Sawhney S, Piplani T, Wada T, Yachie A (2011) Human heme oxygenase-1 deficiency presenting with hemolysis, nephritis, and asplenia. J Pediatr Hematol Oncol 33:74–78
Article CAS PubMed Google Scholar
Chau AS, Cole BL, Debley JS, Nanda K, Rosen ABI, Bamshad MJ, Nickerson DA, Torgerson TR, Allenspach EJ (2020) Heme oxygenase-1 deficiency presenting with interstitial lung disease and hemophagocytic flares. Pediatr Rheumatol Online J 18:80
Article PubMed PubMed Central Google Scholar
Poss KD, Tonegawa S (1997) Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci USA 94:10919–10924
Article CAS PubMed PubMed Central Google Scholar
Tavasoli M, Lahire S, Reid T, Brodovsky M, McMaster CR (2020) Genetic diseases of the Kennedy pathways for membrane synthesis. J Biol Chem 295:17877–17886
Article CAS PubMed PubMed Central Google Scholar
Choudhary P, Armstrong EJ, Jorgensen CC, Piotrowski M, Barthmes M, Torella R, Johnston SE, Maruyama Y, Janiszewski JS, Storer RI, Skerratt SE, Benn CL (2017) Discovery of compounds that positively modulate the high affinity choline transporter. Front Mol Neurosci 10:40
Comments (0)