African swine fever virus A151R downregulates cGAS-STING-mediated IFN-β production by promoting lipid peroxidation through ferritinophagy-induced ferroptosis

Zhuo Y, Guo Z, Ba T, Zhang C, He L, Zeng C, Dai H (2021) African swine fever virus MGF360-12L inhibits type I interferon production by blocking the interaction of importin α and NF-κB signaling pathway. Virol Sin 36(2):176–186

Article  PubMed  CAS  Google Scholar 

Gaudreault NN, Madden DW, Wilson WC, Trujillo JD, Richt JA (2020) African swine fever virus: an emerging DNA arbovirus. Front Veterinary Sci 7:215

Article  Google Scholar 

Afe AE, Shen ZJ, Guo X, Zhou R, Li K (2023) African swine fever virus interaction with host innate immune factors. Viruses 15(6)

Li Z, Chen W, Qiu Z, Li Y, Fan J, Wu K, Li X, Zhao M, Ding H, Fan S et al (2022) African swine fever virus: A review. Life (Basel Switzerland) 12(8)

Guo Z, Zhuo Y, Li K, Niu S, Dai H (2021) Recent advances in cell homeostasis by African swine fever virus-host interactions. Res Vet Sci 141:4–13

Article  PubMed  CAS  Google Scholar 

Taguchi T, Mukai K (2019) Innate immunity signalling and membrane trafficking. Curr Opin Cell Biol 59:1–7

Article  PubMed  CAS  Google Scholar 

Sularea VM, Sugrue JA, O’Farrelly C (2023) Innate antiviral immunity and immunometabolism in hepatocytes. Curr Opin Immunol 80:102267

Article  PubMed  CAS  Google Scholar 

Zheng C, Zhang L (2025) DNA PAMPs as Molecular Tools for the cGAS-STING Signaling Pathways. Methods Mol Biol (Clifton, NJ) 2854:117–125

Article  PubMed  Google Scholar 

Tong J, Song J, Zhang W, Zhai J, Guan Q, Wang H, Liu G, Zheng C (2024) When DNA-damage responses meet innate and adaptive immunity. Cellular and molecular life sciences: CMLS 81(1):185

Article  Google Scholar 

Chen C, Xu P (2023) Cellular functions of cGAS-STING signaling. Trends Cell Biol 33(8):630–648

Article  PubMed  CAS  Google Scholar 

Ding C, Song Z, Shen A, Chen T, Zhang A (2020) Small molecules targeting the innate immune cGAS–STING–TBK1 signaling pathway. Acta Pharm Sinica B 10(12):2272–2298

Article  CAS  Google Scholar 

Zhu H, Zhang R, Yi L, Tang YD, Zheng C (2022) UNC93B1 attenuates the cGAS-STING signaling pathway by targeting STING for autophagy-lysosome degradation. J Med Virol 94(9):4490–4501

Article  Google Scholar 

Hopfner KP, Hornung V (2020) Molecular mechanisms and cellular functions of cGAS-STING signalling. Nat Rev Mol Cell Biol 21(9):501–521

Article  PubMed  CAS  Google Scholar 

Jia M, Qin D, Zhao C, Chai L, Yu Z, Wang W, Tong L, Lv L, Wang Y, Rehwinkel J et al (2020) Redox homeostasis maintained by GPX4 facilitates STING activation. Nat Immunol 21(7):727–735

Article  PubMed  CAS  Google Scholar 

Chen B, Hong Y, Zhai X, Deng Y, Hu H, Tian S, Zhang Y, Ren X, Zhao J, Jiang C (2023) m6A and m5C modification of GPX4 facilitates anticancer immunity via STING activation. Cell Death Dis 14(12):809

Article  PubMed  PubMed Central  CAS  Google Scholar 

Seibt TM, Proneth B, Conrad M (2019) Role of GPX4 in ferroptosis and its pharmacological implication. Free Radic Biol Med 133:144–152

Article  CAS  Google Scholar 

Li Q, Jia M, Song H, Peng J, Zhao W, Zhang W (2024) Astaxanthin inhibits STING carbonylation and enhances antiviral responses. J Immunol 212(7):1188–1195

Article  PubMed  CAS  Google Scholar 

Qiu B, Zandkarimi F, Saqi A, Castagna C, Tan H, Sekulic M, Miorin L, Hibshoosh H, Toyokuni S, Uchida K et al (2024) Fatal COVID-19 pulmonary disease involves ferroptosis. Nat Commun 15(1):3816

Article  PubMed  PubMed Central  Google Scholar 

Wang Y, Han J, Zhan S, Guo C, Yin S, Zhan L, Zhou Q, Liu R, Yan H, Wang X et al (2024) Fucoidan alleviates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via Nrf2/GPX4 pathway. Int J Biol Macromol 276:133792

Article  PubMed  CAS  Google Scholar 

Zhao D, Gao Y, Chen Y, Zhang Y, Deng Y, Niu S, Dai H (2024) L-Citrulline ameliorates Iron metabolism and mitochondrial quality control via activating AMPK pathway in intestine and improves microbiota in mice with Iron overload. Mol Nutr Food Res 68(6):e2300723

Article  PubMed  Google Scholar 

Chen Z, Zhang J, Gao S, Jiang Y, Qu M, Gu J, Wu H, Nan K, Zhang H, Wang J et al (2024) Suppression of Skp2 contributes to sepsis-induced acute lung injury by enhancing ferroptosis through the ubiquitination of SLC3A2. Cell Mol Life Sci 81(1):325

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao Y, Deng Y, Li W, Wang J, Liu M, Dai H (2025) CXCR3 Inhibition ameliorates mitochondrial function to mitigate oxidative damage through NCOA4-mediated ferritinophagy and improves the gut microbiota in mice. Free Radic Biol Med 229:384–398

Article  PubMed  CAS  Google Scholar 

Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC (2014) Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature 509(7498):105–109

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jin X, Jiang C, Zou Z, Huang H, Li X, Xu S, Tan R (2023) Ferritinophagy in the etiopathogenic mechanism of related diseases. J Nutr Biochem 117:109339

Article  PubMed  CAS  Google Scholar 

Qian S, Zhang D, Li R, Sha X, Lu S, Pan L, Hui X, Zhao T, Song X, Yu L (2025) Downregulation of FcRn promotes ferroptosis in herpes simplex virus-1-induced lung injury. Cell Mol Life Sci 82(1):36

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu GZ, Xu XW, Tao SH, Gao MJ, Hou ZH (2021) HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression. J Biomed Sci 28(1):67

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hémon A, Louandre C, Lailler C, Godin C, Bottelin M, Morel V, François C, Galmiche A, Saidak Z (2020) SLC7A11 as a biomarker and therapeutic target in HPV-positive head and neck squamous cell carcinoma. Biochem Biophys Res Commun 533(4):1083–1087

Article  PubMed  Google Scholar 

Zhu W, Li Q, Yin Y, Chen H, Si Y, Zhu B, Cao S, Zhao Z, Ye J (2024) Ferroptosis contributes to JEV-induced neuronal damage and neuroinflammation. Virol Sin 39(1):144–155

Article  PubMed  CAS  Google Scholar 

Cheng J, Tao J, Li B, Shi Y, Liu H (2022) Swine influenza virus triggers ferroptosis in A549 cells to enhance virus replication. Virol J 19(1):104

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhang D, Wu X, Xue X, Li W, Zhou P, Lv Z, Zhao K, Zhu F (2024) Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia. Virol Sin 39(1):31–43

Article  PubMed  Google Scholar 

Li Z, Zhao B, Zhang Y, Fan W, Xue Q, Chen X, Wang J, Qi X (2024) Mitochondria-mediated ferroptosis contributes to the inflammatory responses of bovine viral diarrhea virus (BVDV) in vitro. J Virol 98(2):e0188023

Article  PubMed  Google Scholar 

Kan X, Yin Y, Song C, Tan L, Qiu X, Liao Y, Liu W, Meng S, Sun Y, Ding C (2021) Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells. iScience 24(8):102837

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ohta K, Saka N, Nishio M (2021) Human parainfluenza virus type 2 V protein modulates Iron homeostasis. J Virol 95(6)

Gao Q, Yang Y, Luo Y, Chen X, Gong T, Wu D, Feng Y, Zheng X, Wang H, Zhang G et al (2023) African swine fever virus envelope glycoprotein CD2v interacts with host CSF2RA to regulate the JAK2-STAT3 pathway and inhibit apoptosis to facilitate virus replication. J Virol 97(4):e0188922

Article  PubMed 

Comments (0)

No login
gif