Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation

Piché ME, Tchernof A, Després JP (2020) Obesity phenotypes, diabetes, and cardiovascular diseases. Circ Res 126:1477–1500

Article  PubMed  Google Scholar 

Flegal KM, Kit BK, Orpana H, Graubard BI (2013) Association of all-cause mortality with overweight and obesity using standard body mass index categories: a systematic review and meta-analysis. JAMA 309:71–82

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chavakis T, Alexaki VI, Ferrante AW Jr (2023) Macrophage function in adipose tissue homeostasis and metabolic inflammation. Nat Immunol 24:757–766

Article  CAS  PubMed  Google Scholar 

Cai Z, Huang Y, He B (2022) New insights into adipose tissue macrophages in obesity and insulin resistance. Cells 11:1424

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cox N, Crozet L, Holtman IR, Loyher PL, Lazarov T, White JB, Mass E, Stanley ER, Elemento O, Glass CK, Geissmann F (2021) Diet-regulated production of PDGFcc by macrophages controls energy storage. Science 373:eabe9383

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pirzgalska RM, Seixas E, Seidman JS, Link VM, Sanchez NM, Mahu I, Mendes R, Gres V, Kubasova N, Morris I, Arus BA, Larabee CM, Vasques M, Tortosa F, Sousa AL, Anandan S, Tranfield E, Hahn MK, Iannacone M, Spann NJ, Glass CK, Domingos AI (2017) Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine. Nat Med 23:1309–1318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Y, He Y, Wang X, Liang Z, He G, Zhang P, Zhu H, Xu N, Liang S (2017) Protein SUMOylation modification and its associations with disease. Open Biol 7:170167

Article  PubMed  PubMed Central  Google Scholar 

Sahin U, de Thé H, Lallemand-Breitenbach V (2022) Sumoylation in physiology, pathology and therapy. Cells 11:814

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai Z, Wang Z, Yuan R, Cui M, Lao Y, Wang Y, Nie P, Shen L, Yi J, He B (2021) Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of beta-catenin and regulation of its stability. EBioMedicine 67:103386

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang M, Cai Z, Jiang Y, Huo H, Shen L, He B (2022) SENP2 promotes VSMC phenotypic switching via Myocardin De-SUMOylation. Int J Mol Sci 23:12637

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haindl M, Harasim T, Eick D, Muller S (2008) The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing. EMBO Rep 9:273–279

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fanis P, Gillemans N, Aghajanirefah A, Pourfarzad F, Demmers J, Esteghamat F, Vadlamudi RK, Grosveld F, Philipsen S, van Dijk TB (2012) Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation. Mol Cell Proteomics 11:1263–1273

Article  PubMed  PubMed Central  Google Scholar 

Guo C, Hildick KL, Luo J, Dearden L, Wilkinson KA, Henley JM (2013) SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia. Embo j 32:1514–1528

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh ET, Chen Y, Cang H, Li H, Shi G, Cheng J, Tang X, Yi J (2009) SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J 28:2748–2762

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han Y, Huang C, Sun X, Xiang B, Wang M, Yeh ET, Chen Y, Li H, Shi G, Cang H, Sun Y, Wang J, Wang W, Gao F, Yi J (2010) SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem 285:12906–12915

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ren YH, Liu KJ, Wang M, Yu YN, Yang K, Chen Q, Yu B, Wang W, Li QW, Wang J, Hou ZY, Fang JY, Yeh ET, Yang J, Yi J (2014) De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells. Oncotarget 5:7093–7104

Article  PubMed  PubMed Central  Google Scholar 

Zhou Z, Wang M, Li J, Xiao M, Chin YE, Cheng J, Yeh ET, Yang J, Yi J (2016) SUMOylation and SENP3 regulate STAT3 activation in head and neck cancer. Oncogene 35:5826

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu M, Yan M, Lv H, Wang B, Lv X, Zhang H, Xiang S, Du J, Liu T, Tian Y, Zhang X, Zhou F, Cheng T, Zhu Y, Jiang H, Cao Y, Ai D (2020) Macrophage K63-linked ubiquitination of YAP promotes its nuclear localization and exacerbates atherosclerosis. Cell Rep 32:107990

Article  CAS  PubMed  Google Scholar 

Mia MM, Cibi DM, Abdul Ghani SAB, Song W, Tee N, Ghosh S, Mao J, Olson EN, Singh MK (2020) YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction. PLoS Biol 18:e3000941

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou X, Li W, Wang S, Zhang P, Wang Q, Xiao J, Zhang C, Zheng X, Xu X, Xue S, Hui L, Ji H, Wei B, Wang H (2019) YAP aggravates inflammatory bowel disease by regulating M1/M2 macrophage polarization and gut microbial homeostasis. Cell Rep 27:1176-1189.e5

Article  CAS  PubMed  Google Scholar 

Levy D, Adamovich Y, Reuven N, Shaul Y (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29:350–361

Article  CAS  PubMed  Google Scholar 

Li B, He J, Lv H, Liu Y, Lv X, Zhang C, Zhu Y, Ai D (2019) c-Abl regulates YAPY357 phosphorylation to activate endothelial atherogenic responses to disturbed flow. J Clin Invest 129:1167–1179

Article  PubMed  PubMed Central  Google Scholar 

Cui M, Cai Z, Chu S, Sun Z, Wang X, Hu L, Yi J, Shen L, He B (2016) Orphan nuclear receptor Nur77 inhibits angiotensin II-induced vascular remodeling via downregulation of beta-catenin. Hypertension 67:153–162

Article  CAS  PubMed  Google Scholar 

Bouloumié A, Curat CA, Sengenès C, Lolmède K, Miranville A, Busse R (2005) Role of macrophage tissue infiltration in metabolic diseases. Curr Opin Clin Nutr Metab Care 8:347–354

Article  PubMed  Google Scholar 

Feng D, Tang Y, Kwon H, Zong H, Hawkins M, Kitsis RN, Pessin JE (2011) High-fat diet-induced adipocyte cell death occurs through a cyclophilin D intrinsic signaling pathway independent of adipose tissue inflammation. Diabetes 60:2134–2143

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112:1796–1808

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA, Chen H (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112:1821–1830

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cai Z, He B (2023) Adipose tissue aging: an update on mechanisms and therapeutic strategies. Metabolism 138:155328

Article  CAS  PubMed  Google Scholar 

Kuk JL, Saunders TJ, Davidson LE, Ross R (2009) Age-related changes in total and regional fat distribution. Ageing Res Rev 8:339–348

Article  PubMed  Google Scholar 

Liu XM, Chan HC, Ding GL, Cai J, Song Y, Wang TT, Zhang D, Chen H, Yu MK, Wu YT, Qu F, Liu Y, Lu YC, Adashi EY, Sheng JZ, Huang HF (2015) FSH regulates fat accumulation and redistribution in aging through the Galphai/Ca(2+)/CREB pathway. Aging Cell 14:409–420

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Yang J, Yang K, Cang H, Huang XZ, Li H, Yi J (2012) The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress. Acta Pharmacol Sin 33:953–963

Article  PubMed  PubMed Central  Google Scholar 

Kumar A, Zhang KY (2015) Advances in the development of SUMO specific protease (SENP) inhibitors. Comput Struct Biotechnol J 13:204–211

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bawa-Khalfe T, Lu LS, Zuo Y, Huang C, Dere R, Lin FM, Yeh ET (2012) Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Proc Natl Acad Sci U S A 109:17466–17471

Article 

Comments (0)

No login
gif