Bray F., Laversanne M., Sung H., Ferlay J., Siegel R.L., Soerjomataram I., Jemal A. 2024. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA—Cancer J. Clin. 74, 229–263.

PubMed  Google Scholar 

Hu Y., Dong Z., Liu K. 2024. Unraveling the complexity of STAT3 in cancer: Molecular understanding and drug discovery. J. Exp. Clin. Cancer Res. 43, 23.

PubMed  PubMed Central  Google Scholar 

Ding H., Wang G., Yu Z., Sun H., Wang L. 2022. Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection and cancer development: IFN-γ-dependent or independent pathway. Biomed. Pharmacother. 155, 113683.

CAS  PubMed  Google Scholar 

Barrat F.J., Crow M.K., Ivashkiv L.B. 2019. Interferon target-gene expression and epigenomic signatures in health and disease. Nat. Immunol. 20, 1574–1583.

CAS  PubMed  PubMed Central  Google Scholar 

Park H., Lee S., Lee J., Moon H., Ro S.W. 2023. Exploring the JAK/STAT signaling pathway in hepatocellular carcinoma: unraveling signaling complexity and therapeutic implications. Int. J. Mol. Sci. 24, 13764.

CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Lezana T., Lopez-Canovas J.L., Villanueva A. 2021. Signaling pathways in hepatocellular carcinoma. Adv. Cancer Res. 149, 63–101.

CAS  PubMed  Google Scholar 

Masuzaki R., Kanda T., Sasaki R., Matsumoto N., Nirei K., Ogawa M., Karp S.J., Moriyama M., Kogure H. 2022. Suppressors of cytokine signaling and hepatocellular carcinoma. Cancers (Basel). 14, 2549.

CAS  PubMed  PubMed Central  Google Scholar 

Niwa Y., Kanda H., Shikauchi Y., Saiura A., Matsubara K., Kitagawa T., Yamamoto J., Kubo T., Yoshikawa H. 2005. Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma. Oncogene. 24, 6406–6417.

CAS  PubMed  Google Scholar 

Darvish L., Bahreyni Toossi M.T., Azimian H., Shakeri M., Dolat E., Ahmadizad Firouzjaei A., Rezaie S., Amraee A., Aghaee-Bakhtiari S.H. 2023. The role of microRNA-induced apoptosis in diverse radioresistant cancers. Cell Signal. 104, 110580.

CAS  PubMed  Google Scholar 

Mallela V.R., Rajtmajerová M., Trailin A., Liška V., Hemminki K., Ambrozkiewicz F. 2024. miRNA and lncRNA as potential tissue biomarkers in hepatocellular carcinoma. Noncoding RNA Res. 9, 24–32.

CAS  PubMed  Google Scholar 

Baltayiannis G., Baltayiannis N., Tsianos E.V. 2008. Suppressors of cytokine signaling as tumor repressors. Silencing of SOCS3 facilitates tumor formation and growth in lung and liver. J. BUON. 13, 263–265.

CAS  PubMed  Google Scholar 

Lin J. 2021. C1QTNF1-AS1 regulates the occurrence and development of hepatocellular carcinoma by regulating miR-221-3p/SOCS3. Hepatol. Int. 15 (2), 526.

PubMed  Google Scholar 

Wu L., Huang G., Hong H., Xu X., Lu X., Li J. 2023. MiR-452-5p facilitates retinoblastoma cell growth and invasion via the SOCS3/JAK2/STAT3 pathway. J. Biochem. Mol. Toxic. 37, e23501.

CAS  Google Scholar 

Zhang S., Ji W.W., Wei W., Zhan L.X., Huang X. 2021. Long noncoding RNA Meg3 sponges miR-708 to inhibit intestinal tumorigenesis via SOCS3-repressed cancer stem cells growth. Cell Death Dis. 13, 25.

PubMed  PubMed Central  Google Scholar 

Zhou Q., Zhou L., Li J. 2023. MiR-218-5p-dependent SOCS3 downregulation increases osteoblast differentiation inpostmenopausal osteoporosis. J. Orthop. Surg. Res. 18, 109.

PubMed  PubMed Central  Google Scholar 

Zhang J.W., Wang X., Li G.C., Wang D., Han S., Zhang Y.D., Luo C.H., Wang H.W., Jiang W.J., Li C.X., Li X.C. 2020. MiR-30a-5p promotes cholangiocarcinoma cell proliferation through targeting SOCS3. J. Cancer. 11, 3604–3614.

CAS  PubMed  PubMed Central  Google Scholar 

Wang S., Ma J., Qiu H., Liu S., Zhang S., Liu H., Zhang P., Ge R.L., Li G., Cui S. 2023. Plasma exosomal microRNA expression profiles in patients with high-altitude polycythemia. Blood Cell Mol. Dis. 98, 102707.

CAS  Google Scholar 

Qiu L., Zhang L., Qi R., Gao X., Chen H., Xiao T. 2020. miR-1291 Functions as a potential serum biomarker for bullous pemphigoid. Dis. Markers. 2020, 9505312.

PubMed  PubMed Central  Google Scholar 

Liu P., Qiu C.G., Li B.F., Ding X.Z., Wang Z.H., L Y.F., D Y.P., Liu Y.G., Li W.G., Hu T.Y., H Z.W. 2014. Clinical impact of circulating miR-133, miR-1291 and miR-663b in plasma of patients with acute myocardial infarction. Diagn. Pathol. 9, 89.

Google Scholar 

Wang B., Wang X., Li P., Niu X., Liang X., Liu G., Liu Z., Ge H. 2022. Osteosarcoma cell-derived exosomal ELFN1-AS1 mediates macrophage M2 polarization via sponging miR-138-5p and miR-1291 to promote the tumorgenesis of osteosarcoma. Front Oncol. 12, 881022.

CAS  PubMed  PubMed Central  Google Scholar 

Cai Q., Zhao A., Ren L., Chen J., Liao K., Wang Z., Zhang W. 2019. MicroRNA-1291 mediates cell proliferation and tumorigenesis by downregulating MED1 in prostate cancer. Oncol Lett. 17, 3253–3260.

CAS  PubMed  PubMed Central  Google Scholar 

Wang J., Yokoyama Y., Hirose H., Shimomura Y., Bonkobara S., Itakura H., Kouda S., Morimoto Y., Minami K., Takahashi H., Shibata S., Kobayashi S., Uemura M., Tanaka S., Wu X., Tanaka S., Mori M., Yamamoto H. 2022. Functional assessment of miR‑1291 in colon cancer cells. Int. J. Oncol. 60, 13.

CAS  PubMed  PubMed Central  Google Scholar 

Yamasaki T., Seki N., Yoshino H., Itesako T., Yamada Y., Tatarano S., Hidaka H., Yonezawa T., Nakagawa M., Enokida H. 2013. Tumor-suppressive microRNA-1291 directly regulates glucose transporter 1 in renal cell carcinoma. Cancer Sci. 104, 1411–1419.

CAS  PubMed  PubMed Central  Google Scholar 

Alspach E., Lussier D.M., Schreiber R.D. 2019. Interferon γ and its important roles in promoting and inhibiting spontaneous and therapeutic cancer immunity. Cold Spring Harb. Perspect. Biol. 11, a028480.

CAS  PubMed  PubMed Central  Google Scholar 

Štancl P., Gršković P., Držaić S., Vičić A., Karlić R., Korać P. 2024. RNA-sequencing identification of genes supporting HepG2 as a model cell line for hepatocellular carcinoma or hepatocytes. Genes (Basel). 15, 1460.

PubMed  PubMed Central  Google Scholar 

Hagag N.A., Ali Y.B.M., Elsharawy A.A., Talaat R.M. 2020. Clinical impact of circulated miR-1291 in plasma of patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC): Implication on glypican-3 expression. J. Gastrointest. Cancer. 51, 234–241.

CAS  PubMed  Google Scholar 

Ferragut Cardoso A.P., Banerjee M., Nail A.N., Lykoudi A., States J.C. 2021. miRNA dysregulation is an emerging modulator of genomic instability. Semin. Cancer Biol. 76, 120–131.

CAS  PubMed  PubMed Central  Google Scholar 

Kursunel M.A., Esendagli G. 2016. The untold story of IFN-γ in cancer biology. Cytokine Growth Factor Rev. 31, 73–81.

PubMed  Google Scholar 

Han J., Wu M., Liu Z. 2023. Dysregulation in IFN-γ signaling and response: The barricade to tumor immunotherapy. Front Immunol. 14, 1190333.

CAS  PubMed  PubMed Central  Google Scholar 

Lakshmi Narendra B., Eshvendar Reddy K., Shantikumar S., Ramakrishna S. 2013. Immune system: A double-edged sword in cancer. Inflammation Res. 62, 823–834.

CAS  Google Scholar 

Gocher A.M., Workman C.J., Vignali D.A.A. 2022. Interferon-γ: Teammate or opponent in the tumour microenvironment? Nat. Rev. Immunol. 22, 158–172.

CAS  PubMed  Google Scholar 

Zhang J., Lu Y., Mao Y., Yu Y., Wu T., Zhao W., Zhu Y., Zhao P., Zhang F. 2022. IFN-γ enhances the efficacy of mesenchymal stromal cell-derived exosomes via miR-21 in myocardial infarction rats. Stem Cell Res. Ther. 13, 333.

CAS  PubMed  PubMed Central  Google Scholar 

Yang R., Huang H., Cui S., Zhou Y., Zhang T., Zhou Y. 2020. IFN-γ promoted exosomes from mesenchymal stem cells to attenuate colitis via miR-125a and miR-125b. Cell Death Dis. 11, 603.

CAS  PubMed  PubMed Central  Google Scholar 

Imaizumi T., Tanaka H., Tajima A., Yokono Y., Matsumiya T., Yoshida H., Tsuruga K., Aizawa-Yashiro T., Hayakari R., Inoue I., Ito E., Satoh K. 2010. IFN-γ and TNF-α synergistically induce microRNA-155 which regulates TAB2/IP-10 expression in human mesangial cells. Am. J. Nephrol. 32, 462–468.

CAS  PubMed  Google Scholar 

Xia G., Xie Y., He Q. 2021. Hepatitis B virus affected serum microRNA-203a level in hepatocellular carcinoma. Clin. Lab. 67 (3).

Su Y., Xie R., Xu Q. 2021. Upregulation of miR-1266-5p serves as a prognostic biomarker of hepatocellular carcinoma and facilitates tumor cell proliferation, migration and invasion. Acta Biochim. Pol. 68, 293–300.

CAS  PubMed