Moss B.J., Ryter S.W., Rosas I.O. 2022. Pathogenic mechanisms underlying idiopathic pulmonary fibrosis. Annu. Rev. Pathol. 17, 515–546.
Shinde A.V., Humeres C., Frangogiannis N.G. 2017. The role of α-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. Biochim. Biophys. Acta, Mol. Basis Dis. 1863, 298–309.
Pardali E., Sanchez-Duffhues G., Gomez-Puerto M.C., Ten Dijke. P. 2017. TGF-β-induced endothelial-mesenchymal transition in fibrotic diseases. Int. J. Mol. Sci. 18, 2157.
PubMed PubMed Central Google Scholar
Lu J., Shi J., Li M., Gui B., Fu R., Yao G., Duan Z., Lv Z., Yang Y., Chen Z., Jia L., Tian L. 2015. Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts. Life Sci. 127, 59–65.
Bai X., Zhao G., Chen Q., Li Z., Gao M., Ho W., Xu X., Zhang X.Q. 2022. Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. Sci. Adv. 8, eabn7162.
Andugulapati S.B., Gourishetti K., Tirunavalli S.K., Shaikh T.B., Sistla R. 2020. Biochanin-A ameliorates pulmonary fibrosis by suppressing the TGF-β mediated EMT, myofibroblasts differentiation and collagen deposition in in vitro and in vivo systems. Phytomedicine. 78, 153298.
CAS PubMed PubMed Central Google Scholar
Zhao H., Bian H., Bu X., Zhang S., Zhang P., Yu J., Lai X., Li D., Zhu C., Yao L., Su J. 2016. Targeting of discoidin domain receptor 2 (DDR2) prevents myofibroblast activation and neovessel formation during pulmonary fibrosis. Mol. Ther. 24, 1734–1744.
CAS PubMed PubMed Central Google Scholar
Yu D., Xiang Y., Gou T., Tong R., Xu C., Chen L., Zhong L., Shi J. 2023. New therapeutic approaches against pulmonary fibrosis. Bioorg. Chem. 138, 106592.
Zhang D., Gou Z., Qu Y., Su X. 2024. Understanding how methyltransferase-like 3 functions in lung diseases: From pathogenesis to clinical application. Biomed. Pharmacother. 179, 117421.
Su X., Qu Y., Mu D. 2024. Methyltransferase-like 3 modifications of RNAs: Implications for the pathology in the endocrine system. Biochim. Biophys. Acta, Mol. Basis. Dis. 1870, 167010.
Zhang M., Gou Z., Qu Y., Su X. 2024. The indispensability of methyltransferase-like 3 in the immune system: from maintaining homeostasis to driving function. Front. Immunol. 15, 1456891.
CAS PubMed PubMed Central Google Scholar
Zhang J.X., Huang P.J., Wang D.P., Yang W.Y., Lu J., Zhu Y., Meng X.X., Wu X., Lin Q.H., Lv H., Xie H., Wang R.L. 2021. m(6)A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation. Mol. Ther. 29, 3436–3448.
CAS PubMed PubMed Central Google Scholar
Wu T., Liu B., Wei Y., Li Z. 2023. TGF-β Regulates m(6)A RNA Methylation after PM(2.5) exposure. Toxics. 11, 1026.
CAS PubMed PubMed Central Google Scholar
Sun Y., Ge J., Shao F., Ren Z., Huang Z., Ding Z., Dong L., Chen J., Zhang J., Zang Y. 2023. Long noncoding RNA AI662270 promotes kidney fibrosis through enhancing METTL3-mediated m(6) A modification of CTGF mRNA. FASEB J. 37, e23071.
Sun Y., Zhang X.C., Li M.D., Bu L.G., Wang B., Li T.Y., Ding N.Z., Ni H. 2023. METTL3 promotes proliferation of goat endometrial epithelial cells by regulating CTGF in an m6A-dependent manner. Biol. Reprod. 108, 902–911.
Lu Y., Liu Z., Zhang Y., Wu X., Bian W., Shan S., Yang D., Ren T. 2023. METTL3-mediated m6A RNA methylation induces the differentiation of lung resident mesenchymal stem cells into myofibroblasts via the miR-21/PTEN pathway. Respir. Res. 24, 300.
CAS PubMed PubMed Central Google Scholar
Wanna-Udom S., Terashima M., Lyu H., Ishimura A., Takino T., Sakari M., Tsukahara T., Suzuki T. 2020. The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB. Biochem. Biophys. Res. Commun. 524, 150–155.
Jung H.R., Lee J., Hong S.P., Shin N., Cho A., Shin D.J., Choi J.W., Kim J.I., Lee J.P., Cho S.Y. 2024. Targeting the m(6)A RNA methyltransferase METTL3 attenuates the development of kidney fibrosis. Exp. Mol. Med. 56, 355–369.
CAS PubMed PubMed Central Google Scholar
Yankova E., Blackaby W., Albertella M., Rak J., De Braekeleer E., Tsagkogeorga G., Pilka E.S., Aspris D., Leggate D., Hendrick A.G., Webster N.A., Andrews B., Fosbeary R., Guest P., Irigoyen N., Eleftheriou M., Gozdecka M., Dias J.M.L., Bannister A.J., Vick B., Jeremias I., Vassiliou G.S., Rausch O., Tzelepis K., Kouzarides T. 2021. Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia. Nature. 593, 597–601.
CAS PubMed PubMed Central Google Scholar
Xiao Y., Yang Y., Hu D. 2021. Knockdown of METTL3 inhibits enterovirus 71-induced apoptosis of mouse Schwann cell through regulation of autophagy. Pathog. Dis. 79, ftab036.
Hickman D.L. 2023. Euthanasia of neonatal rats and mice using carbon monoxide. J. Am. Assoc. Lab. Anim. Sci. 62, 274–278.
PubMed PubMed Central Google Scholar
Vinje M.A., Friedman D.A. 2023. Exogenous spike-in mouse RNAs for accurate differential gene expression analysis in barley using RT-qPCR. Biol. Methods Protoc. 8, bpad034.
Tan M., Liu S., Liu L. 2024. N6-methyladenosine (m6A) RNA modification in fibrosis and collagen-related diseases. Clin. Epigenetics. 16, 127.
CAS PubMed PubMed Central Google Scholar
Xue T., Qiu X., Liu H., Gan C., Tan Z., Xie Y., Wang Y., Ye T. 2021. Epigenetic regulation in fibrosis progress. Pharmacol. Res. 173,105910.
He C., Ji Y., Zhang Y., Ou J., Wu D., Qin H., Hua J., Li Q., Zheng H. 2025. Inhibition of Mettl3 by STM2457 and loss of macrophage Mettl3 alleviate pulmonary hypertension and right heart remodeling. Lung. 203, 34.
Bolívar S., Pérez-Cantillo M., Monterroza-Torres J., Vásquez-Trincado C., Castellar-Lopez J., Mendoza-Torres E. 2023. The Role of METTL3 in the progression of cardiac fibrosis. Curr. Top. Med. Chem. 23, 2427–2435.
Li T., Zhuang Y., Yang W., Xie Y., Shang W., Su S., Dong X., Wu J., Jiang W., Zhou Y., Li Y., Zhou X., Zhang M., Lu Y., Pan Z. 2021.Silencing of METTL3 attenuates cardiac fibrosis induced by myocardial infarction via inhibiting the activation of cardiac fibroblasts. FASEB J. 35, e21162.
Isshiki T., Naiel S., Vierhout M., Otsubo K., Ali P., Tsubouchi K., Yazdanshenas P., Kumaran V., Dvorkin-Gheva A., Kolb M.R.J., Ask K. 2024.Therapeutic strategies to target connective tissue growth factor in fibrotic lung diseases. Pharmacol. Ther. 253,108578.
Yanagihara T., Tsubouchi K., Gholiof M., Chong S.G., Lipson K.E., Zhou Q., Scallan C., Upagupta C., Tikkanen J., Keshavjee S., Ask K., Kolb M.R.J. 2022. Connective-tissue growth factor contributes to TGF-β1-induced lung fibrosis. Am. J. Respir. Cell Mol. Biol. 66, 260–270.
Kasam R.K., Ghandikota S., Soundararajan D., Reddy G.B., Huang S.K., Jegga A.G., Madala S.K. 2020. Inhibition of Aurora Kinase B attenuates fibroblast activation and pulmonary fibrosis. EMBO Mol. Med. 12, e12131.
CAS PubMed PubMed Central Google Scholar
Richeldi L., Collard H.R., Jones M.G. 2017. Idiopathic pulmonary fibrosis. Lancet. 389, 1941–1952.
Marcoux V., Lok S.D., Mondal P., Assayag D., Fisher J.H., Shapera S., Morisset J., Manganas H., Fell C.D., Hambly N., Cox P.G., Kolb M., Gershon A.S., To T., Sadatsafavi M., Khalil N., Wong A.W., Wilcox P.G., Ryerson C.J., Vu T., Johannson K.A. 2024. Impact of surgical lung biopsy on lung function and survival in patients with idiopathic pulmonary fibrosis in a multi-centre registry cohort. Respirology. 29, 596–604.
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