Chen, Y., Yang, Y. & Zhang, F. Noninvasive in vivo microscopy of single neutrophils in the mouse brain via NIR-II fluorescent nanomaterials. Nat. Protoc. 19, 2386–2407 (2024).

Article  CAS  PubMed  Google Scholar 

Wang, F. et al. In vivo NIR-II fluorescence imaging for biology and medicine. Nat. Photon. 18, 535–547 (2024).

Article  CAS  Google Scholar 

Wang, X. et al. An emerging toolkit of Ho3+ sensitized lanthanide nanocrystals with NIR-II excitation and emission for in vivo bioimaging. J. Am. Chem. Soc. 147, 2182–2192 (2025).

Article  CAS  PubMed  Google Scholar 

Li, J. et al. Progressive optimization of lanthanide nanoparticle scintillators for enhanced triple-activated radioluminescence imaging. Angew. Chem. Int. Ed. 63, e202401683 (2024).

Article  CAS  Google Scholar 

Kou, Y. et al. Fluorine doping mediated epitaxial growth of NaREF4 on TiO2 for boosting NIR light utilization in bioimaging and photodynamic therapy. Angew. Chem. Int. Ed. 63, e202405132 (2024).

Article  CAS  Google Scholar 

Chang, Y. et al. Bright Tm3+-based downshifting luminescence nanoprobe operating around 1800 nm for NIR-IIb and c bioimaging. Nat. Commun. 14, 1079–1088 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, Q. et al. All-inorganic perovskite nanocrystal scintillators. Nature 561, 88–93 (2018).

Article  CAS  PubMed  Google Scholar 

Chen, S. et al. Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science 359, 679–684 (2018).

Article  CAS  PubMed  Google Scholar 

Casar, J. R. et al. Upconverting microgauges reveal intraluminal force dynamics in vivo. Nature 637, 76–83 (2025).

Article  CAS  PubMed  Google Scholar 

Wang, F. et al. Simultaneous phase and size control of upconversion nanocrystals through lanthanide doping. Nature 463, 1061–1065 (2010).

Article  CAS  PubMed  Google Scholar 

Ou, X. et al. High-resolution X-ray luminescence extension imaging. Nature 590, 410–415 (2021).

Article  CAS  PubMed  Google Scholar 

Schiattarella, C. et al. Directive giant upconversion by supercritical bound states in the continuum. Nature 626, 765–771 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou, M. et al. Ultrafast upconversion superfluorescence with a sub-2.5 ns lifetime at room temperature. Nat. Commun. 15, 9880 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, L. & Li, Y. Controlled synthesis and luminescence of lanthanide doped NaYF4 nanocrystals. Chem. Mater. 19, 727–734 (2007).

Article  CAS  Google Scholar 

Pei, P. et al. X-ray-activated persistent luminescence nanomaterials for NIR-II imaging. Nat. Nanotechnol. 16, 1011–1018 (2021).

Article  CAS  PubMed  Google Scholar 

Han, S. et al. Multicolour synthesis in lanthanide-doped nanocrystals through cation exchange in water. Nat. Commun. 7, 13059 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lei, L. et al. Manipulation of time-dependent multicolour evolution of X-ray excited afterglow in lanthanide-doped fluoride nanoparticles. Nat. Commun. 13, 5739 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wen, S. et al. Advances in highly doped upconversion nanoparticles. Nat. Commun. 9, 2415–2426 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Jiang, Z. et al. Ultra-wideband-responsive photon conversion through co-sensitization in lanthanide nanocrystals. Nat. Commun. 14, 827 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, G. et al. Li/Na substitution and Yb3+ co-doping enabling tunable near-infrared emission in LiIn2SbO6:Cr3+ phosphors for light-emitting diodes. iScience 24, 102250 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, Y. et al. Blue LED-pumped intense short-wave infrared luminescence based on Cr3+-Yb3+-co-doped phosphors. Light Sci. Appl. 11, 136 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi, B. et al. Efficient and stable NIR-II phosphorescence of metallophilic molecular oligomers for in vivo single-cell tracking and time-resolved imaging. Angew. Chem. Int. Ed. 63, e202410118 (2024).

CAS  Google Scholar 

Chen, Z. et al. An extended NIR-II superior imaging window from 1500 to 1900 nm for high-resolution in vivo multiplexed imaging based on lanthanide nanocrystals. Angew. Chem. Int. Ed. 62, e202311883 (2023).

Article  CAS  Google Scholar 

Chen, Y., Wang, S. & Zhang, F. Near-infrared luminescence high-contrast in vivo biomedical imaging. Nat. Rev. Bioeng. 1, 60–78 (2023).

Article  CAS  Google Scholar 

Yang, Y., Jiang, Q. & Zhang, F. Nanocrystals for deep-tissue in vivo luminescence imaging in the near-infrared region. Chem. Rev. 124, 554–628 (2024).

Article  CAS  PubMed  Google Scholar 

Zhu, X., Zhang, H. & Zhang, F. Expanding NIR-II lanthanide toolboxes for improved biomedical imaging and detection. Acc. Mater. Res. 4, 536–547 (2023).

Article  CAS  Google Scholar 

Li, S. et al. Emerging ultrasmall luminescent nanoprobes for in vivo bioimaging. Chem. Soc. Rev. 52, 1672–1696 (2023).

Article  CAS  PubMed  Google Scholar 

Cheng, X. et al. Recent development in sensitizers for lanthanide-doped upconversion luminescence. Chem. Rev. 122, 15998–16050 (2022).

Article  CAS  PubMed  Google Scholar 

Fang, Z. et al. Oxyhaemoglobin saturation NIR-IIb imaging for assessing cancer metabolism and predicting the response to immunotherapy. Nat. Nanotechnol. 19, 124–130 (2023).

Article  PubMed  Google Scholar 

Wei, X. et al. Longer and stronger: improving persistent luminescence in size-tuned zinc gallate nanoparticles by alcohol-mediated chromium doping. ACS Nano 14, 12113–12124 (2020).

Article  CAS  PubMed  Google Scholar 

He, F. Q. et al. A general ammonium salt assisted synthesis strategy for Cr3+-doped hexafluorides with highly efficient near infrared emissions. Adv. Funct. Mater. 31, 2103743 (2021).

Article  CAS  Google Scholar 

Garfield, D. J. et al. Enrichment of molecular antenna triplets amplifies upconverting nanoparticle emission. Nat. Photon. 12, 402–407 (2018).

Article  CAS  Google Scholar 

Xu, H. Anomalous upconversion amplification induced by surface reconstruction in lanthanide sublattices. Nat. Photon. 15, 732–737 (2021).

Article  CAS  Google Scholar 

Han, S. et al. Lanthanide-doped inorganic nanoparticles turn molecular triplet excitons bright. Nature 587, 594–599 (2020).