Ostrom, Q. T. et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017. Neuro Oncol. 22, iv1–iv96 (2020).
Article PubMed PubMed Central Google Scholar
Torp, S. H., Solheim, O. & Skjulsvik, A. J. The WHO 2021 classification of central nervous system tumours: a practical update on what neurosurgeons need to know-a minireview. Acta Neurochir. 164, 2453–2464 (2022).
Brás, J. P. et al. TERTmonitor-qPCR detection of TERTp mutations in glioma. Genes 14, 1693 (2023).
Article PubMed PubMed Central Google Scholar
Miller, J. J. Targeting IDH-mutant glioma. Neurotherapeutics 19, 1724–1732 (2022).
Article CAS PubMed PubMed Central Google Scholar
Han, S. et al. IDH mutation in glioma: molecular mechanisms and potential therapeutic targets. Br. J. Cancer 122, 1580–1589 (2020).
Article PubMed PubMed Central Google Scholar
McClellan, B. L. et al. Impact of epigenetic reprogramming on antitumor immune responses in glioma. J. Clin. Investig. 133, e163450 (2023).
Article CAS PubMed PubMed Central Google Scholar
Wu, Q., Berglund, A. E. & Etame, A. B. The impact of epigenetic modifications on adaptive resistance evolution in glioblastoma. Int. J. Mol. Sci. 22, 8324 (2021).
Article CAS PubMed PubMed Central Google Scholar
Yan, H. et al. The heterogeneous cellular states of glioblastoma stem cells revealed by single cell analysis. Stem Cells 41, 111–125 (2023).
Guo, X. et al. Neuronal activity promotes glioma progression by inducing proneural-to-mesenchymal transition in glioma stem cells. Cancer Res 84, 372–387 (2024).
Article CAS PubMed Google Scholar
Singh, S. et al. Unveiling novel avenues in mTOR-targeted therapeutics: advancements in glioblastoma treatment. Int. J. Mol. Sci. 24, 14960 (2023).
Article CAS PubMed PubMed Central Google Scholar
Sharma, P., Aaroe, A., Liang, J. & Puduvalli, V. K. Tumor microenvironment in glioblastoma: current and emerging concepts. Neurooncol. Adv. 5, vdad009 (2023).
PubMed PubMed Central Google Scholar
Zhang, L., Jiang, Y., Zhang, G. & Wei, S. The diversity and dynamics of tumor-associated macrophages in recurrent glioblastoma. Front. Immunol. 14, 1238233 (2023).
Article CAS PubMed PubMed Central Google Scholar
Singh, S., Chen, C. C., Kim, S., Singh, A. & Singh, G. Role of Extracellular vesicle microRNAs and RNA binding proteins on glioblastoma dynamics and therapeutics development. Extracell. Vesicle 4, 100049 (2024).
Ratti, M. et al. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as new tools for cancer therapy: first steps from bench to bedside. Target. Oncol. 15, 261–278 (2020).
Article PubMed PubMed Central Google Scholar
Uppaluri, K. R. et al. Unlocking the potential of non-coding RNAs in cancer research and therapy. Transl. Oncol. 35, 101730 (2023).
Article CAS PubMed PubMed Central Google Scholar
Nakajima, N. et al. BRAF V600E, TERT promoter mutations and CDKN2A/B homozygous deletions are frequent in epithelioid glioblastomas: a histological and molecular analysis focusing on intratumoral heterogeneity. Brain Pathol. 28, 663–673 (2017).
Article PubMed PubMed Central Google Scholar
Louis, D. N. et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 131, 803–820 (2016).
Louis, D. N. et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol. 23, 1231–1251 (2021).
Article CAS PubMed PubMed Central Google Scholar
Phillips, H. S. et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157–173 (2006).
Article CAS PubMed Google Scholar
Verhaak, R. G. W. et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17, 98–110 (2010).
Article CAS PubMed PubMed Central Google Scholar
Sharma, A. et al. Angiogenic gene signature derived from subtype specific cell models segregate proneural and mesenchymal glioblastoma. Front. Oncol. 7, 146 (2017).
Article PubMed PubMed Central Google Scholar
Brennan, C. W. et al. The somatic genomic landscape of glioblastoma. Cell 155, 462–477 (2013).
Article CAS PubMed PubMed Central Google Scholar
Ma, H. et al. Specific glioblastoma multiforme prognostic-subtype distinctions based on DNA methylation patterns. Cancer Gene Ther. 27, 702–714 (2020).
Article CAS PubMed Google Scholar
Molenaar, R. J., Maciejewski, J. P., Wilmink, J. W. & van Noorden, C. J. F. Wild-type and mutated IDH1/2 enzymes and therapy responses. Oncogene 37, 1949–1960 (2018).
Article CAS PubMed PubMed Central Google Scholar
Yang, H., Ye, D., Guan, K.-L. & Xiong, Y. IDH1 and IDH2 mutations in tumorigenesis: mechanistic insights and clinical perspectives. Clin. Cancer Res. 18, 5562–5571 (2012).
Article CAS PubMed PubMed Central Google Scholar
Cohen, A. L., Holmen, S. L. & Colman, H. IDH1 and IDH2 mutations in gliomas. Curr. Neurol. Neurosci. Rep. 13, 345 (2013).
Article PubMed PubMed Central Google Scholar
Mukasa, A. et al. Significance of IDH mutations varies with tumor histology, grade, and genetics in Japanese glioma patients. Cancer Sci. 103, 587–592 (2012).
Article CAS PubMed PubMed Central Google Scholar
Juratli, T. A. et al. The prognostic value of IDH mutations and MGMT promoter status in secondary high-grade gliomas. J. Neurooncol. 110, 325–333 (2012).
Article CAS PubMed Google Scholar
Ramos-Fresnedo, A. et al. The survival outcomes of molecular glioblastoma IDH-wildtype: a multicenter study. J. Neurooncol. 157, 177–185 (2022).
Article CAS PubMed Google Scholar
Duncan, C. G. et al. A heterozygous IDH1R132H/WT mutation induces genome-wide alterations in DNA methylation. Genome Res 22, 2339–2355 (2012).
Article CAS PubMed PubMed Central Google Scholar
Beiko, J. et al. IDH1 mutant malignant astrocytomas are more amenable to surgical resection and have a survival benefit associated with maximal surgical resection. Neuro Oncol. 16, 81–91 (2014).
Comments (0)