Pattern recognition receptors: function, regulation and therapeutic potential

Metschnikoff, E. Lecture on phagocytosis and immunity. Br. Med. J. 1, 213–217 (1891).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Paul, E. Croonian lecture—on immunity with special reference to cell life. Proc. R. Soc. Lond. 66, 424–448 (1900).

Paul, W. E. Bridging innate and adaptive immunity. Cell 147, 1212–1215 (2011).

Article  CAS  PubMed  Google Scholar 

Jenkins, M. K. & Schwartz, R. H. Pillars article: antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165, 302–319 (1987).

Land, W. et al. The beneficial effect of human recombinant superoxide dismutase on acute and chronic rejection events in recipients of cadaveric renal transplants. Transplantation 57, 211–217 (1994).

Article  CAS  PubMed  Google Scholar 

Matzinger, P. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12, 991–1045 (1994).

Article  CAS  PubMed  Google Scholar 

Seong, S. Y. & Matzinger, P. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat. Rev. Immunol. 4, 469–478 (2004).

Article  CAS  PubMed  Google Scholar 

Land, W. Allograft injury mediated by reactive oxygen species: from conserved proteins of Drosophila to acute and chronic rejection of human transplants. Part III: interaction of (oxidative) stress-induced heat shock proteins with Toll-like receptor-bearing cells. Transpl. Rev. 17, 67–86 (2003).

Article  Google Scholar 

Matzinger, P. The danger model: a renewed sense of self. Science 296, 301–305 (2002).

Article  CAS  PubMed  Google Scholar 

Sundaram, B., Tweedell, R. E., Prasanth Kumar, S. & Kanneganti, T. D. The NLR family of innate immune and cell death sensors. Immunity 57, 674–699 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong, T., Liu, L., Jiang, W. & Zhou, R. DAMP-sensing receptors in sterile inflammation and inflammatory diseases. Nat. Rev. Immunol. 20, 95–112 (2020).

Article  CAS  PubMed  Google Scholar 

Roudaire, T. et al. Cross kingdom immunity: the role of immune receptors and downstream signaling in animal and plant cell death. Front. Immunol. 11, 612452 (2020).

Article  CAS  PubMed  Google Scholar 

Yang, X., Lin, G., Han, Z. & Chai, J. Structural biology of NOD-Like receptors. Adv. Exp. Med. Biol. 1172, 119–141 (2019).

Article  CAS  PubMed  Google Scholar 

Rumpret, M., von Richthofen, H. J., Peperzak, V. & Meyaard, L. Inhibitory pattern recognition receptors. J. Exp. Med. 219, e20211463 (2022).

Huang, Y., Jiang, W. & Zhou, R. DAMP sensing and sterile inflammation: intracellular, intercellular and inter-organ pathways. Nat. Rev. Immunol. 24, 703–719 (2024).

Fitzgerald, K. A. & Kagan, J. C. Toll-like receptors and the control of immunity. Cell 180, 1044–1066 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lemaitre, B. et al. The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973–983 (1996).

Article  CAS  PubMed  Google Scholar 

Kawai, T., Ikegawa, M., Ori, D. & Akira, S. Decoding Toll-like receptors: recent insights and perspectives in innate immunity. Immunity 57, 649–673 (2024).

Article  CAS  PubMed  Google Scholar 

Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085–2088 (1998).

Article  CAS  PubMed  Google Scholar 

Rock, F. L. et al. A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. USA 95, 588–593 (1998).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Takeuchi, O. et al. TLR6: a novel member of an expanding toll-like receptor family. Gene 231, 59–65 (1999).

Article  CAS  PubMed  Google Scholar 

Temperley, N. D. et al. Evolution of the chicken Toll-like receptor gene family: a story of gene gain and gene loss. BMC Genomics 9, 62 (2008).

Article  PubMed  PubMed Central  Google Scholar 

Lauw, F. N., Caffrey, D. R. & Golenbock, D. T. Of mice and man: TLR11 (finally) finds profilin. Trends Immunol. 26, 509–511 (2005).

Article  CAS  PubMed  Google Scholar 

Mathur, R., Zeng, W., Hayden, M. S. & Ghosh, S. Mice lacking TLR11 exhibit variable Salmonella typhi susceptibility. Cell 164, 829–830 (2016).

Article  CAS  PubMed  Google Scholar 

Andrade, W. A. et al. Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice. Cell Host Microbe 13, 42–53 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Palti, Y. Toll-like receptors in bony fish: from genomics to function. Dev. Comp. Immunol. 35, 1263–1272 (2011).

Article  CAS  PubMed  Google Scholar 

Chuang, T. & Ulevitch, R. J. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim. Biophys. Acta 1518, 157–161 (2001).

Article  CAS  PubMed  Google Scholar 

Wang, K. et al. Toll-like receptors in health and disease. MedComm5, e549 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chuenchor, W., Jin, T., Ravilious, G. & Xiao, T. S. Structures of pattern recognition receptors reveal molecular mechanisms of autoinhibition, ligand recognition and oligomerization. Curr. Opin. Immunol. 26, 14–20 (2014).

Article  CAS  PubMed  Google Scholar 

Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783–801 (2006).

Article  CAS  PubMed  Google Scholar 

Gao, D. & Li, W. Structures and recognition modes of toll-like receptors. Proteins 85, 3–9 (2017).

Article  CAS  PubMed  Google Scholar 

Enkhbayar, P. et al. Structural principles of leucine-rich repeat (LRR) proteins. Proteins 54, 394–403 (2004).

Article  CAS  PubMed  Google Scholar 

Kim, H. M. et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130, 906–917 (2007).

Article  CAS  PubMed  Google Scholar 

Gay, N. J. & Gangloff, M. Structure and function of Toll receptors and their ligands. Annu. Rev. Biochem 76, 141–165 (2007).

Article  CAS  PubMed  Google Scholar 

Armant, M. A. & Fenton, M. J. Toll-like receptors: a family of pattern-recognition receptors in mammals. Genome Biol. 3, Reviews3011 (2002).

Article  PubMed  PubMed Central 

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