Venkatesh, H. S. et al. Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma. Nature 549, 533–537 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Venkatesh, H. S. et al. Electrical and synaptic integration of glioma into neural circuits. Nature 573, 539–545 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Venkataramani, V. et al. Glutamatergic synaptic input to glioma cells drives brain tumor progression. Nature 573, 532–538 (2019).

Article  CAS  PubMed  Google Scholar 

Balood, M. et al. Nociceptor neurons affect cancer immunosurveillance. Nature 611, 405–412 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hanahan, D. & Monje, M. Cancer hallmarks intersect with neuroscience in the tumor microenvironment. Cancer Cell 41, 573–580 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi, D. D. et al. Therapeutic avenues for cancer neuroscience: translational frontiers and clinical opportunities. Lancet Oncol. 23, e62–e74 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stupp, R. et al. Effect of tumor-treating fields plus maintenance temozolomide vs maintenance temozolomide alone on survival in patients with glioblastoma: a randomized clinical trial. Jama 318, 2306–2316 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hiller, J. G. et al. Preoperative β-blockade with propranolol reduces biomarkers of metastasis in breast cancer: a phase II randomized trial. Clin. Cancer Res. 26, 1803–1811 (2020).

Article  CAS  PubMed  Google Scholar 

Ayala, G. E. et al. In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer. Prostate 49, 213–223 (2001).

Article  CAS  PubMed  Google Scholar 

Ayala, G. E. et al. Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin. Cancer Res. 14, 7593–7603 (2008).

Article  CAS  PubMed  Google Scholar 

Mauffrey, P. et al. Progenitors from the central nervous system drive neurogenesis in cancer. Nature 569, 672–678 (2019).

Article  CAS  PubMed  Google Scholar 

Amit, M. et al. Loss of p53 drives neuron reprogramming in head and neck cancer. Nature 578, 449–454 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monje, M. et al. Roadmap for the emerging field of cancer neuroscience. Cell 181, 219–222 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan, C. & Winkler, F. Insights and opportunities at the crossroads of cancer and neuroscience. Nat. Cell Biol. 24, 1454–1460 (2022).

Article  CAS  PubMed  Google Scholar 

Mancusi, R. & Monje, M. The neuroscience of cancer. Nature 618, 467–479 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keough, M. B. & Monje, M. Neural signaling in cancer. Annu. Rev. Neurosci. 45, 199–221 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zahalka, A. H. & Frenette, P. S. Nerves in cancer. Nat. Rev. Cancer 20, 143–157 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Varn, F. S. et al. Glioma progression is shaped by genetic evolution and microenvironment interactions. Cell 185, 2184–2199.e2116 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hoogstrate, Y. et al. Transcriptome analysis reveals tumor microenvironment changes in glioblastoma. Cancer Cell 41, 678–692.e677 (2023).

Article  CAS  PubMed  Google Scholar 

Liu, J. et al. Multi-scale signaling and tumor evolution in high-grade gliomas. Cancer Cell 42, 1217–1238.e1219 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Venkatesh, H. S. et al. Neuronal activity promotes glioma growth through neuroligin-3 secretion. Cell 161, 803–816 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park, M. et al. CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits. Neuron 70, 742–757 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeong, J. et al. Regulation of NLGN3 and the synaptic Rho-GEF signaling pathway by CDK5. J. Neurosci. 43, 7264–7275 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu, N. et al. Integrated proteogenomic characterization of urothelial carcinoma of the bladder. J. Hematol. Oncol. 15, 76 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan, Y. et al. NF1 mutation drives neuronal activity-dependent initiation of optic glioma. Nature 594, 277–282 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Taylor, K. R. et al. Glioma synapses recruit mechanisms of adaptive plasticity. Nature 623, 366–374 (2023).

Li, Z. et al. NLGN3 promotes neuroblastoma cell proliferation and growth through activating PI3K/AKT pathway. Eur. J. Pharm. 857, 172423 (2019).

Article  CAS  Google Scholar 

Wei, J. et al. Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway. Acta Pharm. Sin. B 12, 3861–3876 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yun, E. J. et al. Targeting Wnt/β-catenin-mediated upregulation of oncogenic NLGN3 suppresses cancer stem cells in glioblastoma. Cell Death Dis. 14, 423 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, J. et al. Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis. J. Exp. Clin. Cancer Res. 43, 28 (2024).

Article  PubMed  PubMed Central  Google Scholar 

Wang, J. et al. LINC00665 activating Wnt3a/β-catenin signaling by bond with YBX1 promotes gastric cancer proliferation and metastasis. Cancer Gene Ther. 30, 1530–1542 (2023).

Article  CAS