Relationship Between GLP-1 Concentration and Protein Kinase Activation in Isolated Rat Hearts Under Physiological Conditions

Ban K, Noyan-Ashraf MH, Hoefer J, Bolz SS, Drucker DJ, Husain M (2008) Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor-dependent and -independent pathways. Circulation 117:2340–2350. https://doi.org/10.1161/CIRCULATIONAHA.107.739938

Article  CAS  PubMed  Google Scholar 

Bedioune I, Gandon-Renard M, Dessillons M, Barthou A, Varin A, Mika D, Bichali S, Cellier J, Lechène P, Karam S, Dia M, Gomez S, Pereira de Vasconcelos W, Mercier-Nomé F, Mateo P, Dubourg A, Stratakis CA, Mercadier JJ, Benitah JP, Algalarrondo V, Leroy J, Fischmeister R, Gomez AM, Vandecasteele G (2024) Essential role of the RIα subunit of cAMP-dependent protein kinase in regulating cardiac contractility and heart failure development. Circulation 150:2031–2045. https://doi.org/10.1161/circulationaha.124.068858

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Benedetto G, Zoccarato A, Lissandron V, Terrin A, Li X, Houslay MD, Baillie GS, Zaccolo M (2008) Protein kinase A type I and type II define distinct intracellular signaling compartments. Circ Res 103:836–844. https://doi.org/10.1161/circresaha.108.174813

Article  CAS  PubMed  Google Scholar 

Huisamen B, Genade S, Lochner A (2008) Signalling pathways activated by glucagon-like peptide-1 (7–36) amide in the rat heart and their role in protection against ischaemia. Cardiovasc J Afr 19:77–83

CAS  PubMed  PubMed Central  Google Scholar 

Hullon D, Subeh GK, Volkova Y, Janiec K, Trach A, Mnevets R (2025) The role of glucagon-like peptide-1 receptor (GLP-1R) agonists in enhancing endothelial function: a potential avenue for improving heart failure with preserved ejection fraction (HFpEF). Cardiovasc Diabetol 24:70. https://doi.org/10.1186/s12933-025-02607-w

Article  PubMed  PubMed Central  Google Scholar 

Iwasa M, Kobayashi H, Yasuda S, Kawamura I, Sumi S, Yamada Y, Shiraki T, Yamaki T, Ushikoshi H, Aoyama T, Nishigaki K, Takemura G, Fujiwara T, Fujiwara H, Minatoguchi S (2010) Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide-1 receptors and the phosphoinositide 3-kinase–Akt–endothelial nitric oxide synthase pathway in rabbits. J Cardiovasc Pharmacol 55:625–634. https://doi.org/10.1097/FJC.0b013e3181dcd240

Article  CAS  PubMed  Google Scholar 

Krall J, Taskén K, Staheli J, Jahnsen T, Movsesian MA (1999) Identification and quantitation of cAMP-dependent protein kinase R subunit isoforms in subcellular fractions of failing human myocardium. J Mol Cell Cardiol 31:971–980. https://doi.org/10.1006/jmcc.1999.0926

Article  CAS  PubMed  Google Scholar 

Latronico MVG, Costinean S, Lavitrano ML, Peschle C, Condorelli G (2004) Regulation of cell size and contractile function by AKT in cardiomyocytes. Ann N Y Acad Sci 1015:250–260. https://doi.org/10.1196/annals.1302.021

Article  CAS  PubMed  Google Scholar 

Lubberding AF, Veedfald S, Achter JS, Nissen SD, Soattin L, Sorrentino A, Vega ET, Linz B, Eggertsen CHE, Mulvey J, Toräng S, Larsen SA, Nissen A, Petersen LG, Bilir SE, Bentzen BH, Rosenkilde MM, Hartmann B, Lilleør TNB, Qazi S, Møller CH, Tfelt-Hansen J, Sattler SM, Jespersen T, Holst JJ, Lundby A (2024) Glucagon-like peptide-1 increases heart rate by a direct action on the sinus node. Cardiovasc Res 120:1427–1441. https://doi.org/10.1093/cvr/cvae120

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luna-Marco C, Iannantuoni F, Hermo-Argibay A, Devos D, Salazar JD, Víctor VM, Rovira-Llopis S (2024) Cardiovascular benefits of SGLT2 inhibitors and GLP-1 receptor agonists through effects on mitochondrial function and oxidative stress. Free Radic Biol Med 213:19–35. https://doi.org/10.1016/j.freeradbiomed.2024.01.015

Article  CAS  PubMed  Google Scholar 

Marso SP, Daniels GH, Brown-Frandsen K, Kristensen P, Mann JFE, Nauck MA, Nissen SE, Pocock S, Poulter NR, Ravn LS, Steinberg WM, Stockner M, Zinman B, Bergenstal RM, Buse JB, LEADER Steering Committee, LEADER Trial Investigators (2016) Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med 375:311–322. https://doi.org/10.1056/NEJMoa1603827

Article  CAS  PubMed  PubMed Central  Google Scholar 

McLean BA, Wong CK, Kabir MG, Drucker DJ (2022) Glucagon-like peptide-1 receptor Tie2 + cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction. Mol Metab 66:101641. https://doi.org/10.1016/j.molmet.2022.101641

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moberly SP, Berwick ZC, Kohr M, Svendsen M, Mather KJ, Tune JD (2012) Intracoronary glucagon-like peptide 1 preferentially augments glucose uptake in ischemic myocardium independent of changes in coronary flow. Exp Biol Med (Maywood) 237:334–342. https://doi.org/10.1258/ebm.2011.011288

Article  CAS  PubMed  PubMed Central  Google Scholar 

Omiya K, Nakadate Y, Oguchi T, Sato T, Matsuoka T, Abe M, Kawakami A, Matsukawa T, Sato H (2022) Cardioprotective effects of enteral vs. parenteral lactoferrin administration on myocardial ischemia-reperfusion injury in a rat model of stunned myocardium. BMC Pharmacol Toxicol 23:78. https://doi.org/10.1186/s40360-022-00619-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Omiya K, Nakadate Y, Sato H, Oguchi T, Matsuoka T, Kawakami A, Schricker T, Matsukawa T (2023) Role of the protein kinase A signaling pathway and identification of mediators in the cardioprotective effects of enteral lactoferrin for ischemia-reperfusion injury in an isolated rat heart model. Nutrition 113:112088. https://doi.org/10.1016/j.nut.2023.112088

Article  CAS  PubMed  Google Scholar 

Omiya K, Nakadate Y, Kawakami A, Abe M, Oguchi T (2025) Enteral lactoferrin mitigates myocardial ischemia-reperfusion injury via enteral lactoferrin-induced glucagon-like peptide-1 in isolated rat heart model. Int J Pept Res Ther 31:91. https://doi.org/10.1007/s10989-025-10753-8

Article  CAS  Google Scholar 

Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, Würbel H (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. BMC Vet Res 16:242. https://doi.org/10.1186/s12917-020-02451-y

Article  PubMed  PubMed Central  Google Scholar 

Ravassa S, Zudaire A, Díez J (2012) GLP-1 and cardioprotection: from bench to bedside. Cardiovasc Res 94:316–323. https://doi.org/10.1093/cvr/cvs123

Article  CAS  PubMed  Google Scholar 

Skålhegg BS, Huang Y, Su T, Idzerda RL, McKnight GS, Burton KA (2002) Mutation of the Calpha subunit of PKA leads to growth retardation and sperm dysfunction. Mol Endocrinol 16:630–639. https://doi.org/10.1210/mend.16.3.0793

Article  PubMed  Google Scholar 

Vilsbøll T, Krarup T, Deacon CF, Madsbad S, Holst JJ (2001) Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 50:609–613. https://doi.org/10.2337/diabetes.50.3.609

Article  PubMed  Google Scholar 

Walker-Gray R, Stengel F, Gold MG (2017) Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches. Proc Natl Acad Sci U S A 114:10414–10419. https://doi.org/10.1073/pnas.1701782114

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao T, Parikh P, Bhashyam S, Bolukoglu H, Poornima I, Shen YT, Shannon RP (2006) Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts. J Pharmacol Exp Ther 317:1106–1113. https://doi.org/10.1124/jpet.106.100982

Article  CAS  PubMed  Google Scholar 

Comments (0)

No login
gif