Ban GY, Kim SH, Park HS (2021) Persistent eosinophilic inflammation in adult asthmatics with high serum and urine levels of leukotriene E4. J Asthma Allergy 14:1219–1230. https://doi.org/10.2147/JAA.S325499
Article CAS PubMed PubMed Central Google Scholar
Baran J, Sobiepanek A, Mazurkiewicz-Pisarek A, Rogalska M, Gryciuk A, Kuryk L, Abraham SN, Staniszewska M (2023) Mast cells as a target-a comprehensive review of recent therapeutic approaches. Cells 12:1187. https://doi.org/10.3390/cells12081187
Article CAS PubMed PubMed Central Google Scholar
Bramos A, Perrault D, Yang S, Jung E, Hong YK, Wong AK (2016) Prevention of postsurgical lymphedema by 9-cis retinoic acid. Ann Surg 264:353–361. https://doi.org/10.1097/SLA.0000000000001525
Article PubMed PubMed Central Google Scholar
Castillo JR, Peters SP, Busse WW (2017) Asthma exacerbations: pathogenesis, prevention, and treatment. J Allergy Clin Immunol Pract 5:918–927. https://doi.org/10.1016/j.jaip.2017.05.001
Article PubMed PubMed Central Google Scholar
Dahlén SE, Hedqvist P, Hammarström S, Samuelsson B (1980) Leukotrienes are potent constrictors of human bronchi. Nature 288:484–486. https://doi.org/10.1038/288484a0
Ding Y, Tang W, Pei F, Fu L, Ma P, Bai J, Lin M, Liu Y, Hou Q (2021) Brusatol derivative-34 attenuates allergic airway inflammation via inhibition of the spleen tyrosine kinase pathway. Front Pharmacol 12:587417. https://doi.org/10.3389/fphar.2021.587417
Article CAS PubMed PubMed Central Google Scholar
Gehlhaar P, Schaper-Gerhardt K, Gutzmer R, Hasler F, Röhn TA, Werfel T, Mommert S (2025) Histamine and TH2 cytokines regulate the biosynthesis of cysteinyl-leukotrienes and expression of their receptors in human mast cells. Inflamm Res 74:32. https://doi.org/10.1007/s00011-024-01974-6
Article CAS PubMed PubMed Central Google Scholar
Ghorbanzadeh B, Mansouri MT, Sahraei H, Alboghobeish S (2016) Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of Montelukast in the animal models of pain. Eur J Pharmacol 779:38–45. https://doi.org/10.1016/j.ejphar.2016.03.010
Article CAS PubMed Google Scholar
Gohal G, Moni SS, Bakkari MA, Elmobark ME (2024) A review on asthma and allergy: current understanding on molecular perspectives. J Clin Med 13:5775. https://doi.org/10.3390/jcm13195775
Article CAS PubMed PubMed Central Google Scholar
Haeggström JZ (2018) Leukotriene biosynthetic enzymes as therapeutic targets. J Clin Invest 128:2680–2690. https://doi.org/10.1172/JCI97945
Article PubMed PubMed Central Google Scholar
Heffler E, Madeira LNG, Ferrando M, Puggioni F, Racca F, Malvezzi L, Passalacqua G, Canonica GW (2018) Inhaled corticosteroids safety and adverse effects in patients with asthma. J Allergy Clin Immunol Pract 6:776–781. https://doi.org/10.1016/j.jaip.2018.01.025
Henderson WR Jr (1994) The role of leukotrienes in inflammation. Ann Intern Med 121:684–697. https://doi.org/10.7326/0003-4819-121-9-199411010-00010
Article CAS PubMed Google Scholar
Hisamuddin N, Shaik Mossadeq WM, Sulaiman MR, Abas F, Leong SW, Kamarudin N, Ong HM, Ahmad Azmi AF, Ayumi RR, Talib M (2019) Anti-edematogenic and anti-granuloma activity of a synthetic curcuminoid analog, 5-(3,4-dihydroxyphenyl)-3-hydroxy-1-(2-hydroxyphenyl)penta-2,4-dien-1-one, in mouse models of inflammation. Molecules 24:2614. https://doi.org/10.3390/molecules24142614
Article CAS PubMed PubMed Central Google Scholar
Inoue H, Nagata N, Koshihara Y (1995) Inhibition by actinomycin D of neurogenic mouse ear oedema. Inflamm Res 44:125–130. https://doi.org/10.1007/BF01782023
Article CAS PubMed Google Scholar
Jayasooriya SM, Devereux G, Soriano JB, Singh N, Masekela R, Mortimer K, Burney P (2025) Asthma: epidemiology, risk factors, and opportunities for prevention and treatment. Lancet Respir Med 13:725–738. https://doi.org/10.1016/S2213-2600(24)00383-7
Kanaoka Y, Maekawa A, Austen KF (2013) Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. J Biol Chem 288:10967–10972. https://doi.org/10.1074/jbc.C113.453704
Article CAS PubMed PubMed Central Google Scholar
Lee M, Boyce JA, Barrett NA (2025) Cysteinyl leukotrienes in allergic inflammation. Annu Rev Pathol 20:115–141. https://doi.org/10.1146/annurev-pathmechdis-111523-023509
Article CAS PubMed PubMed Central Google Scholar
Maekawa A, Kanaoka Y, Xing W, Austen KF (2008) Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. Proc Natl Acad Sci U S A 105:16695–16700. https://doi.org/10.1073/pnas.0808993105
Article PubMed PubMed Central Google Scholar
Mishra NC, Rir-sima-ah J, Boyd RT, Singh SP, Gundavarapu S, Langley RJ, Razani-Boroujerdi S, Sopori ML (2010) Nicotine inhibits Fc epsilon RI-induced cysteinyl leukotrienes and cytokine production without affecting mast cell degranulation through α7/α9/α10-nicotinic receptors. J Immunol 185:588–596. https://doi.org/10.4049/jimmunol.0902227
Article CAS PubMed PubMed Central Google Scholar
Mosala P, Mpotje T, Abdel Aziz N, Ndlovu H, Musaigwa F, Nono JK, Brombacher F (2024) Cysteinyl leukotriene receptor-1 as a potential target for host-directed therapy during chronic schistosomiasis in murine model. Front Immunol 15:1279043. https://doi.org/10.3389/fimmu.2024.1279043
Article CAS PubMed PubMed Central Google Scholar
Nakagome K, Imamura M, Kawahata K, Harada H, Okunishi K, Matsumoto T, Sasaki O, Tanaka R, Kano MR, Chang H, Hanawa H, Miyazaki J, Yamamoto K, Dohi M (2011) High expression of IL-22 suppresses antigen-induced immune responses and eosinophilic airway inflammation via an IL-10-associated mechanism. J Immunol 187:5077–5089. https://doi.org/10.4049/jimmunol.1001560
Article CAS PubMed Google Scholar
Nayak A, Langdon RB (2007) Montelukast in the treatment of allergic rhinitis: an evidence-based review. Drugs 67:887–901. https://doi.org/10.2165/00003495-200767060-00005
Article CAS PubMed Google Scholar
Ohira M, Uwamizu A, Hori K, Obinata Y, Uta D, Aoki J, Ebina K, Matsumoto T, Sato A (2025) Biotinylated heptapeptides with D-amino acids suppress allergic reactions by inhibiting mast cell activation and antagonizing the histamine receptor. Int J Pept Res Ther 31:9. https://doi.org/10.1007/s10989-024-10670-2
Osorio-Perez RM, Rodríguez-Manzo G, Espinosa-Riquer ZP, Cruz SL, González-Espinosa C (2023) Endocannabinoid modulation of allergic responses: focus on the control of FcεRI-mediated mast cell activation. Eur J Cell Biol 102:151324. https://doi.org/10.1016/j.ejcb.2023.151324
Article CAS PubMed Google Scholar
Papi A, Brightling C, Pedersen SE, Reddel HK (2018) Asthma. Lancet 391:783–800. https://doi.org/10.1016/S0140-6736(17)33311-1
Patel R, Naqvi SA, Griffiths C, Bloom CI (2020) Systemic adverse effects from inhaled corticosteroid use in asthma: a systematic review. BMJ Open Respir Res 7:e000756. https://doi.org/10.1136/bmjresp-2020-000756
Article PubMed PubMed Central Google Scholar
Pyasi K, Tufvesson E, Moitra S (2016) Evaluating the role of leukotriene-modifying drugs in asthma management: are their benefits ‘losing in translation’? Pulm Pharmacol Ther 41:52–59. https://doi.org/10.1016/j.pupt.2016.09.006
Comments (0)