Kolb, H. C., Finn, M. G. & Sharpless, K. B. Click chemistry: diverse chemical function from a few good reactions. Angew. Chem. Int. Ed. 40, 2004–2021 (2001).
Rostovtsev, V. V., Green, L. G., Fokin, V. V. & Sharpless, K. B. A stepwise Huisgen cycloaddition process: copper(I)-catalyzed regioselective ‘ligation’ of azides and terminal alkynes. Angew. Chem. Int. Ed. 41, 2596–2599 (2002).
Dong, J., Krasnova, L., Finn, M. G. & Sharpless, K. B. Sulfur(VI) fluoride exchange (SuFEx): another good reaction for click chemistry. Angew. Chem. Int. Ed. 53, 9430–9448 (2014).
Tornøe, C. W., Christensen, C. & Meldal, M. Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(I)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. J. Org. Chem. 67, 3057–3064 (2002).
Paioti, P. H. S. et al. Click processes orthogonal to CuAAC and SuFEx forge selectively modifiable fluorescent linkers. Nat. Chem. 16, 426–436 (2024).
Article CAS PubMed Google Scholar
Homer, J. A. et al. Sulfur fluoride exchange. Nat. Rev. Methods Primers 3, 58 (2023).
Article CAS PubMed PubMed Central Google Scholar
Békés, M., Langley, D. R. & Crews, C. M. PROTAC targeted protein degraders: the past is prologue. Nat. Rev. Drug Discov. 21, 181–200 (2022).
Article PubMed PubMed Central Google Scholar
Liu, J. et al. Cancer selective target degradation by folate-caged PROTACs. J. Am. Chem. Soc. 143, 7380–7387 (2021).
Article CAS PubMed PubMed Central Google Scholar
Chen, Y. et al. Proteolysis-targeting chimera (PROTAC) delivery system: advancing protein degraders towards clinical translation. Chem. Soc. Rev. 51, 5330–5350 (2022).
Article CAS PubMed PubMed Central Google Scholar
Imaide, S. et al. Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity. Nat. Chem. Biol. 17, 1157–1167 (2021).
Article CAS PubMed PubMed Central Google Scholar
Li, K. L. & Crews, C. M. PROTACs: past, present and future. Chem. Soc. Rev. 51, 5214–5236 (2022).
Article CAS PubMed PubMed Central Google Scholar
Zhao, J. et al. Radical-mediated click-clip reactions. Science 385, 1354–1359 (2024).
Article CAS PubMed Google Scholar
Yamazaki, C. M. et al. Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance. Nat. Commun. 12, 3528 (2021).
Article CAS PubMed PubMed Central Google Scholar
Fu, Q. et al. Bioorthogonal chemistry for prodrug activation in vivo. Chem. Soc. Rev. 52, 7737–7772 (2023).
Article CAS PubMed Google Scholar
Min, Q. & Ji, X. Bioorthogonal bond cleavage chemistry for on-demand prodrug activation: opportunities and challenges. J. Med. Chem. 66, 16546–16567 (2023).
Article CAS PubMed Google Scholar
Kondengadan, S. M. et al. Click chemistry and drug delivery: a bird’s-eye view. Acta Pharma. Sin. B 13, 1990–2016 (2023).
Lei, K. et al. Research progress in the application of bile acid-drug conjugates: a ‘trojan horse’ strategy. Steroids 173, 108879 (2021).
Article CAS PubMed Google Scholar
Dean, T. T., Jelú-Reyes, J., Allen, A. & Moore, T. W. Peptide-drug conjugates: an emerging direction for the next generation of peptide therapeutics. J. Med. Chem. 67, 1641–1661 (2024).
Article CAS PubMed PubMed Central Google Scholar
Askari Rizvi, S. F., Zhang, L., Zhang, H. & Fang, Q. Peptide-drug conjugates: design, chemistry, and drug delivery system as a novel cancer theranostic. ACS Pharmacol. Transl. Sci. 7, 309–334 (2024).
Meng, F., Jang, H., Jung, B. & Hoveyda, A. H. Cu-catalyzed chemoselective preparation of 2-(pinacolato)boron-substituted allylcopper complexes and their in situ site-, diastereo-, and enantioselective additions to aldehydes and ketones. Angew. Chem. Int. Ed. 52, 5046–5051 (2013).
Sies, H. & Jones, D. P. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat. Rev. Mol. Cell Bio. 21, 363–383 (2020).
Sies, H. et al. Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology. Nat. Rev. Mol. Cell Bio. 23, 499–515 (2022).
Pelicano, H., Carney, D. & Huang, P. ROS stress in cancer cells and therapeutic implications. Drug Resist. Updates 7, 97–110 (2004).
Paravicini, T. M. & Touyz, R. M. Redox signaling in hypertension. Cardiovasc. Res. 71, 247–258 (2006).
Article CAS PubMed Google Scholar
Sies, H. Role of metabolic H2O2 generation: redox signaling and oxidative stress. J. Biol. Chem. 289, 8733–8741 (2014).
Wu, Y. et al. An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy. Chem. Sci. 10, 7068–7075 (2019).
Article CAS PubMed PubMed Central Google Scholar
Ashman, N. et al. Peroxide-cleavable linkers for antibody–drug conjugates. Chem. Commun. 59, 1841–1844 (2023).
Hull, M. A., Gardner, S. H. & Hawcroft, G. Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer. Cancer Treat. Rev. 29, 309–320 (2003).
Article CAS PubMed Google Scholar
Shagufta & Ahmad, I. Tamoxifen a pioneering drug: an update on the therapeutic potential of tamoxifen derivatives. Eur. J. Med. Chem. 143, 515–531 (2018).
Article CAS PubMed Google Scholar
Kolate, A. et al. PEG—a versatile conjugating ligand for drugs and drug delivery systems. J. Control. Release 192, 67–81 (2014).
Article CAS PubMed Google Scholar
Sun, S. et al. Phosphorus fluoride exchange: multidimensional catalytic click chemistry from phosphorus connective hubs. Chem 9, 2128–2143 (2023).
Article CAS PubMed PubMed Central Google Scholar
Hao, G., Xu, Z. P. & Li, L. Manipulating extracellular tumour pH: an effective target for cancer therapy. RSC Adv. 8, 22182–22192 (2018).
Article CAS PubMed PubMed Central Google Scholar
Michl, J. et al. Acid-adapted cancer cells alkalinize their cytoplasm by degrading the acid-loading membrane transporter anion exchanger 2, SLC4A2. Cell Rep. 42, 112601 (2023).
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