Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229–63.

PubMed  Google Scholar 

Yang BW, Shi JL. Ascorbate tumor chemotherapy by an iron-engineered nanomedicine-catalyzed tumor-specific pro-oxidation. J Am Chem Soc. 2020;142(52):21775–85.

Article  CAS  PubMed  Google Scholar 

Rapp TL, Kopyeva I, Adhikari A, DeForest CA. Bioluminescence resonance energy transfer (BRET)-mediated protein release from self-illuminating photoresponsive biomaterials. J Am Chem Soc. 2024;146(37):25397–402.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang NY, Hou DY, Hu XJ, Liang JX, Wang MD, Song ZZ, et al. Nano proteolysis targeting chimeras (PROTACs) with anti-hook effect for tumor therapy. Angew Chem Int Ed. 2023;62(37):e202308049.

Article  CAS  Google Scholar 

Gao J, Jiang XY, Lei SM, Cheng WH, Lai Y, Li M, et al. A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy. Nat Commun. 2024;15(1):6608.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu P, Pu YY, Wang M, Wu WC, Qin HL, Shi JL. MnOOH-catalyzed autoxidation of glutathione for reactive oxygen species production and nanocatalytic tumor innate immunotherapy. J Am Chem Soc. 2023;145(10):5803–15.

Article  CAS  PubMed  Google Scholar 

Zhang C, Huang JS, Xu MK, Yu J, Wei X, He SS, et al. Eosinophil-activating semiconducting polymer nanoparticles for cancer photo-immunotherapy. Angew Chem Int Ed. 2024;63(30):e202405358.

Article  CAS  Google Scholar 

Zhang C, Xu MK, Zeng ZL, Wei X, He SS, Huang JS, et al. A polymeric extracellular matrix nanoremodeler for activatable cancer photo-immunotherapy. Angew Chem Int Ed. 2023;62(12):e202217339.

Article  CAS  Google Scholar 

Liu WK, He S, Ma X, Lv CY, Gu H, Cao JF, et al. Near-infrared heptamethine cyanine photosensitizers with efficient singlet oxygen generation for anticancer photodynamic therapy. Angew Chem Int Ed. 2024. https://doi.org/10.1002/anie.202411802.

Article  Google Scholar 

Yang YJ, Liu Y, Tu DT, Chen MM, Zhang YQ, Gao H, et al. Tumor-microenvironment-responsive biodegradable nanoagents based on lanthanide nucleotide self-assemblies toward precise cancer therapy. Angew Chem Int Ed. 2022;61(14):e202116983.

Article  CAS  Google Scholar 

Chen JJ, Zhu YF, Wu CT, Shi JL. Nanoplatform-based cascade engineering for cancer therapy. Chem Soc Rev. 2020;49(24):9057–94.

Article  CAS  PubMed  Google Scholar 

Miao JF, Huo YY, Yao GX, Feng Y, Weng JJ, Zhao W, et al. Heavy atom-free, mitochondria-targeted, and activatable photosensitizers for photodynamic therapy with real-Time in-situ therapeutic monitoring. Angew Chem Int Ed. 2022;61(25):e202201815.

Article  CAS  Google Scholar 

Liu LX, Li CB, Gong JY, Zhang Y, Ji WW, Feng LN, et al. A Highly water-soluble aggregation-induced emission luminogen with anion-π(+) interactions for targeted NIR imaging of cancer cells and type I photodynamic therapy. Angew Chem Int Ed. 2023;62(33):e202307776.

Article  CAS  Google Scholar 

Liu XY, Zhan WJ, Gao G, Jiang QC, Zhang XP, Zhang HB, Sun XB, Han W, Wu FG, Liang GL. Apoptosis-amplified assembly of Pnanofiber enhances photodynamic therapy of oral tumor. J Am Chem Soc. 2023;145(14):7918–30.

Article  CAS  PubMed  Google Scholar 

Teng KX, Zhang D, Liu BK, Liu ZF, Niu LY, Yang QZ. Photo-induced disproportionation-mediated photodynamic therapy: simultaneous oxidation of tetrahydrobiopterin and generation of superoxide radicals. Angew Chem Int Ed. 2024;63(12):e202318783.

Article  CAS  Google Scholar 

Hu XM, Fang ZT, Sun FW, Zhu CJ, Jia MX, Miao XF, et al. Deciphering oxygen-independent augmented photodynamic oncotherapy by facilitating the separation of electron-hole pairs. Angew Chem Int Ed. 2024;63(15):e202401036.

Article  CAS  Google Scholar 

Xiong JH, Wang XY, Kim J, Gong JK, Mao ZQ, Kim JS, et al. Tumor-activated prodrug with synergistic anti-stemness chemical and photodynamic therapies. Adv Funct Mater. 2024;34(10):2312590.

Article  CAS  Google Scholar 

Qian ZL, He KD, Feng R, Chen J, Li BQ, Zhang YH, et al. Intelligent biogenic missile for two-photon fluorescence imaging-guided combined photodynamic therapy and chemotherapy in tumors. Anal Chem. 2024;96(17):6674–82.

Article  CAS  PubMed  Google Scholar 

Zhang RY, Zhang C, Lu Q, Liang CH, Tian MG, Li Z, Yang YZ, Li XQ, Deng YL. Cancer-cell-specific self-reporting photosensitizer for precise identification and ablation of cancer cells. Anal Chem. 2024;96(4):1659–67.

Article  CAS  PubMed  Google Scholar 

Igney FH, Krammer PH. Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer. 2002;2(4):277–88.

Article  CAS  PubMed  Google Scholar 

Mishchenko T, Balalaeva I, Gorokhova A, Vedunova M, Krysko DV. Which cell death modality wins the contest for photodynamic therapy of cancer? Cell Death Dis. 2022;13(5):455.

Article  PubMed  PubMed Central  Google Scholar 

Han HH, Wang HM, Jangili P, Li M, Wu L, Zang Y, Sedgwick AC, Li J, He XP, James TD, Kim JS. The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy. Chem Soc Rev. 2023;52(3):879–920.

Article  CAS  PubMed  Google Scholar 

Guo YD, Hu P, Shi JL. Nanomedicine remodels tumor microenvironment for solid tumor immunotherapy. J Am Chem Soc. 2024;146(15):10217–33.

Article  CAS  PubMed  Google Scholar 

Li L, Zhang XY, Ren YX, Yuan Q, Wang YZ, Bao B, et al. Chemiluminescent conjugated polymer nanoparticles for deep-tissue inflammation imaging and photodynamic therapy of cancer. J Am Chem Soc. 2024;146(9):5927–39.

Article  CAS  PubMed  Google Scholar 

Yuan J, Zhou QH, Xu S, Zuo QP, Li W, Zhang XX, et al. Enhancing the release efficiency of a molecular chemotherapeutic prodrug by photodynamic therapy. Angew Chem Int Ed. 2022;61(33):e202206169.

Article  CAS  Google Scholar 

Tian J, Li B, Zhang F, Yao Z, Song W, Tang Y, et al. Activatable type i photosensitizer with quenched photosensitization pre and post photodynamic therapy. Angew Chem Int Ed. 2023;62(46):e202307288.

Article  CAS  Google Scholar 

Li M, Xu Y, Peng X, Kim JS. From low to no O2-dependent hypoxia photodynamic therapy (hPDT): a new perspective. Acc Chem Res. 2022;55(22):3253–64.

Article  CAS  PubMed  Google Scholar 

Li W, Yin SL, Shen Y, Li HY, Yuan L, Zhang XB. Molecular engineering of ph-responsive NIR oxazine assemblies for evoking tumor ferroptosis via triggering lysosomal dysfunction. J Am Chem Soc. 2023;145(6):3736–47.

Article  CAS  PubMed  Google Scholar 

Yin JL, Zhan JT, Hu QX, Huang SH, Lin WY. Fluorescent probes for ferroptosis bioimaging: advances, challenges, and prospects. Chem Soc Rev. 2023;52(6):2011–30.

Article  CAS  PubMed  Google Scholar 

Yuan H, Han Z, Chen Y, Qi F, Fang H, Guo ZJ, et al. Ferroptosis photoinduced by new cyclometalated iridium(III) complexes and its synergism with apoptosis in tumor cell inhibition. Angew Chem Int Ed. 2021;60(15):8174–81.

Article  CAS  Google Scholar 

Liang C, Zhang XL, Yang MS, Dong XC. Recent progress in ferroptosis inducers for cancer therapy. Adv Mater. 2019;31(51):e1904197.

Article  PubMed  Google Scholar 

Xiong JH, Chi WJ, Ye MT, Zhang L, Wang XY, Mao ZQ, Liu ZH. Activatable phototherapeutic prodrug conquering hypoxia limitation to enhance chemical drug delivery efficiency. ACS Mater Lett. 2024;6(7):2548–58.

Article  CAS  Google Scholar 

Sharma A, Lee MG, Won M, Koo S, Arambula JF, Sessler JL, Chi SG, Kim JS. Targeting heterogeneous tumors using a multifunctional molecular prodrug. J Am Chem Soc. 2019;141(39):15611–8.