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Design of Experiments Assisted Formulation Optimization and Evaluation of Efavirenz Solid Dispersion Adsorbate for Improvement in Dissolution and Flow Properties
Design of Experiments Assisted Formulation Optimization and Evaluation of Efavirenz Solid Dispersion Adsorbate for Improvement in Dissolution and Flow Properties
Developing a solid dispersion adsorbate (SDA) to enhance the dissolution rate and flow properties of Efavirenz (EFZ) for s...
Quantitative Proteomic Study Reveals Amygdalin Alleviates Liver Fibrosis Through Inhibiting mTOR/PDCD4/JNK Pathway in Hepatic Stellate Cells
Quantitative Proteomic Study Reveals Amygdalin Alleviates Liver Fibrosis Through Inhibiting mTOR/PDCD4/JNK Pathway in Hepatic Stellate Cells
Aiming to elucidate the potential pharmaceutical mechanism of action of amygdalin against liver fibrosis.
Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study
Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study
To assess the pharmacokinetics (PK) and safety profiles of HRS-1780 in subjects with renal impairment.
A Natural Compound Methylnissolin: Physicochemical Properties, Pharmacological Activities, Pharmacokinetics and Resource Development
A Natural Compound Methylnissolin: Physicochemical Properties, Pharmacological Activities, Pharmacokinetics and Resource Development
Methylnissolin and its glycoside compounds in terms of physicochemical properties, biological activity, pharmacokinetics, ...
Ethnobotanical Use, Phytochemistry, Pharmacology, and Toxicity of Canavalia gladiata
Ethnobotanical Use, Phytochemistry, Pharmacology, and Toxicity of Canavalia gladiata
This review provides a thorough insight into the ethnobotanical use, phytochemistry, pharmacology, and toxicity of C. glad...
A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions
A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions
Exploring the research hotspots and development trends of microneedle-mediated drug delivery. Read more
Computational and Experimental Investigation of Antidiabetic Drugs on Tofacitinib Metabolism: Molecular Docking, in vitro, and in vivo Studies
Computational and Experimental Investigation of Antidiabetic Drugs on Tofacitinib Metabolism: Molecular Docking, in vitro, and in vivo Studies
Investigating the effects of gliquidone and linagliptin, two hypoglycemic agents on the pharmacokinetics of tofacitinib in...
Enhancing Cartilage Repair in Osteoarthritis Using Platelet Lysates and Arthroscopic Microfracture
Enhancing Cartilage Repair in Osteoarthritis Using Platelet Lysates and Arthroscopic Microfracture
Examining whether combined treatment of MF and Platelet lysate can inhibit the promotion of cartilage repair and antifibro...
Biochemical and Molecular Studies on the Role of Celecoxib and Some Related Bipyrazoles in Mitigating Induced Liver Injury in Experimental Animals
Biochemical and Molecular Studies on the Role of Celecoxib and Some Related Bipyrazoles in Mitigating Induced Liver Injury in Experimental Animals
Fluorinated analog HR3 could serve as a novel therapeutic candidate for the amelioration of liver fibrosis that deserves f...
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway
Exploring the mechanism of Huashi Jiedu Decoction synergizing with 5-fluorouracil in gastric cancer therapy. Read more
Yi-Fei-Tong-Bi Decoction Alleviates Bleomycin Induced Pulmonary Fibrosis in Mice
Yi-Fei-Tong-Bi Decoction Alleviates Bleomycin Induced Pulmonary Fibrosis in Mice
To investigate the protective effect and the underlying mechanism of Yi-Fei-Tong-Bi decoction on bleomycin-induced pulmona...
ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity
ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity
Investigating the effect of SQSKG on CKD, focusing on regulating the PI3K/AKT/mTOR pathway, autophagy, and mitochondrial h...
Design and Evaluation of Andrographolide Analogues as SARS-CoV-2 Main Protease Inhibitors: Molecular Modeling and in vitro Studies
Design and Evaluation of Andrographolide Analogues as SARS-CoV-2 Main Protease Inhibitors: Molecular Modeling and in vitro Studies
Designing C-12 dithiocarbamate andrographolide analogues as potential SARS-CoV-2 Mpro inhibitors using computational and e...
Effect of Subanesthetic Dose of Esketamine on Liver Function Following Microvascular Reconstruction for Head and Neck Cancer: A Randomized Controlled Trial
Effect of Subanesthetic Dose of Esketamine on Liver Function Following Microvascular Reconstruction for Head and Neck Cancer: A Randomized Controlled Trial
Effect of Subanesthetic Dose of Esketamine on Liver Function Following Microvascular Reconstruction for Head and Neck Canc...
Inhibition of Dormant Lung Cancer Cell Reactivation by Punica Granatum Peel and Dioscorea Nipponica: Involving MYC, SKP2 and p27
Inhibition of Dormant Lung Cancer Cell Reactivation by Punica Granatum Peel and Dioscorea Nipponica: Involving MYC, SKP2 and p27
This study evaluates Punica granatum peel & Dioscorea Nipponica for their ability to sustain dormancy in lung cancer c...
Research Trends on Nanomaterials and Hepatocellular Carcinoma From 1999 to 2024: A Bibliometric Analysis
Research Trends on Nanomaterials and Hepatocellular Carcinoma From 1999 to 2024: A Bibliometric Analysis
Evolution and trends in this field through bibliometric analysis.
The Median Effective Concentration (EC50) of Alfentanil Combined with Propofol Closed-Loop Targeted Infusion in Super-Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP)
The Median Effective Concentration (EC50) of Alfentanil Combined with Propofol Closed-Loop Targeted Infusion in Super-Elderly Patients Undergoing Endoscopic Retrograde Cholangiopancreatography (ERCP)
The EC50 of alfentanil combined with propofol by closed-loop target-controlled infusion during ERCP in super-elderly patie...
A Real-Time Plasma Concentration Prediction Model for Voriconazole in Elderly Patients via Machine Learning Combined with Population Pharmacokinetics
A Real-Time Plasma Concentration Prediction Model for Voriconazole in Elderly Patients via Machine Learning Combined with Population Pharmacokinetics
Our study aimed to establish a prediction model for VCZ plasma concentration in elderly patients by incorporating PPK para...
Noninferiority of 0.25% versus 0.375% Ropivacaine in Popliteal Sciatic and Saphenous Nerve Blocks for Analgesia After Foot and Ankle Surgery: A Randomized Self-Paired Noninferiority Trial
Noninferiority of 0.25% versus 0.375% Ropivacaine in Popliteal Sciatic and Saphenous Nerve Blocks for Analgesia After Foot and Ankle Surgery: A Randomized Self-Paired Noninferiority Trial
0.25% ropivacaine is non-inferior to 0.375% ropivacaine for postoperative analgesia after foot and ankle surgery by poplit...
ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification
ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification
Identifying the target gene ITGA4 through network pharmacology, and conducting further research on its synergistic effect ...
Identification of cholest-4-ene-3,6-dione as a Novel Neuroprotectant in Ischemic Stroke and Its Lipidomics
Identification of cholest-4-ene-3,6-dione as a Novel Neuroprotectant in Ischemic Stroke and Its Lipidomics
Indicating that 78, a novel neuroprotectant, is a promising therapeutic candidate with comprehensive neuroprotective effec...
Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway
Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on Rheumatoid Arthritis by Inhibiting Inflammation via IL-17/NF-κB Pathway
Integrated Network Pharmacology and Experimental Approach to Investigate the Protective Effect of Jin Gu Lian Capsule on R...
Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients with Hip Fracture: A Prospective Randomized Controlled Trial
Effect of Intraoperative Intravenous Lidocaine on Postoperative Delirium in Elderly Patients with Hip Fracture: A Prospective Randomized Controlled Trial
Evaluating the effects of intraoperative intravenous lidocaine on postoperative delirium in elderly patients with hip frac...
Application of Butorphanol versus Sufentanil in Multimode Analgesia via Patient Controlled Intravenous Analgesia After Hepatobiliary Surgery: A Retrospective Cohort Study
Application of Butorphanol versus Sufentanil in Multimode Analgesia via Patient Controlled Intravenous Analgesia After Hepatobiliary Surgery: A Retrospective Cohort Study
Acute postoperative pain remains to be one of the most common challenges in patients undergoing hepatobiliary surgery. Rea...
Tripterygium wilfordii Hook. F. and Its Extracts for Psoriasis: Efficacy and Mechanism
Tripterygium wilfordii Hook. F. and Its Extracts for Psoriasis: Efficacy and Mechanism
Exploring the effectiveness and mechanisms of Tripterygium wilfordii Hook. F. and its extracts in psoriasis treatment.
Immunoinformatics Prediction and Protective Efficacy of Vaccine Candidate PiuA-PlyD4 Against Streptococcus Pneumoniae
Immunoinformatics Prediction and Protective Efficacy of Vaccine Candidate PiuA-PlyD4 Against Streptococcus Pneumoniae
Evaluating the immune protective efficacy of the novel S. pneumoniae protein vaccine PiuA-PlyD4 through immunoinformatics ...
A Review on the Pharmacological Aspects of Engeletin as Natural Compound
A Review on the Pharmacological Aspects of Engeletin as Natural Compound
Engeletin (ENG) is a natural flavonoid known for its physiological and pharmacological effects, such as anti-inflammatory,...
Co-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling
Co-Housing and Fecal Microbiota Transplantation: Technical Support for TCM Herbal Treatment of Extra-Intestinal Diseases Based on Gut Microbial Ecosystem Remodeling
Technical support for Traditional Chinese Medicine herbal treatment of extra-intestinal diseases based on gut microbial ec...
Different Sedation Strategies in Older Patients Receiving Spinal Anesthesia for Hip Surgery on Postoperative Delirium: A Randomized Clinical Trial
Different Sedation Strategies in Older Patients Receiving Spinal Anesthesia for Hip Surgery on Postoperative Delirium: A Randomized Clinical Trial
Comparing how sedation strategies administered during spinal anesthesia influenced POD in older patients undergoing electi...
The Role of AMPK Signaling in Ulcerative Colitis
The Role of AMPK Signaling in Ulcerative Colitis
Providing comprehensive overview of the mechanisms of AMPK in UC, a compilation of pharmacological agents capable of activ...
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