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Effective Dose of Oliceridine for Inhibiting Hemodynamic Elevation Induced by Tracheal Intubation: An Up-and-Down Sequential Trial
Effective Dose of Oliceridine for Inhibiting Hemodynamic Elevation Induced by Tracheal Intubation: An Up-and-Down Sequential Trial
to determine the effective dose of oliceridine for suppressing hemodynamic responses to tracheal intubation in patients d...
Investigating Effective Application Times for Topical Anesthetics in Non-Coring Needle Insertion Over Totally Implantable Venous Access Devices
Investigating Effective Application Times for Topical Anesthetics in Non-Coring Needle Insertion Over Totally Implantable Venous Access Devices
Investigating Effective Application Times for Topical Anesthetics in Non-Coring Needle Insertion Over Totally Implantable ...
SGLT2 Inhibitors in Combination Therapies for Tumors: A Novel Approach to Synergistic Treatment Strategies
SGLT2 Inhibitors in Combination Therapies for Tumors: A Novel Approach to Synergistic Treatment Strategies
This review aims to elucidate their emerging role in cancer treatment.
Discovery of Pyrazoline Benzenesulfonamide Derivatives as Anticancer Agents: A Review
Discovery of Pyrazoline Benzenesulfonamide Derivatives as Anticancer Agents: A Review
Recent developments in the discovery and synthesis of pyrazoline benzenesulfonamide derivatives as potent anticancer agent...
Xenin-Derived Peptides: Multifaceted Regulators and Therapeutic Innovations in Metabolic Diseases
Xenin-Derived Peptides: Multifaceted Regulators and Therapeutic Innovations in Metabolic Diseases
This review comprehensively examines xenin’s physiological roles, structural optimization strategies, and therapeuti...
Poikilospermum suaveolens (Blume) Merr.: Phytochemical, Ethnomedicinal Uses, and Pharmacological Potential
Poikilospermum suaveolens (Blume) Merr.: Phytochemical, Ethnomedicinal Uses, and Pharmacological Potential
Consolidating current data on the bioactive chemicals & therapeutic potential of Poikilospermum spp. with an emphasis ...
The Effects of Obesity on Lung Physiology, the Prevalence and Severity of Chronic Pulmonary Diseases, and Inhalation Treatment
The Effects of Obesity on Lung Physiology, the Prevalence and Severity of Chronic Pulmonary Diseases, and Inhalation Treatment
The Effects of Obesity on Lung Physiology, the Prevalence and Severity of Chronic Pulmonary Diseases, and Inhalation Treat...
Protective Effect of Dexmedetomidine Combined with Butorphanol on Perioperative Pulmonary Function in Patients Undergoing Laparoscopic Colorectal Cancer Resection: A Randomized, Double-Blind, 2 * 2 Factorial-Controlled Trial
Protective Effect of Dexmedetomidine Combined with Butorphanol on Perioperative Pulmonary Function in Patients Undergoing Laparoscopic Colorectal Cancer Resection: A Randomized, Double-Blind, 2 * 2 Factorial-Controlled Trial
The protective effects of dexmedetomidine or metoprolol on lung function during laparoscopic resection of colorectal cance...
Effects of Remimazolam-Propofol Anesthesia on Recovery and Sleep Quality in Older Adult Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial
Effects of Remimazolam-Propofol Anesthesia on Recovery and Sleep Quality in Older Adult Patients Undergoing Laparoscopic Colorectal Cancer Surgery: A Randomized Controlled Trial
This study aimed to evaluate the effects of combined sub-anesthetic doses of remimazolam & propofol on anesthesia reco...
Efficacy of Paroxetine as an Adjuvant Therapy in Rheumatoid Arthritis Patients: A Randomized Controlled Study
Efficacy of Paroxetine as an Adjuvant Therapy in Rheumatoid Arthritis Patients: A Randomized Controlled Study
To assess the therapeutic efficacy of paroxetine when administered as adjuvant therapy with csDMARDs in patients with rheu...
Plasma Concentrations of Prophylactic Posaconazole and Risk Factors for Subtherapeutic Exposure in Taiwanese Patients with Hematologic Malignancies
Plasma Concentrations of Prophylactic Posaconazole and Risk Factors for Subtherapeutic Exposure in Taiwanese Patients with Hematologic Malignancies
Plasma Concentrations of Prophylactic Posaconazole and Risk Factors for Subtherapeutic Exposure in Taiwanese Patients with...
Sugammadex versus Neostigmine Reversal After Thoracoscopic Thymectomy in Myasthenia Gravis: A Multicenter, Randomized Controlled Trial
Sugammadex versus Neostigmine Reversal After Thoracoscopic Thymectomy in Myasthenia Gravis: A Multicenter, Randomized Controlled Trial
Comparing efficacy of sugammadex vs neostigmine for reversing residual neuromuscular blockade in patients with mild myasth...
Effects of Remimazolam on Perioperative Inflammatory Response and Neurocognitive Disorders in Elderly Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial
Effects of Remimazolam on Perioperative Inflammatory Response and Neurocognitive Disorders in Elderly Patients Undergoing Video-Assisted Thoracic Surgery: A Randomized Controlled Trial
Remimazolam, a newer benzodiazepine anesthetic, has unknown anti-inflammatory properties and uncertain effects on elderly ...
A Comparison of the Effect of Remimazolam and Midazolam on Recovery and Preserved Memory Function for Patients with Dental Extraction Anxiety
A Comparison of the Effect of Remimazolam and Midazolam on Recovery and Preserved Memory Function for Patients with Dental Extraction Anxiety
This study was a randomized, parallel triple-blinded trial conducted between 30 April 2022 & 24 June 2024 for impacted...
Drug Repurposing as an Effective Drug Discovery Strategy: A Critical Review
Drug Repurposing as an Effective Drug Discovery Strategy: A Critical Review
Demonstrating that drug repurposing provides a viable solution for accelerating the process of drug discovery and addressi...
Impact of High Tacrolimus Exposure on Graft Function and Development of a Prediction Model in Kidney Transplant Recipients: A Single-Center Retrospective Cohort Study
Impact of High Tacrolimus Exposure on Graft Function and Development of a Prediction Model in Kidney Transplant Recipients: A Single-Center Retrospective Cohort Study
To evaluate the impact of early postoperative high TAC exposure on graft outcomes, hematological and metabolic parameters,...
Solidification of SNEDDS Using Mesoporous Carriers (2020–2025): A Review of Design, Biopharmaceutical Enhancement, and Therapeutic Impact
Solidification of SNEDDS Using Mesoporous Carriers (2020–2025): A Review of Design, Biopharmaceutical Enhancement, and Therapeutic Impact
This review focuses on recent developments in mesoporous-based self-nanoemulsifying drug delivery systems (SNEDDS).
Therapeutic Targeting of Signaling Pathways in Abdominal Aortic Aneurysm: From Pathogenesis to Precision Medicine
Therapeutic Targeting of Signaling Pathways in Abdominal Aortic Aneurysm: From Pathogenesis to Precision Medicine
To provide a framework for designing effective pharmacological strategies that could transform AAA management from surgica...
Copper-Induced Cell Death in Renal Diseases: Molecular Mechanisms and Therapeutic Implications
Copper-Induced Cell Death in Renal Diseases: Molecular Mechanisms and Therapeutic Implications
Consolidating evidence linking cuproptosis to various renal disorders, including acute kidney injury, diabetic nephropathy...
Targeting Esophageal Cancer: Promising Drugs for the Clinical Landscape and Key Knowledge Gaps
Targeting Esophageal Cancer: Promising Drugs for the Clinical Landscape and Key Knowledge Gaps
Current clinical strategies for esophageal cancer, emphasizing clinically validated biomarkers that inform therapeutic sel...
Design of Experiments Assisted Formulation Optimization and Evaluation of Efavirenz Solid Dispersion Adsorbate for Improvement in Dissolution and Flow Properties
Design of Experiments Assisted Formulation Optimization and Evaluation of Efavirenz Solid Dispersion Adsorbate for Improvement in Dissolution and Flow Properties
Developing a solid dispersion adsorbate (SDA) to enhance the dissolution rate and flow properties of Efavirenz (EFZ) for s...
Quantitative Proteomic Study Reveals Amygdalin Alleviates Liver Fibrosis Through Inhibiting mTOR/PDCD4/JNK Pathway in Hepatic Stellate Cells
Quantitative Proteomic Study Reveals Amygdalin Alleviates Liver Fibrosis Through Inhibiting mTOR/PDCD4/JNK Pathway in Hepatic Stellate Cells
Aiming to elucidate the potential pharmaceutical mechanism of action of amygdalin against liver fibrosis.
Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study
Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study
To assess the pharmacokinetics (PK) and safety profiles of HRS-1780 in subjects with renal impairment.
A Natural Compound Methylnissolin: Physicochemical Properties, Pharmacological Activities, Pharmacokinetics and Resource Development
A Natural Compound Methylnissolin: Physicochemical Properties, Pharmacological Activities, Pharmacokinetics and Resource Development
Methylnissolin and its glycoside compounds in terms of physicochemical properties, biological activity, pharmacokinetics, ...
Ethnobotanical Use, Phytochemistry, Pharmacology, and Toxicity of Canavalia gladiata
Ethnobotanical Use, Phytochemistry, Pharmacology, and Toxicity of Canavalia gladiata
This review provides a thorough insight into the ethnobotanical use, phytochemistry, pharmacology, and toxicity of C. glad...
A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions
A Bibliometric Analysis of Microneedle-Mediated Drug Delivery: Trends, Hotspots, and Future Directions
Exploring the research hotspots and development trends of microneedle-mediated drug delivery. Read more
Computational and Experimental Investigation of Antidiabetic Drugs on Tofacitinib Metabolism: Molecular Docking, in vitro, and in vivo Studies
Computational and Experimental Investigation of Antidiabetic Drugs on Tofacitinib Metabolism: Molecular Docking, in vitro, and in vivo Studies
Investigating the effects of gliquidone and linagliptin, two hypoglycemic agents on the pharmacokinetics of tofacitinib in...
Enhancing Cartilage Repair in Osteoarthritis Using Platelet Lysates and Arthroscopic Microfracture
Enhancing Cartilage Repair in Osteoarthritis Using Platelet Lysates and Arthroscopic Microfracture
Examining whether combined treatment of MF and Platelet lysate can inhibit the promotion of cartilage repair and antifibro...
Biochemical and Molecular Studies on the Role of Celecoxib and Some Related Bipyrazoles in Mitigating Induced Liver Injury in Experimental Animals
Biochemical and Molecular Studies on the Role of Celecoxib and Some Related Bipyrazoles in Mitigating Induced Liver Injury in Experimental Animals
Fluorinated analog HR3 could serve as a novel therapeutic candidate for the amelioration of liver fibrosis that deserves f...
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway
Huashi Jiedu Decoction Enhances 5-Fluorouracil Efficacy in Gastric Cancer via miRNA-21-3p/p53 Pathway
Exploring the mechanism of Huashi Jiedu Decoction synergizing with 5-fluorouracil in gastric cancer therapy. Read more
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