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Novel peptaibiotics identified from clade
Novel peptaibiotics identified from clade
This study focuses on the peptaibiome produced by different species of Trichoderma belonging to clade Viride: T. koningii ...
Initial shoot regeneration in the selenium hyperaccumulator and in vitro test system for selenium tolerance and accumulation
Initial shoot regeneration in the selenium hyperaccumulator and in vitro test system for selenium tolerance and accumulation
The trace element selenium is essential for human nutrition but is distributed unevenly in soils worldwide with&a...
Ginkgetin from : mechanistic insights into anticancer efficacy
Ginkgetin from : mechanistic insights into anticancer efficacy
The extraction of anticancer agents from medicinal plants represents a highly promising research frontier. Ginkgetin, a na...
Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives
Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives
Natural product tanshinone I exhibits weak potency and poor drug-like properties, which have restricted its clinical devel...
Harnessing Actinobacteria secondary metabolites for tuberculosis drug discovery: Historical trends, current status and future outlooks
Harnessing Actinobacteria secondary metabolites for tuberculosis drug discovery: Historical trends, current status and future outlooks
Tuberculosis (TB) is a leading infectious disease killer and one of the major causes of deaths worldwide. Although TB is a...
Correction: Xiaoyankangjun tablet alleviates dextran sulfate sodium‑induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Correction: Xiaoyankangjun tablet alleviates dextran sulfate sodium‑induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Concise syntheses of natural diarylheptanoids containing a 1,4‑pentadiene unit
Correction: Concise syntheses of natural diarylheptanoids containing a 1,4‑pentadiene unit
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy
Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy
Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells, and traditional ...
Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2
Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2
Depression promotes breast cancer progression. Given the lack of specific targets for depression-associated breast cancer,...
(+)-/(−)-Ormohenins A and B, two pairs of ormosanine-type enantiomers and their derivatives with neuroprotective activity from Prain
(+)-/(−)-Ormohenins A and B, two pairs of ormosanine-type enantiomers and their derivatives with neuroprotective activity from Prain
Two pairs of undescribed alkaloid enantiomers, (+)-/(−)-ormohenins A (1) and B (2), were isolated from the seeds of ...
Correction: New acetogenin katsuurallene from collected from Katsuura, Japan
Correction: New acetogenin katsuurallene from collected from Katsuura, Japan
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
A novel polysaccharide in : structure elucidation, the activities of anti-inflammatory and the regulation of gut microbiota in vitro
A novel polysaccharide in : structure elucidation, the activities of anti-inflammatory and the regulation of gut microbiota in vitro
Polysaccharides are the primary active constituents of Polygonatum kingianum Coll. et Hemsl. However, the comprehensive ch...
Stingless bee propolis: a comprehensive review of chemical constituents and health efficacy
Stingless bee propolis: a comprehensive review of chemical constituents and health efficacy
Propolis, consisting of plant-derived materials, wax, and bee secretions, is abundant in bioactive constituents like flavo...
Nidulin stimulates glucose uptake in myotubes through the IRS-AKT pathway and alters redox balance and intracellular calcium
Nidulin stimulates glucose uptake in myotubes through the IRS-AKT pathway and alters redox balance and intracellular calcium
Nidulin is a secondary metabolite of the depsidone family produced by Aspergillus spp., and has shown promises in pharmaco...
Chalasoergodimers A–E, heterodimers with multiple polymerization modes from a marine-derived sp. fungus
Chalasoergodimers A–E, heterodimers with multiple polymerization modes from a marine-derived sp. fungus
Five new heterodimers, chalasoergodimers A–E (1–5), and three known heterodimers (6–8), along with four ...
Kaemphenolide: a cyclobutane-bearing phenylpropanoid from L. with nitric oxide inhibitory activity
Kaemphenolide: a cyclobutane-bearing phenylpropanoid from L. with nitric oxide inhibitory activity
An undescribed phenylpropanoid dimer featuring a rare cyclobutane ring was isolated from the rhizomes of Kaempferia galang...
Discovery of structurally diverse sesquiterpenoids from isolated from feces and their antifungal activities
Discovery of structurally diverse sesquiterpenoids from isolated from feces and their antifungal activities
Thirty-six structurally diverse sesquiterpenoids, including caryolanes (1–12), germacranes (13–16), isodaucane...
Diterpene chemical space of Briq. aerial part
Diterpene chemical space of Briq. aerial part
The Plectranthinae clade, which includes genera such as Plectranthus, Ocimum, and Aeollanthus, is well known for its diver...
Euchrestifolines A–O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from
Euchrestifolines A–O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from
Fifteen novel carbazole alkaloids, euchrestifolines A–O (1–15), were obtained from Murraya euchrestifolia. The...
Widely targeted metabolomics analysis reveals differences in volatile metabolites among four species
Widely targeted metabolomics analysis reveals differences in volatile metabolites among four species
Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies h...
Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science
Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science
The integration of phytochemistry into forensic science has emerged as a groundbreaking frontier, providing unprecedented ...
Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations
Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations
In the twenty-first century, we have witnessed multiple coronavirus pandemics. Despite declining SARS-CoV-2 cases, continu...
New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract
New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract
Chemically engineered extracts represent a promising source of new bioactive semi-synthetic molecules. Prepared through di...
Discovery of a parallel family of euglenatide analogs in
Discovery of a parallel family of euglenatide analogs in
The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracili...
Novel -clerodane diterpenoids from and their anti-ferroptosis effect
Novel -clerodane diterpenoids from and their anti-ferroptosis effect
Teucrifarides A–D (1–4), four previously unreported neo-clerodane-type diterpenoids, combined with sixteen kno...
Dibohemamines I–O from sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Thunb.
Dibohemamines I–O from sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Thunb.
A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb...
Metabolomic and transcriptomic analyses revealed potential mechanisms of Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation
Metabolomic and transcriptomic analyses revealed potential mechanisms of Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation
Anchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. Howev...
The need for smart microalgal bioprospecting
The need for smart microalgal bioprospecting
Microalgae’s adaptability and resilience to Earth’s diverse environments have evolved these photosynthetic mic...
Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management
Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management
Mosquitoes (Diptera: Culicidae) are vectors of various pathogens of public health concern and replacing conventio...
Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)
Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)
Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential thera...
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