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Discovery of structurally diverse sesquiterpenoids from isolated from feces and their antifungal activities
Discovery of structurally diverse sesquiterpenoids from isolated from feces and their antifungal activities
Thirty-six structurally diverse sesquiterpenoids, including caryolanes (1–12), germacranes (13–16), isodaucane...
Diterpene chemical space of Briq. aerial part
Diterpene chemical space of Briq. aerial part
The Plectranthinae clade, which includes genera such as Plectranthus, Ocimum, and Aeollanthus, is well known for its diver...
Euchrestifolines A–O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from
Euchrestifolines A–O, fifteen novel carbazole alkaloids with potent anti-ferroptotic activity from
Fifteen novel carbazole alkaloids, euchrestifolines A–O (1–15), were obtained from Murraya euchrestifolia. The...
Widely targeted metabolomics analysis reveals differences in volatile metabolites among four species
Widely targeted metabolomics analysis reveals differences in volatile metabolites among four species
Angelica L. has attracted global interest for its traditional medicinal uses and commercial values. However, few studies h...
Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science
Phytochemical fingerprinting of phytotoxins as a cutting-edge approach for unveiling nature’s secrets in forensic science
The integration of phytochemistry into forensic science has emerged as a groundbreaking frontier, providing unprecedented ...
Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations
Unveiling the mechanism of action of a novel natural dual inhibitor of SARS-CoV-2 Mpro and PLpro with molecular dynamics simulations
In the twenty-first century, we have witnessed multiple coronavirus pandemics. Despite declining SARS-CoV-2 cases, continu...
New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract
New semisynthetic α-glucosidase inhibitor from a doubly-chemically engineered extract
Chemically engineered extracts represent a promising source of new bioactive semi-synthetic molecules. Prepared through di...
Discovery of a parallel family of euglenatide analogs in
Discovery of a parallel family of euglenatide analogs in
The euglenatides are a family of hybrid polyketide-nonribosomal peptides produced by the unicellular algae Euglena gracili...
Novel -clerodane diterpenoids from and their anti-ferroptosis effect
Novel -clerodane diterpenoids from and their anti-ferroptosis effect
Teucrifarides A–D (1–4), four previously unreported neo-clerodane-type diterpenoids, combined with sixteen kno...
Dibohemamines I–O from sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Thunb.
Dibohemamines I–O from sp. GZWMJZ-662, an endophytic actinomycete from the medicinal and edible plant Thunb.
A chemical investigation of Streptomyces sp. GZWMJZ-662, an endophytic actinomycete isolated from Houttuynia cordata Thunb...
Metabolomic and transcriptomic analyses revealed potential mechanisms of Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation
Metabolomic and transcriptomic analyses revealed potential mechanisms of Retz. in alleviating cerebral ischemia–reperfusion injury via Wnt/β-catenin pathway modulation
Anchusa italica Retz. (AIR), a traditional herbal remedy, is commonly applied in managing heart and brain disorders. Howev...
The need for smart microalgal bioprospecting
The need for smart microalgal bioprospecting
Microalgae’s adaptability and resilience to Earth’s diverse environments have evolved these photosynthetic mic...
Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management
Essential oil and furanosesquiterpenes from myrrh oleo-gum resin: a breakthrough in mosquito vector management
Mosquitoes (Diptera: Culicidae) are vectors of various pathogens of public health concern and replacing conventio...
Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)
Marine natural products as a source of novel anticancer drugs: an updated review (2019–2023)
Marine natural products have long been recognized as a vast and diverse source of bioactive compounds with potential thera...
Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents
Design, synthesis and biological evaluation of buthutin derivatives as cardioprotective agents
Natural products are the important sources in cardiovascular drug development. In this study, twenty-nine buthutin derivat...
Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications
Structure–function insights of natural polysaccharides: advances in biosynthesis and functional food applications
Ganoderma polysaccharides (GPs), derived from various species of the Ganoderma genus, exhibit diverse bioactivities, inclu...
Emestrin-type epipolythiodioxopiperazines from with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways
Emestrin-type epipolythiodioxopiperazines from with cytotoxic activities by regulating PI3K/AKT and mitochondrial apoptotic pathways
Five novel emestrin-type epipolythiodioxopiperazines (ETPs), prenylemestrins C−G (1–5), along with two known E...
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of
Asprecosides A–J, ten new pentacyclic triterpenoid glycosides with cytotoxic activity from the roots of
Phytochemical study of the n-BuOH extract of Ilex asprella resulted in the discovery of ten new pentacyclic triterpenoid g...
Newly isolated terpenoids (covering 2019–2024) from species and their potential for the discovery of novel antimicrobials
Newly isolated terpenoids (covering 2019–2024) from species and their potential for the discovery of novel antimicrobials
The rapid emergence of drug-resistant microbial pathogens has posed challenges to global health in the twenty-first centur...
Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression
Natural product rhynchophylline prevents stress-induced hair graying by preserving melanocyte stem cells via the β2 adrenergic pathway suppression
Norepinephrine (NA), a stress hormone, can accelerate hair graying by binding to β2 adrenergic receptors (β2AR) ...
Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis
Kaemtakols A–D, highly oxidized pimarane diterpenoids with potent anti-inflammatory activity from Kaempferia takensis
Four highly oxidized pimarane diterpenoids were isolated from Kaempferia takensis rhizomes. Kaemtakols A–C possess a...
A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra
A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra
Sarcandra glabra (Thunb.) Nakai is a perennial evergreen herb categorised within the Sarcandra Gardner genus under the Chl...
Quinones from Cordia species from 1972 to 2023: isolation, structural diversity and pharmacological activities
Quinones from Cordia species from 1972 to 2023: isolation, structural diversity and pharmacological activities
Plants of the genus Cordia (Boraginaceae family) are widely distributed in the tropical regions of America, Africa, and As...
Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
Ginsenoside compound-K attenuates OVX-induced osteoporosis via the suppression of RANKL-induced osteoclastogenesis and oxidative stress
Osteoporosis (OP), a systemic and chronic bone disease, is distinguished by low bone mass and destruction of bone microarc...
The alkynyl-containing compounds from mushrooms and their biological activities
The alkynyl-containing compounds from mushrooms and their biological activities
Mushrooms have been utilized by humans for thousands of years due to their medicinal and nutritional properties. They are ...
A recent update on development, synthesis methods, properties and application of natural products derived carbon dots
A recent update on development, synthesis methods, properties and application of natural products derived carbon dots
Natural resources are practically infinitely abundant in nature, which stimulates scientists to create new materials with ...
Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies
Bioactive molecules from terrestrial and seafood resources in hypertension treatment: focus on molecular mechanisms and targeted therapies
Hypertension (HTN), a complex cardiovascular disease (CVD), significantly impacts global health, prompting a growing inter...
Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus
Three previously undescribed metabolites from Cordyceps cicadae JXCH-1, an entomopathogenic fungus
Three previously undescribed compounds, cordycicadione (1), cordycicadin F (2), and 7-hydroxybassiatin (3), were isolated ...
Occurrence of D-amino acids in natural products
Occurrence of D-amino acids in natural products
Since the identified standard genetic code contains 61 triplet codons of three bases for the 20 L-proteinogenic amino acid...
l-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis
l-Palmitoylcarnitine potentiates plasmin and tPA to inhibit thrombosis
l-Palmitoylcarnitine (L-PC) is an important endogenous fatty acid metabolite. Its classical biological functions are invol...
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