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GNPS2 molecular networking reveals metabolic diversity in fungi isolated from protease-rich fruits
GNPS2 molecular networking reveals metabolic diversity in fungi isolated from protease-rich fruits
Fungi are a rich source of chemical diversity for bioprospecting, yet most of their metabolic potential remains unexplored...
Limonene and its metabolite perillyl alcohol inhibit Chlamydia trachomatis growth by altering host isoprenoid metabolism
Limonene and its metabolite perillyl alcohol inhibit Chlamydia trachomatis growth by altering host isoprenoid metabolism
The obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial sexually transmitted infection glo...
Deacetylforskolin ameliorates bleomycin-induced pulmonary fibrosis by suppressing inflammation and TGF-β1-induced epithelial–mesenchymal transition
Deacetylforskolin ameliorates bleomycin-induced pulmonary fibrosis by suppressing inflammation and TGF-β1-induced epithelial–mesenchymal transition
Pulmonary fibrosis (PF) is a chronic, progressive and irreversible inflammatory disease with limited therapeutic methods i...
Sophflarines F–K: matrine-based alkaloids with a rare aromatic system from and their anti-inflammatory and synergistic antibacterial effects
Sophflarines F–K: matrine-based alkaloids with a rare aromatic system from and their anti-inflammatory and synergistic antibacterial effects
Six new matrine-based alkaloids, sophflarines F–K (1–6), featuring a rare aromatic system, were obtained from ...
Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase
Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase
Peptides from natural sources have often served as valuable leads in drug discovery. Plant-derived protease inhibitors are...
Artificial intelligence-based screening of phytochemicals for targeted cancer therapy
Artificial intelligence-based screening of phytochemicals for targeted cancer therapy
Cancer remains one of the leading causes of death worldwide and continues to pose a serious public health challenge. The l...
Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in
Natural monoterpenoid geraniol promotes antioxidant defense and stress tolerance via SKN-1/Nrf2 activation in
Oxidative stress (OS) is a major contributor to aging and the pathogenesis of numerous conditions, including diabetes, neu...
Prenylated acylphloroglucinols from the fruits of
Prenylated acylphloroglucinols from the fruits of
Twenty-eight prenylated acylphloroglucinols, including the new hypulatones C–F (1–4), have been isolated from ...
Diversity of oligosaccharides in lipooligosaccharides of and its anti-atherosclerotic activity
Diversity of oligosaccharides in lipooligosaccharides of and its anti-atherosclerotic activity
As an important and beneficial gut commensal, Akkermansia muciniphila plays a crucial role in regulating host metabolism a...
Cytotoxic trichothecene derivatives from sp. DWS815
Cytotoxic trichothecene derivatives from sp. DWS815
Ten novel trichothecene sesquiterpenoids including two new seco-trichothecenes, trichotheciumones A (1) and B (2), a new t...
Facile synthesis and biological evaluation of glomuferrin and rhizoferrin as ferroptosis inhibitors in rice blast disease
Facile synthesis and biological evaluation of glomuferrin and rhizoferrin as ferroptosis inhibitors in rice blast disease
Iron homeostasis has recently emerged as a key determinant in the early stages of plant–pathogen interactions, parti...
Mechanistic insights into polyphenolic constituents from traditional Chinese medicines in inhibiting colorectal cancer metastasis
Mechanistic insights into polyphenolic constituents from traditional Chinese medicines in inhibiting colorectal cancer metastasis
Colorectal cancer (CRC) is the third most predominant cancer caused by genetic, environmental and nutritional factors and ...
First total synthesis of (±)-spirobroussonin B via electromediated oxidative coupling for constructing spirodienone ring
First total synthesis of (±)-spirobroussonin B via electromediated oxidative coupling for constructing spirodienone ring
An electromediated oxidative coupling strategy for constructing spirodienone fragment has been developed and applied as th...
Four new Cyclohexenone with antibacterial activity from the coral-derived fungus
Four new Cyclohexenone with antibacterial activity from the coral-derived fungus
Marine fungus-derived natural products are an important source of new drugs and lead compounds. In this study, guided by t...
New patchoulol- and guaiane-type sesquiterpenoids from with anti-melanogenic activity
New patchoulol- and guaiane-type sesquiterpenoids from with anti-melanogenic activity
Twelve new sesquiterpenoids, sanguisorbaols A–L (1–12), along with twenty-five known compounds (13–37), ...
Distribution and bioactivities of tirucallane-type triterpenoids from Meliaceae family
Distribution and bioactivities of tirucallane-type triterpenoids from Meliaceae family
Tirucallane-type triterpenoids are one of the most structurally diverse classes of secondary metabolites in Meliaceae fami...
Exploring the global mosaic of medicinal plant databases: unveiling nature’s pharmacopoeia
Exploring the global mosaic of medicinal plant databases: unveiling nature’s pharmacopoeia
Medicinal plants have long served as an important asset in the treatment of diseases. Recent developments in computer scie...
Elucidating therapeutic mechanisms of naringin and phloridzin on ulcerative colitis mice by metabolomics-based comparative analysis
Elucidating therapeutic mechanisms of naringin and phloridzin on ulcerative colitis mice by metabolomics-based comparative analysis
Naringin and phloridzin are structurally similar flavonoids with anti-inflammatory, antioxidant, and antimicrobial propert...
Rapid exploration of anti-MRSA components from plants of
Rapid exploration of anti-MRSA components from plants of
Plants of Salvia are frequently used for treatment infections of boils and sores in Traditional Chinese medicine, which mi...
Sesamol derivatives bearing a quinazolin moiety: synthesis, antifungal efficacy against tea plant pathogens, and mechanistic insights
Sesamol derivatives bearing a quinazolin moiety: synthesis, antifungal efficacy against tea plant pathogens, and mechanistic insights
Pestalotiopsis sp. and Colletotrichum camelliae are two devastating fungal pathogens that cause significant yield losses a...
Novel peptaibiotics identified from clade
Novel peptaibiotics identified from clade
This study focuses on the peptaibiome produced by different species of Trichoderma belonging to clade Viride: T. koningii ...
Initial shoot regeneration in the selenium hyperaccumulator and in vitro test system for selenium tolerance and accumulation
Initial shoot regeneration in the selenium hyperaccumulator and in vitro test system for selenium tolerance and accumulation
The trace element selenium is essential for human nutrition but is distributed unevenly in soils worldwide with&a...
Ginkgetin from : mechanistic insights into anticancer efficacy
Ginkgetin from : mechanistic insights into anticancer efficacy
The extraction of anticancer agents from medicinal plants represents a highly promising research frontier. Ginkgetin, a na...
Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives
Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives
Natural product tanshinone I exhibits weak potency and poor drug-like properties, which have restricted its clinical devel...
Harnessing Actinobacteria secondary metabolites for tuberculosis drug discovery: Historical trends, current status and future outlooks
Harnessing Actinobacteria secondary metabolites for tuberculosis drug discovery: Historical trends, current status and future outlooks
Tuberculosis (TB) is a leading infectious disease killer and one of the major causes of deaths worldwide. Although TB is a...
Correction: Xiaoyankangjun tablet alleviates dextran sulfate sodium‑induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Correction: Xiaoyankangjun tablet alleviates dextran sulfate sodium‑induced colitis in mice by regulating gut microbiota and JAK2/STAT3 pathway
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Correction: Concise syntheses of natural diarylheptanoids containing a 1,4‑pentadiene unit
Correction: Concise syntheses of natural diarylheptanoids containing a 1,4‑pentadiene unit
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy
Dual inhibition of FAS and HAS2/3 by 4-MU in Realgar-Coptis chinensis unveils a metabolic checkpoint for liver cancer therapy
Modern pharmacology has found that both Realgar and Coptis chinensis can induce apoptosis in tumor cells, and traditional ...
Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2
Senkyunolide H reverses depression-induced breast cancer progression by regulating CXCR2
Depression promotes breast cancer progression. Given the lack of specific targets for depression-associated breast cancer,...
(+)-/(−)-Ormohenins A and B, two pairs of ormosanine-type enantiomers and their derivatives with neuroprotective activity from Prain
(+)-/(−)-Ormohenins A and B, two pairs of ormosanine-type enantiomers and their derivatives with neuroprotective activity from Prain
Two pairs of undescribed alkaloid enantiomers, (+)-/(−)-ormohenins A (1) and B (2), were isolated from the seeds of ...
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