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Mechanisms underlying the dynamic changes in tannins associated with food processing and plant growth
Mechanisms underlying the dynamic changes in tannins associated with food processing and plant growth
This review describes the chemical mechanisms behind the structural changes in selected tannins associated with food proce...
Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor
Nobiletin alleviates hypoxia-induced pulmonary hypertension by inhibiting calcium-sensing receptor
Pulmonary hypertension is a disease characterized by complex diagnosis, challenging treatment, and a shortage of clinical ...
Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases
Traditional medicine meets modern science: Halofuginone’s role in combating autoimmune diseases
Dichroa febrifuga Lour., a traditional Chinese medicinal herb historically used for malaria treatment, contains the active...
Anti-cancer activity of the glycyrrhetinic acid derivatives with an inhibitory inflammatory microenvironment
Anti-cancer activity of the glycyrrhetinic acid derivatives with an inhibitory inflammatory microenvironment
The tumor inflammatory microenvironment plays an important role in tumor development, and the compounds which modulate tum...
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression
Multi-omics analysis reveals the mechanism of action of Atractylodin against depression
Atractylodin (ATR) is a natural sesquiterpene compound primarily isolated from the rhizomes of Atractylodes, a plant of th...
Metabolite derived from green tea polyphenol increases and activates plasmacytoid dendritic cells
Metabolite derived from green tea polyphenol increases and activates plasmacytoid dendritic cells
The immune system plays a crucial role in protecting the body from harmful bacterial, viral infections and vital for cance...
Drimane sesquiterpenoids from cultures of basidiomycete
Drimane sesquiterpenoids from cultures of basidiomycete
Nine previously undescribed drimane sesquiterpenoids, ganoresinosins A–I (1–9), were isolated from cultures of...
Ameliorative role of leaf extract in aluminum chloride-induced neurotoxicity flies possibly mediated by -methyl--aspartate receptor antagonistic and anticholinesterase active compounds
Ameliorative role of leaf extract in aluminum chloride-induced neurotoxicity flies possibly mediated by -methyl--aspartate receptor antagonistic and anticholinesterase active compounds
Polyscias fruticosa leaves have been used in traditional medicine to aid in the therapy of brain and nerve-related disorde...
Apoptosis-inducing activity of a steroidal glycoside from G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress
Apoptosis-inducing activity of a steroidal glycoside from G. Don. bulbs in human small-cell lung cancer cells via mitochondrial dysfunction and ER stress
A saponin fraction from Allium chinense G. Don. bulbs has previously been reported to exhibit cytotoxicity against melanom...
ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation
ameliorated LPS-induced depression-like behaviors via suppression of acute neuroinflammation
Research context reveals that major depressive disorder (MDD), as a prevalent chronic relapsing psychiatric condition affe...
Advanced multidimensional quality evaluation of encapsulated peppermint oil products in various formulas
Advanced multidimensional quality evaluation of encapsulated peppermint oil products in various formulas
We investigated the actual label indications and quality of encapsulated peppermint oil (PO) products marketed as medicina...
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway
Diosmetin alleviates osteoarthritis through modulating the polarization of macrophages by inhibiting the PI3K/Akt signaling pathway
Osteoarthritis (OA) is the most common degenerative musculoskeletal disorder worldwide. Diosmetin is the aglycone of diosm...
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice
Anti-allergic actions and pharmacokinetics of orally administered 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acid in mice
In this study, we explored the anti-allergic actions of 18α-glycyrrhetinic acid and 18β-glycyrrhetinic acids (18...
Unprecedented triterpenes with anti-inflammatory activity from
Unprecedented triterpenes with anti-inflammatory activity from
Four triterpenes with the unprecedented pentacyclic skeletons were isolated from Limax maximus, the traditional medicine o...
Metabolism of coclaurine into the WADA-banned substance higenamine: a doping-relevant analytical evaluation of Kampo extracts
Metabolism of coclaurine into the WADA-banned substance higenamine: a doping-relevant analytical evaluation of Kampo extracts
Higenamine, a β2-agonist, has been listed as a prohibited substance by the World Anti-Doping Agency (WADA) since 2017...
Berberine attenuates the expression of NLRP3 and downstream inflammasome effectors in diabetic retinopathy
Berberine attenuates the expression of NLRP3 and downstream inflammasome effectors in diabetic retinopathy
The objective of this study is to investigate the protective effects of berberine (BBR) on diabetic retinopathy (DR) and i...
Investigation and development of natural products that target chemotherapy resistance factors in cancer cells
Investigation and development of natural products that target chemotherapy resistance factors in cancer cells
Heat shock proteins (HSPs) play an important role in several tumors; contribute to anti-cancer drug resistance, cell proli...
Anti-neuroinflammatory effects of epivernodalol, a sesquiterpene from (L.) Willd., in lipopolysaccharide-stimulated murine microglial cells
Anti-neuroinflammatory effects of epivernodalol, a sesquiterpene from (L.) Willd., in lipopolysaccharide-stimulated murine microglial cells
Four terpenes—epivernodalol [Epl], cynaropicrin, vernonilide A, and vernodalin—were isolated from Vernonia ant...
Discovery of active compounds in Danshen–Chuanxiong formula for blood–brain barrier protection: a multi-parametric study using an OGD/R-induced spheroid model
Discovery of active compounds in Danshen–Chuanxiong formula for blood–brain barrier protection: a multi-parametric study using an OGD/R-induced spheroid model
Blood–brain barrier (BBB) dysfunction is a well-established pathological phenotype of ischemic stroke, and targeting...
Chemical and pharmaceutical evaluation of roasted Ephedra herba and elucidation of the health hazards caused by white smoke generated during processing
Chemical and pharmaceutical evaluation of roasted Ephedra herba and elucidation of the health hazards caused by white smoke generated during processing
In traditional Chinese medicine and traditional Japanese medicine (Kampo medicine), crude drugs are processed to obtain di...
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Currently, there are no effective prophylactic or therapeutic drugs for the treatment of paclitaxel (PTX)-induced peripher...
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Epilepsy, characterized by recurrent seizures, often accompanies neurocognitive impairments and is associated with increas...
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis
Macrocyclization of peptides reduces conformational flexibilities, potentially leading to improved drug-like properties. H...
Research on the quality evaluation of crude drugs
Research on the quality evaluation of crude drugs
As crude drugs are natural products, their quality may vary. However, the degradation of the active ingredients in the com...
Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities
Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities
Castanopsis genus (Fagaceae) were rich in plant polyphenols and often used as medicinal plants. In this study, two new lig...
Dendrobium nobile Lindl. alkaloids protect CCl4-induced acute liver injury via upregulating LAMP1 expression and activating autophagy flux
Dendrobium nobile Lindl. alkaloids protect CCl4-induced acute liver injury via upregulating LAMP1 expression and activating autophagy flux
Dendrobium nobile Lindl. alkaloids (DNLA) are considered important active ingredients of Dendrobium, which have a variety ...
Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta
Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta
The number of patients with Alzheimer’s disease (AD) is expected to increase as the population ages. The amyloid cas...
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Cardiotoxicity is one of the major obstacles to anthracycline chemotherapy. Anthracycline cardiotoxicity is closely associ...
Isolation of new indole alkaloid triglucoside from the aqueous extract of Uncaria rhynchophylla
Isolation of new indole alkaloid triglucoside from the aqueous extract of Uncaria rhynchophylla
Uncaria rhynchophylla (Miq.) Miq. (Rubiaceae) is widely used as a botanical raw material for traditional Japanese and Chin...
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro
The persistence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of new mutant ...
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