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Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Preventive and therapeutic effects of ephedrine alkaloids-free Ephedra Herb extract on paclitaxel-induced neuropathic pain
Currently, there are no effective prophylactic or therapeutic drugs for the treatment of paclitaxel (PTX)-induced peripher...
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Neuroprotective impact of glycitin on memory impairment in a pentylenetetrazol-induced chronic epileptic rat model: insights into hippocampal histology, oxidative stress, and inflammation
Epilepsy, characterized by recurrent seizures, often accompanies neurocognitive impairments and is associated with increas...
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis
Macrocyclizing-thioesterases in bacterial non-ribosomal peptide biosynthesis
Macrocyclization of peptides reduces conformational flexibilities, potentially leading to improved drug-like properties. H...
Research on the quality evaluation of crude drugs
Research on the quality evaluation of crude drugs
As crude drugs are natural products, their quality may vary. However, the degradation of the active ingredients in the com...
Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities
Two novel butyrolactone lignan dimers from leaves of Castanopsis chinensis and their anti-inflammatory activities
Castanopsis genus (Fagaceae) were rich in plant polyphenols and often used as medicinal plants. In this study, two new lig...
Dendrobium nobile Lindl. alkaloids protect CCl4-induced acute liver injury via upregulating LAMP1 expression and activating autophagy flux
Dendrobium nobile Lindl. alkaloids protect CCl4-induced acute liver injury via upregulating LAMP1 expression and activating autophagy flux
Dendrobium nobile Lindl. alkaloids (DNLA) are considered important active ingredients of Dendrobium, which have a variety ...
Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta
Inhibition of amyloid β aggregation and BACE1, and protective effect on SH-SY5Y cells, by p-terphenyl compounds from mushroom Thelephora aurantiotincta
The number of patients with Alzheimer’s disease (AD) is expected to increase as the population ages. The amyloid cas...
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Preventive effect of imperatorin against doxorubicin-induced cardiotoxicity through suppression of NLRP3 inflammasome activation
Cardiotoxicity is one of the major obstacles to anthracycline chemotherapy. Anthracycline cardiotoxicity is closely associ...
Isolation of new indole alkaloid triglucoside from the aqueous extract of Uncaria rhynchophylla
Isolation of new indole alkaloid triglucoside from the aqueous extract of Uncaria rhynchophylla
Uncaria rhynchophylla (Miq.) Miq. (Rubiaceae) is widely used as a botanical raw material for traditional Japanese and Chin...
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro
Sulfoquinovosyl diacylglycerol, a component of Holy Basil Ocimum tenuiflorum, inhibits the activity of the SARS-CoV-2 main protease and viral replication in vitro
The persistence of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of new mutant ...
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes
Meroterpenoids with BACE1-inhibitory activity from the fruiting bodies of Suillus bovinus and Boletinus cavipes
Alzheimer disease (AD) is the most common type of dementia and accounts for the largest proportion of dementia cases. The ...
Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity
Aromatic polyketides isolated from the marine-derived fungus Didymella aeria and their neuroprotective activity
Two novel aromatic polyketides, penicanesins J and K (1, 2), were isolated from the marine-derived fungus Didymella aeria,...
Cytotoxic activity of C17 polyacetylenes from the roots of Glehnia littoralis against drug-resistant colorectal and lung cancer cells
Cytotoxic activity of C17 polyacetylenes from the roots of Glehnia littoralis against drug-resistant colorectal and lung cancer cells
In the preliminary screening, falcarinol and falcarindiol, C17 polyacetylenes from the roots of Glehnia littoralis F. Schm...
Resveratrol as a BCL6 natural inhibitor suppresses germinal center derived Non-Hodgkin lymphoma cells growth
Resveratrol as a BCL6 natural inhibitor suppresses germinal center derived Non-Hodgkin lymphoma cells growth
Non-Hodgkin lymphomas (NHL), including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma (BL), and follicular lympho...
Ergostane-type steroids from mushrooms of Pleurotus genus
Ergostane-type steroids from mushrooms of Pleurotus genus
Steroids are physiologically important compounds for animals, plants, and fungi, and they have significantly contributed t...
New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities
New cerebrosides and ceramide with other constituents from the aerial parts of Raphidiocystis mannii Hook. f. and their cytotoxic activities
Two new cerebrosides, raphimanosides A (1) and B (2), and a new ceramide, raphimanide (3), were isolated from the aerial p...
Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway
Neuroprotective effect of isovaleraldehyde accompanied with upregulation of BDNF and CREB phosphorylation via the PKA pathway
Recently, the number of patients diagnosed with dementia has increased. The World Health Organization (WHO) estimates that...
Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics
Celastrol ameliorates energy metabolism dysfunction of hypertensive rats by dilating vessels to improve hemodynamics
The impact of hypertension on tissue and organ damage is mediated through its influence on the structure and function of b...
Evaluation and molecular docking study of two flavonoids from Oroxylum indicum (L.) Kurz and their semi-synthetic derivatives as histone deacetylase inhibitors
Evaluation and molecular docking study of two flavonoids from Oroxylum indicum (L.) Kurz and their semi-synthetic derivatives as histone deacetylase inhibitors
Chrysin (5,7-dihydroxyflavone, 6) and galangin 3-methyl ether (5,7-dihydroxy-3-methoxy flavone, 7) were obtained from the ...
Kamikihito reduces β-amyloid25–35-induced axon damage via neurotrophic factors
Kamikihito reduces β-amyloid25–35-induced axon damage via neurotrophic factors
The Japanese herbal medicine kamikihito (KKT) is widely used for insomnia, anorexia, anemia, and depression. Recently, the...
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells
The hypothalamic–pituitary–adrenal (HPA) system plays an important role in stress response. Chronic stress is ...
Three-membered ring formation catalyzed by α-ketoglutarate-dependent nonheme iron enzymes
Three-membered ring formation catalyzed by α-ketoglutarate-dependent nonheme iron enzymes
Epoxides, aziridines, and cyclopropanes are found in various medicinal natural products, including polyketides, terpenes, ...
Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver
Inhibitory effect of trans-tiliroside on very low-density lipoprotein secretion in HepG2 cells and mouse liver
An acylated flavonol glycoside, trans-tiliroside (1), is found in certain parts of different herbs, including the seeds of...
The marine Penicillium sp. GGF16-1-2 metabolite dicitrinone G inhibits pancreatic angiogenesis by regulating the activation of NLRP3 inflammasome
The marine Penicillium sp. GGF16-1-2 metabolite dicitrinone G inhibits pancreatic angiogenesis by regulating the activation of NLRP3 inflammasome
Citrinin derivatives have been found to have various pharmacological activities, such as anti-inflammatory, anti-tumor, an...
Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens
Antibiofilm activity of marine microbial natural products: potential peptide- and polyketide-derived molecules from marine microbes toward targeting biofilm-forming pathogens
Controlling and treating biofilm-related infections is challenging because of the widespread presence of multidrug-resista...
Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine
Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine
Fibroblast growth factor 21 (FGF21) is expressed in several organs, including the liver, adipose tissue, and cardiovascula...
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation
Andrographolide anti-proliferation and metastasis of hepatocellular carcinoma through LncRNA MIR22HG regulation
Hepatocellular carcinoma (HCC) treatment is a major challenge. Although andrographolide (Andro) has an anti-proliferation ...
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway
Celastrus orbiculatus extract suppresses gastric cancer stem cells through the TGF-β/Smad signaling pathway
Cancer stem cells (CSCs) are the primary source of tumor recurrence and chemoresistance, which complicates tumor treatment...
Highly sensitive indirect competitive enzyme-linked immunosorbent assay based on a monoclonal antibody against saikosaponin b2 for quality control of Kampo medicines containing Bupleuri radix
Highly sensitive indirect competitive enzyme-linked immunosorbent assay based on a monoclonal antibody against saikosaponin b2 for quality control of Kampo medicines containing Bupleuri radix
Saikosaponins are naturally occurring oleanane-type triterpenoids that are found in Bupleuri radix (root of Bupleurum falc...
2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs
2(3H)-Dihydrofranolactone metabolites from Pleosporales sp. NUH322 as anti-amyotrophic lateral sclerosis drugs
Amyotrophic lateral sclerosis (ALS) is a devastating motor disease with limited treatment options. A domestic fungal extra...
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