Huang X, Pan T, Yan L et al (2021) The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer. Genes Dis 8(6):781–797
Article CAS PubMed Google Scholar
Lin A, Zhang J, Luo P (2020) Crosstalk between the MSI status and tumor microenvironment in colorectal cancer. Front Immunol 11:2039
Article CAS PubMed PubMed Central Google Scholar
Skytthe MK, Graversen JH, Moestrup SK (2020) Targeting of CD163+ macrophages in inflammatory and malignant diseases. Int J Mol Sci 21(15):5497
Article CAS PubMed PubMed Central Google Scholar
Mantovani A, Dinarello CA, Molgora M et al (2019) Interleukin-1 and related cytokines in the regulation of inflammation and immunity. Immunity 50(4):778–795
Article CAS PubMed PubMed Central Google Scholar
Zhang Q, Wang Y, Wang Z et al (2022) Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond. Bioorg Chem 119:105542
Article CAS PubMed Google Scholar
Lawrence T (2009) The nuclear factor NF- B pathway in inflammation. Cold Spring Harbor Perspect Biol 1(6):a001651-a
Li Y, Xia J, Jiang N et al (2018) Corin protects H2O2-induced apoptosis through PI3K/AKT and NF-κB pathway in cardiomyocytes. Biomed Pharmacother 97:594–599
Article CAS PubMed Google Scholar
Li L, Yu R, Cai T et al (2020) Effects of immune cells and cytokines on inflammation and immunosuppression in the tumor microenvironment. Int Immunopharmacol 88:106939
Article CAS PubMed Google Scholar
Wang Y, Che M, Xin J et al (2020) The role of IL-1β and TNF-α in intervertebral disc degeneration. Biomed Pharmacother 131:110660
Article CAS PubMed Google Scholar
Chen B, Zhu D, Xie C et al (2021) 18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2. Food Funct 12(18):8399–8410
Article CAS PubMed Google Scholar
Mirzaei S, Saghari S, Bassiri F et al (2022) NF-κB as a regulator of cancer metastasis and therapy response: a focus on epithelial–mesenchymal transition. J Cell Physiol 237(7):2770–2795
Article CAS PubMed Google Scholar
Chen R, Kang R, Tang D (2022) The mechanism of HMGB1 secretion and release. Exp Mol Med 54(2):91–102
Article CAS PubMed PubMed Central Google Scholar
Wang S, Zhang Y (2020) HMGB1 in inflammation and cancer. J Hematol Oncol 13(1):116
Article CAS PubMed PubMed Central Google Scholar
Zha C, Meng X, Li L et al (2020) Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis. Cancer Biol Med 17(1):154–168
Article CAS PubMed PubMed Central Google Scholar
Chiappalupi S, Sorci G, Vukasinovic A et al (2020) Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia. J Cachexia Sarcopenia Muscle 11(4):929–946
Article PubMed PubMed Central Google Scholar
Zhang J, Liu Y, Chen H et al (2022) MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization. Cell Death Dis 13(4):411
Article PubMed PubMed Central Google Scholar
Montori M, Scorzoni C, Argenziano ME et al (2022) Cancer-associated fibroblasts in cholangiocarcinoma: current knowledge and possible implications for therapy. J Clin Med 11(21):6498
Article CAS PubMed PubMed Central Google Scholar
Sangaran PG, Ibrahim ZA, Chik Z et al (2021) LPS preconditioning attenuates apoptosis mechanism by inhibiting NF-κB and caspase-3 activity: TLR4 pre-activation in the signaling pathway of LPS-induced neuroprotection. Mol Neurobiol 58(5):2407–2422
Article CAS PubMed Google Scholar
Dang X, He B, Ning Q et al (2020) Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways. Respir Res 21(1):1–11
Ni Q, Gao Y, Yang X et al (2022) Analysis of the network pharmacology and the structure-activity relationship of glycyrrhizic acid and glycyrrhetinic acid. Front Pharmacol 13:1001018
Article CAS PubMed PubMed Central Google Scholar
Jin L, Zhu Z, Hong L et al (2023) ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation. Bioactive Mater 19:38–49
Wang S, Shen Y, Qiu R et al (2017) 18 β-glycyrrhetinic acid exhibits potent antitumor effects against colorectal cancer via inhibition of cell proliferation and migration. Int J Oncol 51(2):615–624
Article CAS PubMed Google Scholar
Yang H, Wang H, Andersson U (2020) Targeting inflammation driven by HMGB1. Front Immunol 11:484
Article CAS PubMed PubMed Central Google Scholar
Qiang X, Peng Y, Wang Z et al (2023) Synthesis of glycyrrhizin analogues as HMGB1 inhibitors and their activity against sepsis in acute kidney injury. Eur J Med Chem 259:115696
Article CAS PubMed Google Scholar
Shi X, Yu L, Zhang Y et al (2020) Glycyrrhetinic acid alleviates hepatic inflammation injury in viral hepatitis disease via a HMGB1-TLR4 signaling pathway. Int Immunopharmacol 84:106578
Article CAS PubMed PubMed Central Google Scholar
Zhang Q, Mohammed EAH, Wang Y et al (2020) Synthesis and anti-hepaticfibrosis of glycyrrhetinic acid derivatives with inhibiting COX-2. Bioorg Chem 99:103804
Article CAS PubMed Google Scholar
Chen Z, Wang C, Yu N et al (2019) INF2 regulates oxidative stress-induced apoptosis in epidermal HaCaT cells by modulating the HIF1 signaling pathway. Biomed Pharmacother 111:151–161
Article CAS PubMed Google Scholar
Sul O-J, Ra SW (2021) Quercetin prevents LPS-induced oxidative stress and inflammation by modulating NOX2/ROS/NF-kB in lung epithelial cells. Molecules 26(22):6949
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