Yu HY, Liu F, Li LQ, Jin MY, Yu X, Liu X, Li Y, Li L, Yan JK (2024) Recent advances in dietary polysaccharides from Allium species: preparation, characterization, and bioactivity. Int J Biol Macromol 277:e134130

Google Scholar 

Yan JK, Zhu J, Liu Y, Chen X, Wang W, Zhang H, Li L (2022) Recent advances in research on Allium plants: functional ingredients, physiological activities, and applications in agricultural and food sciences. Crit Rev Food Sci Nutr 63:8107–8135

PubMed  Google Scholar 

Kawashima K, Mimaki Y, Sashida Y (1991) Steroidal saponins from Allium giganteum and A. aflatunense. Phytochemistry 30:3063–3067

CAS  Google Scholar 

Mimaki Y, Kuroda M, Sashida Y (1999) Steroidal saponins from the bulbs of Allium aflatunense. Nat Med 53:88–93

CAS  Google Scholar 

Mimaki Y, Kawashima K, Kanmoto T, Sashida Y (1993) Steroidal glycosides from Allium albopilosum and A. ostrowskianum. Phytochemistry 34:799–805

CAS  PubMed  Google Scholar 

Mimaki Y, Kuroda M, Sashida Y (1999) Steroidal saponins from the bulbs of Allium ampeloprasum. Nat Med 53:134–137

CAS  Google Scholar 

Shimazaki T, Iguchi T, Kanda A, Yamamoto K, Takahashi N, Mimaki Y (2023) Six unprecedented steroidal glycosides from Allium atropurpureum bulbs and their cytotoxicities against SBC-3 human small-cell lung cancer cells. Phytochem Lett 57:200–209

CAS  Google Scholar 

Shimazaki T, Iguchi T, Takahashi Y, Yamamoto K, Takahashi N, Mimaki Y (2023) Determination of structure and cytotoxicity of ten undescribed steroidal glycosides from Allium cristophii x A. macleanii ‘Globemaster.’ Molecules 28:e6248

Google Scholar 

Sashida Y, Kawashima K, Mimaki Y (1991) Novel polyhydroxylated steroidal saponins from Allium giganteum. Chem Pharm Bull 39:698–703

CAS  Google Scholar 

Mimaki Y, Nikaido T, Matsumoto K, Sashida Y, Ohmoto T (1994) New steroidal saponins from the bulbs of Allium giganteum exhibiting potent inhibition of cAMP phosphodiesterase activity. Chem Pharm Bull 42:710–714

CAS  Google Scholar 

Mimaki Y, Kuroda M, Fukasawa T, Sashida Y (1999) Steroidal glycosides from the bulbs of Allium jesdianum. J Nat Med 62:194–197

CAS  Google Scholar 

Mimaki Y, Kuroda M, Fukasawa T, Sashida Y (1999) Steroidal saponins from the bulbs of Allium karataviense. Chem Pharm Bull 47:738–743

CAS  Google Scholar 

Kuroda M, Ori K, Takayama H, Sakagami H, Mimaki Y (2015) Karataviosides G-K, five new bisdesmosidic steroidal glycosides from the bulbs of Allium karataviense. Steroids 93:96–104

CAS  PubMed  Google Scholar 

Inoue T, Mimaki Y, Sashida Y, Nishino A, Satomi Y, Nishino H (1995) Steroidal glycosides from Allium macleanii and A. senescens, and their inhibitory activity on tumour promoter-induced phospholipid metabolism of HeLa cells. Phytochemistry 40:521–525

CAS  PubMed  Google Scholar 

Mimaki Y, Satou T, Ohmura M, Sashida Y (1996) Steroidal saponins from the bulbs of Allium narcissiflorum. Nat Med 50:308

CAS  Google Scholar 

Kawashima K, Mimaki Y, Sashida Y (1991) Schubertosides A-D, new (22S)-hydroxycholestane glycosides from Allium schubertii. Chem Pharm Bull 39:2761–2763

CAS  Google Scholar 

Kawashima K, Mimaki Y, Sashida Y (1993) Steroidal saponins from the bulbs of Allium schubertii. Phytochemistry 32:1267–1272

CAS  PubMed  Google Scholar 

Mimaki Y, Satou T, Kuroda M, Kameyama A, Sashida Y, Li HY, Harada N (1996) A new furostanol saponin with six sugars from the bulbs of Allium sphaerosephalon structural elucidation by modern NMR techniques. Chem Lett 6:431–432

Google Scholar 

Baba M, Ohmura M, Kishi N, Okada Y, Shibata S, Peng J, Yao SS, Nishino H, Okuyama T (2000) Saponins isolated from Allium chinense G. Don and antitumor-promoting activities of isoliquiritigenin and laxogenin from the same drug. Biol Pharm Bull 23:660–662

CAS  PubMed  Google Scholar 

Li X, Yan S, Lu J, Wang R, Ma X, Xiao X, Zhang Y, Jin H (2023) Two new phenolic amides from Allium chinense. Chin Herb Med 15:603–606

PubMed  PubMed Central  Google Scholar 

Yu Z, Zhang T, Zhou F, Xiao X, Ding X, He H, Rang J, Quan M, Wang T, Zuo M, Xia L (2015) Anticancer activity of saponins from Allium chinense against the B16 melanoma and 4T1 breast carcinoma cell. Evid Based Complement Alternat Med 2015:1–12

Google Scholar 

Veronika P, Dorothea PM, Clemens A, Joachim W, Kristiina B, Zsolt M, Balazs D (2025) Prophylactic cranial irradiation for small cell lung cancer in the era of immunotherapy and molecular subtypes. Curr Opin Oncol 37:27–34

Google Scholar 

Bertaglia V, Petrelli F, Dottorini L, Carnio S, Morelli AM, Nepote A, Maccioni A, Scartozzi M, Solinas C, Novello S (2025) Chemotherapy plus immunotherapy as first line combination in order patients with extensive stage small cell lung cancer: a systematic review and meta-analysis. Semin Oncol 52:14–18

CAS  PubMed  Google Scholar 

Qiang M, Liu H, Yang L, Wang H, Guo R (2024) Immunotherapy for small cell lung cancer: the current state and future trajectories. Discov Oncol 15:e355

Google Scholar 

Matsuura H, Ushiroguchi T, Itakura Y, Fuwa T (1989) A furostanol glycoside from Allium chinense G. Don Chem Pharm Bull 37:1390–1391

CAS  Google Scholar 

Kuroda M, Mimaki Y, Kameyama A, Sashida Y, Nikaido T (1995) Steroidal saponins from Allium chinense and their inhibitory activities on cyclic AMP phosphodiesterase and Na+/K+ ATPase. Phytochemistry 40:1071–1076

CAS  PubMed  Google Scholar 

Kubo S, Mimaki Y, Sashida Y, Nikaido T, Ohmoto T (1992) Steroidal saponins from the rhizomes of Smilax sieboldii. Phytochemistry 31:2445–2450

CAS  PubMed  Google Scholar 

Skhirtladze AV, Benidze MN, Kemertelidze EP, Grigolava BL, Sturm S, Ganzera M (2015) Steroid composition of fruit from Yucca gloriosa introduced into Georgia. Chem Nat Comp 51:283–288

CAS  Google Scholar 

Su L, Chen G, Feng SG, Wang W, Li ZF, Chen H, Liu YX, Pei YH (2009) Steroidal saponins from Tribulus terrestris. Steroids 74:399–403

CAS  PubMed  Google Scholar 

Koopman G, Reutelingsperger CPM, Kuijten GAM, Keehnen RMJ, Pals ST, van Oers MHJ (1994) Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood 84:1415–1420

CAS  PubMed  Google Scholar 

Eeva J, Nuutinen U, Ropponen A, Mättö M, Eray M, Pellinen R, Wahlfors J, Pelkonen J (2009) The involvement of mitochondrial and the capase-9 activation pathway in rituximab-induced apoptosis in FL cells. Apoptosis 14:687–698

CAS  PubMed  Google Scholar 

Fleury C, Mignotte B, Vayssière JL (2002) Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84:131–141

CAS  PubMed  Google Scholar 

Conza GD, Ho PC (2020) ER stress response: an emerging modulator for innate immunity. Cells 9:e695

Google Scholar 

Liu J, Ren LJ, Wang HW, Li Z (2023) Isoquercitrin induces endoplasmic reticulum stress and immunogenic cell death in gastric cancer cells. Biochem Genet 61:1128–1142

CAS  PubMed  Google Scholar 

Chen P, Zhang X, Fang Q, Zhao Z, Lin C, Zhou Y, Liu F, Zhu C, Wu A (2024) Betulinic acid induces apoptosis of HeLa cells via ROS-dependent ER stress and autophagy in vitro and in vino. J Nat Med 78:677–692

CAS  PubMed  Google Scholar 

Peng SY, Tang JY, Lan TH, Shiau JP, Chen KL, Jeng JH, Yen CY, Chang HW (2023) Oxidative-stress-mediated ER stress is involved in Regulating manoalide-induced antiproliferation in oral cancer cells. Int J Mol Sci 24:e3987

Google Scholar 

Ge G, Yan Y, Cai H (2017) Ginsenoside Rh2 inhibited proliferation by inducing ROS mediated ER stress dependent apoptosis in lung cancer cells. Biol Pharm Bull 40:2117–2124

CAS  PubMed  Google Scholar 

Wang YY, Lee KT, Lim MC, Choi JH (2020) TRPV1 antagonist DWP05195 induces ER stress-dependent apoptosis through the ROS-p38-CHOP pathway in human ovarian cancer cells. Cancers 12:e1702

Google Scholar 

Oyadomari S, Mori M (2004) Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11:381–389

CAS  PubMed  Google Scholar 

Bezu L, Sauvat A, Humeau J, Leduc M, Kepp O, Kroemer G (2018) eIF2α phosphorylation: a hallmark of immunogenic cell death. Oncoimmunology 7:e1431089

PubMed  PubMed Central  Google Scholar 

Gardai SJ, McPhillips KA, Frasch SC, Janssen WJ, Starefeldt A, Murphy-Ullrich JE, Bratton DL, Oldenborg PA, Michalak M, Henson PM (2005) Cell-surface calreticulin initiates clearance of viable or apoptotic cell through trans-activation of LRP on the phagocyte. Cell 123:321–334

CAS  PubMed  Google Scholar 

Zitvogel L, Kepp O, Senovilla L, Menger L, Chaput N, Kroemer G (2010) Immunogenic tumor cell death for optimal anticancer therapy: The calreticulin exposure pathway. Clin Cancer Res 16:3100–3104

CAS  PubMed  Google Scholar 

Ahmed A, Tait SWG (2020) Targeting immunogenic cell death in cancer. Mol Oncol 14:2994–3006

CAS  PubMed  PubMed Central  Google Scholar 

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