Kim EA, Kim SY, Kim J, Oh JY, Kim HS, Yoon WJ, Kang DH, Heo SJ (2019) Tuberatolide B isolated from Sargassum macrocarpum inhibited LPS-stimulated inflammatory response via MAPKs and NF-κB signaling pathway in RAW264.7 cells and zebrafish model. J Funct Foods 52:109–115

Article  CAS  Google Scholar 

Kamei Y, Sueyoshi M, Hayashi K, Terada R, Nozaki H (2009) The novel anti-Propionibacterium acnes compound, Sargafuran, found in the marine brown alga Sargassum macrocarpum. J Antibiot 62:259–263

Article  CAS  Google Scholar 

Sugiura Y, Misumi S, Yamatani H, Kusakawa M, Katsuzaki H, Hayashi Y, Murase N (2025) Three antiallergic meroterpenoids derived from the brown alga Sargassum macrocarpum. J Appl Phycol 37:2095–2105

Article  CAS  Google Scholar 

Cao L, Lee B, Lee BH, Lee S, Kim HR (2024) Sargahydroquinoic acid from Sargassum macrocarpum attenuates TNF-α and UV-induced skin aging in human dermal fibroblasts. Algal Res 78:1030410

Article  Google Scholar 

Niwa H, Kurimoto SI, Kubota T, Sekiguchi M (2021) Macrocarquinoids A-C, new meroterpenids from Sargassum macrocarpum. J Nat Med 75:194–200

Article  PubMed  CAS  Google Scholar 

Shinoda S, Kurimoto SI, Kubota T, Sekiguchi M (2022) Macrocarquinoid D, new meroterpenoid from Sargassum macrocarpum. Heterocycles 104:1141–1147

Article  CAS  Google Scholar 

Shinoda S, Tozawa Y, Kurimoto SI, Shigemori H, Sekiguchi M (2023) Three new meroterpenoids from Sargassum macrocarpum and their inhibitory activity against amyloid β aggregation. J Nat Med 77:508–515

Article  PubMed  CAS  Google Scholar 

Tozawa Y, Shinoda S, Sekiguchi M, Miyamae Y, Shigemori H (2024) Effect of meroterpenoids from Sargassum macrocarpum on the inhibition of amyloid polypeptide aggregation. Biol Pharm Bull 47:1961–1968

Article  PubMed  CAS  Google Scholar 

Sekiguchi M, Horiuchi M, Tozawa Y, Shigemori H (2025) Seven undescribed meroterpenoids from Sargassum siliquastrum and their inhibitory activity against amyloid β aggregation. J Nat Med 79:73–81

Article  PubMed  CAS  Google Scholar 

Segawa M, Shirahama H (1987) New plastoquinones from the brown alga Sargassum sagamianum var yezoense. Chem Lett. https://doi.org/10.1246/cl.1987.1365

Article  Google Scholar 

Li B, Lee JB, Hayashi K, Ito Y, Sun WJ, Wang X, Kano Y, Hayashi T (2010) Two new monoterpenes from Sibiraea angustata. J Nat Med 64:89–92

Article  PubMed  CAS  Google Scholar 

Imamura T, Isozumi N, Higashimura Y, Koga H, Segawa T, Desaka N, Takagi H, Matsumoto K, Ohki S, Mori M (2022) Red-beet betalain pigments inhibit amyloid-β aggregation and toxicity in amyloid-β expressing Caenorhabditis elegans. Plant Foods Hum Nutr 77:90–97

Article  PubMed  CAS  Google Scholar 

Sekiguchi M, Horiuchi M, Tanaka A, Yamada Y, Tozawa Y, Higashimura Y, Shigemori H (2025) Inhibitory activity of amyloid-β aggregation by flavonoids and rosmarinic acid related compounds isolated from Zostera marina. Biosci Biotechnol Biochem 87:941–944

Article  Google Scholar 

Naiki H, Gejyo F (1999) Kinetic analysis of amyloid fibril formation. Methods Enzymol 309:305–318

Article  PubMed  CAS  Google Scholar 

Link CD (1995) Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans. Proc Natl Acad Sci U S A 92:9368–9372

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chen XQ, Mobley WC (2019) Alzheimer disease pathogenesis: insights from molecular and cellular biology studies of oligomeric Aβ and tau species. Front Neurosci 13:659

Article  PubMed  PubMed Central  Google Scholar