Rai SN, Mishra D, Singh P et al (2021) Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases. Biomed Pharmacother 137:111377. https://doi.org/10.1016/J.BIOPHA.2021.111377
Article PubMed CAS Google Scholar
Spangenberg ET, Moneypenny A, Bozzo GG, Perreault ML (2025) Unveiling the role of erinacines in the neuroprotective effects of Hericium erinaceus: a systematic review in preclinical models. Front Pharmacol 16:1582081. https://doi.org/10.3389/FPHAR.2025.1582081/BIBTEX
Article PubMed PubMed Central CAS Google Scholar
Friedman M (2015) Chemistry, nutrition, and health-promoting properties of hericium erinaceus (Lion’s Mane) mushroom fruiting bodies and mycelia and their bioactive compounds. J Agric Food Chem 63:7108–7123. https://doi.org/10.1021/ACS.JAFC.5B02914
Article PubMed CAS Google Scholar
Cui FJ, Li YH, Zan XY et al (2014) Purification and partial characterization of a novel hemagglutinating glycoprotein from the cultured mycelia of Hericium erinaceus. Process Biochem 49:1362–1369. https://doi.org/10.1016/J.PROCBIO.2014.04.008
Wang K, Bao L, Qi Q et al (2015) Erinacerins C–L, isoindolin-1-ones with α-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus. J Nat Prod 78:146–154. https://doi.org/10.1021/np5004388
Article PubMed CAS Google Scholar
Kostanda E, Musa S, Pereman I (2024) Unveiling the chemical composition and biofunctionality of hericium spp. fungi: a comprehensive overview. Int J Mol Sci 25:5949. https://doi.org/10.3390/IJMS25115949
Article PubMed PubMed Central CAS Google Scholar
Doar E, Meyer KW, Bair ZJ et al (2025) Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus. Fungal Biol Biotechnol 12:4. https://doi.org/10.1186/S40694-025-00194-9
Article PubMed PubMed Central CAS Google Scholar
Chien RC, Chen SY, Mishchuk DO, Slupsky CM (2023) Hydrophilic metabolite composition of fruiting bodies and mycelia of edible mushroom species (Agaricomycetes). Int J Med Mushrooms 25:27–40. https://doi.org/10.1615/INTJMEDMUSHROOMS.2023050034
Bailly C, Gao JM (2020) Erinacine A and related cyathane diterpenoids: molecular diversity and mechanisms underlying their neuroprotection and anticancer activities. Pharmacol Res 159:104953. https://doi.org/10.1016/J.PHRS.2020.104953
Article PubMed CAS Google Scholar
Qi J, Gao YQ, Kang SJ et al (2023) Secondary metabolites of bird’s nest fungi: chemical structures and biological activities. J Agric Food Chem 71:6513–6524. https://doi.org/10.1021/ACS.JAFC.3C00904
Article PubMed CAS Google Scholar
Qi J, Wu J, Kang S et al (2024) The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review. Chin J Nat Med 22:676–698. https://doi.org/10.1016/S1875-5364(24)60590-X
Article PubMed CAS Google Scholar
Li IC, Lee LY, Tzeng TT et al (2018) Neurohealth properties of Hericium erinaceus mycelia enriched with erinacines. Behav Neurol 2018:5802634. https://doi.org/10.1155/2018/5802634
Article PubMed PubMed Central Google Scholar
Othman A, Amen Y, Shimizu K (2025) Hericenones from hericium erinaceus (Bull.) Pers.: a scoping review of structural diversity and health benefits. Chem Biodivers. https://doi.org/10.1002/cbdv.202502560
Kawagishi H, Shimada A, Shirai R et al (1994) Erinacines A, B and C, strong stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett 35:1569–1572. https://doi.org/10.1016/S0040-4039(00)76760-8
Kawagishi H, Simada A, Shizuki K et al (1996) Erinacine D, a stimulator of NGF-synthesis, from the mycelia of hericium erinaceum. Heterocycl Comm 2:51–54. https://doi.org/10.1515/HC.1996.2.1.51/MACHINEREADABLECITATION/RIS
Kawagishi H, Shimada A, Hosokawa S et al (1996) Erinacines E, F, and G, stimulators of nerve growth factor (NGF)-synthesis, from the mycelia of Hericium erinaceum. Tetrahedron Lett 37:7399–7402. https://doi.org/10.1016/0040-4039(96)01687-5
Lee EW, Shizuki K, Hosokawa S et al (2000) Two novel diterpenoids, erinacines H and I from the mycelia of hericium erinaceum. Biosci Biotechnol Biochem 64:2402–2405. https://doi.org/10.1271/BBB.64.2402
Article PubMed CAS Google Scholar
Kenmoku H, Sassa T, Kato N (2000) Isolation of erinacine P, a new parental metabolite of cyathane-xylosides, from Hericium erinaceum and its biomimetic conversion into erinacines A and B. Tetrahedron Lett 41:4389–4393. https://doi.org/10.1016/S0040-4039(00)00601-8
Kenmoku H, Shimai T, Toyomasu T et al (2002) Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete. Biosci Biotechnol Biochem 66:571–575. https://doi.org/10.1271/BBB.66.571
Article PubMed CAS Google Scholar
Shimbo M, Kawagishi H, Yokogoshi H (2005) Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats. Nutr Res 25:617–623. https://doi.org/10.1016/J.NUTRES.2005.06.001
Ma BJ, Zhou Y, Li LZ et al (2008) A new cyathane-xyloside from the mycelia of hericium erinaceum. Zeitschrift fur naturforschung -. Sect B J Chem Sci 63:1241–1242. https://doi.org/10.1515/ZNB-2008-1017/MACHINEREADABLECITATION/RIS
Xu Z, Yan S, Bi K et al (2013) Isolation and identification of a new anti-inflammatory cyathane diterpenoid from the medicinal fungus Cyathus hookeri Berk. Fitoterapia 86:159–162. https://doi.org/10.1016/J.FITOTE.2013.03.002
Article PubMed CAS Google Scholar
Lee KF, Chen JH, Teng CC et al (2014) Protective effects of hericium Erinaceus mycelium and its isolated erinacine A against Ischemia-Injury-Induced neuronal cell death via the Inhibition of iNOS/p38 MAPK and Nitrotyrosine. Int J Mol Sci 2014 15:15073–15089. https://doi.org/10.3390/IJMS150915073
Chen CC, Tzeng TT, Chen CC et al (2016) Erinacine S, a rare sesterterpene from the mycelia of Hericium erinaceus. J Nat Prod 79:438–441. https://doi.org/10.1021/ACS.JNATPROD.5B00474
Article PubMed CAS Google Scholar
Zhang CC, Cao CY, Kubo M et al (2017) Chemical constituents from Hericium erinaceus promote neuronal survival and potentiate neurite outgrowth via the TrkA/Erk1/2 pathway. Int J Mol Sci 18:1659. https://doi.org/10.3390/IJMS18081659
Article PubMed PubMed Central Google Scholar
Tzeng TT, Chen CC, Chen CC et al (2018) The cyanthin diterpenoid and sesterterpene constituents of Hericium erinaceus mycelium ameliorate Alzheimer’s disease-related pathologies in APP/PS1 transgenic mice. Int J Mol Sci 19(2):598. https://doi.org/10.3390/IJMS19020598
Article PubMed PubMed Central Google Scholar
Zhang Y, Liu L, Bao L et al (2018) Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus. J Antibiot 71:818–821. https://doi.org/10.1038/S41429-018-0065-8
Rupcic Z, Rascher M, Kanaki S et al (2018) Two new cyathane diterpenoids from mycelial cultures of the medicinal mushroom Hericium erinaceus and the rare species, Hericium flagellum. Int J Mol Sci 19:740. https://doi.org/10.3390/IJMS19030740
Article PubMed PubMed Central Google Scholar
Wang LY, Huang CS, Chen YH et al (2019) Anti-inflammatory effect of erinacine C on NO production through down-regulation of NF-κB and activation of Nrf2-mediated HO-1 in BV2 microglial cells treated with LPS. Molecules 24:3317. https://doi.org/10.3390/MOLECULES24183317
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