Amara S, Pasumarthi A, Parikh N, Kodali N, Lebwohl M, Monks G (2025) Psoriasis management tree based on comorbidity. Int J Dermatol 64:229–245. https://doi.org/10.1111/ijd.17497
Fernandez-Figueras MT, Puig L (2024) Histopathological diagnosis of psoriasis and psoriasiform dermatitides. Diagn Histopathol 31:87–97. https://doi.org/10.1016/j.mpdhp.2024.11.005
Elkhawaga OY, Ellety MM, Mofty SO, Ghanem MS, Mohamed AO (2023) Review of natural compounds for potential psoriasis treatment. Inflammopharmacology 31:1183–1198. https://doi.org/10.1007/s10787-023-01178-0
Article PubMed PubMed Central CAS Google Scholar
Lee HJ, Kim M (2023) Challenges and future trends in the treatment of psoriasis. Int J Mol Sci 24:13313. https://doi.org/10.3390/ijms241713313
Article PubMed PubMed Central CAS Google Scholar
Yi X, Jiang XJ, Fang ZM (2019) Histone methyltransferase SMYD2: ubiquitous regulator of disease. Clin Epigenetics 11:112. https://doi.org/10.1186/s13148-019-0711-4
Article PubMed PubMed Central Google Scholar
Zeng Y, Qiu R, Yang Y, Gao T, Zheng Y, Huang W et al (2019) Regulation of EZH2 by SMYD2-mediated lysine methylation is implicated in tumorigenesis. Cell Rep 29:1482–1498e4. https://doi.org/10.1016/j.celrep.2019.10.004
Article PubMed CAS Google Scholar
Wu W, Wang J, Xiao C, Su Z, Su H, Zhong W et al (2021) SMYD2-mediated TRAF2 methylation promotes the NF-κB signaling pathways in inflammatory diseases. Clin Transl Med 11:e591. https://doi.org/10.1002/ctm2.591
Article PubMed PubMed Central CAS Google Scholar
Zhao Z, Yang X (2024) Inhibition of SMYD2 attenuates paraquat-induced pulmonary fibrosis by inhibiting the epithelial–mesenchymal transition through the GLIPR2/ERK/p38 axis. Pestic Biochem Physiol 202:105971. https://doi.org/10.1016/j.pestbp.2024.105971
Article PubMed CAS Google Scholar
Xu G, Liu G, Xiong S, Liu H, Chen X, Zheng B (2015) The histone methyltransferase SMYD2 is a negative regulator of macrophage activation by suppressing interleukin-6 and tumor necrosis factor-α production. J Biol Chem 290:5414–5423. https://doi.org/10.1074/jbc.M114.610345
Article PubMed PubMed Central CAS Google Scholar
Romhányi D, Bessenyei Á, Szabó K, Kemény L, Gyulai R, Groma G (2025) Unveiling the role of histone methyltransferases in psoriasis pathogenesis: insights from transcriptomic analysis. Int J Mol Sci 26:6329. https://doi.org/10.3390/ijms26136329
Article PubMed PubMed Central CAS Google Scholar
Dorna D, Grabowska A, Paluszczak J (2025) Natural products modulating epigenetic mechanisms by affecting histone methylation/demethylation: targeting cancer cells. Br J Pharmacol 182:2137–2158. https://doi.org/10.1111/bph.16237
Article PubMed CAS Google Scholar
Müller A, Dickmanns A, Resch C, Schäkel K, Hailfinger S, Dobbelstein M et al (2020) The CDK4/6–EZH2 pathway is a potential therapeutic target for psoriasis. J Clin Invest 130:5765–5781. https://doi.org/10.1172/JCI134217
Article PubMed PubMed Central Google Scholar
Johansen C, Mose M, Ommen P, Bertelsen T, Vinter H, Hailfinger S et al (2015) IκBζ is a key driver in the development of psoriasis. Proc Natl Acad Sci USA 112:E5825–E5833. https://doi.org/10.1073/pnas.1509971112
Article PubMed PubMed Central CAS Google Scholar
Qu S, Liu Z, Wang B (2021) EZH2 is involved in psoriasis progression by impairing miR-125a-5p inhibition of SFMBT1 and leading to inhibition of the TGFβ/SMAD pathway. Ther Adv Chronic Dis 12:2040622320987348. https://doi.org/10.1177/2040622320987348
Article PubMed PubMed Central CAS Google Scholar
Müller A, Hennig A, Lorscheid S, Grondona P, Schulze-Osthoff K, Hailfinger S et al (2018) IκBζ is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes. Proc Natl Acad Sci USA 115:10088–10093. https://doi.org/10.1073/pnas.1801377115
Article PubMed PubMed Central CAS Google Scholar
Zhang T, Yang L, Ke Y, Lei J, Shen S, Shao S et al (2020) EZH2-dependent epigenetic modulation of histone H3 lysine-27 contributes to psoriasis by promoting keratinocyte proliferation. Cell Death Dis 11:826. https://doi.org/10.1038/s41419-020-03028-1
Article PubMed PubMed Central CAS Google Scholar
Liu Y, Luo W, Chen S (2011) Comparison of gene expression profiles reveals aberrant expression of FOXO1, Aurora A/B and EZH2 in lesional psoriatic skins. Mol Biol Rep 38:4219–4224. https://doi.org/10.1007/s11033-010-0544-x
Article PubMed CAS Google Scholar
Sun S, Zhang X, Xu M, Zhang F, Tian F, Cui J et al (2019) Berberine downregulates CDC6 and inhibits proliferation via targeting JAK–STAT3 signaling in keratinocytes. Cell Death Dis 10:274. https://doi.org/10.1038/s41419-019-1510-8
Article PubMed PubMed Central CAS Google Scholar
Phan C, Touvier M, Kesse-Guyot E, Adjibade M, Hercberg S, Wolkenstein P et al (2018) Association between Mediterranean anti-inflammatory dietary profile and severity of psoriasis. JAMA Dermatol 154:1017–1024. https://doi.org/10.1001/jamadermatol.2018.2127
Article PubMed PubMed Central Google Scholar
Barrea L, Balato N, Di Somma C, Macchia PE, Napolitano M, Savanelli MC et al (2015) Nutrition and psoriasis: association between disease severity and adherence to the mediterranean diet. J Transl Med 13:18. https://doi.org/10.1186/s12967-014-0372-1
Article PubMed PubMed Central Google Scholar
Korovesi A, Dalamaga M, Kotopouli M, Papadavid E (2019) Adherence to the mediterranean diet is independently associated with psoriasis risk, severity, and quality of life. Int J Dermatol 58:e164–e165. https://doi.org/10.1111/ijd.14523
Almanza-Aguilera E, Cano A, Gil-Lespinard M, Burguera N, Zamora-Ros R, Agudo A et al (2023) Mediterranean diet and Olive oil, microbiota, and obesity-related cancers. Semin Cancer Biol 95:103–119. https://doi.org/10.1016/j.semcancer.2023.08.001
Article PubMed CAS Google Scholar
Donato-Trancoso A, Correa Atella G, Romana-Souza B (2022) Dietary olive oil intake aggravates psoriatic skin inflammation in mice via Nrf2 activation. Int Immunopharmacol 108:108851. https://doi.org/10.1016/j.intimp.2022.108851
Article PubMed CAS Google Scholar
Rashid SA, Bashir S, Ullah H, Shah KU, Khan DH, Shah PA et al (2021) Methotrexate–olive oil nano-emulsion for topical application. Pak J Pharm Sci 34:205–215. https://doi.org/10.36721/PJPS.2021.34.1.SUP.205-215.1
Article PubMed CAS Google Scholar
De Stefanis D, Costelli P (2025) Extra virgin olive oil components and pro-inflammatory cytokines. Nutrients 17:2334. https://doi.org/10.3390/nu17142334
Article PubMed PubMed Central CAS Google Scholar
Rashid SA, Bashir S, Naseem F, Farid A, Rather IA, Hakeem KR (2021) Olive oil-based methotrexate nanoemulsion gel for psoriasis. Biology (Basel) 10:1121. https://doi.org/10.3390/biology10111121
Article PubMed PubMed Central CAS Google Scholar
Anwar MJ, Anwar MH, Imran M, Noman AM, Hussain M, Raza H, Mohamed HM, Mohamed GA, Ibrahim SRM, Yehuala TF, Alsagaby SA, Al Abdulmonem W, Abdelgawad MA, Mostafa EM, Ghoneim MM, Selim S (2025) Olive oil polyphenols: a promising approach for cancer prevention and therapy. Food Sci Nutr 13:e70976. https://doi.org/10.1002/fsn3.70976
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