Hendriks LEL, Remon J, Faivre-Finn C, Garassino MC, Heymach JV, Kerr KM et al (2024) Non-small-cell lung cancer. Nat Rev Dis Primers 10(1):71
Zhao C, Zhang R, Yang H, Gao Y, Zou Y, Zhang X (2024) Antibody-drug conjugates for non-small cell lung cancer: advantages and challenges in clinical translation. Biochem Pharmacol 226:116378
Article PubMed CAS Google Scholar
Rajaram R, Huang Q, Li RZ, Chandran U, Zhang Y, Amos TB et al (2024) Recurrence-free survival in patients with surgically resected non-small cell lung cancer: A systematic literature review and meta-analysis. Chest 165(5):1260–1270
Petrella F, Rizzo S, Attili I, Passaro A, Zilli T, Martucci F et al (2023) Stage Iii non-small-cell lung cancer: an overview of treatment options. Curr Oncol 30(3):3160–3175
Article PubMed PubMed Central Google Scholar
Talib WH, Alsalahat I, Daoud S, Abutayeh RF, Mahmod AI (2020) Plant-derived natural products in cancer research: Extraction, mechanism of action, and drug formulation. Molecules 25(22):5319
Article PubMed PubMed Central CAS Google Scholar
Lin SR, Chang CH, Hsu CF, Tsai MJ, Cheng H, Leong MK et al (2020) Natural compounds as potential adjuvants to cancer therapy: preclinical evidence. Br J Pharmacol 177(6):1409–1423
Article PubMed CAS Google Scholar
Kretzing S, Abraham G, Seiwert B, Ungemach FR, Krugel U, Teichert J et al (2011) In vivo assessment of antiemetic drugs and mechanism of lycorine-induced nausea and emesis. Arch Toxicol 85(12):1565–1573
Article PubMed CAS Google Scholar
Nair JJ, van Staden J (2014) Cytotoxicity studies of Lycorine alkaloids of the Amaryllidaceae. Nat Prod Commun 9(8):1193–1210
Qi J, Meng M, Liu J, Song X, Chen Y, Liu Y et al (2023) Lycorine inhibits pancreatic cancer cell growth and neovascularization by inducing notch1 degradation and downregulating key vasculogenic genes. Biochem Pharmacol 217:115833
Article PubMed CAS Google Scholar
Yang C, Xiang H, Fu K, Jin L, Yuan F, Xue B et al (2022) Lycorine suppresses cell growth and invasion via down-regulation of nedd4 ligase in bladder cancer. Am J Cancer Res 12(10):4708–4720
PubMed PubMed Central CAS Google Scholar
Li L, Zhang Z, Yang Q, Ning M (2019) Lycorine inhibited the cell growth of non-small cell lung cancer by modulating the mir-186/cdk1 axis. Life Sci 231:116528
Article PubMed CAS Google Scholar
Jiang ZB, Xu C, Xu P, Huang DH, Kang LP (2024) Lycorine suppresses non-small-cell lung cancer progression through activating Sting pathway and stimulating an antitumor immune response. Chem Biol Drug Des 104(6):e70036
Article PubMed CAS Google Scholar
Xia F, Yang H, Wu H, Zhao B (2024) Spindle component 25 predicts the prognosis and the immunotherapy response of cancers: A pan-cancer analysis. Sci Rep 14(1):8452
Article PubMed PubMed Central CAS Google Scholar
Liao LX, Zhang M, Xu X, Zhang S, Guo YZ (2024) Spc25 functions as a prognostic-related biomarker, and its high expression correlates with tumor immune infiltration and Ucec progression. Front Biosci (Landmark Ed) 29(2):69
Chen J, Chen H, Yang H, Dai H (2018) Spc25 upregulation increases cancer stem cell properties in non-small cell lung adenocarcinoma cells and independently predicts poor survival. Biomed Pharmacother 100:233–239
Article PubMed CAS Google Scholar
Lv M, Chen X, Yang Q, Huang C, Lv Y, Zhang T et al (2025) Berberine restrains non-small cell lung cancer cell growth, invasion and Glycolysis via inactivating the spc25/nuf2 pathway. Naunyn Schmiedebergs Arch Pharmacol 398(6):7439–7451
Article PubMed CAS Google Scholar
Shen H, Geng Z, Nie X, Liu T (2023) Erianin induces ferroptosis of renal cancer stem cells via promoting alox12/p53 Mrna n6-methyladenosine modification. J Cancer 14(3):367–378
Article PubMed PubMed Central CAS Google Scholar
Chen N, Li P, Liu L, Zhang J, Cao Z, Chen Z et al (2023) Cucurbitacin Iib extracted from Hemsleya penxianensis induces cell cycle arrest and apoptosis in bladder cancer cells by regulating cell cycle checkpoints and mitochondrial apoptotic pathway. Plant Foods Hum Nutr 78(2):483–492
Article PubMed CAS Google Scholar
Xue Q, Wang B, Feng J, Li C, Yu M, Zhao Y et al (2024) Lycorine (lycoris radiata)-a unique natural medicine on breast cancer. J Cell Mol Med 28(16):e70032
Article PubMed PubMed Central CAS Google Scholar
Zhuo FF, Li L, Liu TT, Liang XM, Yang Z, Zheng YZ et al (2025) Lycorine promotes idh1 acetylation to induce mitochondrial dynamics imbalance in colorectal cancer cells. Cancer Lett 614:217533
Article PubMed CAS Google Scholar
Zhai J, Jiang JF, Shi L (2023) Lycorine weakens Tamoxifen resistance of breast cancer via abrogating haglr-mediated epigenetic suppression on vgll4 by dnmt1. Kaohsiung J Med Sci 39(3):278–289
Article PubMed PubMed Central CAS Google Scholar
Sun Y, Wu P, Sun Y, Sharopov FS, Yang Q, Chen F et al (2018) Lycorine possesses notable anticancer potentials in on-small cell lung carcinoma cells via blocking wnt/beta-catenin signaling and epithelial-mesenchymal transition (emt). Biochem Biophys Res Commun 495(1):911–921
Article PubMed CAS Google Scholar
Wang Q, Zhu Y, Li Z, Bu Q, Sun T, Wang H et al (2019) Up-regulation of spc25 promotes breast cancer. Aging 11(15):5689–5704
Article PubMed PubMed Central CAS Google Scholar
Jiang X, Yang M, Zhang W, Shi D, Li Y, He L et al (2024) Targeting the spc25/riok1/myh9 axis to overcome tumor stemness and platinum resistance in epithelial ovarian cancer. Adv Sci (Weinh) 11(47):e2406688
Article PubMed PubMed Central Google Scholar
Su M, Luo J, Chen W, Li X, Ye D, Zeng X et al (2024) Spc25 activates the Warburg effect to inhibit ferroptosis in prostate cancer cells. Am J Mens Health 18(6):15579883241297880
Article PubMed PubMed Central Google Scholar
Zhang W, Yu L, Xu C, Tang T, Cao J, Chen L et al (2024) Plek2 activates the pi3k/akt signaling pathway to drive lung adenocarcinoma progression by upregulating spc25. Cell Biol Int 48(9):1285–1300
Article PubMed CAS Google Scholar
Liu XS, Zhang Y, Ming X, Hu J, Chen XL, Wang YL et al (2024) Spc25 as a novel therapeutic and prognostic biomarker and its association with glycolysis, ferroptosis and Cerna in lung adenocarcinoma. Aging 16(1):779–798
PubMed PubMed Central CAS Google Scholar
Ye B, Yang G, Li Y, Zhang C, Wang Q, Yu G (2020) Znf143 in chromatin looping and gene regulation. Front Genet 11:338
Article PubMed PubMed Central CAS Google Scholar
Dong Y, Hu M, Tan K, Dai R (2023) Znf143 inhibits hepatocyte mitophagy and promotes non-alcoholic fatty liver disease by targeting increased Lncrna neat1 expression to activate rock2 pathway. Epigenetics 18(1):2239592
Article PubMed PubMed Central Google Scholar
Zhang Y, Li Q, Wei S, Sun J, Zhang X, He L et al (2020) Znf143 suppresses cell apoptosis and promotes proliferation in gastric cancer via ros/p53 axis. Dis Markers 2020:5863178
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