Baos S, Calzada D, Cremades L, Sastre J, Quiralte J, Florido F, Lahoz C, Cárdaba B (2017) Biomarkers associated with disease severity in allergic and nonallergic asthma. Mol Immunol 82:34–45. https://doi.org/10.1016/j.molimm.2016.12.012

Article  CAS  PubMed  Google Scholar 

Bateman ED, Hurd SS, Barnes PJ, Bousquet J, razen JM, FitzGerald JM, Gibson P, Ohta K, O’Byrne P, Pedersen SE, Pizzichini E, Sullivan SD, Wenzel SE, Zar HJ (2008) Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J 31(1) ,143 – 78. https://doi.org/10.1183/09031936.00138707

Kim HY, DeKruyff RH, Umetsu DT (2010) The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol 11(7):577–584. https://doi.org/10.1038/ni.1892

Article  CAS  PubMed  PubMed Central  Google Scholar 

Munroe ME, Businga TR, Kline JN, Bishop GA (2010) Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma. J Immunol 185(9):5586–5597. https://doi.org/10.4049/jimmunol.1000630

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belice PJ, Becker EA (2017) Effective education parameters for trigger remediation in underserved children with asthma: A systematic review. J Asthma 54(2):186–201. https://doi.org/10.1080/02770903.2016.1198374

Article  PubMed  Google Scholar 

Ding G, Ji R, Bao Y (2015) Risk and protective factors for the development of childhood asthma. Paediatr Respir Rev 16(2):133–139. https://doi.org/10.1016/j.prrv.2014.07.004

Article  PubMed  Google Scholar 

Global Initiative for Asthma (2017) Global Strategy Report for Asthma Management and Prevention (online Appendix). http://ginasthma.org/gina-reports

Pilette C, Canonica GW, Chaudhuri R, Chupp G, Lee FE, Lee JK, Almonacid C, Welte T, Alfonso-Cristancho R, Jakes RW, Maxwell A, Price RG, Howarth P (2022) REALITI-A study: Real-World oral Corticosteroid-Sparing effect of mepolizumab in severe asthma. J Allergy Clin Immunology-In Pract 10(10):2646–2656. https://doi.org/10.1016/j.jaip.2022.05.042

Article  CAS  Google Scholar 

Fanta CH (2009) Asthma. N Engl J Med 360(10):1002–1014

Article  CAS  PubMed  Google Scholar 

Bush A, Saglani S (2010) Management of severe asthma in children. Lancet 376(9743):814–825

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li XM, Brown L (2009) Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy. J Allergy Clin Immunol 123(2):297–306. https://doi.org/10.1016/j.jaci.2008.12.026

Article  PubMed  PubMed Central  Google Scholar 

Lin L, Lin C, Wang S, Chao Y, Kao S (2012) The Immunomodulatory effect of You-Gui-Wan on dermatogoides-pteronyssinus-induced asthma. Evidence-Based Complement Altern Med 1–12. https://doi.org/10.1155/2012/476060

Lu Y, Xu JY, Zhang XH, Zhao X (2016) Gu-Ben-Fang-Xiao Decoction attenuates sustained airway inflammation by suppressing ER stress response in a murine asthma remission model of respiratory syncytial virus infection. J Ethnopharmacol 192:496–509. https://doi.org/10.1016/j.jep.2016.09.039

Article  PubMed  Google Scholar 

Lee AR, Chun JM, Lee AY, Kim HS, Gu GJ, Kwon BI (2017) Reduced allergic lung inflammation by root extracts Fromtwo species of peucedanum through Inhibition of Th2 cell activation. J Ethnopharmacol 196:75–83. https://doi.org/10.1016/j.jep.2016.12.015

Article  CAS  PubMed  Google Scholar 

Morel LJF, Azevedo BC, Carmona F, Contini SHT, Teles AM, Ramalho FS, Bertoni BW, França SC, Borges MC, Pereira AMS (2017) A standardized methanol extract of Eclipta prostrata (L.) L. (Asteraceae) reduces bronchial hyperresponsiveness and production of Th2 cytokines in a murine model of asthma. J Ethnopharmacol 198:226–234. https://doi.org/10.1016/j.jep.2016.12.008

Article  PubMed  Google Scholar 

Yuan H, Xu Y, Luo Y, Zhang JR, Zhu XX, Xiao. J.H (2022) Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells. Aging Cell 21(9):e13686. https://doi.org/10.1111/acel.13686

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng HY, Zhong L, Cheng L, Chen L, Tong RS, Shi JY, Bai L (2023) Ganoderma lucidum: current advancements of characteristic components and experimental progress in anti-liver fibrosis. Front Pharmacol 13:1094405. https://doi.org/10.3389/fphar.2022.1094405

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ye T, Ge Y, Jiang X, Song H, Peng C, Liu B (2023) A review of anti-tumor effects of Ganoderma lucidum in Gastrointestinal cancer. Chin Med 18(1):107. https://doi.org/10.1186/s13020-023-00811-y

Article  PubMed  PubMed Central  Google Scholar 

Su HG, Peng XR, Shi QQ, Huang YJ, Zhou L, Qiu MH (2020) Lanostane triterpenoids with anti-inflammatory activities from ganoderma lucidum. Phytochemistry 173:112256. https://doi.org/10.1016/j.phytochem.2019.112256

Article  CAS  PubMed  Google Scholar 

Ahmad MF, Alsayegh A, Ahmad FA, Akhtar MS, Alavudeen SS, Bantun F, Wahab S, Ahmed A, Ali M, Elbendary EY, Raposo A, Kambal N, Abdelrahman H, M (2024) Ganoderma lucidum: insight into antimicrobial and antioxidant properties with development of secondary metabolites. Heliyon 10(3):e25607. https://doi.org/10.1016/j.heliyon.2024.e25607

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo C, Guo D, Fang L, Sang T, Wu J, Guo C, Wang Y, Wang Y, Chen C, Chen J, Chen R, Wang X (2021) Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon. Carbohydr Polym 267:118231. https://doi.org/10.1016/j.carbpol.2021.118231

Article  CAS  PubMed  Google Scholar 

Yuan Y, Yang B, Ye ZW, Zhang ML, Yang XL, Xin CW, Lin M, Huang P (2013) Sceptridium ternatum extract exerts antiasthmatic effects by regulating Th1/Th2 balance and the expression levels of leukotriene receptors in a mouse asthma model. J Ethnopharmacol 149(3):701–706. https://doi.org/10.1016/j.jep.2013.07.032

Article  PubMed  Google Scholar 

Dai C, He L, Ma B, Chen.T (2019) Facile nanolization strategy for therapeutic ganoderma lucidum spore oil to achieve enhanced protection against Radiation-Induced heart disease. Small 15(36):e1902642. https://doi.org/10.1002/smll.201902642

Article  CAS  PubMed  Google Scholar 

Peng XR, Unsicker SB, Gershenzon J, Qiu MH (2023) Structural diversity, hypothetical biosynthesis, chemical synthesis, and biological activity of Ganoderma meroterpenoids. Nat Prod Rep 40(8):1354–1392. https://doi.org/10.1039/d3np00006k

Article  CAS  PubMed  Google Scholar 

He YF, Huang L, Jiang P, Xu GP, Sun. TT (2022) Immunological regulation of the active fraction from Polygonatum sibiricum F. Delaroche based on improvement of intestinal microflora and activation of RAW264.7 cells. J Ethnopharmacol 293:115240. https://doi.org/10.1016/j.jep.2022.115240

Article  CAS  PubMed  Google Scholar 

Sun CB, Xu YT, Xu GP, Ji X, Jiang P, He YF (2024) Active fractions from Jingfang Baidu powder alleviate Klebsiella-induced pneumonia by inhibiting TLR4/Myd88-ERK signaling pathway. J Ethnopharmacol 330:118067. https://doi.org/10.1016/j.jep.2024.118067

Article  CAS  PubMed  Google Scholar 

Galli SJ, Tsai M, Piliponsky AM (2008) The development of allergic inflammation. Nature 454(7203):445–454

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leynaert B, Moual LN, Neukirch C, Siroux V, Varraso. R (2019) Facteurs environnementaux favorisant Le développement d’un asthma. La Presse Médicale 48(3):262–273. https://doi.org/10.1016/j.lpm.2019.02.022

Article  PubMed  Google Scholar 

Susetta. F (2019) Resolution of allergic asthma. Semin Immunopathol 41(6):665–674

Article  Google Scholar 

Mehlhop PD, van de Rijn M, Goldberg AB, Brewer JP, Kurup VP, Martin TR, Oettgen HC (1997) Allergen induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci USA 94(4):1344–1349. https://doi.org/10.1073/pnas.94.4.1344

Article  CAS  PubMed  PubMed Central