Li H, Xiao Z, Quarles LD, Li W (2021) Osteoporosis: Mechanism, molecular target and current status on drug development. Curr Med Chem 28:1489–1507
Article CAS PubMed PubMed Central Google Scholar
Peng S, Zhang G, Wang D (2023) Association of selenium intake with bone mineral density and osteoporosis: the National health and nutrition examination survey. Front Endocrinol 14:1251838
Ohta H, Uemura Y, Sone T, Tanaka S, Soen S, Mori S, Hagino H, Fukunaga M, Nakamura T, Orimo H (2023) Adequate treatment of osteoporosis (A-TOP) research group. Effect of bone resorption inhibitors on serum cholesterol level and fracture risk in osteoporosis: randomized comparative study between minodronic acid and raloxifene. Calcif Tissue Int 112:430–439
Article CAS PubMed PubMed Central Google Scholar
Turzanska K, Tomczyk-Warunek A, Dobrzynski M, Jarzebski M, Patryn R, Niezbecka-Zajac J, Wojciechowska M, Mela A, Zarebska-Mroz A (2023) Strontium Ranelate and strontium chloride supplementation influence on bone microarchitecture and bone turnover Markers-A preliminary study. Nutrients 16:91
Article PubMed PubMed Central Google Scholar
Reis AR, Santos RKF, Dos-Santos CB, Santos BDC, de Carvalho GB, Brandao-Lima PN, de Oliveira ESAM, Pires LV (2023) Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal women without osteoporosis: A systematic review of randomized clinical trials. Nutrition 116:112151
Article CAS PubMed Google Scholar
Voss PJ, Steybe D, Poxleitner P, Schmelzeisen R, Munzenmayer C, Fuellgraf H, Stricker A, Semper-Hogg W (2018) Osteonecrosis of the jaw in patients transitioning from bisphosphonates to denosumab treatment for osteoporosis. Odontology 106:469–480
Article CAS PubMed Google Scholar
Cao G, Hu S, Ning Y, Dou X, Ding C, Wang L, Wang Z, Sang X, Yang Q, Shi J (2024) Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity. Front Pharmacol 15:1370900
Article CAS PubMed PubMed Central Google Scholar
Li J, Fu SF, Yang Y, An R, Liu HY, Mao HP (2022) Clinical practice of traditional Chinese medicine for the treatment of postmenopausal osteoporosis: a literature review. Climacteric 25:562–569
Article CAS PubMed Google Scholar
Wang L, Huang X, Qin J, Qi B, Sun C, Guo X, Liu Q, Liu Y, Ma Y, Wei X (2024) The role of traditional Chinese medicines in the treatment of osteoporosis. Am J Chin Med 52:949–986
Dai Y, Tu FJ, Yao ZH, Ding B, Xu W, Qiu XH, Yao XS (2013) Rapid identification of chemical constituents in traditional Chinese medicine Fufang Preparation Xianling Gubao capsule by LC-linear ion trap/Orbitrap mass spectrometry. Am J Chin Med 41:1181–1198
Article CAS PubMed Google Scholar
Geng JL, Dai Y, Yao ZH, Qin ZF, Wang XL, Qin L, Yao XS (2014) Metabolites profile of Xian-Ling-Gu-Bao capsule, a traditional Chinese medicine prescription, in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis. J Pharm Biomed Anal 96:90–103
Article CAS PubMed Google Scholar
Qiu ZC, Tang XY, Wu QC, Tang ZL, Wong MS, Chen JX, Yao XS, Dai Y (2021) A new strategy for discovering effective substances and mechanisms of traditional Chinese medicine based on standardized drug containing plasma and the absorbed ingredients composition, a case study of Xian-Ling-Gu-Bao capsules. J Ethnopharmacol 279:114396
Article CAS PubMed Google Scholar
Bergen DJM, Kague E, Hammond CL (2019) Zebrafish as an emerging model for osteoporosis: A primary testing platform for screening new Osteo-Active compounds. Front Endocrinol (Lausanne) 10:6
Article PubMed PubMed Central Google Scholar
Lin WY, Dharini KK, Peng CH, Lin CY, Yeh KT, Lee WC, Lin MD (2022) Zebrafish models for glucocorticoid-induced osteoporosis. Tzu Chi Med J 34:373–380
Article PubMed PubMed Central Google Scholar
Wang J, Yang J, Tang Z, Yu Y, Chen H, Yu Q, Zhang D, Yan C (2023) Curculigo Orchioides polysaccharide COP70-1 stimulates osteogenic differentiation of MC3T3-E1 cells by activating the BMP and Wnt signaling pathways. Int J Biol Macromol 248:125879
Article CAS PubMed Google Scholar
Nanashima N, Horie K, Oey I (2024) Blackcurrant extract promotes differentiation of MC3T3-E1 pre-osteoblasts. Biomed Rep 21:121
Article CAS PubMed PubMed Central Google Scholar
Huang HX, Lin H, Lan F, Wu YF, Yang ZG, Zhang JJ (2018) Application of bone Transgenic zebrafish in anti-osteoporosis chemical screening. Anim Model Exp Med 1:53–61
Daina A, Michielin O, Zoete V (2019) SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res 47:W357–W364
Article CAS PubMed PubMed Central Google Scholar
Chen B, McConnell KJ, Wale N, Wild DJ, Gifford EM (2011) Comparing bioassay response and similarity ensemble approaches to probing protein Pharmacology. Bioinformatics 27:3044–3049
Article CAS PubMed Google Scholar
Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F (2024) TTD: therapeutic target database describing target druggability information. Nucleic Acids Res 52:D1465–D1477
Article PubMed PubMed Central Google Scholar
Fishilevich S, Zimmerman S, Kohn A, Iny-Stein T, Olender T, Kolker E, Safran M, Lancet D (2016) Genic insights from integrated human proteomics in genecards. Database (Oxford) baw030
Jiang X, Xu Z, Wang H, Zhao J, Maihemuti N, Jiang S, Xiao M, Zhang K, Liang S, Shi Y, Wang K (2025) Metabolomics and integrated network Pharmacology analysis revealed multi-targeted anti-cancer effect of FuZhengXiaoJi Decoction against non-small cell lung cancer. Phytomedicine 143:156855
Article CAS PubMed Google Scholar
Majeed A, Mukhtar S (2023) Protein-Protein interaction network exploration using cytoscape. Methods Mol Biol 2690:419–427
Article CAS PubMed Google Scholar
Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51:D638–D646
Article CAS PubMed PubMed Central Google Scholar
Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, Imamichi T, Chang W (2022) DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res 50:W216–W221
Article CAS PubMed PubMed Central Google Scholar
Wu QC, Tang XY, Dai ZQ, Dai Y, Xiao HH, Yao XS (2020) Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane Estrogen receptor-α and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells. Phytomedicine 68:153146
Article CAS PubMed Google Scholar
Kang WB, Deng YT, Wang DS, Feng D, Liu Q, Wang XS, Ru JY, Cong Y, Zhao JN, Zhao MG (2015) Osteoprotective effects of Estrogen membrane receptor GPR30 in ovariectomized rats. J Steroid Biochem Mol Biol 154:237–244
Article CAS PubMed Google Scholar
Zhang Y, Jiang T, Ni S, Liu W, Luo P, Hao S, Wang P, Guo L (2022) Effects of Estrogen on proliferation and apoptosis of osteoblasts through regulating GPER/AKT pathway. Cell Mol Biol (Noisy-le-grand) 68:124–129
Jiang Z, Deng L, Li M, Alonge E, Wang Y, Wang Y (2024) Ginsenoside Rg1 modulates PI3K/AKT pathway for enhanced osteogenesis via GPER. Phytomedicine 124:155284
Article CAS PubMed Google Scholar
Ghobadi N, Asoodeh A (2023) Co-administration of Curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets. Phytother Res 37:1688–1702
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