Integrated network pharmacology and pharmacological evaluation to elucidate the effect and mechanism of the novel combination PMS in treatment of osteoporosis

Li H, Xiao Z, Quarles LD, Li W (2021) Osteoporosis: Mechanism, molecular target and current status on drug development. Curr Med Chem 28:1489–1507

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peng S, Zhang G, Wang D (2023) Association of selenium intake with bone mineral density and osteoporosis: the National health and nutrition examination survey. Front Endocrinol 14:1251838

Article  Google Scholar 

Ohta H, Uemura Y, Sone T, Tanaka S, Soen S, Mori S, Hagino H, Fukunaga M, Nakamura T, Orimo H (2023) Adequate treatment of osteoporosis (A-TOP) research group. Effect of bone resorption inhibitors on serum cholesterol level and fracture risk in osteoporosis: randomized comparative study between minodronic acid and raloxifene. Calcif Tissue Int 112:430–439

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turzanska K, Tomczyk-Warunek A, Dobrzynski M, Jarzebski M, Patryn R, Niezbecka-Zajac J, Wojciechowska M, Mela A, Zarebska-Mroz A (2023) Strontium Ranelate and strontium chloride supplementation influence on bone microarchitecture and bone turnover Markers-A preliminary study. Nutrients 16:91

Article  PubMed  PubMed Central  Google Scholar 

Reis AR, Santos RKF, Dos-Santos CB, Santos BDC, de Carvalho GB, Brandao-Lima PN, de Oliveira ESAM, Pires LV (2023) Supplementation of vitamin D isolated or calcium-associated with bone remodeling and fracture risk in postmenopausal women without osteoporosis: A systematic review of randomized clinical trials. Nutrition 116:112151

Article  CAS  PubMed  Google Scholar 

Voss PJ, Steybe D, Poxleitner P, Schmelzeisen R, Munzenmayer C, Fuellgraf H, Stricker A, Semper-Hogg W (2018) Osteonecrosis of the jaw in patients transitioning from bisphosphonates to denosumab treatment for osteoporosis. Odontology 106:469–480

Article  CAS  PubMed  Google Scholar 

Cao G, Hu S, Ning Y, Dou X, Ding C, Wang L, Wang Z, Sang X, Yang Q, Shi J (2024) Traditional Chinese medicine in osteoporosis: from pathogenesis to potential activity. Front Pharmacol 15:1370900

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Fu SF, Yang Y, An R, Liu HY, Mao HP (2022) Clinical practice of traditional Chinese medicine for the treatment of postmenopausal osteoporosis: a literature review. Climacteric 25:562–569

Article  CAS  PubMed  Google Scholar 

Wang L, Huang X, Qin J, Qi B, Sun C, Guo X, Liu Q, Liu Y, Ma Y, Wei X (2024) The role of traditional Chinese medicines in the treatment of osteoporosis. Am J Chin Med 52:949–986

Article  PubMed  Google Scholar 

Dai Y, Tu FJ, Yao ZH, Ding B, Xu W, Qiu XH, Yao XS (2013) Rapid identification of chemical constituents in traditional Chinese medicine Fufang Preparation Xianling Gubao capsule by LC-linear ion trap/Orbitrap mass spectrometry. Am J Chin Med 41:1181–1198

Article  CAS  PubMed  Google Scholar 

Geng JL, Dai Y, Yao ZH, Qin ZF, Wang XL, Qin L, Yao XS (2014) Metabolites profile of Xian-Ling-Gu-Bao capsule, a traditional Chinese medicine prescription, in rats by ultra performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry analysis. J Pharm Biomed Anal 96:90–103

Article  CAS  PubMed  Google Scholar 

Qiu ZC, Tang XY, Wu QC, Tang ZL, Wong MS, Chen JX, Yao XS, Dai Y (2021) A new strategy for discovering effective substances and mechanisms of traditional Chinese medicine based on standardized drug containing plasma and the absorbed ingredients composition, a case study of Xian-Ling-Gu-Bao capsules. J Ethnopharmacol 279:114396

Article  CAS  PubMed  Google Scholar 

Bergen DJM, Kague E, Hammond CL (2019) Zebrafish as an emerging model for osteoporosis: A primary testing platform for screening new Osteo-Active compounds. Front Endocrinol (Lausanne) 10:6

Article  PubMed  PubMed Central  Google Scholar 

Lin WY, Dharini KK, Peng CH, Lin CY, Yeh KT, Lee WC, Lin MD (2022) Zebrafish models for glucocorticoid-induced osteoporosis. Tzu Chi Med J 34:373–380

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Yang J, Tang Z, Yu Y, Chen H, Yu Q, Zhang D, Yan C (2023) Curculigo Orchioides polysaccharide COP70-1 stimulates osteogenic differentiation of MC3T3-E1 cells by activating the BMP and Wnt signaling pathways. Int J Biol Macromol 248:125879

Article  CAS  PubMed  Google Scholar 

Nanashima N, Horie K, Oey I (2024) Blackcurrant extract promotes differentiation of MC3T3-E1 pre-osteoblasts. Biomed Rep 21:121

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang HX, Lin H, Lan F, Wu YF, Yang ZG, Zhang JJ (2018) Application of bone Transgenic zebrafish in anti-osteoporosis chemical screening. Anim Model Exp Med 1:53–61

Article  Google Scholar 

Daina A, Michielin O, Zoete V (2019) SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules. Nucleic Acids Res 47:W357–W364

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B, McConnell KJ, Wale N, Wild DJ, Gifford EM (2011) Comparing bioassay response and similarity ensemble approaches to probing protein Pharmacology. Bioinformatics 27:3044–3049

Article  CAS  PubMed  Google Scholar 

Zhou Y, Zhang Y, Zhao D, Yu X, Shen X, Zhou Y, Wang S, Qiu Y, Chen Y, Zhu F (2024) TTD: therapeutic target database describing target druggability information. Nucleic Acids Res 52:D1465–D1477

Article  PubMed  PubMed Central  Google Scholar 

Fishilevich S, Zimmerman S, Kohn A, Iny-Stein T, Olender T, Kolker E, Safran M, Lancet D (2016) Genic insights from integrated human proteomics in genecards. Database (Oxford) baw030

Jiang X, Xu Z, Wang H, Zhao J, Maihemuti N, Jiang S, Xiao M, Zhang K, Liang S, Shi Y, Wang K (2025) Metabolomics and integrated network Pharmacology analysis revealed multi-targeted anti-cancer effect of FuZhengXiaoJi Decoction against non-small cell lung cancer. Phytomedicine 143:156855

Article  CAS  PubMed  Google Scholar 

Majeed A, Mukhtar S (2023) Protein-Protein interaction network exploration using cytoscape. Methods Mol Biol 2690:419–427

Article  CAS  PubMed  Google Scholar 

Szklarczyk D, Kirsch R, Koutrouli M, Nastou K, Mehryary F, Hachilif R, Gable AL, Fang T, Doncheva NT, Pyysalo S (2023) The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest. Nucleic Acids Res 51:D638–D646

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sherman BT, Hao M, Qiu J, Jiao X, Baseler MW, Lane HC, Imamichi T, Chang W (2022) DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update). Nucleic Acids Res 50:W216–W221

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu QC, Tang XY, Dai ZQ, Dai Y, Xiao HH, Yao XS (2020) Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane Estrogen receptor-α and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells. Phytomedicine 68:153146

Article  CAS  PubMed  Google Scholar 

Kang WB, Deng YT, Wang DS, Feng D, Liu Q, Wang XS, Ru JY, Cong Y, Zhao JN, Zhao MG (2015) Osteoprotective effects of Estrogen membrane receptor GPR30 in ovariectomized rats. J Steroid Biochem Mol Biol 154:237–244

Article  CAS  PubMed  Google Scholar 

Zhang Y, Jiang T, Ni S, Liu W, Luo P, Hao S, Wang P, Guo L (2022) Effects of Estrogen on proliferation and apoptosis of osteoblasts through regulating GPER/AKT pathway. Cell Mol Biol (Noisy-le-grand) 68:124–129

Article  PubMed  Google Scholar 

Jiang Z, Deng L, Li M, Alonge E, Wang Y, Wang Y (2024) Ginsenoside Rg1 modulates PI3K/AKT pathway for enhanced osteogenesis via GPER. Phytomedicine 124:155284

Article  CAS  PubMed  Google Scholar 

Ghobadi N, Asoodeh A (2023) Co-administration of Curcumin with other phytochemicals improves anticancer activity by regulating multiple molecular targets. Phytother Res 37:1688–1702

Article  CAS  PubMed 

Comments (0)

No login
gif