Ginkgetin from : mechanistic insights into anticancer efficacy

Zhao YP, et al. Resequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil. Nat Commun. 2019;10(1):4201.

Article  PubMed Central  PubMed  Google Scholar 

McKenna DJ, Jones K, Hughes K. Efficacy, safety, and use of Ginkgo biloba in clinical and preclinical applications. Altern Ther Health Med. 2001;7(5):70–86.

CAS  PubMed  Google Scholar 

Chen Y, et al. Ginkgo biloba. Trends Genet. 2021;37(5):488–9.

Article  CAS  PubMed  Google Scholar 

Boateng ID. Ginkgols and bilobols in Ginkgo biloba L. a review of their extraction and bioactivities. Phytother Res. 2023;37(8):3211–23.

Article  CAS  PubMed  Google Scholar 

Guo J, et al. Overview and recent progress on the biosynthesis and regulation of flavonoids in Ginkgo biloba L. Int J Mol Sci. 2023. https://doi.org/10.3390/ijms241914604.

Article  PubMed Central  PubMed  Google Scholar 

Mohammadi Zonouz A, Ghasemzadeh Rahbardar M, Hosseinzadeh H. The molecular mechanisms of ginkgo (Ginkgo biloba) activity in signaling pathways: a comprehensive review. Phytomedicine. 2024;126: 155352.

Article  CAS  PubMed  Google Scholar 

Shareena G, Kumar D. Traversing through half a century research timeline on Ginkgo biloba, in transforming a botanical rarity into an active functional food ingredient. Biomed Pharmacother. 2022;153: 113299.

Article  CAS  PubMed  Google Scholar 

Omidkhoda SF, Razavi BM, Hosseinzadeh H. Protective effects of Ginkgo biloba L. against natural toxins, chemical toxicities, and radiation: a comprehensive review. Phytother Res. 2019;33(11):2821–40.

Article  CAS  PubMed  Google Scholar 

Boateng ID. A critical review of current technologies used to reduce ginkgotoxin, ginkgotoxin-5’-glucoside, ginkgolic acid, allergic glycoprotein, and cyanide in Ginkgo biloba L. seed. Food Chem. 2022;382: 132408.

Article  CAS  PubMed  Google Scholar 

Trabert M, Seifert R. Critical analysis of ginkgo preparations: comparison of approved drugs and dietary supplements marketed in Germany. Naunyn Schmiedebergs Arch Pharmacol. 2024;397(1):451–61.

Article  CAS  PubMed  Google Scholar 

Su X, et al. Medicinal values and potential risks evaluation of Ginkgo biloba leaf extract (GBE) drinks made from the leaves in autumn as dietary supplements. Molecules. 2022. https://doi.org/10.3390/molecules27217479.

Article  PubMed Central  PubMed  Google Scholar 

Yuan C, et al. Efficacy and safety of Ginkgo biloba extract as an adjuvant in the treatment of Chinese patients with sudden hearing loss: a meta-analysis. Pharm Biol. 2023;61(1):610–20.

Article  PubMed Central  CAS  PubMed  Google Scholar 

Asiwe JN, et al. Ginkgo biloba supplement modulates mTOR/ERK1/2 activities to mediate cardio-protection in cyclosporin-A-induced cardiotoxicity in Wistar rats. Clin Tradit Med Pharmacol. 2024;5(1): 200134.

Article  Google Scholar 

Yu J, et al. New insight into the mechanisms of Ginkgo biloba leaves in the treatment of cancer. Phytomedicine. 2024;122: 155088.

Article  CAS  PubMed  Google Scholar 

Lu J, et al. Hyperspectral imaging combined with deep transfer learning to evaluate flavonoids content in Ginkgo biloba leaves. Int J Mol Sci. 2024. https://doi.org/10.3390/ijms25179584.

Article  PubMed Central  PubMed  Google Scholar 

Mao D, et al. Function, biosynthesis, and regulation mechanisms of flavonoids in Ginkgo biloba. Fruit Res. 2023. https://doi.org/10.48130/FruRes-2023-0018.

Article  Google Scholar 

Li X, et al. 3’,8″-dimerization enhances the antioxidant capacity of flavonoids: evidence from acacetin and isoginkgetin. Molecules. 2019. https://doi.org/10.3390/molecules24112039.

Article  PubMed Central  PubMed  Google Scholar 

Kovač Tomas M, Jurčević I, Šamec D. Tissue-specific profiling of biflavonoids in Ginkgo (Ginkgo biloba L.). Plants. 2022. https://doi.org/10.3390/plants12010147.

Article  PubMed Central  PubMed  Google Scholar 

Sagrera G, et al. Synthesis and antifungal activities of natural and synthetic biflavonoids. Bioorg Med Chem. 2011;19(10):3060–73.

Article  CAS  PubMed  Google Scholar 

Tao Z, et al. Therapeutic effect of ginkgetin on smoke-induced airway inflammation by down-regulating the c/EBPβ signaling pathway and CCL2 expression. J Ethnopharmacol. 2024;331: 118284.

Article  CAS  PubMed  Google Scholar 

Hu B, et al. Ginkgetin alleviates intervertebral disc degeneration by inhibiting apoptosis, inflammation, and disturbance of extracellular matrix synthesis and catabolism via inactivation of NLRP3 inflammasome. Immunol Invest. 2023;52(5):546–60.

Article  CAS  PubMed  Google Scholar 

Li G, et al. Ginkgetin in vitro and in vivo reduces Streptococcus suis virulence by inhibiting suilysin activity. J Appl Microbiol. 2019;127(5):1556–63.

Article  CAS  PubMed  Google Scholar 

Menezes J, Campos VR. Natural biflavonoids as potential therapeutic agents against microbial diseases. Sci Total Environ. 2021;769: 145168.

Article  CAS  PubMed  Google Scholar 

Castañeda P, et al. Effects of some compounds isolated fromCelaenodendron mexicanum standl (euphorbiaceae) on seeds and phytopathogenic fungi. J Chem Ecol. 1992;18(7):1025–37.

Article  PubMed  Google Scholar 

Jurčević Šangut I, et al. A comparative analysis of radical scavenging, antifungal and enzyme inhibition activity of 3’-8″-biflavones and their monomeric subunits. Antioxidants. 2023. https://doi.org/10.3390/antiox12101854.

Article  PubMed Central  PubMed  Google Scholar 

Patel CN, et al. Computational investigation of natural compounds as potential main protease [M(pro)] inhibitors for SARS-CoV-2 virus. Comput Biol Med. 2022;151(Pt A): 106318.

Article  PubMed Central  CAS  PubMed  Google Scholar 

Sharma S, et al. Avocado-derived extracellular vesicles loaded with ginkgetin and berberine prevent inflammation and macrophage foam cell formation. J Cell Mol Med. 2024;28(7): e18177.

Article  PubMed Central  CAS  PubMed  Google Scholar 

Wang LT, et al. Biflavonoids from Ginkgo biloba leaves as a novel anti-atherosclerotic candidate: inhibition potency and mechanistic analysis. Phytomedicine. 2022;102: 154053.

Article  CAS  PubMed  Google Scholar 

Cho YL, et al. Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation. Pharmacol Res. 2019;139:325–36.

Article  CAS  PubMed  Google Scholar 

Akbar A, Ijaz MU. Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics-instigated testicular toxicity in rats: a biochemical, spermatological, and histopathological assessment. Environ Sci Pollut Res Int. 2024;31(6):9031–44.

Article  CAS  PubMed  Google Scholar 

Yamaguchi LF, et al. Biflavonoids from Brazilian pine Araucaria angustifolia as potentials protective agents against DNA damage and lipoperoxidation. Phytochemistry. 2005;66(18):2238–47.

Article  CAS  PubMed  Google Scholar 

Liu Y, et al. Gi

Comments (0)

No login
gif