Muchowska, K. B., Varma, S. J. & Moran, J. Synthesis and breakdown of universal metabolic precursors promoted by iron. Nature 569, 104–107 (2019).
Article CAS PubMed PubMed Central Google Scholar
Andreini, C., Putignano, V., Rosato, A. & Banci, L. The human iron-proteome. Metallomics 10, 1223–1231 (2018).
Article CAS PubMed Google Scholar
Jiang, H. et al. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. J. Exp. Med. https://doi.org/10.1084/jem.20210739 (2022).
Article PubMed PubMed Central Google Scholar
Antoszczak, M. et al. Iron-sensitive prodrugs that trigger active ferroptosis in drug-tolerant pancreatic cancer cells. J. Am. Chem. Soc. 144, 11536–11545 (2022).
Article CAS PubMed Google Scholar
Cheng, Y., Zak, O., Aisen, P., Harrison, S. C. & Walz, T. Structure of the human transferrin receptor–transferrin complex. Cell 116, 565–576 (2004).
Article CAS PubMed Google Scholar
Yu, Y. et al. Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis. Blood 136, 726–739 (2020).
Article CAS PubMed PubMed Central Google Scholar
Bartnikas, T. B. Known and potential roles of transferrin in iron biology. Biometals 25, 677–686 (2012).
Article CAS PubMed PubMed Central Google Scholar
Parrow, N. L. et al. Lobe specificity of iron binding to transferrin modulates murine erythropoiesis and iron homeostasis. Blood 134, 1373–1384 (2019).
Article CAS PubMed PubMed Central Google Scholar
Levy, J. E., Jin, O., Fujiwara, Y., Kuo, F. & Andrews, N. C. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat. Genet. 21, 396–399 (1999).
Article CAS PubMed Google Scholar
Wang, S. et al. Transferrin receptor 1-mediated iron uptake plays an essential role in hematopoiesis. Haematologica 105, 2071–2082 (2020).
Article CAS PubMed PubMed Central Google Scholar
Xu, W. et al. Lethal cardiomyopathy in mice lacking transferrin receptor in the heart. Cell Rep. 13, 533–545 (2015).
Article PubMed PubMed Central Google Scholar
Matak, P. et al. Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proc. Natl Acad. Sci. USA 113, 3428–3435 (2016).
Article CAS PubMed PubMed Central Google Scholar
Barrientos, T. et al. Metabolic catastrophe in mice lacking transferrin receptor in muscle. EBioMedicine 2, 1705–1717 (2015).
Article PubMed PubMed Central Google Scholar
Jabara, H. H. et al. A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. Nat. Genet. 48, 74–78 (2016).
Article CAS PubMed Google Scholar
Wang, Z. et al. Iron drives T helper cell pathogenicity by promoting RNA-binding protein PCBP1-mediated proinflammatory cytokine production. Immunity 49, 80–92.e7 (2018).
Article CAS PubMed Google Scholar
Das, B. K. et al. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. eLife https://doi.org/10.7554/eLife.73539 (2022).
Article PubMed PubMed Central Google Scholar
Li, J. et al. Transferrin receptor 1 regulates thermogenic capacity and cell fate in brown/beige adipocytes. Adv. Sci. 7, 1903366 (2020).
Zhang, Z. et al. Adipocyte iron levels impinge on a fat–gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity. Cell Metab. 33, 1624–1639.e9 (2021).
Article CAS PubMed PubMed Central Google Scholar
Fillebeen, C. et al. Transferrin receptor 1 controls systemic iron homeostasis by fine-tuning hepcidin expression to hepatocellular iron load. Blood 133, 344–355 (2019).
Article CAS PubMed Google Scholar
Fisher, A. L. et al. Functional role of endothelial transferrin receptor 1 in iron sensing and homeostasis. Am. J. Hematol. 97, 1548–1559 (2022).
Article CAS PubMed Google Scholar
Khalil, S. et al. A specialized pathway for erythroid iron delivery through lysosomal trafficking of transferrin receptor 2. Blood Adv. 1, 1181–1194 (2017).
Article CAS PubMed PubMed Central Google Scholar
Pantopoulos, K. Inherited disorders of iron overload. Front. Nutr. 5, 103 (2018).
Article PubMed PubMed Central Google Scholar
Nai, A. et al. The second transferrin receptor regulates red blood cell production in mice. Blood 125, 1170–1179 (2015).
Article CAS PubMed PubMed Central Google Scholar
Montemiglio, L. C. et al. Cryo-EM structure of the human ferritin–transferrin receptor 1 complex. Nat. Commun. 10, 1121 (2019).
Article PubMed PubMed Central Google Scholar
Radoshitzky, S. R. et al. Transferrin receptor 1 is a cellular receptor for New World haemorrhagic fever arenaviruses. Nature 446, 92–96 (2007).
Article CAS PubMed PubMed Central Google Scholar
Gruszczyk, J. et al. Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax. Science 359, 48–55 (2018).
Article CAS PubMed PubMed Central Google Scholar
Coulon, S. et al. Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia. Nat. Med. 17, 1456–1465 (2011).
Article CAS PubMed Google Scholar
Senyilmaz, D. et al. Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature 525, 124–128 (2015).
Article CAS PubMed PubMed Central Google Scholar
Jian, J., Yang, Q. & Huang, X. Src regulates Tyr20 phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival. J. Biol. Chem. 286, 35708–35715 (2011).
Article CAS PubMed PubMed Central Google Scholar
Schmidt, P. J., Toran, P. T., Giannetti, A. M., Bjorkman, P. J. & Andrews, N. C. The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab. 7, 205–214 (2008).
Article PubMed PubMed Central Google Scholar
Chen, A. C., Donovan, A., Ned-Sykes, R. & Andrews, N. C. Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. Proc. Natl Acad. Sci. USA 112, 11714–11719 (2015).
Article CAS PubMed PubMed Central Google Scholar
Ned, R. M., Swat, W. & Andrews, N. C. Transferrin receptor 1 is differentially required in lymphocyte development. Blood 102, 3711–3718 (2003).
Article CAS PubMed Google Scholar
Truman-Rosentsvit, M. et al. Ferritin is secreted via 2 distinct nonclassical vesicular pathways. Blood 131, 342–352 (2018).
Article CAS PubMed PubMed Central Google Scholar
Li, J. Y. et al. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev. Cell 16, 35–46 (2009).
Article CAS PubMed PubMed Central Google Scholar
Chen, T. T. et al. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J. Exp. Med. 202, 955–965 (2005).
Article CAS PubMed PubMed Central Google Scholar
Han, J. et al. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS ONE 6, e23800 (2011).
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