Different role of the gut microbiota in postmenopausal and senile osteoporosis

Fan, Y. & Pedersen, O. Gut microbiota in human metabolic health and disease. Nat. Rev. Microbiol. 19, 55–71 (2021).

Article  CAS  PubMed  Google Scholar 

Li, J. Y. et al. Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J. Clin. Invest. 126, 2049–2063 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Guan, Z. et al. Estrogen deficiency induces bone loss through the gut microbiota. Pharmacol. Res. 196, 106930 (2023).

Article  CAS  PubMed  Google Scholar 

Schepper, J. D. et al. Involvement of the gut microbiota and barrier function in glucocorticoid-Induced osteoporosis. J. Bone Miner. Res. 35, 801–820 (2020).

Article  CAS  PubMed  Google Scholar 

Chen, C. Y. et al. Glucocorticoid-induced loss of beneficial gut bacterial extracellular vesicles is associated with the pathogenesis of osteonecrosis. Sci. Adv. 8, 8335 (2022).

Article  Google Scholar 

Guss, J. D. et al. The microbial metagenome and bone tissue composition in mice with microbiome-induced reductions in bone strength. Bone 127, 146–154 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, S., Wang, N., Zhang, P., Wu, W. & Fu, L. Fecal microbiota transplantation mitigates bone loss by improving gut microbiome composition and gut barrier function in aged rats. PeerJ 9, 12293 (2021).

Article  Google Scholar 

Zhang, Y. W. et al. Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function. J. Orthop. Transl. 37, 46–60 (2022).

Google Scholar 

Bose, S. & Sharan, K. Effect of probiotics on postmenopausal bone health: a preclinical meta-analysis. Br. J. Nutr. 131, 567–580 (2024).

Article  CAS  PubMed  Google Scholar 

Ding, M. et al. Human breastmilk-derived Bifidobacterium longum subsp. infantis CCFM1269 regulates bone formation by the GH/IGF axis through PI3K/AKT pathway. Gut Microbes 16, 2290344 (2024).

Article  PubMed  Google Scholar 

Chinese Society of Osteoporosis and Bone Mineral Research. Guidelines for the diagnosis and treatment of primary osteoporosis (2022). Chin. Gen. Pract. 26, 1671–1691 (2023).

Google Scholar 

You, X. et al. Bone loss with aging is independent of gut microbiome in mice. Bone Res 12, 65 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qi, X., Yun, C., Pang, Y. & Qiao, J. The impact of the gut microbiota on the reproductive and metabolic endocrine system. Gut Microbes 13, 1–21 (2021).

Article  PubMed  Google Scholar 

Baker, J. M., Al-Nakkash, L. & Herbst-Kralovetz, M. M. Estrogen–gut microbiome axis: Physiological and clinical implications. Maturitas 103, 45–53 (2017).

Article  CAS  PubMed  Google Scholar 

Akinsuyi, O. S. & Roesch, L. F. W. Meta-analysis reveals compositional and functional microbial changes associated with osteoporosis. Microbiol. Spectr. 11, 0032223 (2023).

Article  Google Scholar 

Okoro, P. C. et al. A two-cohort study on the association between the gut microbiota and bone density, microarchitecture, and strength. Front. Endocrinol. (Lausanne) 14, 1237727 (2023).

Article  PubMed  Google Scholar 

Yan, L. et al. Characteristics of the gut microbiota and serum metabolites in postmenopausal women with reduced bone mineral density. Front. Cell. Infect. Microbiol. 14, 1367325 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie, X. et al. Study on gut microbiota and metabolomics in postmenopausal women. BMC Women’s. Health 24, 608 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shim, J., Iwaya, C., Ambrose, C. G., Suzuki, A. & Iwata, J. Micro-computed tomography assessment of bone structure in aging mice. Sci. Rep. 12, 8117 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang, C. et al. Incidence of and trends in hip fracture among adults in urban China: A nationwide retrospective cohort study. PLoS Med 17, e1003180 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Zheng, X.-Q. et al. Incidence and cost of vertebral fracture in urban China: A five-year population-based cohort study. Int. J. Surg. 109, 1910–1918 (2023).

PubMed  PubMed Central  Google Scholar 

Piemontese, M. et al. Old age causes de novo intracortical bone remodeling and porosity in mice. JCI Insight 2, e93771 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Comments (0)

No login
gif