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Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance
Research ArticleImmunologyInfectious diseaseVirology Open Access | 10.1172/jci.insight.186182 ...
Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis
Clinical Research and Public HealthImmunologyInfectious disease Open Access | 10.1172/jci.insight.193826 ...
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma
Sex as a biological variable. Male mice were specifically used when studying response to HDM as previous studies in our l...
Identification of bacteriophage DNA in human umbilical cord blood
Bacteriophage DNA is present in human umbilical cord blood. To test the hypothesis that the fetus is exposed to bacteriop...
Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice
GBA1 L444P PD patient-derived cortical neurons have increased total C16:1 and C18:1 fatty acid associating with decreased...
Polyfunctional T follicular helper cells drive checkpoint-inhibitor diabetes and are targeted by JAK inhibitor therapy
Research ArticleOncology Open Access | 10.1172/jci.insight.188843 Nicole L. Huang,1 Jessi...
Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia
Research ArticleInflammationMetabolism Open Access | 10.1172/jci.insight.191649 John Q. Yap,1...
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19
Research ArticleCOVID-19Immunology Open Access | 10.1172/jci.insight.191314 Anita E. Qualls,1...
Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression
Sex as a biological variable. Sex was not considered as a biological variable in this study. Cell culture. THP-1 and Raw2...
A CARD9 deficiency mouse model recapitulates human chronic CNS candidiasis identifying defective monocytic cell responses in immunopathogenesis
Research ArticleGeneticsImmunology Open Access | 10.1172/jci.insight.176676 Marija Landekic,1...
Macrophage-derived Spp1 promotes intramuscular fat in dystrophic muscle
Research ArticleGeneticsMuscle biology Open Access | 10.1172/jci.insight.181946 Philip K. Far...
MTOR signaling regulates the development of airway mucous cell metaplasia associated with severe asthma
Research ArticleCell biologyPulmonology Open Access | 10.1172/jci.insight.187904 Katrina M. K...
Distinct cell types along thick ascending limb express pathways for monovalent and divalent cation transport
Research ArticleMetabolismNephrology Open Access | 10.1172/jci.insight.190992 Hasan Demirci,1...
Impact of the IL-15 superagonist N-803 on lymphatic reservoirs of HIV
Clinical Research and Public HealthAIDS/HIVInfectious disease Open Access | 10.1172/jci.insight.190831 ...
An amphiregulin reporter mouse enables transcriptional and clonal expansion analysis of reparative lung Tregs
The AregThy1.1 reporter mouse delineates active Areg production from Tregs during models of lung damage. Due to the inabi...
Label-free single-cell phenotyping to determine tumor cell heterogeneity in pancreatic cancer in real time
Research ArticleGastroenterologyOncology Open Access | 10.1172/jci.insight.169105 Katja Witte...
Opposing roles for myeloid and smooth muscle cell STING in pulmonary hypertension
Sex as a biological variable For studies using human and animal samples, sex is specified as appropriate to the design of...
Involvement of impaired carnitine-induced fatty acid oxidation in experimental and human diabetic kidney disease
Middle-to-long-chain Acyl-C and ectopic lipid accumulation are increased in patients with DKD. First, to investigate whet...
ADAR1 expression is associated with cervical cancer progression and negatively regulates NK cell activity
Research ArticleImmunologyInflammationOncology Open Access | 10.1172/jci.insight.190244 Valen...
NEXN regulates vascular smooth muscle cell phenotypic switching and neointimal hyperplasia
Research ArticleCell biologyVascular biology Open Access | 10.1172/jci.insight.190089 Zexuan ...
CD4 T cell–activating neoantigens enhance personalized cancer vaccine efficacy
Mice and study approval. Five- to 6-week-old male C57BL/6 mice were purchased from The Jackson Laboratory and were allowe...
Vaccines based on the fusion protein consensus sequence protect Syrian hamsters from Nipah virus infection
Research ArticleVaccinesVirology Open Access | 10.1172/jci.insight.175461 Mingqing Lu,1,2 Y...
Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency
Research ArticleMetabolismOncology Open Access | 10.1172/jci.insight.170105 Gatikrushna Panigra...
Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival
Research ArticleGastroenterology Open Access | 10.1172/jci.insight.171657 Charles H. Danan,1,2,...
Single-cell transcriptomics reveals variations in monocytes and Tregs between gout flare and remission
Single-cell transcriptome profiling of peripheral blood mononuclear cells (PBMCs) from gout flare and remission. Peripher...
A CD6-targeted antibody-drug conjugate as a potential therapy for T cell–mediated disorders
Research Article Open Access | 10.1172/jci.insight.172914 Lingjun Zhang,1 Liping Luo,1 ...
Validation of a murine proteome-wide phage display library for identification of autoantibody specificities
Technical AdvanceImmunology Open Access | 10.1172/jci.insight.174976 Elze Rackaityte,1 Irin...
Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesis
DYRK1A is overexpressed in human T21 cells. To assess the role of DYRK1A in the pathogenesis of ML-DS arising from fetal ...
Gut mucosal cells transfer α-synuclein to the vagus nerve
Mice. Mice expressing EGFP in CCK cells [Tg(Cck-EGFP)BJ203Gsat/Mmmh], referred to as Cck-eGFP, were obtained from Mutant ...
Intratumoral aluminum hydroxide–anchored IL-12 drives potent antitumor activity by remodeling the tumor microenvironment
IL-12-ABP protein forms a stable complex with Alhydrogel and maintains activity. ANK-101 is composed of a single-chain hu...
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