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Structural modeling and functional characterization of a novel gain-of-function TLR8 variant causing severe inflammatory syndrome
Research ArticleGeneticsImmunologyInfectious disease Open Access | 10.1172/jci.insight.187422 ...
Single-cell capture of on-ART SIV transcription reveals TGF-β–mediated metabolic control of viral latency
Research ArticleAIDS/HIVImmunologyMetabolism Open Access | 10.1172/jci.insight.198810 Romaila...
Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 mediator kinase inhibition
Research ArticleCell biologyOncology Open Access | 10.1172/jci.insight.192113 Mehri Monavaria...
IL-21 enhances the cytotoxicity of intratumoral CD8+ T cells, improving radiation efficacy
Sex as a biological variable. Human samples were deliberately sourced from male and female individuals. For mouse experim...
Dose-dependent IFN programs in myeloid cells after mRNA and adenovirus COVID-19 vaccination
Clinical Research and Public HealthImmunologyPublic Health Open Access | 10.1172/jci.insight.199245 ...
SARS-CoV-2 antibody–dependent enhancement of infection depends on antibody binding to both ACE2 and Fc receptors
Research ArticleImmunologyVirology Open Access | 10.1172/jci.insight.197773 Natalia A. Kuzmin...
HDAC1 modulates sepsis-induced immunosuppression by driving the exhaustion of CD8+ T cells
Research ArticleImmunologyInfectious diseaseInflammation Open Access | 10.1172/jci.insight.197224 ...
New approaches to uncover COPD pathobiology and develop therapies
Review Open Access | 10.1172/jci.insight.199693 Yohannes Tesfaigzi,1 Ali Önder Yildirim,2...
Pathophysiological and therapeutic implications of C-type natriuretic peptide/cyclic GMP signaling in pulmonary fibrosis
Among various types of lung cells, GC-B expression is greatest in fibroblasts. The CNP receptor, GC-B, is expressed in se...
Characteristics of anti–integrin αvβ6 autoantibodies in patients with ulcerative colitis
Sex as a biological variable. This study included samples from 4 male and 3 female patients with UC. Sex was not consider...
IRP1 deficiency alters mitochondrial metabolism and protects against metabolic syndrome pathologies
Research ArticleHepatologyMetabolism Open Access | 10.1172/jci.insight.183247 Wen Gu,1 Ni...
Decoding muscle-resident Schwann cell dynamics during neuromuscular junction remodeling
scRNA-Seq captures muscle-resident SCs across healthy and denervated muscles. SC regenerative responses are activated by ...
Erythropoietin alleviates syndrome-associated intellectual disability and autism-like behavior in Zbtb20-haploinsufficient Primrose syndrome mouse model
Research ArticleClinical ResearchNeuroscience Open Access | 10.1172/jci.insight.200021 Martin...
A porcine commotio retinae model for preclinical evaluation of posttraumatic photoreceptor degeneration
Research ArticleNeuroscienceOphthalmology Open Access | 10.1172/jci.insight.192799 Juan Amara...
Characterization of the clonal hierarchy and immunophenotype of PTPN11 mutations in acute myeloid leukemia
Research ArticleHematologyOncology Open Access | 10.1172/jci.insight.193779 Sydney Fobare,1,2...
Pyruvate kinase deficiency modifies sickle hemoglobin carrier and sickle cell disease phenotypes in mice
AA, AS, and SS Townes mice with Pklr-null mutations are viable, lack PKR expression, and have intact expression of other ...
Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin
Sex as a biological variable. Sex was not considered as a biological variable. Both male and female mice were used in thi...
Antiretroviral treatment does not prevent extrapulmonary tuberculosis during SIV/Mtb coinfection in macaques
Research ArticleAIDS/HIVImmunologyInfectious disease Open Access | 10.1172/jci.insight.199314 ...
Phosphoproteomics identification of ERK-dependent activation of Rps6kb1 in cardiac hypertrophy
Research ArticleCardiologyCell biology Open Access | 10.1172/jci.insight.190760 Chao Li,1,2 ...
Unbiased cleavage site prediction uncovers viral antagonism of host innate immunity by SARS-CoV-2 3C-like protease
Research ArticleCOVID-19Virology Open Access | 10.1172/jci.insight.185739 Nora Yucel,1 Si...
Pan-H7 influenza human antibody virus neutralization depends on avidity and steric hindrance
Research ArticleImmunologyInfectious diseaseVirology Open Access | 10.1172/jci.insight.186182 ...
Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis
Clinical Research and Public HealthImmunologyInfectious disease Open Access | 10.1172/jci.insight.193826 ...
Allergen induces pulmonary neuroendocrine cell hyperplasia in a model of asthma
Sex as a biological variable. Male mice were specifically used when studying response to HDM as previous studies in our l...
Identification of bacteriophage DNA in human umbilical cord blood
Bacteriophage DNA is present in human umbilical cord blood. To test the hypothesis that the fetus is exposed to bacteriop...
Stearoyl-CoA desaturase inhibition normalizes brain lipid saturation, α-synuclein homeostasis, and motor function in mutant Gba1-Parkinson mice
GBA1 L444P PD patient-derived cortical neurons have increased total C16:1 and C18:1 fatty acid associating with decreased...
Polyfunctional T follicular helper cells drive checkpoint-inhibitor diabetes and are targeted by JAK inhibitor therapy
Research ArticleOncology Open Access | 10.1172/jci.insight.188843 Nicole L. Huang,1 Jessi...
Myocardial pyruvate dehydrogenase kinase 4 drives sex-specific cardiac responses to endotoxemia
Research ArticleInflammationMetabolism Open Access | 10.1172/jci.insight.191649 John Q. Yap,1...
High-affinity CD16A polymorphism associated with reduced risk ofsevere COVID-19
Research ArticleCOVID-19Immunology Open Access | 10.1172/jci.insight.191314 Anita E. Qualls,1...
Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression
Sex as a biological variable. Sex was not considered as a biological variable in this study. Cell culture. THP-1 and Raw2...
A CARD9 deficiency mouse model recapitulates human chronic CNS candidiasis identifying defective monocytic cell responses in immunopathogenesis
Research ArticleGeneticsImmunology Open Access | 10.1172/jci.insight.176676 Marija Landekic,1...
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