Research ArticleHematologyOncology Open Access | 10.1172/jci.insight.193779

Sydney Fobare,1,2 Chia Sharpe,2 Kate Quinn,2 Kinsey Bryant,2 Linde A. Miles,3,4,5 Robert L. Bowman,6 Carolyn Cheney,2 Casie Furby,2 Marissa Long,2 Kaytlynn Fyock,2 Ben Wronowski,2 James R. Lerma,2 Krzysztof Mrózek,7 Deedra Nicolet,7,8 Thomas M. Sesterhenn,2 Megan E. Johnstone,2 Jianmin Pan,9,10,11 Shesh N. Rai,9,10,11 Chandrashekhar Pasare,4 Nives Zimmermann,12 Wen-Mei Yu,13 Cheng-Kui Qu,13 Andrew Carroll,14 Richard Stone,15 Eunice S. Wang,16 Jonathan Kolitz,17 Bayard Powell,18 John P. Perentesis,5 Ann-Kathrin Eisfeld,7,19 Erin Hertlein,2 and John C. Byrd2

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Fobare, S. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

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1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Quinn, K. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Bryant, K. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Miles, L. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Bowman, R. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Cheney, C. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Furby, C. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Long, M. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Fyock, K. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Wronowski, B. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Lerma, J. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Mrózek, K. in: PubMed | Google Scholar |

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Nicolet, D. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd, UPMC Hillman Cancer Center, Associate Vice Chancellor for Cancer Affairs, University of Pittsburgh, UPMC Cancer Pavilion, Suite 500, 5150 Centre Avenue, Pittsburgh, Pennsylvania, 15232, USA. Phone: 412.623.3205; Email: byrdjc@upmc.edu. Or to: Erin Hertlein, Division of Hematology-Oncology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0551, Room 7009, Cincinnati, Ohio, 45267, USA. Phone: 513.558.0858; Email: hertleek@ucmail.uc.edu.

Authorship note: SF and CS contributed equally to this work and have been designated as co–first authors. EH and JCB contributed equally to this work and have been designated as co–senior authors.

Find articles by Sesterhenn, T. in: PubMed | Google Scholar

1Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

2Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

3Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

4Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA.

5Cancer and Blood Diseases Institute, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.

6Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

7Clara D. Bloomfield Center for Leukemia Outcomes Research, and

8Alliance Statistics and Data Management Center, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

9Biostatistics and Informatics Shared Resource, University of Cincinnati Cancer Center, Cincinnati, Ohio, USA.

10Cancer Data Science Center, and

11Department of Biostatistics, Health Informatics and Data Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

12Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

13Aflac Cancer and Blood Disorders Center, Department of Pediatrics, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.

14Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

15Dana-Farber/Partners CancerCare, Boston, Massachusetts, USA.

16Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.

17Monter Cancer Center, Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York, USA.

18Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, USA.

19Division of Hematology, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.

Address correspondence to: John C. Byrd,