Research ArticleGastroenterologyOncology Open Access | 10.1172/jci.insight.169105

Katja Wittenzellner,1,2 Manuel Lengl,3 Stefan Röhrl,3 Carlo Maurer,1,2 Christian Klenk,4 Aristeidis Papargyriou,1,2,5,6,7,8 Laura Schmidleitner,1,2,5,6 Nicole Kabella,9 Akul Shastri,1,2,5,6 David E. Fresacher,3 Farid Harb,3 Nawal Hafez,3 Stefanie Bärthel,10,11,12 Daniele Lucarelli,10,11,12,13 Carmen Escorial-Iriarte,1,4 Felix Orben,1,2 Rupert Öllinger,14 Ellen Emken,4 Lisa Fricke,1,2 Joanna Madej,1,2 Patrick Wustrow,1,2 I. Ekin Demir,15 Helmut Friess,15 Tobias Lahmer,2 Roland M. Schmid,2 Roland Rad,10,13 Günter Schneider,16 Bernhard Kuster,5 Dieter Saur,10,11,12 Oliver Hayden,4 Klaus Diepold,3 and Maximilian Reichert1,2,6,7,8,11

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Wittenzellner, K. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Lengl, M. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Röhrl, S. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Maurer, C. in: PubMed | Google Scholar |

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Klenk, C. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Papargyriou, A. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Schmidleitner, L. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Kabella, N. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Shastri, A. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Fresacher, D. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Harb, F. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Hafez, N. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Bärthel, S. in: PubMed | Google Scholar |

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Lucarelli, D. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Escorial-Iriarte, C. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Orben, F. in: PubMed | Google Scholar |

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Öllinger, R. in: PubMed | Google Scholar |

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

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1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Fricke, L. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Madej, J. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, Munich, Germany.

11German Cancer Consortium (DKTK), partner site Munich, a partnership between German Cancer Research Center (DKFZ) and University Hospital Klinikum rechts der Isar, Munich, Germany.

12DKFZ and DKTK, Heidelberg, Germany.

13Department of Computational Health, Institute of Computational Biology, Helmholtz, Munich, Germany.

14Institute of Molecular Oncology and Functional Genomics, TranslaTUM, TUM School of Medicine, and

15Department of Surgery, University Medical Center, Klinikum rechts der Isar, TUM, Munich, Germany.

16Department of General, Visceral and Pediatric Surgery, University Medical Center Göttingen, Göttingen, Germany.

Address correspondence to: Maximilian Reichert, Medical Clinic and Polyclinic II, Klinikum rechts der Isar, Technical University Munich, Ismaninger Str. 22, 81675 Munich, Germany. Email: maximilian.reichert@tum.de.

Find articles by Wustrow, P. in: PubMed | Google Scholar

1Translational Pancreatic Cancer Research Center and

2Technical University Munich (TUM) School of Medicine and Health, Department of Clinical Medicine – Clinical Department for Internal Medicine II, University Medical Center, TUM, Munich, Germany.

3Chair for Data Processing, TUM, Munich, Germany.

4Heinz Nixdorf Chair of Biomedical Electronics, TranslaTUM;

5Center for Protein Assemblies (CPA); and

6Center for Organoid Systems (COS), TUM, Garching, Germany.

7Bavarian Cancer Research Center (BZKF), Munich, Germany.

8Institute of Stem Cell Research, Helmholtz Center Munich, Neuherberg, Germany.

9Chair of Proteomics and Bioanalytics, TUM, Freising, Germany.

10Institute for Translational Cancer Research and Experimental Cancer Therapy, TranslaTUM, TUM, M