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Quercetin alleviates depression in CUMS rats via modulating immune plasticity in the choroid plexus to inhibit hippocampal microglial activation
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Minocycline relieves depressive-like behaviors of mice subjected to ropivacaine-induced seizures
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Discovery of two new co-drugs of celecoxib and gabapentinoids for treating chemotherapy-induced peripheral neuropathy
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Lactobacillus plantarum CCFM639 ameliorates vascular dysfunction in mice with Kawasaki disease involving eNOS/NO pathway
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Clinical significance of intervention in the renin-angiotensin-aldosterone-apelinergic system
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12-HEPE promotes cardiomyocyte proliferation by activating glycolysis and histone lactylation via Hippo signaling
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Luteolin alleviates right ventricular hypertrophy in high altitude pulmonary hypertension rats by regulating PI3K/AKT/mTOR signalling pathway
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Nitrous oxide increases peripheral blood flow and decreases plasma adrenaline and noradrenaline concentrations in human volunteers: An in vivo nonrandomized clinical and in vitro chromaffin cell culture study
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Optimizing dose selection for doxorubicin-induced cardiotoxicity in mice: A comprehensive analysis of single and multiple-dose regimens
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EDIL3 regulates pulmonary artery smooth muscle cell proliferation and migration via integrin αVβ3/ERK1/2 axis in pulmonary hypertension
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Lithospermic acid improves diabetic kidney fibrosis by regulating Piezo1/TGF-β1/Smad signaling pathway
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Significance of ALDH3A2, a mitochondrial metabolism and glycolysis related gene, in pulmonary arterial hypertension
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Mesenchymal stem cells overexpressing CYP46A1 inhibit lipopolysaccharide-induced lipid accumulation and neuroinflammation in N9 microglial cells
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FS145 exerts anti-inflammatory and analgesic effects through blocking integrin αvβ3 on macrophages
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A 1:1 combination of cannabidiol and Δ9-tetrahydrocannabinol inhibit toll-like receptor 7- and 8-mediated inflammation in human immune cells
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Hydroxypropyl-β-cyclodextrin inclusion complex improves the percutaneous therapeutic effect of eugenol on psoriasis mice
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Eupatilin protects against isotretinoin induced hepatotoxicity through immunomodulation of TLR4/MyD88/TRAF6 and NF-κB/NrF2 pathways
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Assessing biosimilarity of insulin aspart injection and NovoRapid® through pharmacokinetic and pharmacodynamic comparisons in healthy volunteers: A double-blind, randomized, crossover study
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Novel mechanisms of metformin-induced vasorelaxation of mesenteric arterioles via endothelium-dependent hyperpolarization to treat murine colitis
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IRAS/Nischarin is associated with attenuated deficit of cognition during morphine abstinence in mice
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Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
CCR4 and CD25 are highly expressed on the surface of cutaneous T-cell lymphoma (CTCL). The two receptors can be used for t...
Corrigendum to “SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation”[Eur. J. Pharmacol. 924 (2022) 174980]
Corrigendum to “SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation”[Eur. J. Pharmacol. 924 (2022) 174980]
Volume 968, 5 April 2024, 176456Author links open overlay panelAnbo Gao a c, Jin Zou e, Zhenjiang Mao b, Hong Zhou d, Gaof...
A new era of immune therapeutics for pancreatic cancer: Monoclonal antibodies paving the way
A new era of immune therapeutics for pancreatic cancer: Monoclonal antibodies paving the way
Pancreatic cancer, with the prevalent form being pancreatic ductal adenocarcinoma (PDAC), accounts for more than 90% of pa...
Pharmacological insights on novel oral selective estrogen receptor degraders in breast cancer
Pharmacological insights on novel oral selective estrogen receptor degraders in breast cancer
The therapeutic landscape of estrogen receptor (ER)-positive breast cancer includes endocrine treatments with aromatase in...
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway
Diabetes, characterized by chronically elevated blood glucose levels, primarily manifests as Type 2 diabetes mellitus (T2D...
Ursolic acid alleviates cancer cachexia by inhibiting STAT3 signaling pathways in C2C12 myotube and CT26 tumor-bearing mouse model
Ursolic acid alleviates cancer cachexia by inhibiting STAT3 signaling pathways in C2C12 myotube and CT26 tumor-bearing mouse model
Cancer cachexia is a multifactorial wasting syndrome accompanied by an unwanted loss of body weight, primarily reflected i...
Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
Fluoroquinolones (FQs), commonly known for their antibiotic properties, exhibit additional pharmacological potential with ...
FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury
FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury
Stroke is the second leading cause of disability and death worldwide (Campbell et al., 2019), In 2016, there were 13.7 mil...
MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells
MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells
Pancreatic cancer is an extremely malignant tumor, and only a few clinical treatment options exist. MFG-E8 and kindlin-2 a...
The blockade of neuropeptide FF receptor 1 and 2 differentially contributed to the modulating effects on fentanyl-induced analgesia and hyperalgesia in mice
The blockade of neuropeptide FF receptor 1 and 2 differentially contributed to the modulating effects on fentanyl-induced analgesia and hyperalgesia in mice
The endogenous opioid-modulating peptide Neuropeptide FF (NPFF, FLFQPQRFamide) activates Neuropeptide FF Receptors 1 and 2...
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