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Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
Toxicology, pharmacokinetics, and immunogenicity studies of CCR4-IL2 bispecific immunotoxin in rats and minipigs
CCR4 and CD25 are highly expressed on the surface of cutaneous T-cell lymphoma (CTCL). The two receptors can be used for t...
Corrigendum to “SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation”[Eur. J. Pharmacol. 924 (2022) 174980]
Corrigendum to “SUMO2-mediated SUMOylation of SH3GLB1 promotes ionizing radiation-induced hypertrophic cardiomyopathy through mitophagy activation”[Eur. J. Pharmacol. 924 (2022) 174980]
Volume 968, 5 April 2024, 176456Author links open overlay panelAnbo Gao a c, Jin Zou e, Zhenjiang Mao b, Hong Zhou d, Gaof...
A new era of immune therapeutics for pancreatic cancer: Monoclonal antibodies paving the way
A new era of immune therapeutics for pancreatic cancer: Monoclonal antibodies paving the way
Pancreatic cancer, with the prevalent form being pancreatic ductal adenocarcinoma (PDAC), accounts for more than 90% of pa...
Pharmacological insights on novel oral selective estrogen receptor degraders in breast cancer
Pharmacological insights on novel oral selective estrogen receptor degraders in breast cancer
The therapeutic landscape of estrogen receptor (ER)-positive breast cancer includes endocrine treatments with aromatase in...
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway
Diabetes, characterized by chronically elevated blood glucose levels, primarily manifests as Type 2 diabetes mellitus (T2D...
Ursolic acid alleviates cancer cachexia by inhibiting STAT3 signaling pathways in C2C12 myotube and CT26 tumor-bearing mouse model
Ursolic acid alleviates cancer cachexia by inhibiting STAT3 signaling pathways in C2C12 myotube and CT26 tumor-bearing mouse model
Cancer cachexia is a multifactorial wasting syndrome accompanied by an unwanted loss of body weight, primarily reflected i...
Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
Fluoroquinolones upregulate insulin-like growth factor–binding protein 3, inhibit cell growth and insulin-like growth factor signaling
Fluoroquinolones (FQs), commonly known for their antibiotic properties, exhibit additional pharmacological potential with ...
FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury
FDA compound library screening Baicalin upregulates TREM2 for the treatment of cerebral ischemia-reperfusion injury
Stroke is the second leading cause of disability and death worldwide (Campbell et al., 2019), In 2016, there were 13.7 mil...
MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells
MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells
Pancreatic cancer is an extremely malignant tumor, and only a few clinical treatment options exist. MFG-E8 and kindlin-2 a...
The blockade of neuropeptide FF receptor 1 and 2 differentially contributed to the modulating effects on fentanyl-induced analgesia and hyperalgesia in mice
The blockade of neuropeptide FF receptor 1 and 2 differentially contributed to the modulating effects on fentanyl-induced analgesia and hyperalgesia in mice
The endogenous opioid-modulating peptide Neuropeptide FF (NPFF, FLFQPQRFamide) activates Neuropeptide FF Receptors 1 and 2...
γ-Glutamylcysteine ameliorates blood-brain barrier permeability and neutrophil extracellular traps formation after ischemic stroke by modulating Wnt/β-catenin signalling in mice
γ-Glutamylcysteine ameliorates blood-brain barrier permeability and neutrophil extracellular traps formation after ischemic stroke by modulating Wnt/β-catenin signalling in mice
The blood-brain barrier (BBB), often referred to as the guardian of the brain, plays a fundamental role in establishing an...
Effects of olanzapine on hippocampal CA3 and the prefrontal cortex local field potentials
Effects of olanzapine on hippocampal CA3 and the prefrontal cortex local field potentials
Olanzapine is an atypical antipsychotic that is reported to be effective without producing the disabling extrapyramidal si...
Prolame produces anxiolytic- and antidepressant-like effects in middle-aged female rats with less uterotrophic effects than 17β-estradiol
Prolame produces anxiolytic- and antidepressant-like effects in middle-aged female rats with less uterotrophic effects than 17β-estradiol
Estrogen hormone replacement therapy (EHRT), improving women's life quality at menopause, reduces anxiety and depression s...
siRNA as potential therapeutic strategy for hypertension
siRNA as potential therapeutic strategy for hypertension
A growing worldwide health concern is hypertension, which is defined by European criteria as an office systolic blood pres...
Tyrosol attenuates NASH features by reprogramming the hepatic immune milieu
Tyrosol attenuates NASH features by reprogramming the hepatic immune milieu
Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, and no drugs have been approved for its t...
Demotion of canonical/non-canonical inflammasome and pyroptosis alleviates ischemia/reperfusion-induced acute kidney injury: Novel role of the D2/D3 receptor agonist ropinirole
Demotion of canonical/non-canonical inflammasome and pyroptosis alleviates ischemia/reperfusion-induced acute kidney injury: Novel role of the D2/D3 receptor agonist ropinirole
Acute renal injury (AKI) is triggered by different factors, but the chief reason is ischemia/reperfusion (I/R) accompanied...
Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κB pathway by a different mechanism from alantolactone
Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κB pathway by a different mechanism from alantolactone
The nuclear factor κB (NF-κB) family of transcription factors comprises five members forming hetero- and homo-dimers that ...
Drug repurposing screen identifies novel anti-inflammatory activity of sunitinib in macrophages
Drug repurposing screen identifies novel anti-inflammatory activity of sunitinib in macrophages
Inflammation is a driver of human disease and an unmet clinical need exists for new anti-inflammatory medicines. As a key ...
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity
The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity
The burden of NAFLD is increasing due to the global obesity epidemic, affecting approximately one-third of the population ...
Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer
Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer
Pancreatic cancer, one of the most severe gastrointestinal malignancies, ranks as the fourth leading cause of tumour-relat...
Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma
Celastrol, which targets IL-2/CD25 binding inhibition, induces T cell-mediated antitumor activity in melanoma
Melanoma is the most aggressive skin cancer and tends to metastasize to other tissues; therefore appropriate treatment in ...
Protective effect of the natural flavonoid naringenin in mouse models of retinal injury
Protective effect of the natural flavonoid naringenin in mouse models of retinal injury
One of the most common causes of irreversible blindness worldwide is glaucoma, which is characterized by cupping or excava...
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Beyond neuromuscular activity: botulinum toxin type A exerts direct central action on spinal control of movement
Used as a pharmaceutical-grade purified low dose preparation, botulinum neurotoxin serotype A (BoNT-A) is employed in vari...
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of Aβ1-42 and tau through regulation of PI3K/Akt signaling pathway
Alzheimer's disease (AD), a common neurodegenerative disease, is characterized by a progressive decline in both cognitive ...
Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats
Microglial activation and toll-like receptor 4-Dependent regulation of angiotensin II type I receptor-mu-opioid receptor 1 heterodimerization and hypertension in fructose-fed rats
Our previous study reported that the heterodimer of Angiotensin II Type I Receptor (AT1R) and Mu-Opioid Receptor 1 (MOR1) ...
Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways
Salidroside attenuates myocardial remodeling in DOCA-salt-induced mice by inhibiting the endothelin 1 and PI3K/AKT/NFκB signaling pathways
Myocardial remodeling, which is a widely recognized independent risk factor for cardiac events (Xie et al., 2022; Yin et a...
maresin2 fine-tunes ULK1 O-GlcNAcylation to improve post myocardial infarction remodeling
maresin2 fine-tunes ULK1 O-GlcNAcylation to improve post myocardial infarction remodeling
Myocardial infarction with a pathogenic basis of thrombosis or vascular occlusion remains a global medical concern charact...
OXM-104, a potential candidate for the treatment of obesity, NASH and type 2 diabetes
OXM-104, a potential candidate for the treatment of obesity, NASH and type 2 diabetes
Non-alcoholic fatty liver disease (NAFLD) is an umbrella term representing two subtypes: non-alcoholic fatty liver and non...
Targets, trials and tribulations in Alzheimer therapeutics
Targets, trials and tribulations in Alzheimer therapeutics
Developing disease-modifying drugs for the treatment of neurodegenerative dis-eases such as Alzheimer's disease (AD) has t...
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy
Vanin1 (VNN1) in chronic diseases: Future directions for targeted therapy
Vanin1 (VNN1) is an exogenous enzyme with pantetheinase activity that mainly exerts physiological functions through enzyme...
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