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FDA approves new non-opioid pain drug
Discover the world’s best science and medicine | Nature.com
The multiple myeloma drug market
The multiple myeloma drug market
Discover the world’s best science and medicine | Nature.com
Novel strategies to manage CAR-T cell toxicity
Novel strategies to manage CAR-T cell toxicity
The immune-related adverse events associated with chimeric antigen receptor (CAR)-T cell therapy result in substa...
Voltage-gated sodium channels in excitable cells as drug targets
Voltage-gated sodium channels in excitable cells as drug targets
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densiti...
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Integrating QSAR modelling and deep learning in drug discovery: the emergence of deep QSAR
Quantitative structure–activity relationship (QSAR) modelling, an approach that was introduced 60 years ago, is wide...
Extracellular targeted protein degradation: an emerging modality for drug discovery
Extracellular targeted protein degradation: an emerging modality for drug discovery
Targeted protein degradation (TPD) has emerged in the past decade as a major new drug modality to remove intracellular pro...
Top product forecasts for 2024
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Upcoming market catalysts in Q1 2024
Upcoming market catalysts in Q1 2024
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FDA approves first chikungunya vaccine
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PROTAC in clinic for autoimmune skin disease
PROTAC in clinic for autoimmune skin disease
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Gene therapy zeroes in on Parkinson disease brain circuits
Gene therapy zeroes in on Parkinson disease brain circuits
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FDA approves first-in-class AKT inhibitor
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A decade of HCV drugs
A decade of HCV drugs
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Antibodies achieve leptin balancing act
Antibodies achieve leptin balancing act
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γ-secretase inhibitor notches first approval
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De-risking rare disease acquisitions: a win–win–win for patients, biotech and investors
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tRNA therapeutics for genetic diseases
tRNA therapeutics for genetic diseases
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their therapeutic potential for the t...
CAAR T cells to treat encephalitis
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A safer polyene antifungal
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USP30 inhibition protects dopaminergic neurons
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Open-science drug discovery for COVID-19
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Antibodies combat Gram-negative pathogen
Antibodies combat Gram-negative pathogen
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Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets
Diseases associated with chronic inflammation constitute a major health burden across the world. As central instigators of...
Tailor made: the art of therapeutic mRNA design
Tailor made: the art of therapeutic mRNA design
mRNA medicine is a new and rapidly developing field in which the delivery of genetic information in the form of mRNA is us...
A call to adapt the regulation of HLA testing for T cell receptor-based therapeutics
Current regulation of T cell receptor (TCR)-based therapeutics may require repeated testing of patients for specific HLA a...
The renal cell carcinoma drug market
The renal cell carcinoma drug market
Discover the world’s best science and medicine | Nature.com
Targeting synapse function and loss for treatment of neurodegenerative diseases
Targeting synapse function and loss for treatment of neurodegenerative diseases
Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate with cognitive decline. However, t...
CRISPR gets the glory in landmark approval, but haemoglobin research made it possible
CRISPR gets the glory in landmark approval, but haemoglobin research made it possible
Stuart Orkin, of Harvard Medical School and HHMI, discusses how the discovery of BCL11A paved the way for Vertex and CRISP...
The pipeline and market for migraine drugs
The pipeline and market for migraine drugs
Discover the world’s best science and medicine | Nature.com
Phosphatase inhibitor drives anticancer immune responses
Phosphatase inhibitor drives anticancer immune responses
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